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EP1980249A3 - Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser - Google Patents

Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser Download PDF

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Publication number
EP1980249A3
EP1980249A3 EP08154993A EP08154993A EP1980249A3 EP 1980249 A3 EP1980249 A3 EP 1980249A3 EP 08154993 A EP08154993 A EP 08154993A EP 08154993 A EP08154993 A EP 08154993A EP 1980249 A3 EP1980249 A3 EP 1980249A3
Authority
EP
European Patent Office
Prior art keywords
insulin
combination
receptor antagonist
secretion enhancer
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08154993A
Other languages
German (de)
French (fr)
Other versions
EP1980249A2 (en
Inventor
Malcolm Allison
Marjorie Regan Gatlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Original Assignee
Novartis Pharma GmbH Austria
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24581689&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP1980249(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma GmbH Austria, Novartis AG filed Critical Novartis Pharma GmbH Austria
Priority to EP09171372A priority Critical patent/EP2138175A3/en
Publication of EP1980249A2 publication Critical patent/EP1980249A2/en
Publication of EP1980249A3 publication Critical patent/EP1980249A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a combination, especially a pharmaceutical composition, comprising as active ingredients
(i) an AT1-receptor antagonist or a pharmaceutically acceptable salt thereof;
(ii) (a) an insulin secretion enhancer or a pharmaceutically acceptable salt thereof or (b) an insulin sensitizer or a pharmaceutically acceptable salt thereof; and,
in case of a pharmaceutical composition, a pharmaceutically acceptable carrier.
EP08154993A 2000-08-22 2001-08-20 Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser Withdrawn EP1980249A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09171372A EP2138175A3 (en) 2000-08-22 2001-08-20 Formulations comprising valsartan for treating diabetes or microalbuminuria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64364100A 2000-08-22 2000-08-22
EP01967289A EP1351683B1 (en) 2000-08-22 2001-08-20 Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP01967289A Division EP1351683B1 (en) 2000-08-22 2001-08-20 Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser
EP01967289.8 Division 2001-08-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP09171372A Division EP2138175A3 (en) 2000-08-22 2001-08-20 Formulations comprising valsartan for treating diabetes or microalbuminuria
EP09171372.7 Division-Into 2009-09-25

Publications (2)

Publication Number Publication Date
EP1980249A2 EP1980249A2 (en) 2008-10-15
EP1980249A3 true EP1980249A3 (en) 2010-04-28

Family

ID=24581689

Family Applications (3)

Application Number Title Priority Date Filing Date
EP01967289A Expired - Lifetime EP1351683B1 (en) 2000-08-22 2001-08-20 Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser
EP09171372A Withdrawn EP2138175A3 (en) 2000-08-22 2001-08-20 Formulations comprising valsartan for treating diabetes or microalbuminuria
EP08154993A Withdrawn EP1980249A3 (en) 2000-08-22 2001-08-20 Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP01967289A Expired - Lifetime EP1351683B1 (en) 2000-08-22 2001-08-20 Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser
EP09171372A Withdrawn EP2138175A3 (en) 2000-08-22 2001-08-20 Formulations comprising valsartan for treating diabetes or microalbuminuria

Country Status (15)

Country Link
US (1) US20040034065A1 (en)
EP (3) EP1351683B1 (en)
JP (4) JP2004514654A (en)
AR (1) AR033390A1 (en)
AT (1) ATE399010T1 (en)
AU (1) AU2001287698A1 (en)
CL (1) CL2009001899A1 (en)
CY (1) CY1111698T1 (en)
DE (1) DE60134575D1 (en)
DK (1) DK1351683T3 (en)
MY (1) MY141012A (en)
PE (1) PE20020617A1 (en)
PT (1) PT1351683E (en)
TW (3) TWI327469B (en)
WO (1) WO2002015933A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060089389A1 (en) 2000-08-22 2006-04-27 Malcolm Allison Combination
AR033390A1 (en) * 2000-08-22 2003-12-17 Novartis Ag A PHARMACEUTICAL COMPOSITION THAT INCLUDES AN ATTA RECEIVER ANTAGONIST AND A POTENTIATOR OF THE INSULIN SECRETION, THE USE OF SUCH COMPOSITION FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PARTS KIT
BR0308316A (en) * 2002-03-11 2004-12-28 Novartis Ag Nateglinide Salts
EP1515701B1 (en) 2002-06-17 2014-09-17 Inventia Healthcare Private Limited Process for the manufacture of multilayer tablet compositions comprising thiazolidinedione and biguanide
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
WO2004060399A1 (en) * 2002-12-27 2004-07-22 Takeda Pharmaceutical Company Limited Body weight gain inhibitor
CN1798576B (en) * 2003-04-15 2012-09-26 三共株式会社 Drug for preventing or treating angiogenic eye diseases
JP4783733B2 (en) * 2003-05-16 2011-09-28 ノバルティス アーゲー Pharmaceutical composition comprising valsartan
WO2005092319A1 (en) * 2004-03-29 2005-10-06 Ranbaxy Laboratories Limited Rapidly disintegrating pharmaceutical compositions comprising nateglinide and a disintegrant
PL1751278T3 (en) 2004-04-29 2015-08-31 U S Smokeless Tobacco Company Llc Nicotiana nucleic acid molecules and uses thereof
US7666899B2 (en) * 2004-05-11 2010-02-23 Kissei Pharmaceutical, Co. Ltd. Pharmaceutical composition for treatment of lipid metabolism disorder
WO2005117591A2 (en) 2004-05-28 2005-12-15 Andrx Labs Llc Novel pharmaceutical formulation containing a biguanide and an angiotensin antagonist
US20070270477A1 (en) * 2004-10-07 2007-11-22 Takeda Pharmaceutical Company Limited Agent for Prophylaxis or Treatment of Metabolic Syndrome
JP2007099764A (en) * 2005-09-09 2007-04-19 Ajinomoto Co Inc Hypoglycaemic agent
WO2010122927A1 (en) * 2009-04-20 2010-10-28 第一三共株式会社 Pharmaceutical agent for prevention or treatment of retarded nerve regeneration induced by diabetes
JP6854384B2 (en) * 2017-07-17 2021-04-07 イーライ リリー アンド カンパニー Pharmaceutical composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000045818A1 (en) * 1999-02-06 2000-08-10 Astrazeneca Ab Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy
WO2001021602A1 (en) * 1999-09-22 2001-03-29 Bristol-Myers Squibb Company Oxa- and thiazole derivatives useful as antidiabetic and antiobesity agents

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2951135A1 (en) 1979-12-19 1981-06-25 Hoechst Ag, 6230 Frankfurt SULFONYL UREAS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
JPS6354321A (en) 1985-03-27 1988-03-08 Ajinomoto Co Inc Blood sugar lowering agent
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5120712A (en) 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
CA1334092C (en) 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
SG52330A1 (en) 1989-06-14 1998-09-28 Smithkline Beecham Corp Imidazolyl-alkenoic acids
EP0512042B1 (en) 1990-01-24 1998-04-08 BUCKLEY, Douglas I. Glp-1 analogs useful for diabetes treatment
DE122010000024I1 (en) 1990-02-19 2010-07-08 Novartis Ag acyl compounds
TW201738B (en) 1990-03-20 1993-03-11 Sanofi Co
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5298497A (en) * 1990-05-15 1994-03-29 E. R. Squibb & Sons, Inc. Method for preventing onset of hypertension employing a cholesterol lowering drug
SI9210098B (en) 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoles, drugs with this compounds, and process for their preparation
US5616599A (en) 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
AU654331B2 (en) 1991-03-30 1994-11-03 Kissei Pharmaceutical Co. Ltd. Succinic acid compounds
KR100496720B1 (en) 1991-06-21 2006-01-27 닥터.칼토매게엠베하 (S) (+)-2-ethoxy-4 [N- [1- (2-piperidinophenyl) -3-methyl-1-butyl] aminocarbonylmethyl] -diabetic agent containing benzoic acid
EP0526171B1 (en) 1991-07-30 1997-03-05 Ajinomoto Co., Inc. Crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine and methods for preparing them
TW226375B (en) 1991-10-24 1994-07-11 American Home Prod
IL111785A0 (en) 1993-12-03 1995-01-24 Ferring Bv Dp-iv inhibitors and pharmaceutical compositions containing them
US5705483A (en) 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
BR9507086A (en) * 1994-03-17 1997-09-16 Ciba Geigy Ag Treatment of diabetic nephrotherapy with valsartan
EP0754042A4 (en) * 1994-03-29 2004-06-23 Merck & Co Inc TREATMENT OF ATHEROSCLEROSIS
US5488510A (en) 1994-07-26 1996-01-30 Lemay; Edward J. Enhanced depth perception viewing device for television
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
PL193365B1 (en) * 1996-04-05 2007-02-28 Takeda Pharmaceutical Pharmaceutical combination containing a compound having angiotensin ii and antagonistic activity
DE122010000020I1 (en) 1996-04-25 2010-07-08 Prosidion Ltd Method for lowering the blood glucose level in mammals
GB9613470D0 (en) * 1996-06-27 1996-08-28 Ciba Geigy Ag Small solid oral dosage form
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
JPH11315034A (en) * 1998-03-04 1999-11-16 Takeda Chem Ind Ltd Sustained release preparation of compound having angiotensin ii antagonism, its production and use
FR2778103A1 (en) * 1998-04-29 1999-11-05 Sanofi Sa PHARMACEUTICAL COMPOSITIONS CONTAINING IN ASSOCIATION A V1A ARGININE-VASOPRESSIN ANTAGONIST AND AN ANGIOTENSIN II AT1 RECEPTOR ANTAGONIST
MY123337A (en) * 1998-05-11 2006-05-31 Takeda Chemical Industries Ltd Oxyiminoalkanoic acid derivatives.
RU2243768C2 (en) * 1998-07-10 2005-01-10 Новартис Аг Hypotensive combination of valsartan and calcium channel blocking agent
CO5150173A1 (en) 1998-12-10 2002-04-29 Novartis Ag COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION
RS50377B (en) * 1999-08-30 2009-11-10 Sanofi-Aventis Deutschland Gmbh., RENIN-ANGIOTENSIN SYSTEM INHIBITORS AND THEIR APPLICATIONS
AU6118001A (en) * 2000-05-03 2001-11-12 Tularik Inc Combination therapeutic compositions and methods of use
AR033390A1 (en) * 2000-08-22 2003-12-17 Novartis Ag A PHARMACEUTICAL COMPOSITION THAT INCLUDES AN ATTA RECEIVER ANTAGONIST AND A POTENTIATOR OF THE INSULIN SECRETION, THE USE OF SUCH COMPOSITION FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A PARTS KIT
US20020037829A1 (en) * 2000-08-23 2002-03-28 Aronson Peter S. Use of DPPIV inhibitors as diuretic and anti-hypertensive agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000045818A1 (en) * 1999-02-06 2000-08-10 Astrazeneca Ab Use of 3-hydroxy-3-methylglutaryl coenzym a reductase inhibitors for the manufacture of a medicament for the treatment of diabetic neuropathy
WO2001021602A1 (en) * 1999-09-22 2001-03-29 Bristol-Myers Squibb Company Oxa- and thiazole derivatives useful as antidiabetic and antiobesity agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CONIGLIARO R L ET AL: "Losartan-induced cough after lisinopril therapy [2]", AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY 20000515 US, vol. 57, no. 10, 15 May 2000 (2000-05-15), pages 996 - 997, XP008120373, ISSN: 1079-2082 *
HAFFNER S ET AL: "Targeting post-prandial hyperglycemia to prevent type 2 diabetes: Rationale and design of the NAVIGATOR trial.", DIABETOLOGIA, vol. 45, no. Supplement 2, August 2002 (2002-08-01), 38th Annual Meeting of the European Association for the Study of Diabetes;Budapest, Hungary; September 01-05, 2002, pages A 106, XP001132045, ISSN: 0012-186X *
KURASHVILI R ET AL: "Hypertension and diabetes: New approaches to complex treatment", EUROPEAN HEART JOURNAL, vol. 21, no. Abstract Supplement, August 2000 (2000-08-01), XXII CONGRESS OF THE EUROPEAN SOCIETY OF CARDIOLOGY; AMSTERDAM, NETHERLANDS; AUGUST 26-30, 2000, pages 93, XP008120384, ISSN: 0195-668X *
ZUNZUNEGUI-PASTOR M V ET AL: "Effects of candesartan, metformin and pravastatin combination on cardiovascular risk factors in a poor controlled hypertensive population with chronic metabolic syndrome.", AMERICAN JOURNAL OF HYPERTENSION, vol. 14, no. 4 Part 2, April 2001 (2001-04-01), Sixteenth Annual Scientific Meeting of the American Society of Hypertension;San Francisco, California, USA; May 15-19, 2001, pages 113A - 114A, XP001128773, ISSN: 0895-7061 *

Also Published As

Publication number Publication date
EP1980249A2 (en) 2008-10-15
DE60134575D1 (en) 2008-08-07
WO2002015933A3 (en) 2003-08-14
TWI315197B (en) 2009-10-01
JP2010043101A (en) 2010-02-25
EP1351683B1 (en) 2008-06-25
AR033390A1 (en) 2003-12-17
JP2004514654A (en) 2004-05-20
CL2009001899A1 (en) 2010-02-12
TW200838503A (en) 2008-10-01
TW200843741A (en) 2008-11-16
PT1351683E (en) 2008-09-18
DK1351683T3 (en) 2008-10-20
CY1111698T1 (en) 2015-10-07
TWI327469B (en) 2010-07-21
AU2001287698A1 (en) 2002-03-04
US20040034065A1 (en) 2004-02-19
EP2138175A2 (en) 2009-12-30
JP2015205909A (en) 2015-11-19
EP2138175A3 (en) 2010-01-13
EP1351683A2 (en) 2003-10-15
WO2002015933A2 (en) 2002-02-28
ATE399010T1 (en) 2008-07-15
TWI327468B (en) 2010-07-21
JP2013049683A (en) 2013-03-14
MY141012A (en) 2010-02-25
PE20020617A1 (en) 2002-08-05

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