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EP2340245A4 - Nouveau co-cristal de bétaïne d'épalrestat - Google Patents

Nouveau co-cristal de bétaïne d'épalrestat

Info

Publication number
EP2340245A4
EP2340245A4 EP09801070A EP09801070A EP2340245A4 EP 2340245 A4 EP2340245 A4 EP 2340245A4 EP 09801070 A EP09801070 A EP 09801070A EP 09801070 A EP09801070 A EP 09801070A EP 2340245 A4 EP2340245 A4 EP 2340245A4
Authority
EP
European Patent Office
Prior art keywords
epalrestat
novel betaine
betaine cocrystal
cocrystal
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09801070A
Other languages
German (de)
English (en)
Other versions
EP2340245A2 (fr
Inventor
Isabel Kalofonos
Patrick G Stahly
William Martin-Doyle
Dimitris Kalofonos
Jeffrey S Stults
Travis L Houston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bionevia Pharmaceuticals Inc
Original Assignee
Bionevia Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionevia Pharmaceuticals Inc filed Critical Bionevia Pharmaceuticals Inc
Publication of EP2340245A2 publication Critical patent/EP2340245A2/fr
Publication of EP2340245A4 publication Critical patent/EP2340245A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
EP09801070A 2008-07-25 2009-07-24 Nouveau co-cristal de bétaïne d'épalrestat Withdrawn EP2340245A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8361908P 2008-07-25 2008-07-25
PCT/US2009/051693 WO2010011926A2 (fr) 2008-07-25 2009-07-24 Nouveau co-cristal de bétaïne d'épalrestat

Publications (2)

Publication Number Publication Date
EP2340245A2 EP2340245A2 (fr) 2011-07-06
EP2340245A4 true EP2340245A4 (fr) 2011-09-28

Family

ID=41570882

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09801070A Withdrawn EP2340245A4 (fr) 2008-07-25 2009-07-24 Nouveau co-cristal de bétaïne d'épalrestat

Country Status (3)

Country Link
EP (1) EP2340245A4 (fr)
EA (1) EA018905B1 (fr)
WO (1) WO2010011926A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697735B2 (en) 2008-07-25 2014-04-15 Bionevia Pharmaceuticals, Inc. Solid forms of epalrestat
EA016904B1 (ru) 2008-09-06 2012-08-30 Бионевия Фармасьютикалс, Инк. Новый холиновый сокристалл эпалрестата
RS54447B1 (sr) 2011-01-20 2016-06-30 Bionevia Pharmaceuticals Inc. Modifikovano oslobađajuće kompozicije epalrestata ili njegovih derivata i postupci njihove upotrebe
ITMI20120586A1 (it) 2012-04-11 2013-10-12 Milano Politecnico Co-cristalli di 3-iodiopropinil butilcarbammato
CN113336718B (zh) * 2021-06-01 2023-02-28 天津大学 依帕司他-二甲双胍盐及其制备方法和应用
CN113277962B (zh) * 2021-06-01 2023-02-07 天津大学 依帕司他-二甲双胍盐水合物及其制备方法和应用
CN115925650B (zh) * 2022-12-13 2023-08-01 山东达因海洋生物制药股份有限公司 一种依帕司他共晶及其制备方法和应用
CN115947699B (zh) * 2023-01-16 2024-01-19 威海海洋职业学院 以烟酰胺为前驱体的依帕司他共晶及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078161A1 (fr) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions co-cristallines pharmaceutiques de medicaments, notamment de carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophene, aspirine, flurbiprofene, phenytoine et ibuprofene
JP2007099680A (ja) * 2005-10-04 2007-04-19 Konica Minolta Chemical Co Ltd エパルレスタット製造法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740478A (en) * 1980-08-22 1982-03-06 Ono Pharmaceut Co Ltd Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
CA2548281C (fr) * 2003-12-09 2013-11-12 Medcrystalforms, Llc Procede de preparation de cocristaux a phase mixte avec des agents actifs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078161A1 (fr) * 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Compositions co-cristallines pharmaceutiques de medicaments, notamment de carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophene, aspirine, flurbiprofene, phenytoine et ibuprofene
JP2007099680A (ja) * 2005-10-04 2007-04-19 Konica Minolta Chemical Co Ltd エパルレスタット製造法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATTHEW L. PETERSON ET AL: "Expanding the Scope of Crystal Form Evaluation in Pharmaceu tical Science", J PHARM PHARMACEUT SCI, 1 January 2006 (2006-01-01), pages 317 - 326, XP055020303, Retrieved from the Internet <URL:http://www.ualberta.ca/~csps/JPPS9_3/Peterson/676_Final.pdf> [retrieved on 20120224] *

Also Published As

Publication number Publication date
WO2010011926A3 (fr) 2010-05-27
EP2340245A2 (fr) 2011-07-06
EA018905B1 (ru) 2013-11-29
WO2010011926A2 (fr) 2010-01-28
EA201100246A1 (ru) 2011-10-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20110330

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: AL BA RS

A4 Supplementary search report drawn up and despatched

Effective date: 20110829

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 3/10 20060101ALI20110823BHEP

Ipc: A61K 31/20 20060101ALI20110823BHEP

Ipc: A61K 31/25 20060101ALI20110823BHEP

Ipc: C07D 277/36 20060101AFI20110823BHEP

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20130319

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INTG Intention to grant announced

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Effective date: 20140228