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EP2054013A1 - Bioquinones pour la stimulation de la synthèse kératinique - Google Patents

Bioquinones pour la stimulation de la synthèse kératinique

Info

Publication number
EP2054013A1
EP2054013A1 EP07788451A EP07788451A EP2054013A1 EP 2054013 A1 EP2054013 A1 EP 2054013A1 EP 07788451 A EP07788451 A EP 07788451A EP 07788451 A EP07788451 A EP 07788451A EP 2054013 A1 EP2054013 A1 EP 2054013A1
Authority
EP
European Patent Office
Prior art keywords
hair
acid
biochinones
cosmetic
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP07788451A
Other languages
German (de)
English (en)
Inventor
Melanie Giesen
Erik Schulze Zur Wiesche
Elisabeth Poppe
Thomas Welss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henkel AG and Co KGaA
Original Assignee
Henkel AG and Co KGaA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel AG and Co KGaA filed Critical Henkel AG and Co KGaA
Publication of EP2054013A1 publication Critical patent/EP2054013A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones

Definitions

  • the present invention relates to the cosmetic use of one or more biochinones to combat age-related changes in the hair follicle, to promote keratin synthesis in the hair and to positively influence the hair structure.
  • the invention further relates to a cosmetic method for combating age-related changes in the hair follicle and to a method for stimulating keratin synthesis in the hair.
  • the amount of a hair-active agent which can usually penetrate transdermally and especially transfollicularly to the hair bulb, is extremely low and depends essentially on the physicochemical properties of the substance itself (for example: size, charge, lipophilicity) and the choice of formulation.
  • Hair follicle cells undergo a genetically determined cycle of growth, regression, and resting phase.
  • the hair follicle is thus the only organ that constantly renews itself and thus, depending on the respective growth phase, has a unique metabolism.
  • the synthesis of structural keratins is also linked to this cycle.
  • This cycle is controlled by a small, highly specialized cell population in the hair bulb, the dermal papilla cells, which controls hair growth through a unique, complex system of molecular signals specific to each phase of the hair cycle (Botchkarev VA et al. (2003) J Invest Dermatol Symp Proc 8: 46-55). If the metabolism of these highly specialized cells is to be modulated by the use of a test formulation, it is essential to have a targeted effect on the corresponding mechanisms.
  • Hepatocyte Growth Factor HGF
  • Keratinocyte Growth Factor KGF
  • HGF Hepatocyte Growth Factor
  • KGF Keratinocyte Growth Factor
  • Topical applications for the treatment of disorders in the hair structure are usually physical processes in which, for example, polymers or structural proteins are applied to the hair.
  • the sustainability of these methods is limited and here too there is the risk of hair
  • Ubiquinone has been used mainly as an antioxidant in skin cosmetics.
  • the application WO200401095 describes the use of a formulation which, inter alia, may contain ubiquinone as an antioxidant to improve the surface texture of the hair.
  • EP-A-1 059 081 claims the use of ubiquinone for reducing oxidative damage to the hair.
  • the applications EP-A-1 059 077 and EP-A-1 059 080 use ubiquinone to improve the hair structure, this is a purely superficial physical effect which is based on improving the combability.
  • the formulation may also contain other antioxidants such as ubiquinone.
  • the application WO2004089326 claims the use of an active ingredient combination of creatinine, creatine and biochinones.
  • this formulation is intended for inflammatory Skin conditions and / or used for skin protection.
  • this application also does not address the effect of ubiquinone on keratin synthesis and thus the prevention of hair aging.
  • keratin synthesis decreases significantly in the aging hair follicle.
  • the hair keratins hHal, hHa3-l, hHa4 and various cytokeratins are affected by the age-related changes.
  • Hair keratins represent the most important structuring part of hair.
  • the importance of hair keratins for the healthy hair fiber is shown by the fact that genetic mutations in the hair keratins hHb6 and hHb1 lead to strong changes, such as hair fiber deformation and hair breakage (Monilethix).
  • mice with a point mutation of the gene Ha3 show a naked phenotype without a fur coat (nude mice).
  • the aim of the present invention was therefore to find suitable active ingredients for the preparation of cosmetic preparations which are applied topically to the scalp and there activate keratin synthesis and thus counteract the aging of hair.
  • the present invention therefore relates to the use of one or more biochinones for the preparation of cosmetic preparations for hair treatment, in particular for the production of cosmetic preparations for combating age-related changes in the hair follicle.
  • biochinones allows the development of new product
  • biochinones in cosmetic hair treatment compositions furthermore counteract or reverse the increase in microinflammation and apoptosis.
  • the preferred ubiquinones according to the invention have the following formula:
  • ubiquinone of the formula where n 10, also known as coenzyme Q10.
  • Quinone ring Particularly preferred according to the invention is the use of 0.0000005 to 1% of one or more biochinones. Particularly preferred is the use of coenzyme Q10.
  • a second subject of the invention is a process for the preparation of a cosmetic or pharmaceutical preparation for combating age-related changes in the hair follicle, in which a cosmetic agent based on one or more biochinones is applied to the hair or to the hairy skin.
  • Preferred according to the invention is a process in which 0.0000005 to 1% of one or more biochinones, in particular coenzyme Q10, are used in a cosmetically suitable preparation.
  • a third aspect of the invention is the use of one or more biochinones for the preparation of cosmetic preparations for hair treatment, in particular for the preparation of cosmetic preparations for promoting keratin synthesis in the hair.
  • biochinones to stimulate the synthesis of the hair keratins affected by the aging hHa3-l, hHa4, hHa2 and hHb ⁇ .
  • biochinones to increase cytokeratin synthesis in the hair follicle.
  • biochinones to stimulate cell vitality, cell production and release of growth factors, and repression of catagen-associated parameters is also preferred in the present invention.
  • biochinone selected from the group of ubiquinones and / or plastoquinones in a concentration of 0.0000005 to 1% has also proven to be particularly advantageous for promoting keratin synthesis in the hair.
  • Coenzyme Q10 is particularly preferred.
  • a fourth subject of the invention is a process for the preparation of a cosmetic or pharmaceutical preparation for stimulating keratin synthesis in the hair, in which a cosmetic agent based on one or more biochinones is applied to the hair or to the hairy skin.
  • Preferred according to the invention is a process in which 0.0000005 to 1% of one or more biochinones, in particular coenzyme Q10, are used in a cosmetically suitable preparation.
  • a fifth subject of the invention is the use of one or more biochinones for the preparation of cosmetic preparations for hair treatment, in particular for the production of cosmetic preparations for positively influencing the internal hair structure.
  • Preferred according to the invention is the use of a biochinone selected from the group of ubiquinones and / or plastoquinones in a concentration of 0.0000005 to 1%.
  • Coenzyme Q10 is particularly preferred.
  • ubiquinone (s) in cosmetic hair treatment agents has been found to positively affect hair growth and metabolism.
  • the gene expression of the important hair genes was significantly regulated by the use according to the invention.
  • the growth-inhibiting markers IGFBP3 and TGFß-2 are repriemiert.
  • a further advantage of the invention is that the use of ubiquinone (s) in cosmetic hair treatment agents leads to stimulation of hair growth and vital hair strengthening. It was possible to increase HGF secretion (hepatocyte growth factor) by treating organotypic hair follicle cell cultures Ubiquinone be detected.
  • HGF secretion hepatocyte growth factor
  • the use according to the invention of the biochinones in cosmetic agents leads to a positive influence on the hair structure by stimulating special hair-specific structural proteins (the hair keratins).
  • the hair keratins special hair-specific structural proteins
  • the hair keratin expression of the hair keratins hHa3-l, hHa4, hHb ⁇ and hHa2 is significantly increased.
  • the hair structure, and thus the hair strengthened and strengthened.
  • the hair can regrow vigorously and healthy, without the age-dependent phenomena thinning, fragility or firmness of the hair occur.
  • biochinones in hair cosmetics continues to provide positive results in terms of biological hair thickening.
  • the hair thickening on a biological basis avoids effects such as "over-care" of the hair.
  • the hair grows from the root to strengthened and with a larger diameter, so that this effect is particularly long-lasting.
  • Water and alcohol may be present in the aqueous alcoholic base in a weight ratio of 1:10 to 10: 1.
  • Water and aqueous-alcoholic mixtures which contain up to 50% by weight, in particular up to 25% by weight, of alcohol, based on the mixture of alcohol / water, may be preferred bases according to the invention.
  • the pH of these preparations can in principle be between 2 and 11. It is preferably between 2 and 7, with values of 3 to 5 being particularly preferred.
  • any acid or base that can be used for cosmetic purposes can be used.
  • acids are used as acids.
  • By-acids are understood to mean those acids which are absorbed as part of the usual food intake and have positive effects on the human organism.
  • Eat acids are, for example, acetic acid, lactic acid, tartaric acid, citric acid, malic acid, ascorbic acid and gluconic acid.
  • citric acid and lactic acid is particularly preferred.
  • Preferred bases are ammonia, alkali hydroxides, monoethanolamine, triethanolamine and N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine.
  • biochinones in preparations remaining on the skin and hair have been found to be particularly effective and may therefore constitute preferred embodiments of the teaching of the invention.
  • preparations that are not in the context of treatment after a period of a few seconds to one hour with the help of water or an aqueous solution again from the skin or rinsed out of the hair , Rather, the preparations remain until the next wash on the skin or hair.
  • the biochinones are used in hair conditioners or hair conditioners. These preparations can be rinsed out after expiry of a contact time with water or an at least predominantly aqueous agent; however, they are preferably left on the hair as stated above.
  • the biochinones may also be used in skin and hair cleansers such as shampoos, make-up removers, facial cleansers, skin and hair conditioning agents such as rinses, day creams, night creams, face masks, or in hair setting agents such as hair fixatives , Mousse, styling gels and hair drier, are used in permanent shaping agents such as perming and fixing agents as well as in hair dyes
  • the biochinones are used in agents that are present as a microemulsion.
  • microemulsions are also understood to be so-called "PIT" emulsions. These emulsions are in principle systems with the three components water, oil and emulsifier which are at room temperature as oil-in-water (O / W).
  • microemulsions When these systems are heated, microemulsions are formed in a certain temperature range (commonly referred to as the phase inversion temperature or "PIT") which, upon further heating, convert to water-in-oil (W / O) emulsions again O ⁇ / V emulsions are formed, but which are also present at room temperature as microemulsions having an average particle diameter of less than 400 nm, in particular having a particle diameter of about 100-300 nm.
  • PIT phase inversion temperature
  • biochinones can also be used according to the invention in cosmetic preparations which are suitable for the treatment of the skin.
  • skin in the sense of the invention are meant in particular human skin and mucous membrane.
  • biochinones in these agents also causes the thickening of epithelial cells and cell layers, especially on the skin, an improvement in the firmness of the skin, the strengthening of the epidermis, a reduction in the thinning of the skin, in particular by aging of the skin, a reduction of the skin transepidermal water loss of the skin, an improvement in skin hydration, the protection of the skin from infections, exogenous factors such as smog, cigarette smoke and against the stress of damaging and / or irritating substance, in particular surfactants and / or frequent water contact.
  • hair growth stimulating agent may be preferred according to the invention.
  • hair growth stimulating agents are those
  • 5- ⁇ -reductase inhibitors are in particular functional C 2 -C 2 -carboxylic acids and their physiologically acceptable metal salts, in particular 10-hydroxydecanoic acid, 10
  • Plant extracts fragrances, flavonoids, isoflavonoids, 6,7-disubstituted
  • derivatives are meant in particular their salts, esters and amides.
  • polymers in addition to the biochinones.
  • polymers are meant both natural and synthetic polymers which may be anionic, cationic or amphoteric charged as well as nonionic.
  • Cationic polymers are polymers which have groups in the main and / or side chain which may be "temporary” or “permanent” cationic.
  • "permanently cationic” refers to those polymers which have a cationic group, irrespective of the pH of the agent. These are usually polymers containing a quaternary nitrogen atom, for example in the form of an ammonium group.
  • Preferred cationic groups are quaternary ammonium groups.
  • . 4- hydrocarbon group are bonded to a constructed from acrylic acid, methacrylic acid or their derivatives polymer backbone have been found to be particularly suitable.
  • R 18 -H or -CH 3
  • R 18 is a methyl group
  • R 19 , R 20 and R 21 are methyl groups m has the value 2.
  • Suitable physiologically acceptable counter ions X include halide ions, sulfate ions, phosphate ions, methosulfate ions and organic ions such as lactate, citrate, tartrate and acetate ions. Preferred are halide ions, particularly chloride.
  • a particularly suitable homopolymer is, if desired, crosslinked, poly (methacryloyloxyethyltrimethylammoniumchlorid) with the INCI name Polyquaternium- 37.
  • the crosslinking if desired, using poly olefinically unsaturated compounds, for example divinylbenzene, tetraallyloxyethane, methylenebisacrylamide, diallyl ether, polyallylpolyglycerylether, or allyl ethers of sugars or Sugar derivatives like Erythritol, pentaerythritol, arabitol, mannitol, sorbitol, sucrose or glucose.
  • Methylenebisacrylamide is a preferred crosslinking agent.
  • the homopolymer is preferably used in the form of a nonaqueous polymer dispersion which should not have a polymer content of less than 30% by weight.
  • Such polymer dispersions are (under the names Salcare ® SC 95 about 50% polymer content, additional components: mineral oil (INCI name: Mineral Oil) and tridecyl-polyoxypropylene-polyoxyethylene-ether (INCI name: PPG-1 trideceth-6) ) and Salcare ® SC 96 (about 50% polymer content, additional components: mixture of diesters of propylene glycol with a mixture of caprylic and capric acid (INCI name: propylene glycol Dicaprylate / Dicaprate) and tridecyl polyoxypropylene-polyoxyethylene-ether (INCI Designation: PPG-1-trideceth-6)) are commercially available.
  • Copolymers containing monomer units according to formula (PI) as the non-ionic monomer preferably acrylamide, methacrylamide, acrylic acid alkyl esters and methacrylic acid CI_ 4 d- 4 -alkyl.
  • the acrylamide is particularly preferred.
  • These copolymers can also be crosslinked, as described above in the case of the homopolymers.
  • a copolymer preferred according to the invention is the crosslinked acrylamide-methacryloyloxyethyltrimethylammonium chloride copolymer.
  • Such copolymers in which the monomers are present in a weight ratio of about 20:80, are commercially available as approximately 50% non-aqueous polymer dispersion 92 under the name Salcare ® SC.
  • Celquat ® H 100, Celquat L 200 and Polymer JR ® ® 400 are preferred quaternized cellulose derivatives
  • honey for example the commercial product Honeyquat ® 50,
  • Products Q2-7224 (manufacturer: Dow Corning, a stabilized trimethylsilylamodimethicone), Dow Corning® 929 emulsion (containing a hydroxylamino-modified silicone, also referred to as amodimethicone), SM-2059 (manufacturer: General Electric), SLM 55067 (manufacturer: Wacker) and AbiP-Quat 3270 and 3272 (manufacturer: Th. Goldschmidt, di-quaternary polydimethylsiloxanes, quaternium-80),
  • quaternized derivatives of dialkylaminoalkyl acrylate and methacrylate such as diethyl sulfate quaternized vinylpyrrolidone dimethylaminoethyl methacrylate copolymers.
  • Such compounds are sold under the names Gafquat ® 734 and Gafquat ® 755 commercially,
  • Vinylpyrrolidone-Vinylimidazoliummethochlorid copolymers such as those under the names Luviquat ® FC 370, FC 550, FC 905 and HM 552 are offered.
  • quaternized polyvinyl alcohol as well as those under the names
  • Polyquaternium 27 known polymers with quaternary nitrogen atoms in the polymer main chain.
  • Can be used as cationic polymers are sold under the names Polyquaternium-24 (commercial product z. B. Quatrisoft ® LM 200), known polymers.
  • Gaffix ® VC 713 manufactured by ISP:
  • the copolymers of vinylpyrrolidone such as the commercial products Copolymer 845 (ISP manufacturer) are Gafquat ® ASCP 1011, Gafquat ® HS 110, Luviquat ® 8155 and Luviquat ® MS 370 available are.
  • cationic polymers are the so-called "temporary cationic" polymers. These polymers usually contain an amino group which, at certain pH values, is present as a quaternary ammonium group and thus cationically.
  • chitosan and its derivatives are preferred as Hydagen CMF ®, Hydagen HCMF ®, Kytamer ® PC and Chitolam ® NB / 101 are freely available commercially, for example under the trade names.
  • Chitosans are deacetylated chitins, which are commercially available in different degrees of deacetylation and different degrees of degradation (molecular weights). Their preparation is described, for example, in DE 44 40 625 A1 and in DE 1 95 03 465 A1.
  • Particularly suitable chitosans have a degree of deacetylation of at least 80% and a molecular weight of 5 10 5 to 5 10 6 (g / mol).
  • the chitosan must be converted into the salt form. This can be done by dissolving in dilute aqueous acids.
  • Suitable acids are both mineral acids such as hydrochloric acid, sulfuric acid and phosphoric acid and organic acids, for example low molecular weight carboxylic acids, polycarboxylic acids and hydroxycarboxylic acids.
  • higher molecular weight alkyl sulfonic acids or alkyl sulfuric acids or organophosphoric acids can be used, provided that they have the required physiological compatibility.
  • Suitable acids for converting the chitosan into the salt form are, for example, acetic acid, glycolic acid, tartaric acid, malic acid, Citric acid, lactic acid, 2-pyrrolidinone-5-carboxylic acid, benzoic acid or salicylic acid. Preference is given to using low molecular weight hydroxycarboxylic acids, for example glycolic acid or lactic acid.
  • anionic polymers which may aid the action of the biochinone (s) used in the present invention are anionic polymers having carboxylate and / or sulfonate groups.
  • anionic monomers from which such polymers may consist are acrylic acid, methacrylic acid, crotonic acid, maleic anhydride and 2-acrylamido-2-methylpropanesulfonic acid.
  • the acidic groups may be wholly or partly present as sodium, potassium, ammonium, mono- or triethanolammonium salt.
  • Preferred monomers are 2-acrylamido-2-methylpropanesulfonic acid and acrylic acid.
  • Anionic polymers which contain 2-acrylamido-2-methylpropanesulfonic acid as the sole or co-monomer can be found to be particularly effective, it being possible for the sulfonic acid group to be wholly or partly present as sodium, potassium, ammonium, mono- or triethanolammonium salt ,
  • the homopolymer of 2-acrylamido-2-methyl propane sulfonic acid which is available for example under the name Rheothik ® 11-80 is commercially.
  • copolymers of at least one anionic monomer and at least one nonionic monomer are preferable to use copolymers of at least one anionic monomer and at least one nonionic monomer.
  • anionic monomers reference is made to the substances listed above.
  • Preferred nonionic monomers are acrylamide, methacrylamide, acrylic esters, methacrylic esters, vinylpyrrolidone, vinyl ethers and vinyl esters.
  • Preferred anionic copolymers are acrylic acid-acrylamide copolymers and in particular polyacrylamide copolymers with sulfonic acid-containing monomers.
  • a particularly preferred anionic copolymer consists of 70 to 55 mol% of acrylamide and 30 to 45 mol% of 2-acrylamido-2-methylpropanesulfonic acid, wherein the sulfonic acid group is wholly or partly in the form of sodium, potassium, ammonium, mono- or triethanolammonium Salt is present.
  • This copolymer may also be crosslinked, with crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylenebisacrylamide are used.
  • crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylenebisacrylamide are used.
  • crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylenebisacrylamide are used.
  • Such a polymer is contained in the commercial product Sepigel ® 305 from SEPPIC.
  • Simulgel ® 600 as a compound with isohexadecane and polysorbate 80 Natriumacryloyldimethyltaurat copolymers have proven to be particularly effective according to the invention.
  • preferred anionic homopolymers are uncrosslinked and crosslinked polyacrylic acids. Allyl ethers of pentaerythritol, sucrose and propylene may be preferred crosslinking agents. Such compounds are for example available under the trademark Carbopol ® commercially.
  • Copolymers of maleic anhydride and methyl vinyl ether, especially those with crosslinks, are also color-retaining polymers.
  • a 1, 9-decadiene crosslinked maleic acid-methyl vinyl ether copolymer is available under the name ® Stabileze QM.
  • amphoteric polymers can be used as constituents as polymers for increasing the effect of the biochinone (s) used according to the invention or (e).
  • amphoteric polymers includes both those polymers which contain in the molecule both free amino groups and free -COOH or SO 3 H groups and are capable of forming internal salts, as well as zwitterionic polymers which in the molecule have quaternary ammonium groups and -COO or -SO 3 " groups, and those polymers comprising -COOH or SO 3 H groups and quaternary ammonium groups.
  • amphopolymer suitable is the acrylic resin commercially available as Amphomer ®, which is a copolymer of tert-butylaminoethyl methacrylate, N- (1, 1, 3,3-tetramethylbutyl) -acrylamide and two or more monomers from the group of acrylic acid, Represents methacrylic acid and its simple esters.
  • Amphomer ® is a copolymer of tert-butylaminoethyl methacrylate, N- (1, 1, 3,3-tetramethylbutyl) -acrylamide and two or more monomers from the group of acrylic acid, Represents methacrylic acid and its simple esters.
  • amphoteric polymers are those polymers which are composed essentially
  • R 22 -CH CR 23 -CO-Z- (C n H 2n ) -N (+) R 24 R 25 R 26 A () (PII)
  • R 22 and R 23 independently of one another are hydrogen or a methyl group and R 24 , R 25 and R 26 independently of one another are alkyl groups having 1 to 4 carbon atoms, Z is an NH group or an oxygen atom, n is an integer from 2 to 5 and A () is the anion of an organic or inorganic acid
  • R 27 and R 28 are independently hydrogen or methyl groups.
  • These compounds can be used both directly and in salt form, which is obtained by neutralization of the polymers, for example with an alkali metal hydroxide, according to the invention.
  • alkali metal hydroxide an alkali metal hydroxide
  • R 27 and R 28 are independently hydrogen or methyl groups.
  • These compounds can be used both directly and in salt form, which is obtained by neutralization of the polymers, for example with an alkali metal hydroxide, according to the invention.
  • monomers of the type (a) are used in which R 24 , R 25 and R 26 are methyl groups, Z is an NH group and A () is a halide, methoxysulfate or ethoxysulfate ion is; Acrylamidopropyl trimethyl ammonium chloride is a particularly preferred monomer (a).
  • Acrylic acid is preferably used as monomer (b) for the stated polymers.
  • nonionic polymers may also be preferred according to the invention.
  • Suitable nonionic polymers are, for example:
  • Vinylpyrrolidone / vinyl ester copolymers such as, for example, under the trademark
  • Luviskol ® (BASF). Luviskol ® VA 64 and Luviskol ® VA 73, each
  • Vinyl pyrrolidone / vinyl acetate copolymers are also preferred nonionic polymers.
  • Cellulose ethers such as hydroxypropyl cellulose, hydroxyethyl cellulose and
  • Methylhydroxypropylcellulose as used for example under the trademarks Culminal ® and
  • Siloxanes These siloxanes can be both water-soluble and water-insoluble. Both volatile and nonvolatile siloxanes are suitable, nonvolatile siloxanes being understood as meaning those compounds whose boiling point is above 200 ° C. under normal pressure.
  • Preferred siloxanes are polydialkylsiloxanes, such as, for example, polydimethylsiloxane, polyalkylarylsiloxanes, such as, for example, polyphenylmethylsiloxane, ethoxylated polydialkylsiloxanes and polydialkylsiloxanes which contain amine and / or hydroxyl groups. Glycosidically substituted silicones.
  • the term polymer also means special preparations of polymers, such as spherical polymer powders.
  • Various methods are known for producing such microspheres from different monomers, for example by special polymerization processes or by dissolving the polymer in a solvent and spraying it into a medium in which the solvent can evaporate or diffuse out of the particles.
  • Suitable polymers are, for example, polycarbonates, polyurethanes, polyacrylates, polyolefins, polyesters or Polyamides. Particularly suitable are those spherical polymer powders whose primary particle diameter is less than 1 micron.
  • Such products based on a polymethacrylate copolymer are, for example, under the trademark Polytrap ® Q5-6603 (Dow Corning) in the trade.
  • Other polymer powders for example based on polyamides (nylon 6, nylon 12) having a particle size of 2 - (10 microns (90%) and a specific surface area of about 10 m 2 / g under the trade name Orgasol ® 2002 DU Nat Cos Atochem SA, Paris).
  • spherical polymer powders which are suitable for the purpose according to the invention are, for example, the polymethacrylates (Micropearl M) from SEPPIC or (Plastic Powder A) from NIKKOL, the styrene-divinylbenzene copolymers (Plastic Powder FP) from NIKKOL, the polyethylene and polypropylene AKZO powder (ACCUREL EP 400) or silicone polymers (Silicone Powder X2-1605) from Dow Corning or spherical cellulose powders.
  • the polymethacrylates (Micropearl M) from SEPPIC or (Plastic Powder A) from NIKKOL
  • Plastic Powder FP styrene-divinylbenzene copolymers
  • ACCUREL EP 400 polyethylene and polypropylene AKZO powder
  • silicone polymers Silicone Powder X2-1605
  • polymers in amounts of from 0.01 to 10% by weight, based on the total agent, is preferred according to the invention. Amounts of from 0.1 to 5, in particular from 0.1 to 3,% by weight are particularly preferred.
  • Protein hydrolysates are product mixtures obtained by acid, alkaline or enzymatically catalyzed degradation of proteins (proteins).
  • protein hydrolysates of both vegetable and animal origin can be used.
  • Animal protein hydrolysates are, for example, elastin, collagen, keratin, silk and milk protein protein hydrolysates, which may also be present in the form of salts.
  • Such products are, for example, under the trademarks Dehylan ® (Cognis), Promois® ® (Interorgana) Collapuron ® (Cognis), Nutrilan® ® (Cognis), Gelita-Sol ® (German Gelatinefabriken Stoess & Co), Lexein ® (Inolex) and kerasol tm ® (Croda) sold.
  • Preferred according to the invention is the use of protein hydrolysates of plant origin, eg. Soybean, almond, rice, pea, potato and wheat protein hydrolysates.
  • Such products are, for example, under the trademarks Gluadin ® (Cognis), diamine ® (Diamalt) ® (Inolex) and Crotein ® (Croda) available.
  • protein hydrolysates amino acid mixtures or individual amino acids obtained otherwise, such as, for example, arginine, lysine, histidine or pyrroglutamic acid, may also be used in their place.
  • derivatives of protein hydrolysates for example in the form of their fatty acid condensation products. Such products are marketed for example under the names Lamepon ® (Cognis), Gluadin ® (Cognis), Lexein ® (Inolex), Crolastin ® (Croda) or Crotein ® (Croda).
  • Cationized protein hydrolysates can also be used according to the invention, the protein hydrolyzate on which the animal is based, for example from collagen, milk or keratin, from the plant, for example from wheat, maize, rice, potatoes, soy or almonds, from marine life forms, for example from fish collages or algae , or from biotechnologically derived protein hydrolysates, can originate.
  • the protein hydrolyzates on which the cationic derivatives according to the invention are based can be obtained from the corresponding proteins by chemical, in particular alkaline or acid hydrolysis, by enzymatic hydrolysis and / or a combination of both types of hydrolysis.
  • the hydrolysis of proteins usually results in a protein hydrolyzate having a molecular weight distribution of about 100 daltons up to several thousand daltons.
  • Preferred are those cationic protein hydrolysates whose underlying protein content has a molecular weight of 100 to 25,000 daltons, preferably 250 to 5000 daltons.
  • cationic protein hydrolyzates are to be understood as meaning quaternized amino acids and mixtures thereof.
  • the quaternization of the protein hydrolysates or amino acids is often carried out using quaternary ammonium salts such as N, N-dimethyl-N- (n-alkyl) -N- (2-hydroxy-3-chloro-n-propyl) ammonium halides.
  • the cationic protein hydrolysates may also be further derivatized.
  • the cationic protein hydrolyzates and derivatives according to the invention those listed under the INCI names in the International Cosmetic Ingredient Dictionary and Handbook, (seventh edition 1997, The Cosmetic, Toiletry, and Fragrance Association 1101 17 th Street, NW, Suite 300, Washington, DC 20036-4702) and cited: Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimopnium Hydroxypropyl Hydrolyzed Casein, Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed Silica, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat
  • the protein hydrolysates and their derivatives are preferably used in amounts of from 0.01 to 10% by weight, based on the total agent. Amounts of from 0.1 to 5% by weight, in particular from 0.1 to 3% by weight, are very particularly preferred.
  • surfactants is understood to mean surface-active substances which carry an anionic or cationic charge in the molecule. Also, both anionic and cationic charge may be present in the molecule. These zwitterionic or amphoteric surface-active substances can also be used according to the invention. Furthermore, the surface-active substances may also be non-ionic.
  • Suitable anionic surfactants in preparations according to the invention are all anionic surfactants suitable for use on the human body. These are characterized by a water-solubilizing, anionic group such as. Example, a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group having about 8 to 30 carbon atoms. In addition, glycol or polyglycol ether groups, ester, ether and amide groups and hydroxyl groups may be present in the molecule. Examples of suitable anionic surfactants are, in each case in the form of the sodium, potassium and ammonium as well as the mono-, di- and trialkanol ammonium salts having 2 to 4 C atoms in the alkanol group,
  • Ethercarbon Acid the formula RO- (CH 2 -CH 2 O) x -CH 2 -COOH, in which R is a linear
  • Alkyl group having 8 to 30 carbon atoms and x 0 or 1 to 16, acylsarcosides having 8 to 24 carbon atoms in the acyl group, acyl taurides having 8 to 24 carbon atoms in the acyl group, acyl isethionates having 8 to 24 carbon atoms in the acyl group,
  • Sulfobernsteinklamono- and dialkyl ester having 8 to 24 carbon atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethylester having 8 to 24 carbon atoms in the alkyl group and 1 to 6 oxyethyl groups, linear alkanesulfonates having 8 to 24 carbon atoms, linear alpha-olefinsulfonates with 8 to 24 carbon atoms, alpha-sulfofatty acid methyl esters of fatty acids having 8 to 30 carbon atoms,
  • Alkyl sulfates and alkyl polyglycol ether sulfates of the formula RO (CH 2 -CH 2 O) x -OSO 3 H, in which R is a preferably linear alkyl group having 8 to 30 C atoms and x 0 or 1 to 12, Mixtures of surface-active hydroxysulfonates according to DE-A-37 25 030, sulfated hydroxyalkylpolyethylene and / or hydroxyalkylene-propylene glycol ethers according to DE-
  • OX in the R 29 is preferably an aliphatic hydrocarbon radical having 8 to 30 carbon atoms
  • R 30 is hydrogen, a radical (CH 2 CH 2 O) n R 29 or X, n is from 1 to 10 and X is hydrogen, an alkali or alkaline earth metal or NR 31 R 32 R 33 R 34 , with R 31 to R 34 independently of one another represents a C 1 to C 4 hydrocarbon radical, is a sulfated fatty acid alkylene glycol ester of the formula (TII)
  • R 35 CO (AlkO) n SO 3 M (TII) in the R 35 CO- for a linear or branched, aliphatic, saturated and / or unsaturated acyl radical having 6 to 22 C atoms, Alk for CH 2 CH 2 , CHCH 3 CH 2 and / or
  • n is from 0.5 to 5 and M is a cation, as described in DE-OS 197
  • CH 2 O (CH 2 CH 2 O) Z - 3X in the R 36 CO for a linear or branched acyl radical having 6 to 22 carbon atoms, x, y and z in total for 0 or for numbers from 1 to 30, preferably 2 to 10, and X is an alkali or alkaline earth metal.
  • Typical examples of monoglyceride (ether) sulfates suitable for the purposes of the invention are the reaction products of lauric acid monoglyceride, coconut fatty acid monoglyceride, palmitic acid monoglyceride, stearic acid monoglyceride, oleic acid monoglyceride and tallow fatty acid monoglyceride and their ethylene oxide adducts with sulfur trioxide or chlorosulfonic acid in the form of their sodium salts.
  • monoglyceride sulfates of the formula (Till) are used, in which R 36 CO is a linear acyl radical having 8 to 18 carbon atoms.
  • Preferred anionic surfactants are alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule and sulfosuccinic acid mono- and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl ester having 8 to 18 C atoms in the alkyl group and 1 to 6 oxyethyl groups.
  • Zwitterionic surfactants are those surface-active compounds which carry in the molecule at least one quaternary ammonium group and at least one -COO () or -SO 3 () group.
  • Particularly suitable zwitterionic surfactants are the so-called betaines, such as the N-alkyl-N, N-dimethylammonium glycinates, for example the cocoalkyldimethylammoniumglycinate, N-acylaminopropyl-N, N-dimethylammoniumglycinate, for example the cocoacylaminopropyldimethylammoniumglycinate, and 2-alkyl-3-carboxymethyl-3-hydroxyethyl imidazolines having in each case 8 to 18 C atoms in the alkyl or acyl group and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate.
  • a preferred zwitterionic surfactant is the fatty acid amide derivative known by the INCI
  • Ampholytic surfactants are understood as meaning those surface-active compounds which, apart from a C 8 -C 24 -alkyl or -acyl group in the molecule, contain at least one free amino group and at least one -COOH or -SO 3 H group and are capable of forming internal salts
  • suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 24 C atoms in the alkyl group.
  • Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and the C 2
  • Nonionic surfactants contain as hydrophilic group z.
  • Such compounds are, for example
  • alkylphenols having 8 to 15 carbon atoms in the alkyl group such as those available under the trade names Dehydol ® LS, Dehydol ® LT types (Cognis), C 2 -C 3 o-fatty acid mono- and diesters of addition products of 1 to 30 moles of ethylene oxide with glycerol, addition products of 5 to 60 moles of ethylene oxide with castor oil and hydrogenated castor oil, Polyol fatty acid esters, such as the commercial product Hydagen ® HSP (Cognis) or Sovermol - types (Cognis), alkoxylated triglycerides, - alkoxylated fatty acid alkyl esters of the formula R 37 CO- (OCH 2 CHR 38) w OR 39, (TIV) in which R 37 CO is a linear or branched, saturated and / or unsaturated acyl radical having 6 to 22 carbon atoms, R 38 is hydrogen or methyl, R 39
  • Alkyl polyglycosides can only contain one particular alkyl radical R. Usually, however, these compounds are starting from natural fats and oils or
  • sugar building block Z it is possible to use any desired mono- or oligosaccharides.
  • sugars with 5 or 6 carbon atoms and the corresponding oligosaccharides are used.
  • Such sugars are, for example, glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose.
  • Preferred sugar building blocks are glucose, fructose, galactose, arabinose and sucrose; Glucose is particularly preferred.
  • the alkyl polyglycosides which can be used according to the invention contain on average from 1.1 to 5 sugar units. Alkyl polyglycosides having x values of 1.1 to 2.0 are preferred. Very particular preference is given to alkyl glycosides in which x is 1: 1 to 1, 8.
  • the alkoxylated homologs of said alkyl polyglycosides can also be used according to the invention. These homologs may contain on average up to 10 ethylene oxide and / or propylene oxide units per alkyl glycoside unit.
  • the preferred nonionic surfactants are the alkylene oxide addition products of saturated linear fatty alcohols and fatty acids having in each case 2 to 30 moles of ethylene oxide per mole of fatty alcohol or fatty acid. Preparations having excellent properties are also obtained if they contain fatty acid esters of ethoxylated glycerol as nonionic surfactants.
  • the alkyl radical R contains 6 to 22 carbon atoms and may be both linear and branched. Preference is given to primary linear and methyl-branched in the 2-position aliphatic radicals.
  • Such alkyl radicals are, for example, 1-octyl, 1-decyl, 1-lauryl, 1-myristyl, 1-cetyl and 1-stearyl. Particularly preferred are 1-octyl, 1-decyl, 1-lauryl, 1-myristyl.
  • oxo-alcohols compounds with an odd number of carbon atoms in the alkyl chain predominate.
  • the compounds used as surfactant with alkyl groups may each be uniform substances. However, it is usually preferred to start from the production of these substances from native plant or animal raw materials, so as to obtain substance mixtures with different, depending on the particular raw material alkyl chain lengths.
  • both products with a "normal” homolog distribution and those with a narrow homolog distribution can be used.
  • "normal” homolog distribution are meant mixtures of homologs obtained in the reaction of fatty alcohol and alkylene oxide using alkali metals, alkali metal hydroxides or alkali metal alcoholates as catalysts. Narrowed homolog distributions are obtained when, for example, hydrotalcites, alkaline earth metal salts of ether carboxylic acids, alkaline earth metal oxides, hydroxides or alkoxides are used as catalysts. The use of products with narrow homolog distribution may be preferred.
  • surfactants are used in amounts of from 0.1 to 45% by weight, preferably from 1 to 30% by weight and very particularly preferably from 1 to 15% by weight, based on the total agent.
  • nonionic, zwitterionic and / or amphoteric surfactants and mixtures thereof may be preferred.
  • quaternary ammonium compounds are ammonium halides, in particular chlorides and bromides, such as alkyltrimethylammonium chlorides, dialkyldimethylammonium chlorides and trialkyl methylammonium chlorides, eg.
  • cetyltrimethylammonium chloride stearyltrimethylammonium chloride, distearyldimethylammonium chloride, lauryldimethylammonium chloride, lauryldimethylbenzylammonium chloride and tricetylmethylammonium chloride, as well as the imidazolium compounds known under the INCI names Quaternium-27 and Quaternium-83.
  • the long alkyl chains of the above-mentioned surfactants preferably have 10 to 18 carbon atoms.
  • Esterquats are known substances which contain both at least one ester function and at least one quaternary ammonium group as a structural element.
  • Preferred ester quats are quaternized ester salts of fatty acids with triethanolamine, quaternized ester salts of fatty acids with diethanolalkylamines and quaternized ester salts of fatty acids with 1,2-dihydroxypropyldialkylamines.
  • Such products are marketed under the trade names Stepantex® ®, ® and Dehyquart® Armocare® ®.
  • the alkylamidoamines are usually prepared by amidation of natural or synthetic fatty acids and fatty acid cuts with dialkylaminoamines.
  • An inventively particularly suitable compound from this group of substances under the name Tegoamid ® S 18 commercial stearamidopropyl dimethylamine is.
  • the cationic surfactants are preferably used in amounts of 0.05 to 10 wt .-%, based on the total agent. Amounts of 0.1 to 5 wt .-% are particularly preferred.
  • the effect of the or used biochinones can be increased by emulsifiers.
  • emulsifiers are, for example
  • Sugar component are preferred, mixtures of alkyl (oligo) glucosides and fatty alcohols, for example, the commercially available product ® Montanov 68,
  • Sterols are understood to mean a group of steroids which bind to C-atom 3 of the
  • Steroid scaffold carry a hydroxyl group and both from animal tissue
  • Zoosterins are cholesterol and lanosterol. Examples of suitable phytosterols are
  • glucose phospholipids e.g. as lecithins or phosphatidylcholines from e.g. Egg yolk or plant seeds (e.g., soybeans) are understood.
  • Polyglycerols and polyglycerol such as polyglycerol poly-12-hydroxystearate (commercial product Dehymuls® ® PGPH)
  • Linear and branched fatty acids with 8 to 30 C atoms and their Na, K, ammonium,
  • the emulsifiers are preferably used in amounts of from 0.1 to 25% by weight, in particular from 0.5 to 15% by weight, based on the total agent.
  • non-ionic emulsifiers having an HLB value of 8 to 18 can be used.
  • Nonionic emulsifiers having an HLB value of 10 to 15 may be particularly preferred according to the invention.
  • the emulsifiers which do not contain ethylene oxide and / or propylene oxide in the molecule may be very particularly preferred.
  • the effect of the quinone (s) used can be further optimized by fatty substances.
  • Fatty substances are fatty acids, fatty alcohols, natural and synthetic waxes which can be in solid form as well as liquid in aqueous dispersion , and to understand natural and synthetic cosmetic oil components.
  • the fatty acids used can be linear and / or branched, saturated and / or unsaturated fatty acids having 6 to 30 carbon atoms. Preference is given to fatty acids having 10 to 22 carbon atoms. Among these could be mentioned, for example, isostearic as the commercial products Emersol ® 871 and Emersol ® 875, and isopalmitic acids such as the commercial product Edenor ® IP 95, and all other products sold under the trade names Edenor ® (Cognis) fatty acids are more typical examples of such fatty acids caproic , Caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselinic acid, linoleic acid, linolenic acid, elaeostearic acid, arachi
  • fatty acid cuttings obtainable from coconut oil or palm oil;
  • stearic acid is usually preferred.
  • the amount used is 0.1 - 15 wt.%, Based on the total mean. In a preferred embodiment, the amount is 0.5-10% by weight, very particularly preferably amounts of 1-5% by weight.
  • Fatty alcohols which may be used are saturated, mono- or polyunsaturated, branched or unbranched fatty alcohols with C 6 - C 30 -, preferably C 0 - C 22 - and very particularly preferably C 12 - C 22 - carbon atoms.
  • Decanols, octanols, dodecadienol, decadienol, oleyl alcohol, eruca alcohol, ricinoleic alcohol, stearyl alcohol, isostearyl alcohol, cetyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, caprylic alcohol, capric alcohol, linoleyl alcohol, linolenyl alcohol and behenyl alcohol are, for example, decanol, octanolol, dodecadienol, decadienol , as well as their Guerbet alcohols, this list should have exemplary and non-limiting character.
  • the fatty alcohols are derived from preferably natural fatty acids, which can usually be based on recovery from the esters of fatty acids by reduction.
  • those fatty alcohol cuts which are produced by reducing naturally occurring triglycerides such as beef tallow, palm oil, peanut oil, rapeseed oil, cottonseed oil, soybean oil, sunflower oil and linseed oil or fatty acid esters formed from their transesterification products with corresponding alcohols, and thus represent a mixture of different fatty alcohols.
  • Such substances are, for example, under the names Stenol ® such as Stenol ® 1618 or Lanette ® such as Lanette ® O or Lorol ®, for example, Lorol ® C8, Lorol C14 ®, Lorol C18 ®, ® Lorol C8-18, HD-Ocenol ®, Crodacol ® such as Crodacol ® CS, Novol ®, Eutanol ® G, Guerbitol ® 16, Guerbitol ® 18, Guerbitol ® 20, Isofol ® 12, Isofol ® 16, Isofol ® 24, Isofol ® 36, Isocarb ® 12, Isocarb ® 16 or acquire Isocarb® ® 24 for sale.
  • Stenol ® such as Stenol ® 1618 or Lanette ® such as Lanette ® O or Lorol ®
  • Lorol ® C8 Lorol C8-18
  • wool wax alcohols as are commercially available, for example under the names of Corona ®, White Swan ®, Coronet ® or Fluilan ® can be used according to the invention.
  • the fatty alcohols are used in amounts of from 0.1 to 20% by weight, based on the total preparation, preferably in amounts of from 0.1 to 10% by weight.
  • the natural or synthetic waxes used according to the invention are solid paraffins or isoparaffins, carnauba waxes, beeswaxes, candelilla waxes, ozokerites, ceresin, spermaceti, sunflower wax, fruit waxes such as apple wax or citrus wax, microwaxes of PE or PP.
  • Such waxes are available, for example, from Kahl & Co., Trittau.
  • the natural and synthetic cosmetic oil bodies which can increase the activity of the quinone (s) used according to the invention include, for example: vegetable oils.
  • vegetable oils examples include sunflower oil, olive oil, soybean oil, rapeseed oil, almond oil, jojoba oil, orange oil, wheat germ oil, peach kernel oil and the liquid portions of coconut oil.
  • triglyceride oils such as the liquid portions of beef tallow as well as synthetic triglyceride oils.
  • Ester oils are to be understood as meaning the esters of C 6 - C 30 fatty acids with C 2 - C 30 fatty alcohols. The monoesters of the fatty acids with alcohols having 2 to 24 carbon atoms are preferred.
  • fatty acid components used in the esters are caproic acid, caprylic acid, 2-ethylhexanoic acid, capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, elaidic acid, petroselinic acid, linoleic acid, linolenic acid, elaeostearic acid, arachidic acid, gadoleic acid , Behenic acid and erucic acid and their technical mixtures, which are obtained, for example, in the pressure splitting of natural fats and oils, in the oxidation of aldehydes from Roelen's oxo synthesis or the dimerization of unsaturated fatty acids.
  • fatty alcohol components in the ester oils are isopropyl alcohol, caproic alcohol, capryl alcohol, 2-ethylhexyl alcohol, capric alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, elaidyl alcohol, petroselinyl alcohol, linolyl alcohol, linolenyl alcohol, elaeostearyl alcohol, arachyl alcohol, Gadoleyl alcohol, behenyl alcohol, erucyl alcohol and brassidyl alcohol and their technical mixtures, for example, in the high-pressure hydrogenation of technical methyl esters based on fats and oils or aldehydes from the Roelen oxo synthesis and as a monomer fraction in the dimerization of unsaturated fatty alcohols incurred.
  • isopropyl myristate IPM Rilanit ®
  • isononanoic acid C16-18 alkyl ester Cetiol ® SN
  • 2-ethylhexyl palmitate Cegesoft ® 24
  • Stear ⁇ n yarn-2-ethylhexyl ester Cetiol ® 868
  • cetyl oleate glycerol tricaprylate, Kokosfettalkohol- caprate / caprylate (Cetiol ® LC)
  • n-butyl stearate oleyl erucate
  • isopropyl palmitate IPP Rilanit ®
  • oleyl Oleate Cetiol ®
  • hexyl laurate Cetiol ® A
  • di-n-butyl adipate Cetiol ® B
  • Dicarboxylic esters such as di-n-butyl adipate, di- (2-ethylhexyl) adipate, di (2-ethylhexyl) succinate and diisotridecyl acelate
  • diol esters such as ethylene glycol dioleate, ethylene glycol diisotridecanoate, propylene glycol di (2 ethylhexanoate), propylene glycol diisostearate,
  • Mono, - di- and trifatty acid esters of saturated and / or unsaturated linear and / or branched fatty acids with Glycenn such as Monomuls 90-018 ®, Monomuls 90 L12 ® or Cutina ® MD.
  • the amount used is 0, 1-50 wt.% Based on the total agent, preferably 0, 1 to 20 wt.% And particularly preferably 0.1 to 15 wt.% Based on the total agent.
  • the total amount of the oil and fat components which can be used according to the invention is usually from 6 to 45% by weight, based on the total agent. Amounts of 10-35% by weight are preferred according to the invention.
  • hydroxycarboxylic acid esters are full esters of glycolic acid, lactic acid, malic acid, tartaric acid or citric acid.
  • suitable hydroxycarboxylic esters are esters of ⁇ -hydroxypropionic acid, tartronic acid, D-gluconic acid, sugar acid, mucic acid or glucuronic acid.
  • Suitable alcohol components of these esters are primary, linear or branched aliphatic alcohols having 8-22 C atoms, ie, for example, fatty alcohols or synthetic fatty alcohols.
  • esters of C 12 -C 15 fatty alcohols are particularly preferred. Esters of this type are commercially available, eg under the trademark Cosmacol® ® EniChem, Augusta Industriale.
  • the amount of hydroxycarboxylic acid ester used is 0.1 to 15% by weight, based on the agent, preferably 0.1 to 10% by weight and very particularly preferably 0.1 to 5% by weight.
  • biochinone used with vitamins, provitamins and vitamin precursors as well as their derivatives has likewise proved to be advantageous.
  • vitamins, pro-vitamins and vitamin precursors are preferred, which are usually assigned to groups A, B, C, E, F and H.
  • vitamin A includes retinol (vitamin A 1 ) and 3,4-didehydroretinol (vitamin A 2 ).
  • the ß-carotene is the provitamin of retinol.
  • vitamin A component according to the invention for example, vitamin A acid and its esters, vitamin A aldehyde and vitamin A alcohol and its esters such as the palmitate and the acetate into consideration.
  • the vitamin A component is preferably used in amounts of 0.05-1 wt .-%, based on the total preparation.
  • the vitamin B group or the vitamin B complex include u. a.
  • Vitamin B 3 • Vitamin B 3 .
  • the compounds nicotinic acid and nicotinamide (niacinamide) are often performed.
  • Preferred according to the invention is the nicotinic acid amide, which is preferably used in amounts of from 0.05 to 1% by weight, based on the total agent.
  • Vitamin B 5 pantothenic acid and panthenol. Within this group the panthenol is preferred. Derivatives of panthenol which can be used according to the invention in particular the esters and ethers of panthenol as well as cationically derivatized panthenols. Individual representatives are, for example, the panthenol triacetate, the panthenol monoethyl ether and its monoacetate and also the cationic panthenol derivatives disclosed in WO 92/13829. The said compounds of the vitamin B 5 type are preferably used in amounts of 0.05-10% by weight, based on the total agent. Amounts of 0.1-5 wt .-% are particularly preferred. • Vitamin B 6 (pyridoxine and pyridoxamine and pyridoxal).
  • Vitamin C (ascorbic acid).
  • the usual amount used of vitamin C is 0.1 to 3 wt .-%, based on the total agent.
  • Use in the form of palmitic acid ester, glucosides or phosphates may be preferred.
  • the use in combination with tocopherols may also be preferred.
  • Vitamin E tocopherols, especially ⁇ -tocopherol.
  • Tocopherol and its derivatives, including in particular the esters such as the acetate, the nicotinate, the phosphate and the succinate, according to the invention are preferably used in amounts of 0.05-1 wt .-%, based on the total agent.
  • Vitamin F is usually understood as meaning essential fatty acids, in particular linoleic acid, linolenic acid and arachidonic acid.
  • Vitamin H is the compound (3aS, 4S, 6aR) -2-oxohexahydrothienol [3,4-d] - imidazole-4-valeric acid, for which, however, meanwhile, the trivial name biotin has prevailed.
  • Biotin is preferably used in amounts of from 0.0001 to 1.0% by weight, in particular in amounts of from 0.001 to 0.01% by weight.
  • Particularly preferred according to the invention is the additional use of vitamins, provitamins and vitamin precursors from groups A, B, E and H.
  • Panthenol and its derivatives as well as nicotinic acid amide and biotin are particularly preferred.
  • biochinone (s) used in the invention can also be increased by the combined use with plant extracts.
  • extracts are produced by extraction of the whole plant. However, in individual cases it may also be preferred to prepare the extracts exclusively from flowers and / or leaves of the plant.
  • the extracts are especially the extracts of green tea, oak bark, stinging nettle, witch hazel, hops, chamomile, burdock root, horsetail, hawthorn, linden, almond, aloe vera, spruce needle, horse chestnut, sandalwood, juniper, coconut, mango, apricot, lime, wheat , Kiwi, melon, orange, grapefruit, sage, rosemary, birch, mallow, meadowfoam, quenelle, yarrow, thyme, lemon balm, toadstool, coltsfoot, marshmallow, ginseng, ginger root, Echinacea purpurea, Olea europea, Foeniculum vulgaris and Apium graveolens.
  • Especially suitable for the use according to the invention are the extracts of green tea, almond, aloe vera, coconut, mango, apricot, lime, wheat, kiwi and melon.
  • alcohols and mixtures thereof can be used as extraction agent for the preparation of said plant extracts water.
  • the alcohols are lower alcohols such as ethanol and isopropanol, but especially polyhydric alcohols such as ethylene glycol and propylene glycol, both as sole extractant and in admixture with water, are preferred.
  • Plant extracts based on water / propylene glycol in the ratio 1 10 to 10 1 have proved to be particularly suitable.
  • the plant extracts can be used according to the invention both in pure and in diluted form. If they are used in diluted form, they usually contain about 2 to 80 wt .-% of active substance and as a solvent used in their extraction agent or extractant mixture.
  • biochinone (s) used in accordance with the invention can be further increased in combination with substances which contain primary or secondary amino groups.
  • amino compounds include ammonia, monoethanolamine, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-propanediol and basic amino acids such as lysine, arginine or histidine.
  • these amines can also be used in the form of the corresponding salts with inorganic and / or organic acids, such as ammonium carbonate, ammonium citrate, ammonium oxalate, ammonium tartrate or Lysine hydrochloride.
  • the amines are used together with the active compound according to the invention in ratios of from 1:10 to 10: 1, preferably from 3: 1 to 1: 3, and very particularly preferably in stoichiometric amounts.
  • these preparations may in principle contain all other components known to the person skilled in the art for such cosmetic compositions.
  • auxiliaries and additives are, for example:
  • Thickeners such as gelatin or vegetable gums, for example agar-agar, guar-gum,
  • Linseed gums dextrans, cellulose derivatives, e.g. Methylcellulose, hydroxyalkylcellulose and carboxymethylcellulose, starch fractions and derivatives such as amylose,
  • Amylopectin and dextrins, clays and phyllosilicates such.
  • Hydrocolloids such as polyvinyl alcohol, the Ca, Mg or Zn - soaps,
  • Structurants such as maleic acid and lactic acid
  • Solvents and mediators such as ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and diethylene glycol, fiber structure-improving agents, in particular mono-, di- and oligosaccharides such as glucose, galactose, fructose, fructose and lactose, quaternized amines such as methyl-1-alkylamidoethyl -2-alkylimidazolinium methosulfate,
  • Anti-dandruff agents such as Piroctone Olamine, Zinc Omadine and Climbazole,
  • Light stabilizers in particular derivatized benzophenones, cinnamic acid derivatives and
  • Triazines other substances for adjusting the pH, such as ⁇ - and ⁇ -
  • Active ingredients such as allantoin and bisabolol,
  • Swelling and penetration substances such as glycerol, propylene glycol monoethyl ether, carbonates,
  • Ceramides are understood as meaning N-acylsphingosine (fatty acid amides of sphingosine) or synthetic analogs of such lipids (so-called pseudo-ceramides),
  • Opacifiers such as latex, styrene / PVP and styrene / acrylamide copolymers
  • Pearlescing agents such as ethylene glycol mono- and distearate and PEG-3-distearate,
  • Reducing agents such as B. thioglycolic acid and its derivatives, thiolactic acid, cysteamine,
  • Polysaccharides such as fucose or rhamnose.
  • Active ingredients such as allantoin and bisabolol,
  • Bodying agents such as sugar esters, polyol esters or polyol alkyl ethers,
  • Fats and waxes such as spermaceti, beeswax, montan wax and paraffins,
  • Swelling and penetration substances such as glycerol, propylene glycol monoethyl ether, carbonates,
  • Opacifiers such as latex, styrene / PVP and styrene / acrylamide copolymers
  • Pearlescing agents such as ethylene glycol mono- and distearate and PEG-3-distearate,
  • Reducing agents such as B. thioglycolic acid and its derivatives, thiolactic acid, cysteamine,
  • Propellants such as propane-butane mixtures, N 2 O, dimethyl ether, CO 2 and air,
  • the determination of the vitality of cultured cells provides information about the status of the cells. With this analysis, both cell-damaging substance concentrations can be defined, as well as cell-activating drug effects can be determined.
  • the vitality of cultured cells is determined by redox dyes. These dyes penetrate into the cell and are reduced by electron uptake on the outer mitochondrial membrane. This reduction requires a dye change, which is determined photometrically below.
  • the solvent control is set equal to 100% and the measurements of the substance-treated samples referenced thereto. At a relative vitality of less than 80% one speaks of cell-damaging, with greater / equal to 120% of cell-activating substance effects.
  • Hepatocyte Growth Factor (HGF) and Keratinocyte Growth Factor (KGF) are important growth factors that are released by the dermal papilla to control the proliferation of hair keratinocytes responsible for the hair keratin synthesis. They are also characteristic markers for the anagen phase, in which keratin synthesis is also maximal. In addition, it should be noted that hair proliferation decreases the proliferation capacity of the hair follicle cells. In a potentially keratin-activating and anti-aging substance HGF and / or KGF should therefore be induced. TGF-ß2 and IGFBP-3 inhibit growth and are characteristic markers for the catagen phase, in which keratin synthesis in the follicle is switched off. These markers should be repremet in a substance that promotes keratin synthesis.
  • HGF Hepatocyte Growth Factor
  • KGF Keratinocyte Growth Factor
  • RNA is first isolated from the dermal papilla cells using the RNeasy Mini Kit from Qiagen and transcribed into cDNA by means of reverse transcription.
  • the formation of the PCR products is detected online via a fluorescence signal.
  • the fluorescence signal is proportional to the amount of the PCR product formed. The stronger the expression of a particular gene, the greater the amount of PCR product produced and the higher the fluorescence signal.
  • the solvent control is set equal to 1 and the expression of the genes to be determined based on (x-fold expression). Values greater than or equal to twice the expression or less than or equal to the 0.5-fold expression of the untreated control are classified as significantly differentially expressed.
  • Ubiquinone leads to the concentration-dependent differential gene expression of the two investigated catagen-associated marker genes.
  • Hepatocyte Growth Factor (HGF) and Keratinocyte Growth Factor (KGF) are important growth factors that are released by the dermal papilla to control the proliferation of hair keratinocytes responsible for the hair keratin synthesis. They are also characteristic markers for the anagen phase, in which keratin synthesis is also maximal. In addition, it should be noted that hair proliferation decreases the proliferation capacity of the hair follicle cells. In a potentially keratin-activating and anti-aging substance HGF and / or KGF should therefore be induced. The secretion of HGF and KGF can be quantified using commercially available ELISA kits. For this purpose, organotypic cell cultures are incubated with ubiquinone over 72 h and the concentration of growth factors in the medium determined in the manner described.
  • Table 3 KGF and HGF release after treatment of organotypic hair follicle cell cultures compared to solvent control.
  • ubiquinone leads to an increase in HGF release by a maximum of 81% compared to the untreated control (Table 3).
  • An age-related phenomenon is the thinning and increased fragility of the hair.
  • the strength of the hair and the hair structure is essentially dependent on the composition of specific hair-specific structural proteins, the hair keratins.
  • the age-related change in the composition of these specific proteins influences the hair structure on a biological level.
  • the expression of various hair keratin organotypic cell cultures can be investigated by means of the quantitative real-time PCR method described in Example 2.
  • the solvent control is set equal to 1 and the expression of the genes to be determined based on (x-fold expression). Values greater than or equal to twice the expression or less than or equal to the 0.5-fold expression of the untreated control are classified as significantly differentially expressed.
  • Table 4 Hair keratin expression after treatment of organotypic hair follicle cell cultures compared to the solvent control.
  • Ubichinone causes an increase in keratin expression in organotypic cell cultures 6h and 24h after administration (Table 4).
  • Hair aging decreases the proliferation capacity of the hair follicle cells.
  • the activating effect of the test substance used can also be detected on the layer thickness of the hair keratinocytes deposited on the model.
  • increased keratinocyte proliferation should also be detectable on an elevated keratinocyte layer in organotypic cell cultures.
  • three sections of each of three organotypic cell cultures are prepared, which are measured at five points each. For a better overview, the histological sections are stained using eosin & hematoxylin. Using a digital camera and image processing software, the layer thickness of the keratinocyte layer can then be measured.
  • Ubiquinone increased the epithelial thickness at a use concentration of 0.00001% compared to the solvent control by a maximum of 17%.
  • organotypic cell cultures were treated with ubiquinone for 6 h and 24 h, the RNA isolated and the expression of 850 different markers examined with the aid of a cDNA microarray. As a control untreated cell cultures were carried. Both after 6h and after 24h a differential gene regulation was detected for different hair relevant parameters.
  • the untreated control is set equal to 1 and the Expression of the genes to be determined referred to (x-fold expression).
  • values which are greater than or equal to 1.4 times the expression of the untreated control are statistically conspicuous, values which are greater than or equal to 1.9 times the expression of the untreated control are classified as significant.
  • cetylstearyl alcohol INCI name: Cetearyl Alcohol; Cognis

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Abstract

La présente invention concerne l'utilisation cosmétique d'une ou de plusieurs bioquinones pour lutter contre les modifications du follicule pileux liées à l'âge, pour stimuler la synthèse de la kératine capillaire et pour influer positivement sur la structure capillaire. L'invention concerne en outre un procédé cosmétique pour lutter contre les modifications du follicule pileux liées à l'âge, ainsi qu'un procédé de stimulation de la synthèse de la kératine capillaire.
EP07788451A 2006-09-06 2007-08-16 Bioquinones pour la stimulation de la synthèse kératinique Ceased EP2054013A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200610042232 DE102006042232A1 (de) 2006-09-06 2006-09-06 Biochinone zur Stimulierung der Keratinsynthese
PCT/EP2007/058481 WO2008028772A1 (fr) 2006-09-06 2007-08-16 Bioquinones pour la stimulation de la synthèse kératinique

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EP2054013A1 true EP2054013A1 (fr) 2009-05-06

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EP (1) EP2054013A1 (fr)
AU (1) AU2007294011A1 (fr)
DE (1) DE102006042232A1 (fr)
RU (1) RU2009112277A (fr)
WO (1) WO2008028772A1 (fr)

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IL301676B2 (en) * 2014-10-24 2024-09-01 Garuhda Llc Combined hair loss inhibition treatment

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JPS5913710A (ja) * 1982-07-15 1984-01-24 Shiseido Co Ltd 養毛料
AU6482596A (en) * 1995-07-03 1997-02-05 Wilson T. Crandall Transdermal and oral treatment of androgenic alopecia
DE19926170A1 (de) * 1999-06-09 2000-12-14 Beiersdorf Ag Haarkosmetische Mittel mit Ubichinonen
DE10036798A1 (de) * 2000-07-28 2002-02-07 Beiersdorf Ag Mittel zur Behandlung der Haare und der Kopfhaut
JP4603192B2 (ja) * 2001-05-10 2010-12-22 株式会社カネカ 毛髪頭皮用組成物

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