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EP2490530A4 - COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS - Google Patents

COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS

Info

Publication number
EP2490530A4
EP2490530A4 EP10825785.8A EP10825785A EP2490530A4 EP 2490530 A4 EP2490530 A4 EP 2490530A4 EP 10825785 A EP10825785 A EP 10825785A EP 2490530 A4 EP2490530 A4 EP 2490530A4
Authority
EP
European Patent Office
Prior art keywords
compounds
treatment
methods
bacterial infections
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10825785.8A
Other languages
German (de)
French (fr)
Other versions
EP2490530A1 (en
Inventor
James W Janetka
Zhenfu Han
Scott Hultgren
Jerry Pinkner
Corinne Cusumano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Priority to EP18214928.6A priority Critical patent/EP3492483A1/en
Publication of EP2490530A1 publication Critical patent/EP2490530A1/en
Publication of EP2490530A4 publication Critical patent/EP2490530A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP10825785.8A 2009-10-22 2010-10-22 COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS Withdrawn EP2490530A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18214928.6A EP3492483A1 (en) 2009-10-22 2010-10-22 Compounds and methods for treating bacterial infections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25413509P 2009-10-22 2009-10-22
US32173810P 2010-04-07 2010-04-07
US38453510P 2010-09-20 2010-09-20
PCT/US2010/053848 WO2011050323A1 (en) 2009-10-22 2010-10-22 Compounds and methods for treating bacterial infections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18214928.6A Division EP3492483A1 (en) 2009-10-22 2010-10-22 Compounds and methods for treating bacterial infections

Publications (2)

Publication Number Publication Date
EP2490530A1 EP2490530A1 (en) 2012-08-29
EP2490530A4 true EP2490530A4 (en) 2014-01-22

Family

ID=43900714

Family Applications (2)

Application Number Title Priority Date Filing Date
EP10825785.8A Withdrawn EP2490530A4 (en) 2009-10-22 2010-10-22 COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS
EP18214928.6A Withdrawn EP3492483A1 (en) 2009-10-22 2010-10-22 Compounds and methods for treating bacterial infections

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18214928.6A Withdrawn EP3492483A1 (en) 2009-10-22 2010-10-22 Compounds and methods for treating bacterial infections

Country Status (2)

Country Link
EP (2) EP2490530A4 (en)
WO (1) WO2011050323A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2523448C2 (en) 2008-08-04 2014-07-20 СиЭйчДиАй ФАУНДЕЙШН, Инк, Kynurenine-3-monooxygenase inhibitors
WO2012109263A1 (en) 2011-02-07 2012-08-16 The Washington University Mannoside compounds and methods of use thereof
NZ616764A (en) * 2009-12-14 2014-11-28 Univ Basel Mannose derivatives as antagonists of bacterial adhesion
AU2011207229B2 (en) 2010-01-25 2015-02-12 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2012164074A1 (en) * 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
CA2844521A1 (en) 2011-08-30 2013-03-07 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
DK2750677T3 (en) 2011-08-30 2017-07-10 Chdi Foundation Inc KYNURENIN-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND PROCEDURES FOR USE THEREOF
KR102075885B1 (en) 2012-12-18 2020-02-11 버텍스 파마슈티칼스 인코포레이티드 Mannose derivatives for treating bacterial infections
US9890176B2 (en) * 2013-03-12 2018-02-13 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
ES2959183T3 (en) 2013-05-30 2024-02-21 Washington University St Louis Mannose derivatives and their use in the treatment of bacterial infections
CR20170061A (en) 2014-07-17 2017-07-17 Chdi Foundation Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-RELATED DISORDERS
CN104119407B (en) * 2014-07-31 2017-07-28 济南尚博生物科技有限公司 A kind of synthetic method of the oxygen benzyl β D ribopyranoside glycosides of methyl 2,3,4 3
CN105622685B (en) * 2015-12-31 2019-08-23 杭州科本药业有限公司 A kind of glycosyl benzimidazole compound and its preparation method and application
KR20180128937A (en) 2016-03-23 2018-12-04 핌브리온 세러퓨틱스 인코포레이티드 Mannose-derived antagonists of FIMH useful for treating diseases
JP2021500921A (en) 2017-10-16 2021-01-14 アンテローム New tool for evaluating the therapeutic efficiency of FIMH blockers
PT3762368T (en) 2018-03-08 2022-05-06 Incyte Corp Aminopyrazine diol compounds as pi3k-y inhibitors
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
DK3820856T3 (en) 2018-07-10 2022-10-24 Glaxosmithkline Ip Dev Ltd C-Mannoside compounds that can be used to treat urinary tract infections
EP3897630B1 (en) 2018-12-21 2024-01-10 Celgene Corporation Thienopyridine inhibitors of ripk2
BR112021022281A2 (en) * 2019-05-07 2021-12-28 Fimbrion Therapeutics Inc New compounds
WO2020254369A1 (en) 2019-06-19 2020-12-24 Glaxosmithkline Intellectual Property Development Limited Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of fimh
CN111423478A (en) * 2020-04-16 2020-07-17 山东大学 A kind of xylose containing propargyl and its synthesis method
CN117986219A (en) * 2022-08-22 2024-05-07 三峡大学 A method for preparing thioglycosides from 6-aryl/alkylthio-2H-pyran-3-one compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383092A2 (en) * 1989-02-13 1990-08-22 Bayer Corporation Chromogenic merocyanine enzyme substrates
US20070167378A1 (en) * 2003-10-08 2007-07-19 Saraiva Maria Joao M Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420127B1 (en) * 1994-11-18 2002-07-16 Washington University Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
EP1755619A2 (en) * 2004-03-23 2007-02-28 VIB vzw Anti-adhesive compounds to prevent and treat bacterial infections

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383092A2 (en) * 1989-02-13 1990-08-22 Bayer Corporation Chromogenic merocyanine enzyme substrates
US20070167378A1 (en) * 2003-10-08 2007-07-19 Saraiva Maria Joao M Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A. STOLL ET AL: "Das Furocumarin und die beta-D-Glucosido-furocumarinsäure aus den Samen von Coronilla-Arten. 23. Mitteilung über Herzglykoside", HELVETICA CHIMICA ACTA, vol. 33, no. 6, 1 January 1950 (1950-01-01), pages 1637 - 1647, XP055094084, ISSN: 0018-019X, DOI: 10.1002/hlca.19500330631 *
DENNIS A. SHUMAN ET AL: "Synthesis and biological activity of certain 8-mercaptopurine and 6-mercaptopyrimidine S-nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 12, no. 4, 1 July 1969 (1969-07-01), pages 653 - 657, XP055094096, ISSN: 0022-2623, DOI: 10.1021/jm00304a021 *
FAROUK M E ABDEL-MEGEID ET AL: "PREPARATION AND SOME REACTIONS OF D-GLUCOSYL DERIVATIVES OF 2-THIOXO-1,3,4-OXADIAZOLES AND 2-THIOXO- 1,3,4-THIADIAZOLES AND THEIR 2-OXO ANALOGUES*", CARBOHYDRATE RESEARCH, vol. 59, 1 January 1977 (1977-01-01), pages 95 - 102, XP055094075 *
NORIKO NAGAHORI ET AL: "Inhibition of Adhesion of Type 1 Fimbriated Escherichia coli to Highly Mannosylated Ligands Shin-Ichiro Nishimura, [b]", CHEMBIOCHEM, vol. 50, no. 3, 1 January 2002 (2002-01-01), pages 836 - 844, XP055094204 *
R BOGNAR: "N-GLYKOSYL-DERIVATE 'l-F.IL XIII. DER NACHTRÄGLICHE AUSBAU DES AGLYKONS. SYNTHESE VON N-GLYKOSYL- DERIVATEN DES 2-AMINO-THIAZOLS, 2-AMINO-1,3,4-THIADIAZOLS UND 5-AMINO-1,2,3,4-THIATRIAZOLS", CARBOHYDRATE RESEARCH, vol. 5, 1 January 1967 (1967-01-01), pages 320 - 328, XP055094071 *
See also references of WO2011050323A1 *
V. S. TAILE ET AL: "Synthesis and biological evaluation of novel 2-(4-O-[beta]-D-glucosidoxyphenyl)-4,5-disubstituted imidazoles", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 47, no. 4, 17 July 2010 (2010-07-17), pages 903 - 907, XP055094097, ISSN: 0022-152X, DOI: 10.1002/jhet.433 *
W. T. HASKINS: "Reliations between Rotatory Power and Structure in the Sugar Group. XXXV. Some 2'-Naohthyl 1-Thioglycopyranosides and their Acetates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 69, no. 7, 19 July 1947 (1947-07-19), pages 1668 - 1672, XP055094092, ISSN: 0002-7863, DOI: 10.1021/ja01199a030 *
ZHENFU HAN ET AL: "Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 8, 26 April 2012 (2012-04-26), pages 3945 - 3959, XP055065272, ISSN: 0022-2623, DOI: 10.1021/jm300165m *

Also Published As

Publication number Publication date
WO2011050323A1 (en) 2011-04-28
EP3492483A1 (en) 2019-06-05
EP2490530A1 (en) 2012-08-29

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Inventor name: HULTGREN, SCOTT

Inventor name: CUSUMANO, CORINNE

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