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EP2160337B1 - Verschluss mit membran und drehbarer schutzkappe - Google Patents

Verschluss mit membran und drehbarer schutzkappe Download PDF

Info

Publication number
EP2160337B1
EP2160337B1 EP08758932A EP08758932A EP2160337B1 EP 2160337 B1 EP2160337 B1 EP 2160337B1 EP 08758932 A EP08758932 A EP 08758932A EP 08758932 A EP08758932 A EP 08758932A EP 2160337 B1 EP2160337 B1 EP 2160337B1
Authority
EP
European Patent Office
Prior art keywords
closure
cap
protective cap
container
removal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP08758932A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2160337A1 (de
Inventor
Lothar Grunert
Andreas Mrass
Peter Mueller
Kemal Eray
Thorsten Hassenzahl
Klaus Oswald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP2160337A1 publication Critical patent/EP2160337A1/de
Application granted granted Critical
Publication of EP2160337B1 publication Critical patent/EP2160337B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/26—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts
    • B65D47/261—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having a rotational or helicoidal movement
    • B65D47/265—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having a rotational or helicoidal movement between planar parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/32—Caps or cap-like covers with lines of weakness, tearing-strips, tags, or like opening or removal devices, e.g. to facilitate formation of pouring openings
    • B65D41/34—Threaded or like caps or cap-like covers provided with tamper elements formed in, or attached to, the closure skirt
    • B65D41/3404—Threaded or like caps or cap-like covers provided with tamper elements formed in, or attached to, the closure skirt with ratchet-and-pawl mechanism between the container and the closure skirt or the tamper element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2401/00—Tamper-indicating means
    • B65D2401/15—Tearable part of the closure

Definitions

  • the invention relates to a closure for closing an opening of a container for storage and removal of sterile or moisture-sensitive media with a closure cap which is liquid-tightly connected to the container and with a pierceable, self-closing septum, which closes a off-center discharge opening in the cap liquid-tight wherein the closure has a rotatably mounted protective cap with a recess for releasing the removal opening, wherein the recess in the protective cap is adapted to the dimensions of the removal opening.
  • sterile or moisture-sensitive media are often required that are stored for a long period of time and must be kept available for occasional use or substantially continuous removal of small quantities of the medium.
  • the removal of a required amount of the medium should be possible in a simple manner so that contamination of the not yet required medium is possible excluded.
  • suitable containers such as bottles of glass or plastic with a Closing closure having a removal opening, which in turn is sealed liquid-tight with a septum.
  • Known such closures such Containers for this purpose have a removal opening which is covered or sealed liquid-tight on its side facing the interior of the container by a septum covering the removal opening.
  • the septum In order to be able to remove a medium located in the container, the septum is pierced with a cannula and the required amount of the medium is removed.
  • the septum is expediently made of a material which - as well as the container material - is inert to the medium to be stored in the container and at the same time can easily be punctured in order to close automatically liquid-tight again after removal of the medium.
  • each puncturing the septum often visible damage to the material, so that in particular after several removal operations a liquid-tight or sterile closure of the container can not be reliably ensured by the multiple pierced septum.
  • US 2 608 972 A discloses the features of the preamble of claim 1, it is known to arrange a single discharge opening in a septum sealed cap off-center, which can be either covered or released by a pivotally mounted on the cap protective cap. In order to use another area of the septum for a new removal, or piercing with a needle, the cap must be released together with the cap from the container and placed in another orientation again on the container.
  • Object of the present invention is therefore to provide a closure of the type mentioned in such a way that the medium contained in the container is protected as reliably as possible against environmental influences and at the same time a quick and easy removal of the medium is possible.
  • the rotatably mounted protective cap does not have to be detached from the closure or the closure cap in order to release the removal openings arranged in the closure cap.
  • the protective cap only has to be rotated so far that the recess in the protective cap releases a removal opening in the closure cap in a region previously covered by the protective cap and makes it accessible for removal of the medium. It can, however, already
  • the rotatably mounted cap has markings indicating a new, not yet used area of a removal opening and these markers can be repositioned by rotating the cap relative to the removal opening and the removal openings.
  • a cap rotatably mounted on the closure has the additional advantage that the cap does not have to be completely detached from the closure, so that no loose items must be handled, which could complicate the maintenance of sterile or high-purity working conditions. Also, the rotatably mounted cap can be reliably operated with one hand or with the hand gripping the container in a simple manner, so that with a second hand, for example, pierced the septum and located in the container medium can be removed.
  • the closure cap has a plurality of eccentrically arranged removal openings and that the recess in the protective cap is adapted to the dimensions of the removal openings.
  • the closure cap can have, for example, three, five or more preferably circular or circular-segment-shaped removal openings.
  • the several extraction openings are each closed by a septum.
  • the septum can either be configured in one piece and substantially cover the entire opening of the container and thus also all removal openings, or it can be provided several, each having an associated removal opening covering septa.
  • the recess in the protective cap is adapted to the dimensions of the removal openings and corresponds in shape and dimensioning of the expediently uniform configuration of the plurality of removal openings.
  • the recess in the protective cap is significantly smaller than the dimension of the individual removal openings, so that the recesses in the protective cap can be repositioned several times within a removal opening in order to release a region of the septum which has not yet been used, before the recess in the protective cap is positioned over a new removal opening.
  • the closure cap has off-center a region which is not covered by the at least one removal opening and which is larger than the recess in the protective cap. If no medium has to be removed from the container for an extended period of time, and in particular prior to the first use of the container, then the protective cap can be rotated or positioned relative to the closure cap such that the recess of the protective cap is located over a region of the closure cap. which has no removal opening, so that the septum arranged underneath is completely covered either by the closure cap or by the protective cap and protected from external environmental influences.
  • the corresponding area of the septum is accessible from the outside and can be pierced for removal of the medium in the container.
  • the protective cap can be detachably connected to the closure cap in such a manner that a first release of the protective cap from the closure cap can be detected.
  • the medium in the container can be removed from several removal openings.
  • air or a suitable conveying medium is introduced into the container through a removal opening in order to support the removal of the medium in the container through another removal opening.
  • the protective cap can be detached from the closure cap.
  • the closure has a tamper-evident, so that a first-time release of the protective cap of the cap is detectable and can be taken into account in a later use of the container in question.
  • the protective cap is detachably connectable to the closure cap, for example, with appropriate requirements during use easy and quick removal of the cap in case of need to allow.
  • the protective cap can be rotatably mounted on the cap for this purpose, latching or with a snap closure.
  • a suitable fastening device can either be arranged centrally in the region of the axis of rotation of the protective cap or along the circumference of the protective cap, or configured.
  • the closure cap can also be detachably connected to the container in such a manner that a first release of the closure cap from the container can be detected.
  • the cap can be completely detached from the container, so that the opening of the container is released and the medium contained in the container can be removed or, for example, distributed .
  • the closure cap has a tamper-evident protection.
  • the protective cap has at least one laterally projecting formation.
  • the protective cap can also have a polygonal, for example octagonal or dodecagonal cross-sectional area, so that regardless of the respective orientation of the container or the protective cap in a one-handed gripping the container, the protective cap with thumb and forefinger he can be reliably operated and twisted the container gripping hand.
  • the in Fig. 1 shown container 1 has a not visible in this view opening, which is closed by a closure 2.
  • the closure 2 has a closure cap 3 and a protective cap 4 rotatably mounted on the closure cap 3.
  • the protective cap 4 has a recess 5, which is completely covered by a safety cover 6 in the delivery condition of the completely filled container 1.
  • the safety cover 6 In order to be able to remove a sterile or moisture-sensitive medium located in the container 1 for the first time, the safety cover 6 has to be released from the protective cap 4, so that the recess 5 underneath is accessible from the outside and makes it possible to remove the medium.
  • the in Fig. 2 individually illustrated cap 3 a plurality of removal openings 7.
  • five circular removal openings 7 are arranged at a distance from one another and at a distance from a rotation axis 8 of the closure cap 3.
  • Between two adjacent removal openings 7 a not detected by the removal openings 7 area 9 is arranged, the dimensions of which are larger than the dimensions of each removal opening 7.
  • the closure cap 3 basically covers the associated region of the opening of the container 1, regardless of the respective orientation of the protective cap 4.
  • Recess 5 of the protective cap 4 is covered to a predominant extent by the safety cover 6, which is formed integrally on the protective cap 4 and is connected to the protective cap 4 via narrow webs.
  • the protective cap 4 designed in this way can be produced inexpensively and in a simple manner by means of common injection molding processes from a suitable material, such as, for example, polyethylene (PE).
  • the protective cap 4 has a substantially cylindrical inner surface 10 and an outer surface 11, which is divided along a circumference of the protective cap 4 into twelve planar surfaces 12.
  • the flat surfaces 12 each have an angle of 30 ° to an adjacent flat surface 12.
  • the protective cap 4 has in its middle two locking elements 14 which can be inserted into an associated opening in the closure cap 3 and permanently connect the protective cap 4 to the closure cap 3. Should the protective cap 4 want to be detached from the closure cap 3, at least one of the two detent elements 14 would have to be bent or broken off so that a first complete release of the protective cap 4 from the closure cap 3 can be detected at any time. This also represents a protection of originality.
  • a possible and implemented in the embodiment embodiment of the locking elements 14 is in Fig. 6 shown in enlarged again representation.
  • the protective cap 4 has on the inner surface 10 a plurality of, in the embodiment shown, twelve inwardly projecting, bead-like detent elements 15.
  • the locking elements 15 may each be associated with a flat surface 12.
  • the closure cap 3 has a groove 16, which is adapted to the shaping of the catch elements 15 and oriented perpendicular to the circumferential direction, in each of which a catch element 15 can engage.
  • the groove 16 is for example in Fig. 2 shown.
  • the shape of the locking elements 15 is such that on the one hand, a rotation of the protective cap 4 is not unduly hindered, while on the other hand a positioning of the cap 4 is preferred with a engaging in the groove 16 of the cap 3 locking element 15. A user can therefore perceive or feel the predetermined by the locking elements 15 positions of the protective cap 4 and thus the recess 5 relative to the cap 3 upon rotation of the cap 4.
  • FIG. 5 A possible embodiment of the locking elements 15 is shown in the enlarged partial view in Fig. 5 illustrated.
  • Fig. 7 is a sectional view of the container 1 is shown, which is closed in its delivery state with the closure 2.
  • the closure cap 3 of the closure 2 is screwed to the container 1 by means of a screw thread 17.
  • a septum 20 is arranged between an upper edge 18 of the Container and an inner side 19 of the cap 3.
  • the septum 20 is preferably made of silicone, which is coated on a surface facing the interior of the container 1 with an inert material, such as PTFE.
  • the closure cap 3 has on the inner side 19 facing the septum 20, spaced apart from an outer edge, protrusions 21 projecting in the direction of the container interior.
  • protrusions 21 projecting in the direction of the container interior.
  • the screw cap of the cap 3 with the container 1 is provided with a tamper-evident.
  • a plurality of lamellar formations 23 are formed on an end region 22 of the closure cap 3 facing the container 1, which are not aligned radially inward, but each have an angle of approximately 50 ° thereto.
  • the container 1 has an adapted thereto, obliquely projecting formation, which is designed such that the protrusions 23 when screwing the cap 3 on the container 1 almost unhindered over the shape of the container 1) slide away, whereas when the cap 3 the formations 23 with the associated shape of the container 1 engage and with a increased effort must be bent to release the cap 3.
  • the closure 2 can be completely removed from the container 1 in order to completely release the container opening, if this is necessary or desired in individual cases.
  • opening of the container 1 causes a permanent deformation of the lamellar formations 23, which can be determined at any time at any time, which also a tamper-evident is achieved.
  • all injection-moldable polymers can be used, but they are preferably inert to aggressive solvents but also to leaching.
  • a direction of rotation of the protective cap 4 is predetermined relative to the closure cap 3.
  • comparable lamellar formations 23 may be provided on the protective cap 4 or the cap 3, which allow only one direction of rotation of the cap 4 and block the opposite direction of rotation. In this way it can be avoided that the protective cap 4 is rotated several times in different directions and the recess 5 is repeatedly positioned over a removal opening 7, which has already been used for a removal of the medium. With such a measure, the sterility of the medium in the container 1 can be ensured as far as possible even over several removal processes.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Closures For Containers (AREA)
  • Pens And Brushes (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
  • Joints Allowing Movement (AREA)
EP08758932A 2007-06-29 2008-06-02 Verschluss mit membran und drehbarer schutzkappe Active EP2160337B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007030352 2007-06-29
DE102007058349A DE102007058349A1 (de) 2007-06-29 2007-12-03 Verschluss
PCT/EP2008/004363 WO2009003563A1 (de) 2007-06-29 2008-06-02 Verschluss mit membran und drehbarer schutzkappe

Publications (2)

Publication Number Publication Date
EP2160337A1 EP2160337A1 (de) 2010-03-10
EP2160337B1 true EP2160337B1 (de) 2011-09-28

Family

ID=40076110

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08758932A Active EP2160337B1 (de) 2007-06-29 2008-06-02 Verschluss mit membran und drehbarer schutzkappe

Country Status (12)

Country Link
US (1) US10160576B2 (es)
EP (1) EP2160337B1 (es)
JP (1) JP5319669B2 (es)
KR (2) KR20150034810A (es)
CN (1) CN101687581B (es)
AT (1) ATE526249T1 (es)
AU (1) AU2008271686B2 (es)
BR (1) BRPI0813466B1 (es)
DE (1) DE102007058349A1 (es)
ES (1) ES2373868T3 (es)
NZ (1) NZ582880A (es)
WO (1) WO2009003563A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10195112B2 (en) 2012-11-26 2019-02-05 Becton Dickinson France Adaptor for multidose medical container
WO2022194500A1 (de) 2021-03-18 2022-09-22 G.A.S. Gesellschaft Für Analytische Sensorsysteme M.B.H Verschlussaufsatz

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DE102007058349A1 (de) * 2007-06-29 2009-01-02 Merck Patent Gmbh Verschluss
US20090166311A1 (en) * 2007-12-27 2009-07-02 Helvoet Pharma Belgium N.V. Pharmaceutical closure with a laser-applied marking
SG192310A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
US9668939B2 (en) 2012-02-02 2017-06-06 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
SG192312A1 (en) * 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
CN103057830B (zh) * 2013-01-21 2015-04-15 浙江欧诗漫集团有限公司 化妆品软管
JP1526207S (es) 2013-08-05 2015-06-15
DE202013012012U1 (de) 2013-12-20 2014-12-22 Leica Biosystems Nussloch Gmbh Selbstdichtendes Verbindungssystem und Verbindungselement
EP3728548B1 (en) * 2017-12-21 2022-01-19 Global Life Sciences Solutions USA LLC A fluid port
GB2593346B (en) * 2018-11-17 2023-02-01 Ceres Chill Inc Vessel for breast milk collection, preservation, transportation and delivery
USD920803S1 (en) 2019-10-23 2021-06-01 S. C. Johnson & Son, Inc. Dispenser
US12397975B2 (en) 2021-01-27 2025-08-26 Gill, Llc Multi-component sample container cap
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US11975895B2 (en) * 2021-10-06 2024-05-07 Sysler Corporation Multi-purpose container
AU2023245808A1 (en) * 2022-04-01 2024-11-21 Gill, Llc Locking sample cap

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10195112B2 (en) 2012-11-26 2019-02-05 Becton Dickinson France Adaptor for multidose medical container
WO2022194500A1 (de) 2021-03-18 2022-09-22 G.A.S. Gesellschaft Für Analytische Sensorsysteme M.B.H Verschlussaufsatz
DE102021106715A1 (de) 2021-03-18 2022-09-22 G.A.S. Gesellschaft für analytische Sensorsysteme m.b.H. Verschlussaufsatz

Also Published As

Publication number Publication date
AU2008271686A1 (en) 2009-01-08
US10160576B2 (en) 2018-12-25
CN101687581B (zh) 2012-02-22
BRPI0813466B1 (pt) 2018-04-03
KR20100040887A (ko) 2010-04-21
BRPI0813466A2 (pt) 2015-01-06
EP2160337A1 (de) 2010-03-10
US20100176080A1 (en) 2010-07-15
ES2373868T3 (es) 2012-02-09
ATE526249T1 (de) 2011-10-15
AU2008271686B2 (en) 2013-09-12
DE102007058349A1 (de) 2009-01-02
CN101687581A (zh) 2010-03-31
KR20150034810A (ko) 2015-04-03
JP2010531781A (ja) 2010-09-30
JP5319669B2 (ja) 2013-10-16
KR101603348B1 (ko) 2016-03-14
WO2009003563A1 (de) 2009-01-08
NZ582880A (en) 2011-08-26

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