EP2280010A3 - Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine dérivés d'alcanes azabicycliques - Google Patents

Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine dérivés d'alcanes azabicycliques Download PDF

Info

Publication number: EP2280010A3
Authority: EP; European Patent Office
Prior art keywords: receptor activity; acetylcholine receptor; nicotinic acetylcholine; alkane derivatives; activity modulators
Prior art date: 2007-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP10173074A

Other languages

German (de)

English (en)

Other versions

EP2280010A2 (fr

EP2280010B1 (fr

Inventor

Jianguo Ji

Tao Li

Kevin B. Sippy

Chih-Hung Lee

Murali Gopalakrishnan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-21

Filing date

2008-11-20

Publication date

2011-05-04

2008-11-20 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2011-02-02 Publication of EP2280010A2 publication Critical patent/EP2280010A2/fr

2011-05-04 Publication of EP2280010A3 publication Critical patent/EP2280010A3/fr

2012-12-19 Application granted granted Critical

2012-12-19 Publication of EP2280010B1 publication Critical patent/EP2280010B1/fr

Status Active legal-status Critical Current

2028-11-20 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Addiction (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)

EP10173074A 2007-11-21 2008-11-20 Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine dérivés d'alcanes azabicycliques Active EP2280010B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98953807P	2007-11-21	2007-11-21
EP08852111A EP2231657A1 (fr)	2007-11-21	2008-11-20	Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
EP08852111.7 Division		2008-11-20

Publications (3)

Publication Number	Publication Date
EP2280010A2 EP2280010A2 (fr)	2011-02-02
EP2280010A3 true EP2280010A3 (fr)	2011-05-04
EP2280010B1 EP2280010B1 (fr)	2012-12-19

Family

ID=40263587

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP10173074A Active EP2280010B1 (fr)	2007-11-21	2008-11-20	Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine dérivés d'alcanes azabicycliques
EP08852111A Withdrawn EP2231657A1 (fr)	2007-11-21	2008-11-20	Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP08852111A Withdrawn EP2231657A1 (fr)	2007-11-21	2008-11-20	Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine

Country Status (21)

Country	Link
US (2)	US7902222B2 (fr)
EP (2)	EP2280010B1 (fr)
JP (2)	JP5693229B2 (fr)
KR (1)	KR20100090706A (fr)
CN (1)	CN101925599A (fr)
AU (1)	AU2008326360A1 (fr)
BR (1)	BRPI0820418A2 (fr)
CA (1)	CA2705296A1 (fr)
CO (1)	CO6280476A2 (fr)
CR (1)	CR11522A (fr)
DO (1)	DOP2010000149A (fr)
EC (1)	ECSP10010296A (fr)
GT (1)	GT201000146A (fr)
IL (1)	IL205763A0 (fr)
MX (1)	MX2010005648A (fr)
NZ (1)	NZ585055A (fr)
RU (1)	RU2010125121A (fr)
SG (1)	SG186018A1 (fr)
UA (1)	UA99936C2 (fr)
WO (1)	WO2009067579A1 (fr)
ZA (1)	ZA201003289B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
HRP20110917T1 (hr) *	2006-05-19	2012-03-31	Abbott Laboratories	Derivati azabicikličkih alkana supstituirani fuzioniranim bicikloheterociklima aktivni u središnjem živčanom sustavu
NZ585055A (en) *	2007-11-21	2012-07-27	Abbott Lab	Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators
FR2937641A1 (fr) *	2008-10-28	2010-04-30	Sanofi Aventis	Derives d'urees de tropane, leur preparation et leur application en therapeutique
MY173229A (en)	2008-11-19	2020-01-07	Forum Pharmaceuticals Inc	Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
RU2011150248A (ru) *	2009-05-11	2013-06-20	Энвиво Фармасьютикалз, Инк.	Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы
RU2560729C2 (ru)	2010-01-11	2015-08-20	АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи	Модуляторы никотиновых ацетилхолиновых рецепторов
PT3029039T (pt)	2010-05-17	2017-11-28	Forum Pharmaceuticals Inc	Formulações farmacêuticas que compreendem formas cristalinas de cloridrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo(b)tiofeno-2-carboxamida mono-hidratado
AU2012230890A1 (en)	2011-03-22	2013-09-26	Amgen Inc.	Azole compounds as Pim inhibitors
EP2846796A4 (fr)	2012-05-08	2015-10-21	Forum Pharmaceuticals Inc	Procédés de maintien, de traitement ou d'amélioration de la fonction cognitive
US8969562B2 (en)	2013-03-12	2015-03-03	Abbvie, Inc.	Azaadamantane formate ester and process for preparing azaadamantane derivatives
WO2016100184A1 (fr)	2014-12-16	2016-06-23	Forum Pharmaceuticals, Inc.	Composés amide de quinuclidine à substituants géminal, en tant qu'agonistes des récepteurs nicotiniques de l'acétylcholine α7
WO2016201096A1 (fr)	2015-06-10	2016-12-15	Forum Pharmaceuticals, Inc.	Composés d'aminobenzisoxazole en tant qu'agonistes des récepteurs de l'acétylcholine α7-nicotinique
WO2017027600A1 (fr)	2015-08-12	2017-02-16	Forum Pharmaceuticals, Inc.	Composés d'aminobenzisoxazole à substitution géminale utilisés en tant qu'agonistes de récepteurs de l'acétylcholine α7-nicotinique
EP3882236B1 (fr) *	2015-11-10	2023-01-11	Kyushu University National University Corporation	Procédé de production de 2,5-dicyano-3,6-dihalogénopyrazine
CN111499615B (zh)	2017-08-04	2024-02-02	斯基霍克疗法公司	用于调节剪接的方法和组合物
CN109593088B (zh) *	2018-12-27	2022-03-25	华东理工大学	氮杂双环衍生物及其制备和应用
JP2022519294A (ja) *	2019-02-04	2022-03-22	スカイホーク・セラピューティクス・インコーポレーテッド	スプライシングを調節するための方法および組成物
CN114007613A (zh)	2019-02-05	2022-02-01	斯基霍克疗法公司	用于调节剪接的方法和组合物
JP7603595B2 (ja)	2019-02-06	2024-12-20	スカイホーク・セラピューティクス・インコーポレーテッド	スプライシングを調節するための方法および組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000071520A2 (fr) *	1999-05-24	2000-11-30	Targacept, Inc.	Compositions pharmaceutiques et methodes d'utilisation
WO2003062235A1 (fr) *	2002-01-17	2003-07-31	Eli Lilly And Company	Modulateurs de recepteurs de l'acetylcholine
WO2004037823A1 (fr) *	2002-10-28	2004-05-06	Pfizer Products Inc.	Composes puriniques et leurs utilisations comme ligands de recepteurs des cannabinoides
WO2006101745A2 (fr) *	2005-03-18	2006-09-28	Abbott Laboratories	Ligand du recepteur nicotinique neuronal ?7 et compositions antipsychotiques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU222116B1 (hu) *	1993-08-19	2003-04-28	Novo Nordisk A/S	Azabiciklo-tiadiazol- vagy azabiciklo-oxadiazol-származékok alkalmazása antipszichotikus hatású gyógyszerkészítmények előállítására
US5821371A (en) *	1994-10-24	1998-10-13	Eli Lilly And Comany	Heterocyclic compounds and their preparation and use
US5880121A (en) *	1996-01-05	1999-03-09	Hoechst Marion Roussel Inc.	4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
US7202363B2 (en) *	2003-07-24	2007-04-10	Abbott Laboratories	Thienopyridine and furopyridine kinase inhibitors
US20050065178A1 (en) *	2003-09-19	2005-03-24	Anwer Basha	Substituted diazabicycloakane derivatives
GB0415746D0 (en) *	2004-07-14	2004-08-18	Novartis Ag	Organic compounds
US7897766B2 (en) *	2005-09-23	2011-03-01	Abbott Laboratories	Amino-aza-adamantane derivatives and methods of use
TW200806662A (en) *	2005-12-01	2008-02-01	Organon Nv	8-azabicyclo[3.2.1]octane derivatives
HRP20110917T1 (hr) *	2006-05-19	2012-03-31	Abbott Laboratories	Derivati azabicikličkih alkana supstituirani fuzioniranim bicikloheterociklima aktivni u središnjem živčanom sustavu
NZ585055A (en) *	2007-11-21	2012-07-27	Abbott Lab	Biaryl substituted azabicyclic alkane derivatives as nicotinic acetylcholine receptor activity modulators

2008
- 2008-11-20 NZ NZ585055A patent/NZ585055A/en not_active IP Right Cessation
- 2008-11-20 EP EP10173074A patent/EP2280010B1/fr active Active
- 2008-11-20 US US12/274,529 patent/US7902222B2/en not_active Expired - Fee Related
- 2008-11-20 EP EP08852111A patent/EP2231657A1/fr not_active Withdrawn
- 2008-11-20 RU RU2010125121/04A patent/RU2010125121A/ru not_active Application Discontinuation
- 2008-11-20 BR BRPI0820418-7A patent/BRPI0820418A2/pt not_active IP Right Cessation
- 2008-11-20 SG SG2012085437A patent/SG186018A1/en unknown
- 2008-11-20 CA CA2705296A patent/CA2705296A1/fr not_active Abandoned
- 2008-11-20 CN CN2008801252360A patent/CN101925599A/zh active Pending
- 2008-11-20 MX MX2010005648A patent/MX2010005648A/es active IP Right Grant
- 2008-11-20 WO PCT/US2008/084148 patent/WO2009067579A1/fr not_active Ceased
- 2008-11-20 JP JP2010535054A patent/JP5693229B2/ja not_active Expired - Fee Related
- 2008-11-20 KR KR1020107013615A patent/KR20100090706A/ko not_active Withdrawn
- 2008-11-20 AU AU2008326360A patent/AU2008326360A1/en not_active Abandoned
- 2008-11-20 UA UAA201007604A patent/UA99936C2/ru unknown
2010
- 2010-05-10 ZA ZA2010/03289A patent/ZA201003289B/en unknown
- 2010-05-13 IL IL205763A patent/IL205763A0/en unknown
- 2010-05-19 GT GT201000146A patent/GT201000146A/es unknown
- 2010-05-19 DO DO2010000149A patent/DOP2010000149A/es unknown
- 2010-06-03 CO CO10067133A patent/CO6280476A2/es not_active Application Discontinuation
- 2010-06-21 EC EC2010010296A patent/ECSP10010296A/es unknown
- 2010-06-21 CR CR11522A patent/CR11522A/es not_active Application Discontinuation
2011
- 2011-01-27 US US13/014,947 patent/US8853241B2/en not_active Expired - Fee Related
2014
- 2014-12-25 JP JP2014261773A patent/JP2015110583A/ja active Pending

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000071520A2 (fr) *	1999-05-24	2000-11-30	Targacept, Inc.	Compositions pharmaceutiques et methodes d'utilisation
WO2003062235A1 (fr) *	2002-01-17	2003-07-31	Eli Lilly And Company	Modulateurs de recepteurs de l'acetylcholine
WO2004037823A1 (fr) *	2002-10-28	2004-05-06	Pfizer Products Inc.	Composes puriniques et leurs utilisations comme ligands de recepteurs des cannabinoides
WO2006101745A2 (fr) *	2005-03-18	2006-09-28	Abbott Laboratories	Ligand du recepteur nicotinique neuronal ?7 et compositions antipsychotiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
G. P. BASMADJIAN ET AL.: "Pain Mechanism and Management: Design of Novel Nicotinic Acetylcholine Receptor Agonists with Potential Antinociceptive Activity", 1998, IOS PRESS, AMSTERDAM, ISBN: 9051993064, XP002902822 *

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EP2280010A2 (fr)	2011-02-02
JP5693229B2 (ja)	2015-04-01
EP2280010B1 (fr)	2012-12-19
US20110124676A1 (en)	2011-05-26
CA2705296A1 (fr)	2009-05-28
JP2015110583A (ja)	2015-06-18
SG186018A1 (en)	2012-12-28
BRPI0820418A2 (pt)	2015-05-19
US20090192186A1 (en)	2009-07-30
ZA201003289B (en)	2012-10-31
GT201000146A (es)	2012-04-19
US8853241B2 (en)	2014-10-07
CN101925599A (zh)	2010-12-22
ECSP10010296A (es)	2010-07-30
NZ585055A (en)	2012-07-27
WO2009067579A1 (fr)	2009-05-28
RU2010125121A (ru)	2011-12-27
AU2008326360A1 (en)	2009-05-28
CO6280476A2 (es)	2011-05-20
DOP2010000149A (es)	2010-06-30
IL205763A0 (en)	2010-11-30
EP2231657A1 (fr)	2010-09-29
CR11522A (es)	2010-08-12
US7902222B2 (en)	2011-03-08
JP2011504181A (ja)	2011-02-03
KR20100090706A (ko)	2010-08-16
MX2010005648A (es)	2010-06-02
UA99936C2 (en)	2012-10-25

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EP2280010A3 (fr)	2011-05-04	Dérivés d'alcane azabicyclique à substitution biaryle en tant que modulateurs de l'activité du récepteur nicotinique de l'acétylcholine dérivés d'alcanes azabicycliques
WO2007109120A3 (fr)	2007-12-27	Composés d'imidazolothiazole pour le traitement de maladies
WO2007076070A3 (fr)	2007-10-25	Modulateurs de recepteurs muscariniques
WO2010054158A3 (fr)	2010-08-19	Modulateurs stéroïdiens du récepteur des glucocorticoïdes
WO2009129267A3 (fr)	2010-02-04	Inhibiteurs de petites molécules du domaine d'homologie de la pleckstrine, et leurs méthodes d'utilisation
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WO2011032169A3 (fr)	2011-07-21	Compositions et formulations pharmaceutiques comprenant des inhibiteurs du domaine d'homologie à la pleckstrine et leurs méthodes d'utilisation
WO2009100294A3 (fr)	2009-11-12	Dérivés d'amide en tant que modulateurs allostériques positifs et procédés d'utilisation associés
WO2008021375A3 (fr)	2008-07-24	Modulateurs de récepteurs muscariniques
MY148780A (en)	2013-05-31	Tricyclic compounds, compositions, and methods
WO2010127152A3 (fr)	2011-09-29	Composés et compositions comme inhibiteurs de la prostaglandine e synthase-1 microsomale
WO2010033543A3 (fr)	2010-11-18	Composés inédits utilisables en tant que ligands des récepteurs cannabinoïdes
WO2007100664A3 (fr)	2008-03-06	Modulateurs des récepteurs muscariniques
WO2009145996A3 (fr)	2010-03-18	Dérivés d’amide en tant que modulateurs allostériques positifs et procédés d’utilisation de ceux-ci
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WO2009038673A3 (fr)	2009-08-20	Modulateurs du récepteur d'histamine h4 de types thiéno- et furo-pyrimidine
WO2010102778A3 (fr)	2010-12-16	3-aminoisoxazolopyridines substituées en tant que modulateurs de kcnq 2/3
WO2011149993A3 (fr)	2012-04-05	Octahydrocyclopenta [c] pyrroles substitués utilisés en tant que modulateurs des canaux calciques
WO2009037542A3 (fr)	2009-05-22	Composés spirocycliques en tant qu'inhibiteurs de stéaroyle coa désaturase
WO2008011006A3 (fr)	2008-06-19	Procédé pour traiter la douleur et rechercher systématiquement des composés analgésiques
WO2008059339A3 (fr)	2008-07-24	Dérivés d'isoquinoline comme modulateurs des récepteurs vanilloïdes
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WO2010057088A3 (fr)	2010-10-14	Modulateurs de pyrrolidinyle de récepteurs nicotiniques d'acétylcholine

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