EP1848273A4 - Macrocycles a 18 chainons et leurs analogues - Google Patents

Macrocycles a 18 chainons et leurs analogues

Info

Publication number: EP1848273A4
Authority: EP; European Patent Office
Prior art keywords: macrocycles; analogues; chain; chain macrocycles
Prior art date: 2005-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP05712354A

Other languages

German (de)

English (en)

Other versions

EP1848273A1 (fr

Inventor

Youe-Kong Shue

Chan-Kou Hwang

Yu-Hung Chiu

Alex Romero

Farah Babakhani

Pamela Sears

Franklin Okumu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Optimer Pharmaceuticals LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-31

Filing date

2005-01-31

Publication date

2010-02-24

2005-01-31 Application filed by Optimer Pharmaceuticals LLC filed Critical Optimer Pharmaceuticals LLC

2007-10-31 Publication of EP1848273A1 publication Critical patent/EP1848273A1/fr

2010-02-24 Publication of EP1848273A4 publication Critical patent/EP1848273A4/fr

Status Ceased legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Pest Control & Pesticides (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Plant Pathology (AREA)
Agronomy & Crop Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP05712354A 2005-01-31 2005-01-31 Macrocycles a 18 chainons et leurs analogues Ceased EP1848273A4 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2005/002887 WO2006085838A1 (fr)	2005-01-31	2005-01-31	Macrocycles a 18 chainons et leurs analogues

Publications (2)

Publication Number	Publication Date
EP1848273A1 EP1848273A1 (fr)	2007-10-31
EP1848273A4 true EP1848273A4 (fr)	2010-02-24

Family

ID=36793325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP05712354A Ceased EP1848273A4 (fr)	2005-01-31	2005-01-31	Macrocycles a 18 chainons et leurs analogues

Country Status (10)

Country	Link
EP (1)	EP1848273A4 (fr)
JP (1)	JP5166040B2 (fr)
KR (1)	KR101203118B1 (fr)
CN (2)	CN101128114B (fr)
AU (1)	AU2005327308B2 (fr)
BR (1)	BRPI0519890A2 (fr)
CA (1)	CA2596387C (fr)
MX (2)	MX340742B (fr)
TW (1)	TWI306097B (fr)
WO (1)	WO2006085838A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7906489B2 (en)	2004-05-14	2011-03-15	Optimer Pharmaceuticals, Inc.	18-membered macrocycles and analogs thereof
US7378508B2 (en) *	2007-01-22	2008-05-27	Optimer Pharmaceuticals, Inc.	Polymorphic crystalline forms of tiacumicin B
CA2626698C (fr) *	2005-10-21	2015-12-01	Optimer Pharmaceuticals, Inc.	Methode de traitement d'une diarrhee associee a clostridium difficile
TWI482772B (zh) *	2006-08-21	2015-05-01	Astrazeneca Ab	適合口服且包含三唑并[4,5-d]嘧啶衍生物之組合物
US20080176927A1 (en) *	2007-01-19	2008-07-24	Optimer Pharmaceuticals, Inc.	Compositions of stable tiacumicins
AU2012244278C1 (en) *	2007-01-22	2014-11-06	Merck Sharp & Dohme Llc	Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
ZA200905337B (en) *	2007-01-22	2010-10-27	Optimer Pharmaceuticals Inc	Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
TWI523654B (zh)	2007-11-27	2016-03-01	默沙東藥廠	抗生素巨環化合物以及其製造及使用之方法
PE20140887A1 (es) *	2011-02-04	2014-08-14	Optimer Pharmaceuticals Inc	Tratamiento de infecciones bacterianas
US8722863B2 (en)	2012-05-10	2014-05-13	Teva Pharmaceutical Works Ltd.	Solid state forms of fidaxomycin and processes for preparation thereof
KR20150001802A (ko) *	2012-05-10	2015-01-06	테바 파마슈티칼 웍스 엘티디.	피닥소마이신의 고상 형태 및 이의 제조 방법
JO3464B1 (ar)	2013-01-15	2020-07-05	Astellas Pharma Europe Ltd	التركيبات الخاصة بمركبات التياكوميسين
CN103275152B (zh) *	2013-05-29	2015-11-18	华北制药集团新药研究开发有限责任公司	一种高纯度非达霉素的制备方法
CA2940902C (fr) *	2014-03-18	2022-10-25	Xellia Pharmaceuticals Aps	Polymorphes et etats solides de la tiacumicine b
CN103897003B (zh) *	2014-03-28	2016-07-06	华北制药集团新药研究开发有限责任公司	非达霉素晶型ii及其制备方法
LT3139932T (lt)	2014-05-09	2018-11-12	Astellas Pharma Europe Ltd.	Gydymo režimas su tiakumicino junginiu
CA2990961A1 (fr)	2015-07-03	2017-01-12	Astellas Pharma Europe Ltd.	Nouveau compose de tiacumicine pour regime posologique
CN105237599B (zh) *	2015-10-09	2018-10-02	华北制药集团新药研究开发有限责任公司	闰年霉素a4晶体及其制备方法
CN110183502A (zh) *	2019-05-28	2019-08-30	杭州华东医药集团新药研究院有限公司	一种非达霉素杂质及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4918174A (en) *	1986-09-26	1990-04-17	Abbott Laboratories	Tiacumicin compounds
WO2004014295A2 (fr) *	2002-07-29	2004-02-19	Optimer Pharmaceuticals, Inc.	Fabrication de tiacumicine
WO2005112990A2 (fr) *	2004-05-14	2005-12-01	Optimer Pharmaceuticals, Inc.	Traitement de maladies consecutives a un traitement antibiotique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1458512A (en) *	1973-11-22	1976-12-15	Lepetit Spa	Antibiotic substance
US5583115A (en) *	1995-05-09	1996-12-10	Abbott Laboratories	Dialkyltiacumicin compounds
US5767096A (en) *	1996-07-12	1998-06-16	Abbott Laboratories	Bromotiacumicin compounds

2005
- 2005-01-31 BR BRPI0519890-9A patent/BRPI0519890A2/pt not_active Application Discontinuation
- 2005-01-31 CN CN2005800487153A patent/CN101128114B/zh not_active Expired - Lifetime
- 2005-01-31 AU AU2005327308A patent/AU2005327308B2/en not_active Expired
- 2005-01-31 KR KR1020077019982A patent/KR101203118B1/ko not_active Expired - Fee Related
- 2005-01-31 MX MX2012009525A patent/MX340742B/es unknown
- 2005-01-31 WO PCT/US2005/002887 patent/WO2006085838A1/fr not_active Ceased
- 2005-01-31 CN CN201210032395.4A patent/CN102614207B/zh not_active Expired - Lifetime
- 2005-01-31 CA CA2596387A patent/CA2596387C/fr not_active Expired - Lifetime
- 2005-01-31 EP EP05712354A patent/EP1848273A4/fr not_active Ceased
- 2005-01-31 JP JP2007553073A patent/JP5166040B2/ja not_active Expired - Lifetime
- 2005-01-31 MX MX2007009196A patent/MX2007009196A/es active IP Right Grant
- 2005-05-17 TW TW094115942A patent/TWI306097B/zh not_active IP Right Cessation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4918174A (en) *	1986-09-26	1990-04-17	Abbott Laboratories	Tiacumicin compounds
WO2004014295A2 (fr) *	2002-07-29	2004-02-19	Optimer Pharmaceuticals, Inc.	Fabrication de tiacumicine
WO2005112990A2 (fr) *	2004-05-14	2005-12-01	Optimer Pharmaceuticals, Inc.	Traitement de maladies consecutives a un traitement antibiotique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARNONE A ET AL: "STRUCTURE ELUCIDATION OF THE MACROCYCLIC ANTIBIOTIC LIPIARMYCIN", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, CHEMICAL SOCIETY, LETCHWORTH; GB, 1 January 1987 (1987-01-01), pages 1353 - 1359, XP000578201, ISSN: 0300-922X *
CREDITO K L ET AL: "Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 200411 US, vol. 48, no. 11, November 2004 (2004-11-01), pages 4430 - 4434, XP002563520, ISSN: 0066-4804 *
See also references of WO2006085838A1 *

Also Published As

Publication number	Publication date
TW200626585A (en)	2006-08-01
CA2596387A1 (fr)	2006-08-17
MX340742B (es)	2016-07-21
WO2006085838A1 (fr)	2006-08-17
BRPI0519890A2 (pt)	2009-03-31
TWI306097B (en)	2009-02-11
CN102614207A (zh)	2012-08-01
JP2008528582A (ja)	2008-07-31
KR101203118B1 (ko)	2012-11-20
EP1848273A1 (fr)	2007-10-31
MX2007009196A (es)	2009-02-25
AU2005327308B2 (en)	2011-11-10
JP5166040B2 (ja)	2013-03-21
AU2005327308A1 (en)	2006-08-17
CN101128114A (zh)	2008-02-20
CN102614207B (zh)	2016-01-13
CN101128114B (zh)	2012-03-28
CA2596387C (fr)	2012-11-20
KR20070110504A (ko)	2007-11-19

Publication	Publication Date	Title
EP1848273A4 (fr)	2010-02-24	Macrocycles a 18 chainons et leurs analogues
DK1819670T3 (da)	2012-09-17	12-Aryl-prostaglandinanaloger
DE502005000427D1 (de)	2007-04-19	Flexible Airbagklappe
DE602005015280D1 (de)	2009-08-20	Zahnriemen
DE602005006926D1 (de)	2008-07-03	Treibkette
DE602005010648D1 (de)	2008-12-11	Kettenspannvorrichtung
DE602006000045D1 (de)	2007-09-06	Förderkette
DE602006017356D1 (de)	2010-11-18	Kernlose gleiskette
DE502005002500D1 (de)	2008-02-21	Fördervorrichtung
DE602005006210D1 (de)	2008-06-05	Zahnriemen
FR2870039B1 (fr)	2006-08-04	Autotransformateur a dephasage de 40 degres
DE50300723D1 (de)	2005-08-11	Kettenzug
DE502005011280D1 (de)	2011-06-01	Ketten- oder zahnriementrieb
FI20040870L (fi)	2004-12-25	Tela
DE502005001451D1 (de)	2007-10-25	Fugenabdeckprofil
DE112006003279A5 (de)	2008-09-04	Kette
FI20041287L (fi)	2006-04-05	Tela
DE602005001914D1 (de)	2007-09-20	Förderkette
DE602005014332D1 (de)	2009-06-18	Einen Fußball anstoßende Spielfigur
EP1899623A4 (fr)	2011-07-27	Chaine rigidifiable
FR2879415B1 (fr)	2007-04-20	Epingle a chignon
EP1692125A4 (fr)	2007-08-29	Irciniastatines a et b
DE502004007204D1 (de)	2008-07-03	Kettenzug
ITMI20030161A1 (it)	2004-07-31	Lattometro a passaggio diretto
DE112006003284A5 (de)	2008-09-04	Zahnlaschenkette

Legal Events

Date	Code	Title	Description
2007-09-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2007-10-31	17P	Request for examination filed	Effective date: 20070831
2007-10-31	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
2007-10-31	AX	Request for extension of the european patent	Extension state: AL BA HR LV MK YU
2008-07-18	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1110476 Country of ref document: HK
2010-02-24	A4	Supplementary search report drawn up and despatched	Effective date: 20100127
2010-02-24	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 31/04 20060101ALI20100118BHEP Ipc: A61K 31/70 20060101ALI20100118BHEP Ipc: A01N 43/04 20060101AFI20060822BHEP
2012-01-04	17Q	First examination report despatched	Effective date: 20111130
2013-02-06	TPAC	Observations filed by third parties	Free format text: ORIGINAL CODE: EPIDOSNTIPA
2013-10-09	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: OPTIMER PHARMACEUTICALS, INC.
2014-01-04	TPAC	Observations filed by third parties	Free format text: ORIGINAL CODE: EPIDOSNTIPA
2015-10-07	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: MERCK SHARP & DOHME CORP.
2017-06-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2017-08-25	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1110476 Country of ref document: HK
2018-10-08	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2018-10-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2019-03-13	18R	Application refused	Effective date: 20181008