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EP2190408A4 - Compositions analgésiques et anti-inflammatoires et méthodes permettant de soulager, de prévenir ou de traiter la douleur et l'inflammation - Google Patents

Compositions analgésiques et anti-inflammatoires et méthodes permettant de soulager, de prévenir ou de traiter la douleur et l'inflammation

Info

Publication number
EP2190408A4
EP2190408A4 EP09732937.9A EP09732937A EP2190408A4 EP 2190408 A4 EP2190408 A4 EP 2190408A4 EP 09732937 A EP09732937 A EP 09732937A EP 2190408 A4 EP2190408 A4 EP 2190408A4
Authority
EP
European Patent Office
Prior art keywords
analgesic
inflammation
preventing
reducing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09732937.9A
Other languages
German (de)
English (en)
Other versions
EP2190408A2 (fr
Inventor
John Myers Zanella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Warsaw Orthopedic Inc
Original Assignee
Medtronic Inc
Warsaw Orthopedic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Warsaw Orthopedic Inc filed Critical Medtronic Inc
Publication of EP2190408A2 publication Critical patent/EP2190408A2/fr
Publication of EP2190408A4 publication Critical patent/EP2190408A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP09732937.9A 2008-04-18 2009-04-10 Compositions analgésiques et anti-inflammatoires et méthodes permettant de soulager, de prévenir ou de traiter la douleur et l'inflammation Withdrawn EP2190408A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/105,474 US20090263489A1 (en) 2008-04-18 2008-04-18 Analgesic and anti-inflammatory compositions and methods for reducing, preventing or treating pain and inflammation
PCT/US2009/040229 WO2009129147A2 (fr) 2008-04-18 2009-04-10 Compositions analgésiques et anti-inflammatoires et méthodes permettant de soulager, de prévenir ou de traiter la douleur et l'inflammation

Publications (2)

Publication Number Publication Date
EP2190408A2 EP2190408A2 (fr) 2010-06-02
EP2190408A4 true EP2190408A4 (fr) 2013-06-19

Family

ID=41199663

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09732937.9A Withdrawn EP2190408A4 (fr) 2008-04-18 2009-04-10 Compositions analgésiques et anti-inflammatoires et méthodes permettant de soulager, de prévenir ou de traiter la douleur et l'inflammation

Country Status (3)

Country Link
US (1) US20090263489A1 (fr)
EP (1) EP2190408A4 (fr)
WO (1) WO2009129147A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
US20110027331A1 (en) * 2009-07-29 2011-02-03 Warsaw Orthopedic, Inc. An implantable drug depot having a reversible phase transition material for treatment of pain and/or inflammation
EP2329849B1 (fr) 2009-11-18 2015-04-29 Galderma Research & Development Combinaison d'un agoniste du récepteur alpha-2 adrénergique et d'un agent anti-inflammatoire non stéroïdien pour traiter ou empêcher un trouble cutané inflammatoire
CA2786262A1 (fr) 2010-01-07 2011-07-14 Cheetah Omni, Llc Lasers a fibre, et sources de lumiere dans l'infrarouge moyen, dans des procedes et systemes pour le traitement et la spectroscopie selective de tissus biologiques
US9125902B2 (en) 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
WO2012040623A2 (fr) 2010-09-24 2012-03-29 The Brigham And Women's Hospital, Inc. Gels nanostructurés capables de libération contrôlée d'agents encapsulés
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
EP2707032B1 (fr) * 2011-05-10 2019-06-26 Antecip Bioventures II LLC Dispositif polymère implantable pour la libération prolongée de sufentanil
US9511018B2 (en) 2012-04-05 2016-12-06 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable matrix
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
WO2017193139A1 (fr) 2016-05-06 2017-11-09 The Brigham And Women's Hospital, Inc. Gels auto-assemblés binaires pour l'administration contrôlée d'agents encapsulés dans un cartilage
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
CA3061480A1 (fr) * 2017-05-08 2018-11-15 Alivio Therapeutics, Inc. Formulation de gels nanostructures pour une charge et une adherence d'agent augmentees
US11839605B2 (en) 2018-10-11 2023-12-12 Alivio Therapeutics, Inc. Non-injectable hydrogel formulations for smart release

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060280774A1 (en) * 1995-06-02 2006-12-14 Allergan, Inc. Compositions and methods for treating glaucoma

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3020660A (en) * 1959-11-30 1962-02-13 Scherotto John Collapsible imitation tree
US3190802A (en) * 1961-10-09 1965-06-22 Boehringer Sohn Ingelheim Shaving composition and method of using same
US4765974A (en) * 1985-12-24 1988-08-23 Nitto Electric Industrial Co., Ltd. Preparation for percutaneous administration
US5175052A (en) * 1988-05-11 1992-12-29 Nitto Denko Corporation Adhesive tape preparation of clonidine
US5447947A (en) * 1990-02-26 1995-09-05 Arc 1 Compositions and methods of treatment of sympathetically maintained pain
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5484607A (en) * 1993-10-13 1996-01-16 Horacek; H. Joseph Extended release clonidine formulation
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
US6395303B1 (en) * 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
WO1996024330A1 (fr) * 1995-02-10 1996-08-15 Medtronic, Inc. Procede et dispositif d'administration d'analgesiques
HUP9700322A3 (en) * 1995-06-09 2001-03-28 Euro Celtique Sa Formulations and methods for providing prolonged local anesthesia
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
DE19542281C2 (de) * 1995-11-14 1997-12-04 Boehringer Ingelheim Kg Verwendung von Epinastin für die Behandlung der Migräne
DE19546208A1 (de) * 1995-12-12 1997-06-19 Rombold Syst Gmbh Verfahren und Vorrichtung zum seitlichen Ausrichten der Randkante von bewegten Flachmaterialbahnen
CN1494907A (zh) * 1996-03-25 2004-05-12 治疗疼痛的药物组合物
US5747060A (en) * 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
US5801188A (en) * 1997-01-08 1998-09-01 Medtronic Inc. Clonidine therapy enhancement
DE19701912C1 (de) * 1997-01-10 1998-05-14 Jenapharm Gmbh Injizierbares Implantat
US5919473A (en) * 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
US5942530A (en) * 1997-08-28 1999-08-24 Eli Lilly And Company Method for treating pain
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
US6342250B1 (en) * 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
US6147102A (en) * 1999-10-26 2000-11-14 Curatek Pharmaceuticals Holding, Inc. Clonidine preparations
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
EP1103260B1 (fr) * 1999-11-29 2005-01-26 Novosis AG Système transdermique pour l'administration de clonidine
US6417184B1 (en) * 2000-09-19 2002-07-09 David M. Ockert Triple drug therapy for the treatment and prevention of acute or chronic pain
AU2002248284A1 (en) * 2000-11-01 2002-08-06 Allergan, Inc. Compositions for treatment of ocular neovascularization
IL142933A0 (en) * 2001-05-03 2002-04-21 Dentis Technology Ltd Polymeric dental implant and method for use thereof
US20030022926A1 (en) * 2001-05-07 2003-01-30 Lavand'homme Patricia Method for treating neuropathic pain and pharmaceutical preparation therefor
CA2446904A1 (fr) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Administration d'esters medicamenteux par inhalation
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
US7345065B2 (en) * 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
US7687080B2 (en) * 2002-11-25 2010-03-30 Taraxos Inc. Treatment of neuropathy
US20040208917A1 (en) * 2003-04-16 2004-10-21 Wilfried Fischer Transdermal systems for the release of clonidine
US20040265364A1 (en) * 2003-06-25 2004-12-30 Binnur Ozturk Neuropathy cream
US20050095277A1 (en) * 2003-06-25 2005-05-05 Binnur Ozturk Neuropathy cream
US20050058696A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20050059744A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
CA2930900C (fr) * 2003-10-02 2018-10-16 Jazz Pharmaceuticals International Limited Combinaisons de ziconotide et d'opioides destinees a reduire la douleur
US20050245905A1 (en) * 2004-04-30 2005-11-03 Schmidt Steven P Local drug-delivery system
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
MX2007003789A (es) * 2004-10-04 2007-07-20 Qlt Usa Inc Suministro ocular de formulaciones polimericas para suministro.
US7741273B2 (en) * 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
WO2008079868A1 (fr) * 2006-12-22 2008-07-03 Drugtech Corporation Composition de clonidine et procédé d'utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060280774A1 (en) * 1995-06-02 2006-12-14 Allergan, Inc. Compositions and methods for treating glaucoma

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLASSEN A M ET AL: "Stability of admixture containing morphine sulfate, bupivacaine hydrochloride, and clonidine hydrochloride in an implantable infusion system", JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, ELSEVIER, NEW YORK, NY, US, vol. 28, no. 6, 1 December 2004 (2004-12-01), pages 603 - 611, XP004672214, ISSN: 0885-3924, DOI: 10.1016/J.JPAINSYMMAN.2004.04.011 *
SENDIL-KESKIN D ET AL: "IN VIVO PAIN RELIEF EFFECTIVENESS OF AN ANALGESIC-ANESTHETIC CARRYING BIODEGRADABLE CONTROLLED RELEASE ROD SYSTEMS", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION, VSP, UTRECHT, NL, vol. 14, no. 6, 1 January 2003 (2003-01-01), pages 497 - 514, XP008027324, ISSN: 0920-5063, DOI: 10.1163/15685620360674218 *

Also Published As

Publication number Publication date
EP2190408A2 (fr) 2010-06-02
WO2009129147A4 (fr) 2010-03-04
WO2009129147A2 (fr) 2009-10-22
US20090263489A1 (en) 2009-10-22
WO2009129147A3 (fr) 2009-12-10

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Legal Events

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A4 Supplementary search report drawn up and despatched

Effective date: 20130521

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Ipc: A61K 9/22 20060101ALI20130514BHEP

Ipc: A61K 9/16 20060101ALI20130514BHEP

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Ipc: A61K 9/26 20060101ALI20130514BHEP

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