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EP2061466A4 - COMPOUNDS BASED ON QUINOLINE AND THIO-SUBSTITUTED NAPHTHYRIDINE IN POSITION 4 - Google Patents

COMPOUNDS BASED ON QUINOLINE AND THIO-SUBSTITUTED NAPHTHYRIDINE IN POSITION 4

Info

Publication number
EP2061466A4
EP2061466A4 EP07837234A EP07837234A EP2061466A4 EP 2061466 A4 EP2061466 A4 EP 2061466A4 EP 07837234 A EP07837234 A EP 07837234A EP 07837234 A EP07837234 A EP 07837234A EP 2061466 A4 EP2061466 A4 EP 2061466A4
Authority
EP
European Patent Office
Prior art keywords
thio
quinoline
compounds based
substituted naphthyridine
naphthyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07837234A
Other languages
German (de)
French (fr)
Other versions
EP2061466A2 (en
Inventor
Zhen Yang
Reza Fathi
Qiang Zhu
Hyun Joon Cho
Yixin Liu
Anthony Sandrasagra
Richard C Wobbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
XTL Biopharmaceuticals Ltd
Original Assignee
XTL Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XTL Biopharmaceuticals Ltd filed Critical XTL Biopharmaceuticals Ltd
Publication of EP2061466A2 publication Critical patent/EP2061466A2/en
Publication of EP2061466A4 publication Critical patent/EP2061466A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP07837234A 2006-08-23 2007-08-22 COMPOUNDS BASED ON QUINOLINE AND THIO-SUBSTITUTED NAPHTHYRIDINE IN POSITION 4 Withdrawn EP2061466A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83992206P 2006-08-23 2006-08-23
PCT/US2007/018607 WO2008024423A2 (en) 2006-08-23 2007-08-22 4-thio substituted quinoline and naphthyridine compounds

Publications (2)

Publication Number Publication Date
EP2061466A2 EP2061466A2 (en) 2009-05-27
EP2061466A4 true EP2061466A4 (en) 2010-12-29

Family

ID=39107397

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07837234A Withdrawn EP2061466A4 (en) 2006-08-23 2007-08-22 COMPOUNDS BASED ON QUINOLINE AND THIO-SUBSTITUTED NAPHTHYRIDINE IN POSITION 4

Country Status (5)

Country Link
EP (1) EP2061466A4 (en)
JP (1) JP2010501570A (en)
AU (1) AU2007288188A1 (en)
CA (1) CA2677001A1 (en)
WO (1) WO2008024423A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108473435A (en) 2015-10-05 2018-08-31 纽约市哥伦比亚大学理事会 The treatment of the removing and protein sickness of the activator of autophagy tide and phospholipase D and the protein masses including TAU
EP3853234B1 (en) 2018-09-18 2025-04-23 Nikang Therapeutics, Inc. Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015820A (en) * 1995-07-31 2000-01-18 Centre National De La Recherche Scientifique (Cnrs) 4-Aryl-thio-pyridin-2(1H)-ones, medicines containing them and their uses in the treatment of illnesses linked to HIV
WO2005012288A1 (en) * 2003-08-01 2005-02-10 Genelabs Technologies, Inc Bicyclic imidazol derivatives against flaviviridae

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430153A (en) * 1991-04-03 1995-07-04 Korea Research Institute Of Chemical Technology 2-quinolinone derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015820A (en) * 1995-07-31 2000-01-18 Centre National De La Recherche Scientifique (Cnrs) 4-Aryl-thio-pyridin-2(1H)-ones, medicines containing them and their uses in the treatment of illnesses linked to HIV
WO2005012288A1 (en) * 2003-08-01 2005-02-10 Genelabs Technologies, Inc Bicyclic imidazol derivatives against flaviviridae

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EL-HOSSAIN ALI MOHAMED ET AL: "SYNTHESIS AND BEHAVIOUR OF 2,4-DICHLORO-6-METHYLQUINOLINE AND 4-CHLORO-6-METHYL-2(1H)QUINOLONE TOWARDS SOME NUCLEOPHILIC REAGENTS", JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, BELGRADE, YU, vol. 58, no. 10, 1 January 1993 (1993-01-01), pages 737 - 743, XP009056091, ISSN: 0352-5139 *
MIREK J. ET AL: "Synthesis and pharmacological properties of some 7H-[1]-benzothiopyrano-[3,2-c]quinolin-7-ones", POL. J. PHARMACOL. PHARM., vol. 35, 1 January 1983 (1983-01-01), pages 139 - 149, XP002606763 *
MOSTAFA M ISMAIL ET AL: "Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-2(1H)-one and its Thione An", MOLECULES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, BASEL, CH, vol. 5, no. 12, 1 January 2000 (2000-01-01), pages 1224 - 1239, XP009140312, ISSN: 1420-3049 *

Also Published As

Publication number Publication date
JP2010501570A (en) 2010-01-21
WO2008024423A2 (en) 2008-02-28
CA2677001A1 (en) 2008-02-28
AU2007288188A1 (en) 2008-02-28
EP2061466A2 (en) 2009-05-27
WO2008024423A3 (en) 2008-11-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20090320

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

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111L Licence recorded

Free format text: 0101 PRESIDIO PHARMACEUTICALS INC

Effective date: 20090320

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RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 215/36 20060101ALI20101115BHEP

Ipc: A61K 31/47 20060101AFI20090325BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20101126

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20110625