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EP2039980B1 - Cryostat doté d'un récipient extérieur stabilisé - Google Patents

Cryostat doté d'un récipient extérieur stabilisé Download PDF

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Publication number
EP2039980B1
EP2039980B1 EP20070018697 EP07018697A EP2039980B1 EP 2039980 B1 EP2039980 B1 EP 2039980B1 EP 20070018697 EP20070018697 EP 20070018697 EP 07018697 A EP07018697 A EP 07018697A EP 2039980 B1 EP2039980 B1 EP 2039980B1
Authority
EP
European Patent Office
Prior art keywords
cryostat
base part
vessel
cavity
thickness
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP20070018697
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German (de)
English (en)
Other versions
EP2039980A1 (fr
Inventor
Hannes Dr. Nowak
Sergio Nicola Dr. Erné
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BMDSys Production GmbH
Original Assignee
BMDSys Production GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BMDSys Production GmbH filed Critical BMDSys Production GmbH
Priority to DE200750003414 priority Critical patent/DE502007003414D1/de
Priority to EP20070018697 priority patent/EP2039980B1/fr
Priority to AT07018697T priority patent/ATE463700T1/de
Priority to US12/679,031 priority patent/US20110031253A1/en
Priority to PCT/EP2008/008068 priority patent/WO2009040100A1/fr
Priority to CA 2725703 priority patent/CA2725703A1/fr
Publication of EP2039980A1 publication Critical patent/EP2039980A1/fr
Application granted granted Critical
Publication of EP2039980B1 publication Critical patent/EP2039980B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C3/00—Vessels not under pressure
    • F17C3/02—Vessels not under pressure with provision for thermal insulation
    • F17C3/08—Vessels not under pressure with provision for thermal insulation by vacuum spaces, e.g. Dewar flask
    • F17C3/085—Cryostats
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/03—Thermal insulations
    • F17C2203/0391—Thermal insulations by vacuum
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0602—Wall structures; Special features thereof
    • F17C2203/0612—Wall structures
    • F17C2203/0626—Multiple walls
    • F17C2203/0629—Two walls
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2209/00—Vessel construction, in particular methods of manufacturing
    • F17C2209/23—Manufacturing of particular parts or at special locations
    • F17C2209/232—Manufacturing of particular parts or at special locations of walls
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2260/00—Purposes of gas storage and gas handling
    • F17C2260/02—Improving properties related to fluid or fluid transfer
    • F17C2260/024—Improving metering
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/02—Applications for medical applications

Definitions

  • the invention relates to a cryostat, which is particularly suitable for use in a biomagnetic measuring system, as well as a biomagnetic measuring system comprising such a cryostat.
  • the invention further relates to a method for producing a cryostat, which is particularly suitable for biomagnetic measurements.
  • cryostats and measuring systems can be used in particular in the field of cardiology or in other medical fields, such as neurology. Other applications, such as non-medical applications, such as applications in materials research, are conceivable.
  • biomagnetic measurement systems The basis of biomagnetic measurement systems is the fact that most cell activities in the human or animal body are associated with electrical signals, in particular electrical currents.
  • the measurement of these electrical signals themselves, which are caused by the cell activity, is known for example from the field of electrocardiography.
  • the electrical currents are also connected to a corresponding magnetic field whose measurement is made use of the various known biomagnetic measurement methods.
  • the measurement of magnetic fields of biological samples or patients, or the measurement of temporal changes of these magnetic fields represents a metrological challenge.
  • the magnetic field changes in the human body which are to be measured in the magnetocardiography, about one million times weaker than the magnetic field of the earth.
  • the detection of these changes thus requires extremely sensitive magnetic sensors.
  • superconducting Quantum Interference Devices SQUIDs
  • Such sensors typically need to be cooled to 4 ° K (-269 ° C) to achieve the superconducting state, typically using liquid helium.
  • the SQUIDs are therefore usually arranged individually or in a SQUID array in a so-called. Dewar vessel and are cooled there accordingly.
  • laser-pumped magneto-optic sensors are currently being developed that can have approximately comparable sensitivity.
  • the sensors are usually arranged in an array arrangement in a container for temperature stabilization.
  • cryostat containers for temperature stabilization
  • these may be helium cryostats or other types of cryostat.
  • dewar Between the cryostat and the cryostat vessel, which is also referred to as dewar, is not distinguished below, even if the actual cryostat next to the cryostat vessel may include more parts.
  • the production of the cryostat for receiving biomagnetic sensor systems constructively presents a great challenge.
  • the sensors are usually in one predetermined arrangement in these cryostats introduced, for example in the form of a hexagonal arrangement of SQUIDs or other magnetic sensors.
  • the cryostat comprises an inner vessel, with sensors received therein, as well as an outer vessel.
  • the space between inner vessel and outer vessel is evacuated.
  • the distance between the sensors housed in the inner cryostat vessel and the skin surface of the patient is kept as small as possible, since, for example, the signal strength decreases with a high power of the distance between sensor and skin surface. Accordingly, the distance between the bottoms of the inner and outer vessels must be kept small and extremely constant.
  • cryostats are known from the prior art, which can be used for magnetic measurements.
  • WO 94/03754 a cryostat vessel with an inner Dewar and an outer Dewar.
  • the inner dewar is double-jacketed and features floor panels with curved bottoms. Furthermore, a number of radiation shields are provided.
  • DE 298 09 387 U1 describes a cryostat for radiomagnetic probing methods in which SQUIDs are preferably used.
  • the cryostat has a high electromagnetic high-frequency transparency.
  • a double vessel is again proposed, wherein a sensor is received at the bottom of an inner vessel.
  • This inner vessel is formed in two parts and shows a bottom part with a raised edge which partially encloses a side wall.
  • a vacuum-insulated cryocontainer which can be used for the storage of low-boiling liquefied gases, in particular for combustible cryofuel.
  • This has an outer container and a stored in the outer container, the gases receiving inner container and means for securing the outer container against pressure increase in the space provided between the containers isolation space.
  • a device for overpressure protection is arranged, which releases an opening between the inner container and the insulation space at a predetermined failure pressure.
  • the conventional cryostat used for magnetic measurements have a number of disadvantages and difficulties which can affect the reliability and reproducibility of the measurements.
  • a problem There is, for example, that in particular in transition areas between bottom parts and the side walls of the cryostat vessels tensions can easily occur, which can lead to cracks, which in turn can have a strong negative impact on the quality of the cryostat.
  • deformations may occur, for example, when pumping the gap between the inner and outer vessel, which can lead to the formation of thermal bridges between the bottoms of the vessels.
  • a distance between the two plates should be designed as large as possible to such deformation-te To avoid thermal bridges, but on the other hand, this distance should be kept as small as possible in order to achieve a high signal quality for the sensor signals.
  • the object of the present invention is thus to provide a cryostat which avoids the above-described disadvantages of known cryostats.
  • the cryostat on the one hand to ensure high signal quality and on the other hand allow reliable evacuation of a cavity between an inner vessel and an outer vessel.
  • a cryostat for use in a biomagnetic measuring system, which has at least one inner vessel and at least one outer vessel, and at least one arranged between the inner vessel and the outer vessel cavity.
  • a plurality of such inner and / or outer vessels and / or a plurality of cavities may be provided.
  • the cavity is supposed to be under vacuum be acted upon, so should be able to be sealed in order to be evacuated.
  • inner and outer vessel may, for example, corresponding seals (for example, separate sealing rings and / or sealing adhesions at joints or similar types of seals), a pump connection for connection to a device for generating a vacuum (eg a vacuum pump) or the like.
  • the outer vessel and the inner vessel can be made of a variety of possible materials, which ensure the required mechanical stability of these vessels. It is particularly preferred if these vessels are wholly or partly made of a fiber composite material, ie a composite of a fiber material and a matrix material made of a plastic. Alternatively or additionally, however, a variety of other materials can be used, such as metals, plastics, ceramics or a combination of these materials.
  • the outer vessel has a bottom part.
  • This bottom part can be constructed in one piece with the remaining components of the outer vessel, but can also be supplemented in a modular design by other components of the outer vessel, for example - as described below - a side wall and / or other parts, such as lid parts.
  • this bottom part is particularly critical and should, if possible, have no appreciable deflection when the cavity is pumped out. Typical pressures after pumping off may be in the range from 10 -3 mbar to 10 -4 mbar at room temperature, for example.
  • the invention proposes to make the bottom part of the outer vessel analogous to a bridge construction.
  • a load is met by the bridge having a corresponding arcuate curvature.
  • the bottom part has a thickness variation region which preferably extends over a large area of the bottom part.
  • this thickness variation range can extend over a range between 50 and 100% of the lateral extent of the bottom part.
  • the bottom part has a concentrically varying bottom thickness, wherein the bottom thickness decreases towards the middle of the thickness variation region and assumes a lower value there than in an outside region of the thickness variation region.
  • a "thickness" should always be understood to mean an averaged value over a small area, so that, for example, local unevennesses in the thickness (for example a starting point) can be disregarded.
  • the thickness variation range over the lateral extent of the bottom part or of the thickness variation range can be, for example, between 0.1% and 5%, preferably between 0.5% and 2% and particularly preferably in the range from 0.75% to 1%.
  • the thickness variation can for example be continuous, for example in the form of a parabolic surface profile and / or thickness profile of the bottom thickness. Alternatively or additionally, however, a continuous or stepwise variation of the floor thickness can also take place.
  • the bottom part has for example a round or a polygonal cross-section. Accordingly, the term "concentrically varying” should be understood to mean that this term includes only a decrease in bottom thickness toward the center of the thickness variation range, but not necessarily a round shape of the thickness variation range and / or an axis symmetry of thickness variation, even if a round shape and an axial symmetry about an axis of the cryostat represent a preferred embodiment.
  • the concentrically varying bottom thickness offers the advantage that the overall structure of the bottom part is considerably stabilized, similar to the construction of a bridge arch. In this way, thermal bridges between the outer vessel and the inner vessel are avoided, and even after several Abpumpvor réellen the cryostat and the cryostat comprehensive biomagnetic measuring system can reproducibly and reliably put into operational readiness.
  • the distance between the bottom part of the outer vessel and an inner bottom part of the inner vessel may for example be between 3 mm and 30 mm, in particular between 10 mm and 25 mm and particularly preferably about 20 mm.
  • the bottom part itself or the thickness variation region may have a diameter of, for example, at least 200 mm, preferably a diameter of about 400 mm.
  • the bottom part may have an outwardly facing outside and an inwardly facing inside, wherein the outside at normal pressure in the cavity (ie, when not evacuated cavity) preferably has a substantially planar course.
  • the inside may have a curved surface at normal pressure in the cavity.
  • the bottom part may in particular comprise a fiber material, for example a glass fiber material and / or a carbon fiber material and / or a mineral fiber material.
  • a fiber material for example a glass fiber material and / or a carbon fiber material and / or a mineral fiber material.
  • a curable matrix material can then be used, for example - as described above - a matrix material with an epoxy resin or a similar curable matrix material, which together with the fiber material can form a fiber composite material.
  • the outer vessel may further comprise a side wall connected in a circumferential connection region with the bottom part.
  • this side wall may, for example, have a round or polygonal cross-section, but in principle any cross-sections can be realized.
  • the bottom part may preferably have a raised edge, along which the bottom part is connected to the side wall of the outer vessel. In this case, it is particularly preferred if the raised edge has a step surface, wherein the side wall is seated on this step surface.
  • the step surface may additionally comprise a collar which is arranged concentrically with the side wall, so that the side wall can be supported inwardly on this collar of the step surface. Examples of this construction will be further explained below.
  • biomagnetic measuring system in particular a biomagnetic measuring system according to one or more of the initially described, known from the prior art embodiments, proposed.
  • the biomagnetic measuring system comprises at least one cryostat according to one of the embodiments described above.
  • the biomagnetic measuring system comprises at least one biomagnetic sensor, preferably an array of biomagnetic sensors, which are set up for the detection of a magnetic field.
  • these biomagnetic sensors may include, for example, SQUIDs and / or magneto-optical sensors.
  • a method for producing a cryostat for use in a biomagnetic measuring system is furthermore proposed, in particular a cryostat according to one of the embodiments described above.
  • the cryostat should comprise at least one inner vessel and at least one outer vessel and at least one cavity arranged between the inner vessel and the outer vessel, which can be subjected to a negative pressure.
  • the outer vessel has a bottom part which has a thickness variation area comprising a concentrically varying floor thickness. The floor thickness assumes a lower value in the area of the middle of the thickness variation area than in an outdoor area.
  • the mold may furthermore have at least one second stamp part, wherein the second stamp part has a curvature which is substantially opposite to the first stamp part.
  • the second stamping part can, for example, have a curved surface which is concavely curved in such a way that the curvature points out of the interior of the mold cavity.
  • the two curved surfaces of the stamp parts can then be curved in such a way that the formed intermediate of the bottom part assumes the shape of a curved shell after hardening.
  • the bottom part can be removed from the mold cavity and be subjected to a subsequent cutting process and / or grinding process.
  • the convex surface of the bottom part can then be leveled, for example, in the region of the thickness variation region, and thus a substantially flat underside of the bottom part or the thickness variation region can be produced.
  • FIG. 1 is a possible embodiment of a cryostat 110 according to the invention shown in a sectional view.
  • the cryostat 110 has an inner vessel 112 and an outer vessel 114 enclosing the inner vessel 112.
  • the outer vessel 114 is configured substantially cylindrical and has various flanges 116 and 118. While the lower of these flanges 116 substantially performs support functions, the upper flange 118 serves to receive a lid 120 of the outer vessel 114.
  • Through this cover 120 projects a neck 122 of the inner vessel 112.
  • biomagnetic sensors shown in FIG FIG. 1 not shown
  • leads to these sensors can be led through the neck 122 to the outside and connected to a corresponding electronics, so that measurement signals of these sensors can be queried.
  • a cavity 126 is formed between the inner vessel 112 and the outer vessel 114.
  • This cavity 126 may, for example, by means of a in FIG. 1 Vacuum socket not shown are evacuated. By this evacuation and formation of a negative pressure in this cavity 126, an insulating effect of the cryostat 110 is increased. In this way, the interior of the main vessel 124 of the inner vessel 112 can be cooled, for example, by means of liquid helium, without requiring a replacement or replacement of this liquid helium at short intervals.
  • Both the inner vessel 112 and the outer vessel 114 have substantially continuous fiber composite materials as materials. Furthermore, both the inner vessel 112 and the outer vessel 114 are modular. Thus, for example, the outer vessel 114 next to the lid 120 has a side wall 128 and a bottom part 130.
  • the inner vessel 112 has, in addition to the neck 122 in the region of the main vessel 124, a circular ring 132, which seals the neck 122 relative to the main vessel 124.
  • the inner vessel 112 has an inner side wall 134 and an inner bottom part 136. In this embodiment, the side walls 128, 134 are provided with a cylindrical shape, which is not absolutely necessary. Thus, for example, polygonal cross sections or irregular cross sections can be used.
  • FIG. 1 A particularly critical area in the production of the cryostat 110 is the in FIG. 1 The region of the transition between the base parts 130, 136 and the sidewalls 128, 134 of the outer vessel 114 or of the inner vessel 112, designated by the reference numeral 138, in this region.
  • the forces acting on the evacuation of the cavity 126 affect the inner vessel 112 (in FIG. 1 labeled with F 1 ) and on the outer vessel 114 (in FIG. 1 denoted by F 2 ) particularly critical and can lead to damage of the cryostat 110.
  • the connecting region 140 has a circumferential reinforcing element 142, which in this exemplary embodiment is formed integrally with the inner bottom part 136.
  • a circumferential reinforcing element 142 which in this exemplary embodiment is formed integrally with the inner bottom part 136.
  • non-one-piece embodiments are also conceivable, for example with a separately formed reinforcing element 142.
  • the inner bottom part 136 has a raised, annular edge 144, which is formed in its upper region as a step 146.
  • This step 146 has a lower step surface 148 on which the lower edge of the inner side wall 134 of the inner vessel 112 rests.
  • the step 146 includes a collar 150 which annularly surrounds the lower edge of the side wall 134.
  • the reinforcing element 142 differs from the remaining inner bottom part 136 essentially by its structural properties.
  • the entire inner bottom part 136 is made of a fiber composite material, which preferably comprises an epoxy resin as a matrix material and, for example, glass fibers as a fiber material.
  • other additives may be included.
  • this fiber material which in FIG. 2 is not shown, oriented in the circumferential direction and thus has in FIG. 2 into the drawing plane.
  • the fiber orientation of the fiber material is substantially radially extending, ie in FIG. 2 parallel to the drawing plane.
  • the inner bottom part 136 has a series of recesses 152. These recesses 152 are used to hold biomagnetic sensors, which are not shown in the figures.
  • biomagnetic sensors can be used for this purpose SQUIDs, for example, at one through the neck 122 of the inner vessel 112 are mounted in the main vessel 124 introduced linkage.
  • the biomagnetic sensors may, for example, be accommodated in a hexagonal arrangement in the base part 136 so that they can receive measurement signals over a surface area and thus for example map a chest area of a patient.
  • the depressions 152 serve, for example, for the purpose of fixing the biomagnetic sensors and, moreover, shortening the distance between the sensor and the skin surface of the patient in that the effective bottom thickness of the inner bottom part 136 from the original D to the distance d in FIG. 2 is reduced. Furthermore, in the inner bottom part 136 threaded holes 154 to which, for example, a linkage for holding the biomagnetic sensors can be fixed.
  • the bottom portion 130 of the outer vessel 114 also has a raised edge 156. This one is in FIG. 3 shown in detail.
  • a step 158 is again provided in the raised edge 156 of the bottom part 130.
  • this step 158 has a step surface 160 on which the side wall 128 rests.
  • a collar 162 is provided, which, however, in contrast to the collar 150 in FIG. 2 , Due to the opposite force acting on the force F 1 F 2 is arranged in this case on the inside of the side wall 128 and the transition region between the side wall 128 and the bottom part 130 reinforced.
  • FIG. 1 Between the inner bottom part 136 of the inner vessel 112 and the bottom part 130 of the outer vessel 114, as shown FIG. 1 it can be seen, in a region in which both bottom parts 130, 136 run flat, a distance a, which is typically only between 10 and 25 mm. This preferred distance results in a high signal quality, as magnetic fields generally decrease with a high power of the distance between source and detector.
  • FIG. 1 illustrated construction with the recesses 152, in which the sensors are accommodated, and the small distance a between inner bottom portion 136 and bottom portion 130, the distance between, for example, a patient's breast and the biomagnetic sensors received in the recesses 152 is reduced to a minimum.
  • the bottom part 130 is in FIG. 4 shown in detail without the inner vessel 112.
  • the bottom part 130 like the entire cryostat 110, may be, for example, a round cross-section or a polygonal one Have cross-section.
  • the bottom portion 130 is basically divided into three sections and has an annular bevelled area 164 and a circular, substantially planar, thick variation area 166, in addition to the aforementioned raised edge 156.
  • the substantially flat thickness variation region 166 is preferably the region in which, as shown in FIG FIG.
  • the inner vessel 112 has the smallest distance to the outer vessel 114.
  • This area thus represents the area in which the risk of contact between inner vessel 112 and outer vessel 114 and thus the formation of thermal bridges is particularly high when the force F 1 , which occurs when the cavity 126 is pumped out.
  • this thickness variation region 166 with a concentrically varying ground thickness.
  • the thickness of the bottom part 130 in the thickness variation region 166 decreases from a thickness B 1 in the edge region, ie in the region of the transition of the thickness variation region 166 to the tapered region 164, to a value B 2 in the middle of the thickness variation region 166. This decrease is typically about 1%. If the thickness variation region 166 thus has a diameter of approximately 400 mm, then the value B 1 -B 2 is approximately 3 to 4 mm. In this case, the thickness variation region 166 has an outwardly facing inner side 168 and an outwardly facing surface 170.
  • the outer surface 170 is preferably designed flat. Alternatively, however, this outer surface 170 may be adapted, for example, to other geometries, such as a patient's head surface or breast surface, depending on the field of application of the cryostat 110.
  • FIGS. 5A to 6B the effect of the concentrically varying thickness of the bottom part 130 is illustrated schematically.
  • the show FIGS. 5A and 5B a conventional bottom portion 130 of constant thickness, whereas the Figures 6A and 6B show a bottom part 130 according to the invention with concentrically varying thickness.
  • the thickness variation and the curvature are shown greatly exaggerated in the figures.
  • FIG. 5A a bottom part 130 is shown with a constant, that is not varying thickness, as in the prior art and is used in conventional cryostat. It shows FIG. 5A the unloaded case, so a case in which the cavity 126 has no pressure difference to the area outside of the cryostat 110, so a non-pumped case.
  • FIG. 5B shows the case that the cavity 126 of the cryostat 110 is evacuated. In this case acts inwards, ie towards the cavity 126, a force F 2 on the bottom part 130. Since the bottom part 130 is firmly anchored in its edge region (the raised edge 156 and the tapered portion 164 are neglected in this and subsequent figures), the bottom part 130 curves in the middle up. The resulting deflection is in FIG.
  • FIG. 6A the non-pumped-down case in which, for example, in the cavity 126 normal pressure prevails
  • FIG. 6B represents the case of the pumped state. In this pumped-down state, a force F 2 directed toward the cavity 126 acts on the bottom part 130.
  • FIG. 6B causes in this case, in which the bottom part 130 is configured according to the invention, the force F 2, a deformation of the bottom part 130.
  • this deformation is on the one hand slightly smaller than in the above in FIG. 5B in the prior art case, due to the "bridge arch effect" described above.
  • the concave curvature of the inwardly facing surface 168 of the bottom portion 130 that even in the deformed state, the bottom portion 130 can not bulge upwards, ie toward the inner vessel 112, or that such a bulge compared to the prior art strong is reduced. In this way, the risk of bridge formation in this particularly critical region of the cryostat 110 is greatly reduced.
  • FIGS. 7A and 7B Further possible embodiments of the bottom part 130 are shown (again only the thickness variation region 166 of the bottom part 130 being shown in each case), which show that also other embodiments of the curvature of the surfaces in the thickness variation region 166 than those in FIG. 6A shown curvature are possible.
  • the curvature of the inner surface 168 is continuous and, for example, parabolic, with a concave, parabolic curvature. That this need not necessarily be the case is, for example, in FIG. 7 shown in a very schematic way.
  • the curved surface 168 may also have, for example, a non-continuous thickness variation with steps 172. Since the bottom part 130 is preferably round or polyhedral, these steps can be, for example, ring steps 172.
  • the effect of this stepped embodiment is basically the same as in Figs Figures 6A and 6B shown.
  • FIG. 7B Another example of non-continuous thickness variation is shown.
  • the inwardly facing surface 168 has a generally flat central portion 174 and an adjoining annular curvature portion 176.
  • a manufacturing method is used in which the bottom part 130 is produced by means of a mold 178.
  • This mold 178 has an upper punch 180 and a lower punch 182, which together form a mold cavity 184.
  • This mold nest 184 is in the FIGS. 8 and 9 shown in a simplified way, so for example Again, the beveled portion 164 and / or a raised edge 156 of the bottom portion 130 are disregarded.
  • a "stamp" is not necessarily a movable part of the mold 178 to understand, but it may, for example, to be rigid components of this form 178, wherein the stamp 180, 182 to mold cavity 184 indicative surfaces 186, 188 have.
  • the two punches 180, 182 are along a parting line 190, which in the FIGS.
  • a "dividing line” is not necessarily to be understood as meaning a line, but also, for example, a dividing surface or the like.
  • the punches 180, 182 may include other, for example, movable or exchangeable mold parts to impart further contours to the bottom portion 130.
  • a fiber material 192 is introduced into the mold cavity 184.
  • This fibrous material 192 can be designed, for example, in the form of fiber mats, for example in the form of glass fiber, carbon fiber or mineral fiber mats or mixtures of different fiber materials.
  • the fiber material 192 is in the FIGS. 8 and 9 only schematically indicated and is preferably introduced into the mold cavities 184 so that they are substantially filled.
  • a non-cured matrix material 194 in the FIGS. 8 and 9 indicated by a puncture
  • this matrix material 194 is poured into the mold cavities 184 such that the fiber material 192 is completely impregnated with the uncured matrix material 194.
  • this matrix material 194 may be an epoxy resin.
  • other types of matrix materials 194 are also conceivable, for example other types of thermosetting plastics, thermoplastics or other hardenable matrix materials 194.
  • the matrix material 194 is cured, which can be done for example by simple waiting, thermal initialization, addition of a starter, photochemical activation or other types of activation. In this way, in each case an at least partially cured bottom part 130 is formed in the mold cavities 184.
  • the two in the FIGS. 8 and 9 The methods shown differ essentially in how, in these methods, the concentrically varying bottom thickness of the bottom part 130 is generated.
  • the mold cavity 184 is already designed by appropriate design of the dies 180, 182 in such a way that the bottom part 130 removed from the mold cavity 184 already approximates, for example, the Shape of in FIG. 6A has bottom part 130 shown. This means that even after casting and curing the inwardly facing inside 168 of the bottom part 130 (see FIG. 6A ) has a curvature, whereas the outwardly facing outer side 170 shows, for example, a substantially planar course.
  • the concentrically varying ground thickness is subsequently produced by a cutting process.
  • the two surfaces 186, 188 of the dies 180, 182 have a substantially constant curvature, so that the bottom part 130 removed from the mold cavity 184 after curing initially has a substantially constant bottom thickness, but is curved overall. Also, different curvatures of the surfaces 186, 188 are possible in principle.
  • the concentrically varying ground thickness is subsequently produced by cutting this bottom part along a cutting line 196 (which, in turn, can also be a cut surface). This can be done for example by a simple sawing.
  • a grinding method can be used in which the bottom part 130 in FIG. 9 from below by means of a preferably flat grinding tool to the cutting line 196 is ground. Also in this way, for example, the in FIG. 6A produce illustrated bottom portion 130 with the concentrically varying floor thickness.
  • FIGS. 8 and 9 are only examples of a variety of possible manufacturing processes for producing a bottom part. These examples, especially those in FIG. 9 illustrated cutting or grinding process, but are characterized by a high process reliability, high reproducibility of the generated bottom parts 130 and by comparatively low production costs for the molds 178.

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Magnetic Variables (AREA)

Claims (15)

  1. Cryostat (110), pour l'utilisation dans un système de mesure biomagnétique, comprenant au moins un récipient intérieur (112) et au moins un récipient extérieur (114), ainsi qu'au moins un espace creux (126) disposé entre le récipient intérieur (112) et le récipient extérieur (114), l'espace creux (126) étant susceptible d'être sollicité avec un vide, le récipient extérieur (114) présentant une partie fond (130), caractérisé en ce que la partie fond (130) présente une zone à variation d'épaisseur (166), avec une épaisseur de fond variant concentriquement, l'épaisseur de fond prenant, au centre de la partie fond (130), une plus faible valeur que dans une zone extérieure.
  2. Cryostat (110) selon la revendication précédente, l'épaisseur de fond ayant, sur l'étendue latérale de la partie fond (130), une valeur comprise entre 0,1% et 5%, de préférence comprise entre 0,5% et 2% et, de manière particulièrement préférée, comprise entre 0,75% et 1%.
  3. Cryostat (110) selon l'une des deux revendications précédentes, la variation de l'épaisseur de fond se produit continument ou par degrés.
  4. Cryostat (110) selon l'une des revendications précédentes, la variation de l'épaisseur de fond présente au moins approximativement un profil en forme de parabole.
  5. Cryostat (110) selon l'une des revendications précédentes, la zone à variation d'épaisseur (166) s'étend sur 50% à100% de l'étendue latérale de la partie fond (130).
  6. Cryostat (110) selon l'une des revendications précédentes, l'espacement entre la partie fond (130) du récipient extérieur (114) et une partie de fond intérieur (136) du récipient intérieur (112) est compris entre 3 mm et 30 mm, de préférence entre 10 mm et 25 mm et, de manière particulièrement préférée, est de 20 mm.
  7. Cryostat (110) selon l'une des revendications précédentes, la partie fond (130) présente un diamètre d'au moins 200 mm et, de préférence, un diamètre de 400 mm.
  8. Cryostat (110) selon l'une des revendications précédentes, la partie fond (130) présente une face extérieure (170) tournée vers l'extérieur et une faxe intérieure (168) tournée vers l'intérieur, la face extérieure (170), pour une pression normale dans l'espace creux (126) présentant une allure sensiblement plane, la face intérieure (168), pour une pression normale dans l'espace creux (126), présentant une surface incurvée.
  9. Cryostat (110) selon l'une des revendications précédentes, la partie fond (130) présente un matériau à base de fibres (192), en particulier un matériau à base de fibres de verre et/ou un matériau à base de fibres de carbone et/ou un matériau à base de fibres minérales.
  10. Cryostat (110) selon l'une des revendications précédentes, le récipient extérieur (114) présente en outre une paroi latérale (128), reliée à la partie fond (130) dans une zone de liaison faisant le pourtour.
  11. Cryostat (110) selon la revendication précédente, la partie fond (130) présentant un bord (156) relevé, le bord (156) relevé présentant une face en échelonnement (160), la paroi latérale (128) reposant sur la face en échelonnement (160).
  12. Système de mesure biomagnétique, comprenant au moins un cryostat (110) selon l'une des revendications précédentes, comprenant en outre au moins un capteur biomagnétique, pour la détection d'un champ magnétique.
  13. Procédé de fabrication d'un cryostat (110) pour l'utilisation dans un système de mesure biomagnétique, en particulier un cryostat (110) selon l'une des revendications précédentes, orientées vers un cryostat (110), le cryostat (110) comprenant au moins un récipient intérieur (112) et au moins un récipient extérieur (114), ainsi qu'au moins un espace creux (126) disposé entre le récipient intérieur (112) et le récipient extérieur (114), l'espace creux (126) étant susceptible d'être sollicité avec un vide, le récipient extérieur (114) présentant une partie fond (130), la partie fond (130) présentant une zone à variation d'épaisseur (166), avec une épaisseur de fond variant concentriquement, l'épaisseur de fond prenant, au centre de la partie fond (130), une plus faible valeur que dans une zone extérieure, le procédé de fabrication de la partie fond (130) comprenant les étapes suivantes :
    - au moins un matériau (194) durcissable est introduit dans un moule (178), le moule (178) présentant au moins une poche de formage (184) et au moins une première partie formant poinçon (180), la première partie formant poinçon (180) présentant une surface (186) incurvée dans la poche de formage (184) ;
    - le matériau (192, 194) durcissable est durci.
  14. Procédé la revendication précédente, où, lors de l'introduction du matériau (192, 194) durcissable, au moins un matériau à base de fibres (192) est introduit dans la poche de formage (184), en outre au moins un matériau de matrice (194) est introduit dans la poche de formage (184).
  15. Procédé selon l'une des deux revendications précédentes, le moule (178) présentant au moins une deuxième partie formant poinçon (188), la deuxième partie formant poinçon (188) présentant une courbure sensiblement opposée par rapport à la première partie formant poinçon (186), sachant que, après durcissement du matériau durcissable, la partie de fond (130) est retirée de la poche de formage (184) et, dans un processus de découpage subséquent et/ou un processus de meulage subséquent, une face inférieure (170) sensiblement plane de la partie fond (130) est produite.
EP20070018697 2007-09-24 2007-09-24 Cryostat doté d'un récipient extérieur stabilisé Not-in-force EP2039980B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE200750003414 DE502007003414D1 (de) 2007-09-24 2007-09-24 Kryostat mit stabilisiertem Aussengefäss
EP20070018697 EP2039980B1 (fr) 2007-09-24 2007-09-24 Cryostat doté d'un récipient extérieur stabilisé
AT07018697T ATE463700T1 (de) 2007-09-24 2007-09-24 Kryostat mit stabilisiertem aussengefäss
US12/679,031 US20110031253A1 (en) 2007-09-24 2008-09-24 Cryostat having a stabilized exterior vessel
PCT/EP2008/008068 WO2009040100A1 (fr) 2007-09-24 2008-09-24 Cryostat à cuve extérieure stabilisée
CA 2725703 CA2725703A1 (fr) 2007-09-24 2008-09-24 Cryostat a cuve exterieure stabilisee

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20070018697 EP2039980B1 (fr) 2007-09-24 2007-09-24 Cryostat doté d'un récipient extérieur stabilisé

Publications (2)

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EP2039980A1 EP2039980A1 (fr) 2009-03-25
EP2039980B1 true EP2039980B1 (fr) 2010-04-07

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US (1) US20110031253A1 (fr)
EP (1) EP2039980B1 (fr)
AT (1) ATE463700T1 (fr)
CA (1) CA2725703A1 (fr)
DE (1) DE502007003414D1 (fr)
WO (1) WO2009040100A1 (fr)

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KR101110798B1 (ko) * 2010-10-27 2012-02-24 한국표준과학연구원 생체자기 측정용 저온 수용장치, 이를 포함하는 생체자기 측정장치 및 이의 제조방법
KR101356641B1 (ko) 2011-10-11 2014-02-03 삼성전자주식회사 초전도 전자석 장치
KR101356642B1 (ko) * 2011-10-11 2014-02-03 삼성전자주식회사 초전도 전자석 장치
ES2886979T3 (es) 2012-02-09 2021-12-21 Memed Diagnostics Ltd Distintivos y determinantes para diagnosticar infecciones y métodos para usarlos
EP3180621B1 (fr) 2014-08-14 2020-04-01 Memed Diagnostics Ltd. Analyse computationnelle de données biologiques au moyen d'un collecteur et d'un hyperplan
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof

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US2127712A (en) * 1934-12-05 1938-08-23 Bart Blaslus High pressure tank
AT322438B (de) * 1972-09-25 1975-05-26 Hoell Metallwarenfab Karl Behälter zur aufnahme von unter druck stehenden medien
US4750631A (en) * 1986-07-21 1988-06-14 Sperry Corporation Anti-slosh apparatus for liquid containers
US4773952A (en) * 1987-08-03 1988-09-27 Biomagnetic Technologies, Inc. Nonmetallic cylindrical cryogenic container
US5346570A (en) 1992-07-30 1994-09-13 Biomagnetic Technologies, Inc. Cryogenic dewar and method of fabrication
DE19544593C5 (de) * 1995-11-30 2006-03-09 Air Liquide Deutschland Gmbh Vakuumisolierter Kryobehälter
DE29809387U1 (de) 1998-05-26 1998-08-06 Institut für Luft- und Kältetechnik Gemeinnützige Gesellschaft mbH, 01309 Dresden Kryostat mit hoher elektromagnetischer Hochfrequenz-Transparenz
DE10148586C1 (de) * 2001-03-19 2002-12-05 Hans Zucker Gmbh & Co Kg Wechselbar temperierfähiges Behältnis

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DE502007003414D1 (de) 2010-05-20
US20110031253A1 (en) 2011-02-10
CA2725703A1 (fr) 2009-04-02
EP2039980A1 (fr) 2009-03-25
ATE463700T1 (de) 2010-04-15
WO2009040100A1 (fr) 2009-04-02

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