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EP2113264A3 - Implant containing a surface with decreased thrombogenicity - Google Patents

Implant containing a surface with decreased thrombogenicity Download PDF

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Publication number
EP2113264A3
EP2113264A3 EP09157616A EP09157616A EP2113264A3 EP 2113264 A3 EP2113264 A3 EP 2113264A3 EP 09157616 A EP09157616 A EP 09157616A EP 09157616 A EP09157616 A EP 09157616A EP 2113264 A3 EP2113264 A3 EP 2113264A3
Authority
EP
European Patent Office
Prior art keywords
implant containing
human
implants
animal organism
decreased thrombogenicity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09157616A
Other languages
German (de)
French (fr)
Other versions
EP2113264A2 (en
Inventor
Alexander Borck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotronik VI Patent AG
Original Assignee
Biotronik VI Patent AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotronik VI Patent AG filed Critical Biotronik VI Patent AG
Publication of EP2113264A2 publication Critical patent/EP2113264A2/en
Publication of EP2113264A3 publication Critical patent/EP2113264A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/12—Polypeptides, proteins or derivatives thereof, e.g. degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft Implantate für einen menschlichen oder tierischen Organismus umfassend eine Oberfläche mit verringerten thrombogenen Eigenschaften, Verfahren zur Herstellung der erfindungsgemäßen Implantate sowie Verwendung der erfindungsgemäßen Implantate zur Verringerung der Dosis und/oder der Konzentration der Verabreichung einer systemischen Begleitmedikation mit ein oder mehreren blutgerinnungshemmenden Wirkstoffen vor, während und/oder nach Implantateinsetzung in einen menschlichen oder tierischen Organismus.

Figure imgaf001
The present invention relates to implants for a human or animal organism comprising a surface with reduced thrombogenic properties, methods for producing the implants according to the invention and use of the implants according to the invention for reducing the dose and / or the concentration of administration of a systemic concomitant medication with one or more anticoagulant agents before, during and / or after implant placement in a human or animal organism.
Figure imgaf001
EP09157616A 2008-05-02 2009-04-08 Implant containing a surface with decreased thrombogenicity Withdrawn EP2113264A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008021894A DE102008021894A1 (en) 2008-05-02 2008-05-02 Implant comprising a surface with reduced thrombogenicity

Publications (2)

Publication Number Publication Date
EP2113264A2 EP2113264A2 (en) 2009-11-04
EP2113264A3 true EP2113264A3 (en) 2010-03-31

Family

ID=40996787

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09157616A Withdrawn EP2113264A3 (en) 2008-05-02 2009-04-08 Implant containing a surface with decreased thrombogenicity

Country Status (3)

Country Link
US (1) US20090274737A1 (en)
EP (1) EP2113264A3 (en)
DE (1) DE102008021894A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8496953B2 (en) * 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US20080279909A1 (en) * 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US8986713B2 (en) * 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US9114194B2 (en) * 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
JP2009545407A (en) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド End prosthesis with 3D decomposition control
JP2010503489A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
US8052744B2 (en) 2006-09-15 2011-11-08 Boston Scientific Scimed, Inc. Medical devices and methods of making the same
ATE517590T1 (en) 2006-09-15 2011-08-15 Boston Scient Ltd BIOLOGICALLY ERODABLE ENDOPROTHESES
EP2210625B8 (en) 2006-09-15 2012-02-29 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
JP2010503482A (en) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド Endoprosthesis
EP2277563B1 (en) 2006-12-28 2014-06-25 Boston Scientific Limited Bioerodible endoprostheses and method of making the same
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8435281B2 (en) 2009-04-10 2013-05-07 Boston Scientific Scimed, Inc. Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10852069B2 (en) 2010-05-04 2020-12-01 Fractal Heatsink Technologies, LLC System and method for maintaining efficiency of a fractal heat sink
ES2522265T3 (en) 2010-06-21 2014-11-14 Zorion Medical, Inc. Bioabsorbable Implants
US8986369B2 (en) 2010-12-01 2015-03-24 Zorion Medical, Inc. Magnesium-based absorbable implants
EP2683420B1 (en) 2011-03-11 2018-05-23 W. L. Gore & Associates, Inc. Improvements to immobilised biological entities
CN102872483B (en) * 2012-09-19 2015-02-18 华东理工大学 Poly-(Epsilon-caprolactone) drug eluting stent modification method
CN106798952B (en) * 2017-02-13 2019-12-10 先健科技(深圳)有限公司 absorbable iron-based internal fracture fixation material
CN107376037A (en) * 2017-08-28 2017-11-24 武汉杨森生物技术有限公司 Compound heparin biology anti-freezing coating solution and preparation method and application
WO2021034784A1 (en) 2019-08-16 2021-02-25 Poltorak Technologies, LLC Device and method for medical diagnostics
CN111840637A (en) * 2020-05-08 2020-10-30 陈艳 Material for artificial liver and preparation method thereof
CN111494794B (en) * 2020-05-08 2021-12-28 山东百多安医疗器械股份有限公司 Zinc alloy stent system with blood vessel adjusting function
CN112587734A (en) * 2020-12-15 2021-04-02 济南金泉生物科技有限公司 Multifunctional coating based on bionic dopamine and preparation method and application thereof
CN114081989B (en) * 2021-11-17 2023-02-28 迪格瑞医疗科技(苏州)有限公司 Biodegradable embolism microsphere and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1364664A1 (en) * 2002-05-24 2003-11-26 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Process for coating a stent with a polysaccharide layer and stent made with a such process
DE10230720A1 (en) * 2002-07-08 2004-02-12 Tinox Ag I.Ins. Implant for use in human or animal, e.g. stent, has surface of e.g. glass, glass ceramic, cermet or metal alloy with low angle of contact with water and coating containing albumen
US20040210208A1 (en) * 2003-04-16 2004-10-21 Cook Incorporated Medical device with therapeutic agents
US20070003588A1 (en) * 2004-12-06 2007-01-04 Chinn Joseph A Multifunctional medical articles
US20070065482A1 (en) * 2005-09-21 2007-03-22 Chudzik Stephen J Articles including natural biodegradable polysaccharides and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728152A (en) * 1995-06-07 1998-03-17 St. Jude Medical, Inc. Bioresorbable heart valve support
US5968093A (en) 1996-10-28 1999-10-19 Biotronik Mess-And Therapiegerate Gmbh & Co. Stent
DE19722857A1 (en) 1997-05-23 1998-11-26 Biotronik Mess & Therapieg Stent
US5968083A (en) 1997-11-12 1999-10-19 Pacesetter, Inc. Active overload detection and protection circuit for implantable cardiac therapy devices
WO2000044305A1 (en) * 1999-01-29 2000-08-03 Institut Straumann Ag Osteophilic implants
DE10012460A1 (en) 2000-03-15 2001-09-20 Biotronik Mess & Therapieg Stent
DE10261822A1 (en) 2002-12-20 2004-07-01 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Helix bridge connection
DE10328815A1 (en) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Coating system for implants to increase tissue compatibility
DE10329260A1 (en) 2003-06-23 2005-01-13 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Stent with a coating system
WO2006083328A2 (en) * 2004-09-15 2006-08-10 Massachusetts Institute Of Technology Biologically active surfaces and methods of their use
DE102006018630B4 (en) * 2006-04-21 2010-10-28 Axel Prof. Dr. med. Stemberger Use of a coating for vascular prostheses
DE102006038231A1 (en) * 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Implant of a biocorrodible metallic material with a coating of an organosilicon compound
DE102006038239A1 (en) * 2006-08-07 2008-02-14 Biotronik Vi Patent Ag Drug-coated medical implants
DE102006039346A1 (en) * 2006-08-22 2008-03-13 Biotronik Vi Patent Ag Biocorrodible metallic implant with a coating or cavity filling of a PEG / PLGA copolymer
DE102007003708A1 (en) * 2007-01-25 2008-07-31 Biotronik Vi Patent Ag Stent comprises stent carrier, one or multiple anchor groups on surface of stent carrier, and one or multiple biomolecules, which are connected to anchor groups, where same or different anchor groups are selected from compounds
DE102007007865A1 (en) * 2007-02-14 2008-08-21 Jennissen, Herbert, Prof. Dr. Process for the preparation of storable implants with an ultrahydrophilic surface
US20080208315A1 (en) * 2007-02-27 2008-08-28 National Taiwan University Of Science & Technology Coronary stent having a surface of multi-layer immobilized structures

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1364664A1 (en) * 2002-05-24 2003-11-26 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Process for coating a stent with a polysaccharide layer and stent made with a such process
DE10230720A1 (en) * 2002-07-08 2004-02-12 Tinox Ag I.Ins. Implant for use in human or animal, e.g. stent, has surface of e.g. glass, glass ceramic, cermet or metal alloy with low angle of contact with water and coating containing albumen
US20040210208A1 (en) * 2003-04-16 2004-10-21 Cook Incorporated Medical device with therapeutic agents
US20070003588A1 (en) * 2004-12-06 2007-01-04 Chinn Joseph A Multifunctional medical articles
US20070065482A1 (en) * 2005-09-21 2007-03-22 Chudzik Stephen J Articles including natural biodegradable polysaccharides and uses thereof

Also Published As

Publication number Publication date
DE102008021894A1 (en) 2009-11-05
EP2113264A2 (en) 2009-11-04
US20090274737A1 (en) 2009-11-05

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