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EP1811954A1 - Compositions pour rehausser les levres - Google Patents

Compositions pour rehausser les levres

Info

Publication number
EP1811954A1
EP1811954A1 EP05797681A EP05797681A EP1811954A1 EP 1811954 A1 EP1811954 A1 EP 1811954A1 EP 05797681 A EP05797681 A EP 05797681A EP 05797681 A EP05797681 A EP 05797681A EP 1811954 A1 EP1811954 A1 EP 1811954A1
Authority
EP
European Patent Office
Prior art keywords
lips
vasodilator
composition
physiologically tolerable
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05797681A
Other languages
German (de)
English (en)
Inventor
Rubina Coventry University MIAN
Raymond Coventry University CARSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coventry University
Original Assignee
Coventry University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coventry University filed Critical Coventry University
Publication of EP1811954A1 publication Critical patent/EP1811954A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips

Definitions

  • the present invention relates to cosmetic kits and components therefor as well as to a method of topical cosmetic treatment using such kits for the emphasis of the lips.
  • Lip glosses and lipsticks however have two significant drawbacks - the first is a drying of the lips which is uncomfortable to the wearer - the second is the tendency for lip contact to stain fabrics or leave smears on the skin. Injections or implants involve the services of a physician, are expensive, painful, non-reversible, and sometimes the effect achieved is not precisely that desired by the patient.
  • a cosmetic kit comprising a first composition containing a vasodilator for application to the lip surface and a second composition containing a vasoconstrictor for application to the periphery of the lips,- the combined effect of the two compositions is to emphasize the lips by swelling the body of the lips while tightening the skin around the rim of the lips .
  • the invention provides a cosmetic kit comprising: a first topical cosmetic composition comprising a physiologically tolerable vasodilator and at least one cosmetic carrier or excipient; a second topical cosmetic composition comprising a physiologically tolerable vasoconstrictor and at least one cosmetic carrier or excipient; optionally instructions for the application of said compositions to the lips and lip periphery; and optionally a container or support for said compositions.
  • the invention also provides a topical cosmetic composition comprising a physiologically tolerable vasodilator and at least one cosmetic carrier or excipient, and instructions for the application of said composition to the surface of the lips in conjunction with the application to the periphery of the lips of a further topical cosmetic composition comprising a physiologically tolerable vasoconstrictor.
  • the invention provides a topical cosmetic composition comprising a physiologically tolerable vasoconstrictor and at least one cosmetic carrier or excipient, instructions for the application of said composition to the periphery of the lips in conjunction with the application to the surface of the lips of a further topical cosmetic composition comprising a physiologically tolerable vasodilator.
  • the invention provides a method of cosmetic treatment to emphasize the lips, said method comprising applying to the surface of the lips an effective amount of a physiologically tolerable vasodilator and applying to the periphery of the lips an effective amount of a physiologically tolerable vasoconstrictor.
  • the vasodilator used according to the invention may be a natural or synthetic material and may be a drug substance or a naturally occurring material, e.g. a plant extract or fragment. Most preferably it is a natural plant extract or fragment (e.g. powdered plant material) .
  • the use of natural materials in cosmetics, especially materials which occur naturally in foodstuffs, is particularly preferred as animal testing may be avoided and as customer acceptability is high. Examples of natural vasodilators include Astragalus
  • the vasodilator may typically be present in the vasodilator composition at a concentration of 0.001 to 10% wt, especially 0.01 to 10% wt, particularly 0.1 to 2% wt.
  • the vasoconstrictor used according to the invention likewise may be a natural or synthetic material and may be a drug substance or a naturally occurring material, e.g. a plant extract or fragment. Most preferably it is a natural plant extract or fragment (e.g. powdered plant material) .
  • natural vasoconstrictors include Horse Chestnut, Aloe Vera, Marigold (Calendula Officinalis) , German Chamomile (Chamomilla recutita), Conchona (Cinchona), Lemon (Citrus limon) , Myrrh
  • the vasoconstrictor may typically be present in the vasoconstrictor composition at a concentration of 0.01 to 10% wt, especially 0.05 to 2% wt.
  • the vasodilator is intended to be applied to the majority of the exposed (i.e. external) lip surface, excluding perhaps the outer periphery. It thus may take any administration form suitable for this mode of application, e.g. a stick, powder, cream, paste, ointment, solution, suspension, dispersion, impregnated fabric (e.g. a "wipe" or tissue), spray, etc. Particularly suitably it is in impregnated fabric, cream, lipstick, or liquid form, in the latter case desirably presented in a container provided with an applicator, for example a brush or absorbent pad.
  • the composition may contain other cosmetic components, for example carriers (e.g.
  • alpha- hydroxy acid i.e. a cosmetic component known to plumpen and fill out the skin by causing moisture retention
  • suitable alpha hydroxy acids include glycolic acid, lactic acid, malic acid, citric acid, alpha-hydroxyethanoic acid, alpha-hydroxyoctanoic acid, and alpha-hydroxycaprylic acid, in particular glycolic and malic acids .
  • the vasodilator may wholly or partially be in sustained release form, e.g. dissolved or dispersed in a persistent ointment, or encapsulated in liposomes or absorbed into porous or hollow particulate carriers, for example particles of porous silica or other essentially inert materials, typically particles having a mode particle size of the order of 1 to 10 ⁇ m.
  • all components in the vasodilator composition are naturally occurring organic or inorganic materials, especially plant components, fragments, extracts, or fermentation or digestion products.
  • the composition is free of colorants (the vasodilator itself by increasing blood flow to the lip surface will have the effect of making the lips appear more red) .
  • physiologically tolerable strontium compounds e.g. strontium chloride, which applied topically combat dermal irritation and subdermal pain, may be included in the vasodilator compositions.
  • vasodilator composition may contain mint oil or a local anaesthetic to reduce any sensation perceived by the user.
  • the vasoconstrictor composition likewise may take any administration form suitable for application to the periphery of the lips, e.g. sticks, pencils, liquids, etc. Particularly desirably it is presented in a form which allows a relatively narrow line of composition, e.g. 0.5 to 3 mm wide, to be applied. To this end the composition is preferably presented as a stick or pencil or as a liquid in a container provided with an applicator, for example a brush or absorbent pad.
  • the composition may contain further optional ingredients of the type mentioned above in relation to the vasodilator composition; and again it is preferred that the composition is colorant-free and that it contains only natural components.
  • the composition may if desired contain the vasoconstrictor wholly or partly in sustained release form.
  • the vasodilator where used on the lips, is preferably one having a symmetric action, or, if asymmetric one which counteracts a prevailing asymmetry in lip engorgement .
  • the vasoconstrictor may, if desired, be applied only to the periphery of the lips, e.g. to delineate the lips before the vasodilator is applied.
  • the vasoconstrictor is applied to a surface area greater than that in which a constriction of the skin is desired, and in particular it may be applied, preferably before the vasodilator, to the region in which an engorgement of the skin is desired.
  • the vasoconstrictor may suitably be applied as a general wash or smear over substantially the entire external lip surface (or other treated surface, e.g. as discussed below) .
  • the vasodilator is capsaicin and the vasoconstrictor is witch hazel .
  • the vasoconstrictor is conveniently 50:50 by volume lemon juice and distilled witch hazel solution BPC.
  • the vasodilator is conveniently 100 mg niacin dissolved in 0.5 mL olive oil with 1 mL menthol oil (Japanese oil of peppermint) added together with 1 mL hawthorn berry- extract (2 g/mL in ethanal) and 1 mL 0.0017% wt. capsaicin. This may be mixed with honey and petroleum jelly, e.g. about 1 g of each, and mixed thoroughly.
  • compositions are desirably packaged in kit form with an external container or case containing separate containers containing the two compositions and a printed form or label setting forth instructions for the application of the two compositions to the lips.
  • a single container or support contains both compositions, e.g. in the form of a two- ended lip pencil or combined lipstick/lip pencil.
  • compositions are a lip emphasis which can last for many hours, e.g. at least 5 hours, preferably at least 8 hours.
  • vasodilator composition of the invention may also, if desired, be used as a cheek blusher. This use is also deemed to form part of the present invention.
  • a further aspect of the invention is the use of a composition containing a vasodilator to minimize the appearance of wrinkles or fine lines on the skin's surface, optionally in conjunction with a composition containing a vasoconstrictor.
  • Vasodilation will cause an increase in blood flow which would cause tissue swelling.
  • the use of a combination of vasodilator and vasoconstrictor allows a selective increase and decrease in blood flow to defined regions and thus minimizes the appearance of wrinkles.
  • the invention provides a cosmetic kit comprising: a first topical cosmetic composition comprising a physiologically tolerable vasodilator and at least one cosmetic carrier or excipient; a second topical cosmetic composition comprising a physiologically tolerable vasoconstrictor and at least one cosmetic carrier or excipient; optionally instructions for the application of said compositions to areas affected by wrinkles; and optionally a container or support for said compositions .
  • the invention also provides a topical cosmetic composition comprising a physiologically tolerable vasodilator and at least one cosmetic carrier or excipient, and instructions for the application of said composition to the surface of the skin optionally in conjunction with the application of a further topical cosmetic composition comprising a physiologically tolerable vasoconstrictor to a defined region.
  • the invention provides a method of cosmetic treatment to lessen the appearance of wrinkles, said method comprising applying to the surface of the skin an effective amount of a physiologically tolerable vasodilator and optionally applying to a defined region an effective amount of a physiologically tolerable vasoconstrictor.
  • vasodilator alone is preferred for use on fine lines on the skin's surface, whereas the combination of vasodilator and vasoconstrictor may be preferred to minimize the appearance of deeper wrinkles.
  • the vasodilator composition may be applied to, and around, the area of the wrinkles, whereas the vasoconstrictor composition may be applied to regions where blood flow is desired to be decreased e.g. around the edge of wrinkles to even out the skin's surface.
  • the use need not be limited to wrinkles, the effect of a non-surgical "face-lift" could be achieved by applying vasoconstrictor and/or vasodilator to certain areas of the face.
  • compositions of the invention are also suitable for treatment of wounds as they may promote blood flow in a manner that will optimise the likelihood that healing will occur and particularly after debridement (physical removal of dead and decaying tissue - including biofilm - from in and around the wound) .
  • a further aspect of the present invention provides a formulation for the prevention of the formation of chronic wounds and ulcers (i.e. used as first signs appear or even as a preventative measure before first signs appear) or for the promotion of the healing of wounds before or after they become chronic.
  • compositions of the invention are a) by application directly to the potential wound site b) by application directly to the wound perhaps in combination with other beneficial agents such as an antimicrobial/antibio-film agent in a formulation that would maintain an optimum healing environment c) by application around the wound site.
  • beneficial agents such as an antimicrobial/antibio-film agent in a formulation that would maintain an optimum healing environment c) by application around the wound site.
  • a further use for the compositions of the invention is the alleviation of the symptoms of circulatory- disorders, especially Raynaud's disease. Sufferers of this condition experience pain, tingling or numbness to certain parts of the body, especially the extremities.
  • the present invention provides the use of a first topical composition comprising a physiologically tolerable vasodilator and a second topical composition comprising a physiologically tolerable vasoconstrictor in the manufacture of a medicament for the treatment of circulatory disorders, especially Raynaud's disease.
  • compositions of the invention are also suitable for: combating baldness (for example by increasing blood flow to defined areas of the scalp) ; reducing unwanted hair growth (for example by reducing blood flow to defined areas) ; strengthening nails (for example by increasing blood flow to the nail bed) and the control of acne spots (for example by reducing blood flow during the day to reduce redness and/or increasing blood flow at night to speed up the cell cycle) .
  • Capsaicin 1% wt of Capsaicin is worked into the skin ointment commercially available under the trade name Vaseline®.
  • Unguentum Merck may be used in place of Vaseline® and L- arginine or menthol may be used in place of capsaicin.
  • Hawthorn berry extract Fresh plant tincture Crataegus oxyacantha prepared from organically- cultivated or wild herbs in Switzerland 23.5% New Zealand Clover Honey 23.5% Vaseline
  • Baseline measurements of lip diameter were taken at three points. The same three points were measured throughout the study using, reference points were marked on clear acetate sheet (the same reference points were used for each subject throughout the study) . The diameter of the lips at the three marked reference points was measured using vernier callipers . Photographs of the closed lips were taken using a standard reference point (baseline photographs) . The lip liner (of Example 5) was applied around the perimeter of the lips using a small applicator. Immediately afterwards, either formulation A or B was applied to the surface of the lips . No other colour- enhancers were used.
  • Photographs showed clearly defined enhanced lips of one subject, before and after application of lip liner and Formulation A.
  • the maximum recorded response to the formulation was above 80% augmentation of lip size, which was sustained for up to 250 minutes.
  • Photographs showed clearly defined enhanced lips of one subject, before and after application of lip liner and Formulation A.
  • Formulation A or B plus the lip liner resulted in significant increase in lip size and definition. Both treatments were active over a long time period. The effects were found to be fully reversible and no side- effects were reported. The formulations were well tolerated by subjects. All subjects reported a self- perceived increase in size and definition of the lips. This technique of lip enhancement is non-invasive, simple to apply and uses natural agents .
  • formulation gave an asymmetric effect. Without wishing to be bound by theory, it is thought that this is linked to the human body's asymmetry.
  • the orbicularis oris muscle is one of the muscles lying beneath the lip area. It is a concentric band of muscle that loops around. It is one part actually of the complex group of muscles for facial expression. Functional or anatomical asymmetry in the lips or underlying musculature and vasculature may affect the vasodilator mechanism.
  • the agents act directly on receptors on the blood vessels resulting in sub- maximal vasodilatation of arterioles and capillaries supplying the lips and surrounding musculature and support structures .
  • the resulting slight asymmetry may well reflect the tendency to "right handedness" in the human population as a whole and accentuate any slight differences that may be present in muscle or vasculature responsiveness .
  • Vasoconstriction of the vessels surrounding the vermilion - skin border thereby limiting the vasodilatation of the lips to the red area of the lips and not the surrounding musculature and supporting areas .
  • Vasoconstriction around the circumferential skin-skin border would result in accentuating the vasodilatation and allow a clearer definition of the lips.
  • a randomised double-blind trial is carried out involving application of a standardised quantity of either formulation (A or B) or suitable placebo to the skin of subjects with mild, moderate or severe wrinkles.
  • the degree of wrinkles is assessed using qualitative (self-assessment questionnaires) and quantitative measurements (photography, digitization, computer evaluation of wrinkles) .
  • a randomised double-blind trial design is carried out involving application of standardised quantity of either formulation (A or B) or suitable placebo to skin lesions (mild, moderate and severe) .
  • the formulation is applied either directly to the wound site (alone or in combination with other beneficial agents such as an anti microbial/anti bio-film agent in a formulation that would maintain an optimum healing environment) or around the wound site.
  • beneficial agents such as an anti microbial/anti bio-film agent in a formulation that would maintain an optimum healing environment
  • the rate and degree of wound healing is assessed using qualitative (self-assessment questionnaires) and quantitative measurements of wound healing (photography, digitization, computer evaluation of wound size, degree of scarring, blood flow) .
  • Formulation B was applied to a defined area of skin on the forearm on a non Raynaud's control subject. This resulted in widespread reddening of the immediate area and vicinity of the initial area of application indicating substantial vasodilatation. The effect was long lasting (approx 3 hours) .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention décrit un ensemble cosmétique comprenant : une première composition cosmétique topique comprenant un vasodilatateur physiologiquement tolérable et au moins un véhicule ou excipient cosmétique ; une seconde composition cosmétique topique comprenant un vasoconstricteur physiologiquement tolérable et au moins un véhicule ou excipient cosmétique.
EP05797681A 2004-10-25 2005-10-25 Compositions pour rehausser les levres Withdrawn EP1811954A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0423652.7A GB0423652D0 (en) 2004-10-25 2004-10-25 Kit
PCT/GB2005/004120 WO2006046025A1 (fr) 2004-10-25 2005-10-25 Compositions pour rehausser les levres

Publications (1)

Publication Number Publication Date
EP1811954A1 true EP1811954A1 (fr) 2007-08-01

Family

ID=33485145

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05797681A Withdrawn EP1811954A1 (fr) 2004-10-25 2005-10-25 Compositions pour rehausser les levres

Country Status (8)

Country Link
EP (1) EP1811954A1 (fr)
JP (1) JP2008517985A (fr)
AU (1) AU2005298398A1 (fr)
CA (1) CA2585293A1 (fr)
GB (1) GB0423652D0 (fr)
NO (1) NO20072699L (fr)
WO (1) WO2006046025A1 (fr)
ZA (1) ZA200703513B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5105890B2 (ja) * 2007-02-06 2012-12-26 株式会社 資生堂 Ｖｅｇｆｃ産生促進剤
JP5167042B2 (ja) * 2008-09-18 2013-03-21 花王株式会社 セラミド産生促進剤、保湿剤及び皮膚外用剤
FR2955770B1 (fr) * 2010-02-03 2016-05-13 Lvmh Rech Composition cosmetique.
ES2659066T3 (es) 2013-01-25 2018-03-13 Wintermute Biomedical, Inc. Compuestos terapéuticos
JP6279318B2 (ja) * 2013-12-27 2018-02-14 花王株式会社 口唇化粧料
CA3052047A1 (fr) 2017-02-13 2018-08-16 Wintermute Biomedical, Inc. Compositions therapeutiques anti-pathogenes
JP7206635B2 (ja) * 2018-05-21 2023-01-18 ポーラ化成工業株式会社 口唇用外用剤
CN119656321A (zh) 2018-10-01 2025-03-21 温特穆特生物医学公司 治疗组合物

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WO1984002846A1 (fr) * 1983-01-21 1984-08-02 Advanced Drug Tech Onguent enzymatique
AU630561B2 (en) * 1990-06-12 1992-10-29 Cathy Palou A therapeutic preparation containing myrrh for treating skin disorders
US5658580A (en) * 1993-09-09 1997-08-19 Chanel, Inc. Skin cream composition
US5503825A (en) * 1994-01-10 1996-04-02 Lane; Barry Lip balm composition
US5571794A (en) * 1995-06-22 1996-11-05 Frome; Bruce M. Non-invasive novel method fo cosmetic lip augmentation
US6284797B1 (en) * 1999-04-12 2001-09-04 Donald A. Rhodes Topical treatment of pain and to promote healing
US6322493B1 (en) * 1999-07-01 2001-11-27 40 J's Llc Expanded clitoral sensitizing compounds with methods and apparatus for the delivery of these compounds
FR2802807B1 (fr) * 1999-12-22 2002-09-27 Serobiologiques Lab Sa Preparations cosmetiques de maquillage
CA2325275A1 (fr) * 2000-10-30 2002-04-30 Carol Ryan Cheveux

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2006046025A1 *

Also Published As

Publication number Publication date
CA2585293A1 (fr) 2006-05-04
WO2006046025A1 (fr) 2006-05-04
ZA200703513B (en) 2008-07-30
JP2008517985A (ja) 2008-05-29
AU2005298398A1 (en) 2006-05-04
GB0423652D0 (en) 2004-11-24
NO20072699L (no) 2007-07-25

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