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EP1843772A1 - Intravenous formulations of pde-5 inhibitors - Google Patents

Intravenous formulations of pde-5 inhibitors

Info

Publication number
EP1843772A1
EP1843772A1 EP06706165A EP06706165A EP1843772A1 EP 1843772 A1 EP1843772 A1 EP 1843772A1 EP 06706165 A EP06706165 A EP 06706165A EP 06706165 A EP06706165 A EP 06706165A EP 1843772 A1 EP1843772 A1 EP 1843772A1
Authority
EP
European Patent Office
Prior art keywords
vardenafil
pde
acid
intravenous
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06706165A
Other languages
German (de)
French (fr)
Inventor
Peter Serno
Helmut Haning
Frank Reetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of EP1843772A1 publication Critical patent/EP1843772A1/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Definitions

  • the invention relates to novel applications of intravenous administration forms of PDE inhibitors and novel pharmaceutical formulations for this purpose.
  • PDE in particular the PDE 5 inhibitors are known as potent pharmaceutical active ingredients and are used for the treatment of diseases.
  • the compound vardenafil is systematically named ⁇ 2-ethoxy-5- [4-ethyl-1-piperazinyl) sulfonyl] -phenyl ⁇ -5-methyl-7-propyl-hmidazo [5, l - /] -triazine-4 (3H) -one and their physiologically acceptable salts, for example in WO99 / 24433.
  • Other PDE 5 inhibitors are
  • DA8159 Enantiomers of 5- [2-propyloxy-5- (1-methyl-2-pyrrolidinylethylamidosulfonyl) phenyl] -1-methyl-3-propyl-1,6-dihydro-7 ⁇ -pyrazolo (4,3-d) pyrimidines -7-one as described in WO 2001098304,
  • TA-1790 avanafil, (S) -2- (2-hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) - 5 - [(2-pyrrolidinylmethyl) carbamoyl] pyrimidines
  • EMD-221829 4- ⁇ 4 - [(3-chloro-4-methoxybenzyl) amino] [l] benzothieno [2,3-d] pyrimidin-2-yl ⁇ -cyclohexanecarboxylic acid ethanolamine salt,
  • ABT724 2 - [(4-pyridin-2-yl-piperazin-1-yl) methyl] -1 H-benzimidazole.
  • Vardenafil like sildenafil and tadalafil, inhibits intracellular degradation of cGMP by PDE 5 inhibition.
  • increased intracellular cGMP levels result after NO activation.
  • the mechanism has been used to treat erectile dysfunction and to treat and prevent other diseases such as hypertension, neuronal hypertension, stable and unstable angina, peripheral and cardiovascular diseases, arrhythmias, for the treatment of thromboembolic disorders and ischaemias such as myocardial infarction, stroke, transient ischemic attacks , Angina pectoris, peripheral circulatory disorders, for the prevention of restenosis after thrombolytic therapy, percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA) and bypass.
  • PTA percutaneous transluminal angioplasty
  • PTCA percutaneous transluminal coronary angioplasty
  • the differentiated expression of the phosphodiesterases in different cells, tissues and organs, as well as the differentiated subcellular localization of these enzymes, allow for selective addressing of the various cGMP-regulated processes, in particular in the case of intravenous administration of the PDE inhibitors. Therefore, the preparations according to the invention are suitable for the prophylaxis and / or treatment of diseases in which an increase in cGMP concentration is beneficial, i. Diseases related to; cGMP-regu-. lated processes (usually simply referred to as 'cGMP-related diseases' in English).
  • the PDE 5 inhibitors also enhance the action of substances such as EDRF (endothelium-derived relaxing factor), ANP (atrial natriuretic peptide), nitro-vasodilators and all other substances that in a different way than phosphodiesterase inhibitors cGMP Increase concentration.
  • EDRF endothelium-derived relaxing factor
  • ANP atrial natriuretic peptide
  • nitro-vasodilators all other substances that in a different way than phosphodiesterase inhibitors cGMP Increase concentration.
  • PDE 5 inhibitors now also allow treatment of cardiovascular diseases after administration in the form of the infusion formulations according to the invention.
  • cardiovascular diseases include: hypertension, heart failure, pulmonary hypertension, nitrate-induced tolerance, neuronal hypertension, stable and unstable angina, peripheral and cardiac vascular disease, achieving or improving preconditioning effect, cardiac ischemia, acute myocardial infarction, reperfusion injury, especially after myocardial infarction , Arrhythmias, thromboembolic disorders and ischaemias such as myocardial infarction, coronary heart disease, stroke, transitory. and ischemic attacks, angina pectoris, peripheral circulatory disorders, Raynaud's syndrome and intermittent claudication. They are also useful in the prevention of restenosis following thrombolytic therapy, percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA) and bypass
  • the infusion formulations of PEDE 5 inhibitors according to the invention can be used for the treatment of diseases of the urogenital system such as prostatic hypertrophy, incontinence, bladder diseases, erectile dysfunction, priapism, Peyronie's disease, preterm labor, premature ejaculation, male infertility, insufficient sperm motility, dysmenorrhea, polycystic ovary Syndromes, incontinence (eg urge incontinence), acute and chronic renal failure, renal syndrome, glomerular disease, nephritis, tubulo-intestinal disorders, glomuleropathy, female infertility, female sexual dysfunction and female sexual arousal disorder in the fort Planting medicine is possible, for example to promote growth and survival of oocytes, zygotes, embryos or fetuses, to increase weight in premature birth, to increase milk production in mammals, especially in humans, in premature labor and pre-eclampsia.
  • diseases of the urogenital system
  • Another area of application is the treatment and / or prophylaxis of disorders of perception, concentration performance, learning performance and / or memory performance, especially if the disorder is a consequence of dementia.
  • the formulations used according to the invention are particularly suitable for improving perception, concentration performance, learning performance, or memory performance for cognitive disorders, such as those found particularly in situations / diseases / syndromes such as mild cognitive impairment, age-associated learning and memory disorders, age-associated memory loss, vascular dementia, craniocerebral trauma, stroke, dementia that occurs after strokes ("post stroke dementia”), and post-traumatic brain injury trauma.
  • Alzheimer's disease vascular dementia
  • dementia with Lewy bodies dementia with degeneration of the froirt lobes including Pick's Syndrome, Parkinson's disease, progressive nuclear palsy, dementia with cortic and jasal degeneration, amyolateral sclerosis (ALS), Huntington's disease, multiple sclerosis, thalamic degeneration, Creutzfeld-Jacob dementia, HTV dementia, schizophrenia with dementia or Korsakoff's psychosis, treatment of depression, amnesia, anxiety disorders, autism, speech disorders, Lennox syndrome and epilepsy.
  • ALS amyolateral sclerosis
  • HTV dementia thalamic degeneration
  • schizophrenia with dementia or Korsakoff's psychosis treatment of depression, amnesia, anxiety disorders, autism, speech disorders, Lennox syndrome and epilepsy.
  • inventive intravenous formulations of PDFE 5 inhibitors is possible for the treatment or prophylaxis of ocular disorders such as glaucoma, especially acute glaucoma, central retinal or posterior ciliary artery occlusion, central retinal venous occlusion, optic neuropathy such as anterior ischemic optic neuropathy and glaucomatous optic neuropathy, as well as macular degeneration.
  • ocular disorders such as glaucoma, especially acute glaucoma, central retinal or posterior ciliary artery occlusion, central retinal venous occlusion, optic neuropathy such as anterior ischemic optic neuropathy and glaucomatous optic neuropathy, as well as macular degeneration.
  • diabetes insulin resistance
  • hyperglycemia diabetic gastroparesis
  • diabetic nephropathy diabetic neuropathy
  • diabetic retinopathy diabetic gangrene
  • diabetic glomerulosclerosis diabetic dermatopathy, diabetic arthropathy, diabetic dermatopathy and diabetic cataract.
  • inventive intravenous formulations of PDE 5 inhibitors are also suitable for the treatment of the following disorders: disorders of peristalsis of the stomach and esophagus, liver diseases such as cirrhosis, portal hypertension, pancreatitis, inflammatory bowel disease (eg, Crohn's disease and ulcerative colitis ) Disorders of gastric motility, further supporting and promoting liver regeneration after chimgous liver resection or liver cancer, and inhibiting oesophageal muscle contraction (eg, nutcracker esophagus, spastic esophageal disease).
  • disorders of peristalsis of the stomach and esophagus liver diseases such as cirrhosis, portal hypertension, pancreatitis, inflammatory bowel disease (eg, Crohn's disease and ulcerative colitis )
  • inflammatory bowel disease eg, Crohn's disease and ulcerative colitis
  • oesophageal muscle contraction eg, nutcracker esophagus, spa
  • inventive formulations can be used for the prophylaxis and / or treatment of: osteoporosis, psoriasis, cancer, cystic fibrosis, alopecia, pain, tinnitus, hearing loss, COPD, asthma, bronchitis and allergic rhinitis, fibrotic diseases, arteriosclerosis, leukemia (eg chronic lymphocytic leukemia), platelet adhesion and aggregation in renal ischemia, achalasia, hypertensive LES 5 lupus, scleroderma, hair loss or alopecia, multiple sclerosis and rheumatoid arthritis, allergy, osteoporosis, autoimmune diseases, cachexia, hyperlipidemia and dyslipidemia and migraine.
  • leukemia eg chronic lymphocytic leukemia
  • LES 5 lupus eg chronic lymphocytic leukemia
  • scleroderma eg chronic lymphocytic leukemia
  • Another aspect of the invention are intravenously administrable formulations of PDE 5 inhibitors, in particular vardenafil.
  • vardenafil Solutions of vardenafil and its physiologically acceptable salts are described in WO99 / 2433.
  • the therapeutically active compound should be present in a concentration of 0.5 to 90 wt .-% of the total mixture.
  • concentration of the active ingredient in the formulation only allows rapid intravenous delivery of the drug, for example as a bolus injection or infusion at a very low rate of infusion.
  • an easily handled and well tolerated intravenous formulation of PDE 5 inhibitors such as vardenafil can be obtained when 0.0004 to 0.1% (w / v) of the PDE inhibitor is free base or a salt be dissolved in an aqueous solvent.
  • solutions which contain an acid in addition to the PDE inhibitor In this case, a molar ratio of 1: 0.9 to 1: 2.0 (PDE inhibitor: acid) is particularly preferred.
  • PDE inhibitors in the form of a salt the amount of acid to be added is reduced by the amount that has already been used for salt formation. In the case of polybasic acids, depending on the acid strength of the particular dissociation stage, the stated amount of acid may optionally be divided by the number of protons released per molecule of acid.
  • the infusion solutions according to the invention have the advantage of being well tolerated after parenteral administration Application, a virtually immediate establishment of effective plasma concentrations, good controllability of drug delivery, since the infusion rate can be reduced if undesirable side effects occur.
  • a particular advantage is the very high bioavailability after administration of the preparations according to the invention, which is surprisingly 6 to 7 times greater than that of an orally administered tablet.
  • the PDE 5 inhibitor in amorphous, crystalline or solvent-containing form is dissolved in an aqueous solvent to prepare the solutions according to the invention.
  • one or more acids are added to this.
  • Suitable acids are, for example, acetic acid, adipic acid, ascorbic acid, aspartic acid, benzenesulfonic acid, benzoic acid, citric acid, ethanesulfonic acid, 2-hydroxyethanesulfonic acid, fumaric acid, glucgheptonic acid, gluconic acid, glucuronic acid, glutamic acid, hydrochloric acid, lactic acid, lactobionic acid, maleic acid, malic acid, malonic acid , Methanesulfonic acid, naphthalenesulfonic acid, naphthalene-disulfonic acid, nitric acid, phosphoric acid, succinic acid, sulfuric acid, tartaric acid, toluenesulfonic acid, mono-
  • an isotonizing agent may be added to formulations according to the invention, for example sodium chloride, glucose, fructose, mannitol, sorbitol, glycerol, acetate, citrate, phosphate or lactate buffers or amino acids.
  • the pH of the preparations can be adjusted with one of the acids mentioned or at already too acidic pH with a base such as sodium hydroxide, trometamol, arginine or lysine.
  • a pH range of 3 to 7 is preferred for the formulations according to the invention.
  • parenterally administrable organic solvents such as ethanol, propylene glycol or polyethylene glycol, surfactants or polymers such as polyvinylpyrrolidone, polysorbate, poloxamer, Cremophor, Solutol HS 15, phospholipids and native or substituted cyclodextrins.
  • the formulations according to the invention are filled into known containers for parenteral administration, for example in injection vials or glass infusion bottles with stoppers, in flexibags or in other large or small-volume containers made of plastic, in prefilled syringes or carpules.
  • the filling is also possible in the blow-fill-seal process in plastic containers.
  • Vardenafil or a vardenafil salt for example, are dissolved in the solvent (usually water) together with acid, isotonizing agents and optionally further auxiliaries to produce the preparations according to the invention. After adjusting the pH is made up with water to the total amount used, sterile filtered through 0.2 micron filter membranes and bottled.
  • a sterilization of the filled solution is preferably in the final container, for example for 15 minutes at 121 0 C.
  • the use of packaging materials that survive this temperature is not harmless, is However, aseptic preparation without or with subsequent heat treatment, possibly at lower temperatures than 121 0 C possible.
  • Concentrates represent a particular embodiment of the invention.
  • a concentrated solution of vardenafil is first prepared and marketed.
  • the preparation of the inventive infusion solution is then carried out by the user, for example by adding the concentrate solution to a standard infusion or by continuous dilution of the concentrate via a Y-piece.
  • the infusion solutions according to the invention can be administered intravenously in different ways, depending on the drug dose, the drug concentration and the field of application.
  • the administration as bolus injection, the application in the form of a gravity drip infusion or pumping through an infusion tube pump or infusion syringe pump are possible.
  • the infusions are administered to peripheral veins, but in patients undergoing intensive care, central venous or, in special cases, arterial administration is also possible.
  • Example 1 (comparison):
  • Non-inventive preparation drug concentration 0.005 mg / ml
  • the solution contains to a considerable extent undissolved active substance components and is not suitable for intravenous infusion.
  • Vardenafil dihydrate 0.50 g
  • the solution is unstable. When the solution is prepared, 6.5% of vardenafil N-oxide forms. Its content increases to 11% after heat sterilization of the solution.
  • Vardenafil dihydrate (equivalent to 2.00 mg vardenafil) 2.15 mg
  • Example 6 107.4 mg of vardenafil dihydrate, 27.7 mg of tartaric acid and 9 g of sodium chloride are dissolved in one liter of water for injection purposes. The solution is sterile filtered, filled to 2 ml in pre-filled syringes and sterilized. Each pre-filled syringe contains 0.2 mg vardenafil.
  • Example 6 107.4 mg of vardenafil dihydrate, 27.7 mg of tartaric acid and 9 g of sodium chloride are dissolved in one liter of water for injection purposes. The solution is sterile filtered, filled to 2 ml in pre-filled syringes and sterilized. Each pre-filled syringe contains 0.2 mg vardenafil.
  • Example 6 Example 6
  • vardenafil dimesilate monohydrate is filled in 1000 ml physiological saline.
  • the solution is sterile filtered and filled under aseptic conditions to 250 ml in infusion bottles.
  • Each infusion bottle contains 1 mg vardenafil.
  • tadalafil 0.005 kg of tadalafil is dissolved in 30 kg of polyethylene glycol 400 and 30 kg of ethanol 96%. It is made up to 200 liters with water for injections. The solution is sterile filtered and aseptically filled into infusion bottles to 100 ml.

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Abstract

The invention relates to a novel pharmaceutical dosage form of PDE inhibitors for the intravenous application thereof and application thereof for the treatment of diseases.

Description

INTRAVENÖSE FORMULIERUNGEN VON PDE-5-INHIBITOREN INTRAVENOUS FORMULATIONS OF PDE-5 INHIBITORS
Die Erfindung bezieht sich auf neuartige Anwendungen intravenöser Applikationsformen von PDE-Inhibitoren sowie neuartige pharmazeutische Formulierungen hierzu.The invention relates to novel applications of intravenous administration forms of PDE inhibitors and novel pharmaceutical formulations for this purpose.
PDE-, insbesondere die PDE 5-Inhibitoren sind als potente pharmazeutische Wirkstoffe bekannt und werden zur Behandlung von Krankheiten eingesetzt. So wird zum Beispiel die Verbindung Vardenafil mit der systematischen Bezeichnung{2-Ethoxy-5-[4-ethyl-l-piperazinyl)sulfonyl]- phenyl}-5-methyl-7-propyHmidazo[5,l-/]triazin-4(3H)-on und ihre physiologisch unbedenklichen Salze z.B. in der WO99/24433 beschrieben. Andere PDE 5-Inhibitoren sindPDE, in particular the PDE 5 inhibitors are known as potent pharmaceutical active ingredients and are used for the treatment of diseases. Thus, for example, the compound vardenafil is systematically named {2-ethoxy-5- [4-ethyl-1-piperazinyl) sulfonyl] -phenyl} -5-methyl-7-propyl-hmidazo [5, l - /] -triazine-4 (3H) -one and their physiologically acceptable salts, for example in WO99 / 24433. Other PDE 5 inhibitors are
Sildenafil, Tadalafil,Sildenafil, Tadalafil,
DA8159: Enantiomere von 5-[2-propyloxy-5-(l-methyl-2-pyrroiidinylethylamidosulfonyl)phenyl]- l-methyl-3-propyl-l,6-dihydro-7Η-pyrazolo(4,3-d)pyrimidine-7-on wie in WO 2001098304 beschrieben,DA8159: Enantiomers of 5- [2-propyloxy-5- (1-methyl-2-pyrrolidinylethylamidosulfonyl) phenyl] -1-methyl-3-propyl-1,6-dihydro-7α-pyrazolo (4,3-d) pyrimidines -7-one as described in WO 2001098304,
TA-1790: Avanafil, (S)-2-(2-Hydroxymethyl-l-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)- 5-[(2-pyrftnidinylmethyl)carbamoyl]pyrimidineTA-1790: avanafil, (S) -2- (2-hydroxymethyl-1-pyrrolidinyl) -4- (3-chloro-4-methoxybenzylamino) - 5 - [(2-pyrrolidinylmethyl) carbamoyl] pyrimidines
EMD-221829: 4-{4-[(3-chloro-4-rnethoxybenzyl)amino] [l]benzothieno[2,3-d]pyrimidin-2-yl}- cyclohexanecarboxyl Säure Ethanolamin Salz,EMD-221829: 4- {4 - [(3-chloro-4-methoxybenzyl) amino] [l] benzothieno [2,3-d] pyrimidin-2-yl} -cyclohexanecarboxylic acid ethanolamine salt,
QAD-171A wie in WO00177110 beschrieben,QAD-171A as described in WO00177110,
PTl 31 sowiePTl 31 as well
ABT724 : 2-[(4-pyridin-2-ylpiperazin- 1 -yl)methyl]- 1 H-benzimidazole.ABT724: 2 - [(4-pyridin-2-yl-piperazin-1-yl) methyl] -1 H-benzimidazole.
Vardenafil führt, wie auch Sildenafil und Tadalafil, durch die PDE 5 -Inhibition zu einer Hemmung des intrazellulären Abbaus von cGMP. Als Folge resultieren nach NO-Aktivierung erhöhte intrazellulärer cGMP-Spiegel. Der Mechanismus wurde bislang zur Behandlung der erektilen Dysfunktion sowie zur Behandlung und Prophylaxe weiterer Erkrankungen wie Bluthochdruck, neuronaler Hypertonie, stabiler und instabiler Angina, peripheren und kardialen Gefäßerkrankungen, von Arrhythmien, zur Behandlung von thromboembolischen Erkrankungen und Ischämien wie Myokardinfarkt, Hirnschlag, transitorischen ischämischen Attacken, Angina pectoris, peripheren Durchblutungsstörungen, zur Verhinderung von Restenosen nach Throm- bolysetherapie, percutaner transluminaler Angioplastie (PTA), perkutaner transluminaler Koronarangioplastie (PTCA) und Bypass beschrieben. Neben diesen bekannten Anwendungen wurde nun gefunden, dass PDE 5-Inhibitoren zur Behandlung zahlreicher weiterer Erkrankungen eingesetzt werden können, bei denen eine Therapierbarkeit durch PDE 5-Inhibitoren bislang nicht vermutet worden war, insbesondere wenn die jeweilige Verbindung (oder Verbindungen) intravenös zugeführt wird (oder werden).Vardenafil, like sildenafil and tadalafil, inhibits intracellular degradation of cGMP by PDE 5 inhibition. As a result, increased intracellular cGMP levels result after NO activation. The mechanism has been used to treat erectile dysfunction and to treat and prevent other diseases such as hypertension, neuronal hypertension, stable and unstable angina, peripheral and cardiovascular diseases, arrhythmias, for the treatment of thromboembolic disorders and ischaemias such as myocardial infarction, stroke, transient ischemic attacks , Angina pectoris, peripheral circulatory disorders, for the prevention of restenosis after thrombolytic therapy, percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA) and bypass. In addition to these known applications, it has now been found that PDE 5 inhibitors can be used for the treatment of numerous other diseases in which a therapy by PDE 5 inhibitors has not previously been suspected, especially if the respective compound (or compounds) is administered intravenously ( or)
Die differenzierte Expression der Phosphodiesterasen in verschiedenen Zellen, Geweben und Organen, ebenso wie die differenzierte subzelluläre Lokalisation dieser Enzyme, ermöglichen insbesondere bei intravenöser Zufuhr der PDE-Inhibitoren eine selektive Adressierung der verschiedenen von cGMP regulierten Vorgänge. Daher sind die erfϊndungsgemäßen Zubereitungen geeignet zur Prophylaxe und/oder Behandlung von Erkrankungen, bei denen ein Anstieg der cGMP-Konzentration heilsam ist, d.h. Erkrankungen, die im Zusammenhang mit;cGMP-regu- . lierten Vorgängen stehen (im Englischen meist einfach als 'cGMP-related diseases' bezeichnet). Die PDE 5-Inhibitoren verstärken dabei auch die Wirkung von Substanzen, wie beispielsweise EDRF (Endothelium derived relaxing factor), ANP (atrial natriuretic peptide), von Nitrovaso- dilatoren und allen anderen Substanzen, die auf eine andere Art als Phosphodiesterase-Inhibitoren die cGMP-Konzentration erhöhen.The differentiated expression of the phosphodiesterases in different cells, tissues and organs, as well as the differentiated subcellular localization of these enzymes, allow for selective addressing of the various cGMP-regulated processes, in particular in the case of intravenous administration of the PDE inhibitors. Therefore, the preparations according to the invention are suitable for the prophylaxis and / or treatment of diseases in which an increase in cGMP concentration is beneficial, i. Diseases related to; cGMP-regu-. lated processes (usually simply referred to as 'cGMP-related diseases' in English). The PDE 5 inhibitors also enhance the action of substances such as EDRF (endothelium-derived relaxing factor), ANP (atrial natriuretic peptide), nitro-vasodilators and all other substances that in a different way than phosphodiesterase inhibitors cGMP Increase concentration.
Im Einzeln ermöglichen PDE 5-Inhibitoren nach Applikation in Form der erfϊndungsgemäßen Infusionsformulierungen nunmehr auch eine Behandlung von kardiovaskulären Erkrankungen. Beispiele sind: Bluthochdruck, Herzinsuffizienz, pulmonaler Bluthochdruck, nitrat-induzierte Toleranz, neuronale Hypertonie, stabile und instabile Angina, periphere und kardiale Gefäßerkran- kungen, die Erzielung oder Verbesserung eines Preconditioning Effektes, kardiale Ischämie, akuter Myokardinfarkt, Reperfusionsschäden, speziell nach einem Myokardinfarkt, Arrhythmien, throm- boembolische Erkrankungen und Ischämien wie Myokardinfarkt, koronare Herzkrankheit, Hirnschlag, transitorische. und ischämische Attacken, Angina pectoris, periphere Durchblutungsstörungen, Raynaud's Syndrom und Claudicatio intermittens. Sie eignen sich ferner zur Verhin- derung von Restenosen nach Thrombolysetherapie, percutaner transluminaler Angioplastie (PTA), perkutan transluminalen Koronarangioplastien (PTCA) und BypassIndividually, PDE 5 inhibitors now also allow treatment of cardiovascular diseases after administration in the form of the infusion formulations according to the invention. Examples include: hypertension, heart failure, pulmonary hypertension, nitrate-induced tolerance, neuronal hypertension, stable and unstable angina, peripheral and cardiac vascular disease, achieving or improving preconditioning effect, cardiac ischemia, acute myocardial infarction, reperfusion injury, especially after myocardial infarction , Arrhythmias, thromboembolic disorders and ischaemias such as myocardial infarction, coronary heart disease, stroke, transitory. and ischemic attacks, angina pectoris, peripheral circulatory disorders, Raynaud's syndrome and intermittent claudication. They are also useful in the prevention of restenosis following thrombolytic therapy, percutaneous transluminal angioplasty (PTA), percutaneous transluminal coronary angioplasty (PTCA) and bypass
Weiterhin können die erfindungsgemäßen Infusionsformulierungen von PEDE 5-Inhibitoren eingesetzt werden für die Behandlung von Erkrankungen des Urogenitalsystems wie Prostatahypertrophie, Inkontinenz, Blasenerkrankungen, erektile Dysfunktion, Priapismus, Peyronie's disease, vorzeitige Wehen, vorzeitige Ejakulation, männliche Unfruchtbarkeit, unzureichende Spermienmotilität, Dysmenorrhea, Polycystic ovary Syndrome, Inkontinenz (z. B. „urge inconti- nence"), akutes und chronisches Nierenversagen, renales Syndrom, glomeruläre Erkrankung, Nephritis, Tubulo-intestinale Erkrankungen, Glomuleropathy, weibliche Infertilität, weibliche sexueller Dysfunktion und weibliche sexuelle Erregungsstörung. Auch ein Einsatz in der Fort- pflanzungsmedizin ist möglich, beispielsweise zur Wachstumsförderung und Überlebensverbesserung von Oocyten, Zygoten, Embryos oder Föten, zur Gewichtssteigerung bei Frühgeburten, zur Steigerung der Milchproduktion bei Säugetieren, speziell beim Menschen, bei vorzeitigen Wehen und Präeklampsie.Furthermore, the infusion formulations of PEDE 5 inhibitors according to the invention can be used for the treatment of diseases of the urogenital system such as prostatic hypertrophy, incontinence, bladder diseases, erectile dysfunction, priapism, Peyronie's disease, preterm labor, premature ejaculation, male infertility, insufficient sperm motility, dysmenorrhea, polycystic ovary Syndromes, incontinence (eg urge incontinence), acute and chronic renal failure, renal syndrome, glomerular disease, nephritis, tubulo-intestinal disorders, glomuleropathy, female infertility, female sexual dysfunction and female sexual arousal disorder in the fort Planting medicine is possible, for example to promote growth and survival of oocytes, zygotes, embryos or fetuses, to increase weight in premature birth, to increase milk production in mammals, especially in humans, in premature labor and pre-eclampsia.
Ein weiterer Anwendungsbereich ist die Behandlung und/oder Prophylaxe von Störungen der Wahrnehmung, der Konzentrationsleistung, der Lernleistung und/oder Gedächtnisleistung, insbesondere wenn die Störung eine Folge von Demenz ist. Besonders eignen sich die erfindungsgemäß verwendeten Formulierungen zur Verbesserung der Wahrnehmung, Konzentrationsleistung, Lernleistung, oder Gedächtnisleistung nach kognitiven Störungen, wie sie insbesondere bei Situatio- nen/Krankheiten/Syndromen auftreten wie „Mild cognitive impairment", altersassoziierten Lern- und Gedächtnisstörungen, altersassoziierten Gedächtnisverlusten, vaskulärer Demenz, Schädel- Hirn-Trauma, Schlaganfall, Demenz, die nach Schlaganfällen auftritt („post stroke dementia"), und post-traumatischem Schädel Hirn Trauma. Ferner ist ein Einsatz möglich bei Konzentrationsstörungen bei Kindern mit Lern- und Gedächtnisproblemen, Alzheimerscher Krankheit, vaskulärer Demenz, Demenz mit Lewy-Körperchen, Demenz mit Degeneration der Froirtallappen einschließlich des Pick's Syndroms, Parkinsonscher Krankheit, progressiver nuclear palsy, Demenz mit kortik&jasaler Degeneration, Amyolateralsklerose (ALS), Huntingtonscher Krankheit, multipler Sklerose, thalamischer Degeneration, Creutzfeld-Jacob-Demenz, HTV-Demenz, Schizophrenie mit Demenz oder Korsakoff-Psychose, Behandlung von Depression, Amnesie, Bewußt- seinsstörungen, Autismus, Sprachstörungen, Lennox Syndrom und Epilepsie.Another area of application is the treatment and / or prophylaxis of disorders of perception, concentration performance, learning performance and / or memory performance, especially if the disorder is a consequence of dementia. The formulations used according to the invention are particularly suitable for improving perception, concentration performance, learning performance, or memory performance for cognitive disorders, such as those found particularly in situations / diseases / syndromes such as mild cognitive impairment, age-associated learning and memory disorders, age-associated memory loss, vascular dementia, craniocerebral trauma, stroke, dementia that occurs after strokes ("post stroke dementia"), and post-traumatic brain injury trauma. It is also possible to use in the case of impaired concentration in children with learning and memory problems, Alzheimer's disease, vascular dementia, dementia with Lewy bodies, dementia with degeneration of the froirt lobes including Pick's Syndrome, Parkinson's disease, progressive nuclear palsy, dementia with cortic and jasal degeneration, amyolateral sclerosis (ALS), Huntington's disease, multiple sclerosis, thalamic degeneration, Creutzfeld-Jacob dementia, HTV dementia, schizophrenia with dementia or Korsakoff's psychosis, treatment of depression, amnesia, anxiety disorders, autism, speech disorders, Lennox syndrome and epilepsy.
Darüber hinaus ist ein Einsatz erfϊndungsgemäßer intravenöser Formulierungen von PDFE 5- Inhibitoren möglich zur Behandlung oder Prophylaxe von Erkankungen des Auges wie Glaukom, im besonderen den akuten Glaukomanfall, zentraler retinaler oder posteriorer zilliarer Arterienokklusion, zentraler retinaler Venenokklusion, optischer Neuropathie wie anteriorer ischämischer optischer Neuropathie und glaukomatöser optischer Neuropathie, sowie von makulärer Degeneration.In addition, use of inventive intravenous formulations of PDFE 5 inhibitors is possible for the treatment or prophylaxis of ocular disorders such as glaucoma, especially acute glaucoma, central retinal or posterior ciliary artery occlusion, central retinal venous occlusion, optic neuropathy such as anterior ischemic optic neuropathy and glaucomatous optic neuropathy, as well as macular degeneration.
Weitere Einsatzgebiete sind Diabetes, Insulin-Resistenz, Hyperglycämie, diabetische Gastroparese, diabetische Nephropathie, diabetische Neuropathie, diabetische Retinopathie, diabetisches Gangrän, diabetische Glomerulosklerose, diabetische Dermopathie, diabetische Arthropathy, diabetische Dermatopathie und diabetischer Katarakt.Further fields of use are diabetes, insulin resistance, hyperglycemia, diabetic gastroparesis, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic gangrene, diabetic glomerulosclerosis, diabetic dermatopathy, diabetic arthropathy, diabetic dermatopathy and diabetic cataract.
Die erfmdungsgemäßen intravenösen Formulierungen von PDE 5-Inhibitoren eignen sich auch zur Behandlung folgender Erkrankungen: Störungen der Peristaltik von Magen und Speiseröhre, Lebererkrankungen wie z.B. Leberzirrhose, portale Hypertension, Pankreatitis, entzündliche Darmerkrankung ("Inflammatory bowel disease" wie z.B. Morbus crohn und Colitis Ulcerosa), Störungen der Magenbeweglichkeit, ferner zur Unterstützung und Förderung der Leberregeneration nach chimgischer Leberresektion oder Leberkrebs und zur Inhibition der Kontraktion der Ösophagusmuskulatur (z. B. Nußknacker Ösophagus, spastische Ösophagus Erkrankung).The inventive intravenous formulations of PDE 5 inhibitors are also suitable for the treatment of the following disorders: disorders of peristalsis of the stomach and esophagus, liver diseases such as cirrhosis, portal hypertension, pancreatitis, inflammatory bowel disease (eg, Crohn's disease and ulcerative colitis ) Disorders of gastric motility, further supporting and promoting liver regeneration after chimgous liver resection or liver cancer, and inhibiting oesophageal muscle contraction (eg, nutcracker esophagus, spastic esophageal disease).
Darüber hinaus können die erfmdungsgemäßen Formulierungen eingesetzt werden zur Prophylaxe und/oder Behandlung von: Osteoporose, Psoriasis, Krebs, zystischer Fibrose, Alopecia, Schmerz, Tinnitus, Gehörsturz, COPD, Asthma, Bronchitis und allergische Rhinitis, fibrotische Erkrankungen, Arteriosklerose, Leukämie (z.B. chronische lymphocytische Leukämia), Plättchen Adhäsion und Aggregation bei renaler Ischämie, Achalasie, hypertensive LES5 Lupus, Scleroderma, Haarverlust oder Haarausfall, multiple Sklerose und rheumatoide Arthritis, Allergie, Osteoporose, Autoimmunerkrankungen, Cachexia, Hyperlipidämie und Dyslipidämie sowie Migräne.In addition, the inventive formulations can be used for the prophylaxis and / or treatment of: osteoporosis, psoriasis, cancer, cystic fibrosis, alopecia, pain, tinnitus, hearing loss, COPD, asthma, bronchitis and allergic rhinitis, fibrotic diseases, arteriosclerosis, leukemia (eg chronic lymphocytic leukemia), platelet adhesion and aggregation in renal ischemia, achalasia, hypertensive LES 5 lupus, scleroderma, hair loss or alopecia, multiple sclerosis and rheumatoid arthritis, allergy, osteoporosis, autoimmune diseases, cachexia, hyperlipidemia and dyslipidemia and migraine.
Ein weiterer Aspekt der Erfindung stellen intravenös applizierbare Formulierungen von PDE 5- Inhibitoren, insbesondere Vardenafil, dar.Another aspect of the invention are intravenously administrable formulations of PDE 5 inhibitors, in particular vardenafil.
Lösungen von Vardenafil und seiner physiologisch unbedenklichen Salze werden in der WO99/24$33 beschrieben. Zu ihrer Herstellung soll die therapeutisch wirksame Verbindung in einer Konzentration von 0,5 bis 90 Gew.-% der Gesamtmischung vorhanden sein. Es hat sich jedoch herausgestellt, dass die geringe Wasserlöslichkeit und Instabilität von Vardenafil in zahlreichen organischen Lösungsmitteln einer üblichen Formulierung von Vardenafil zu intravenös anwendbaren Zubereitungen entgegenstehen. Ferner erlaubt die genannte Konzentration des Wirkstoffes in der Formulierung nur eine rasche intravenöse Zufuhr des Wirkstoffes, beispielsweise als Bolus-Injektion oder eine Infusion bei sehr geringer Infusionsgeschwindigkeit.Solutions of vardenafil and its physiologically acceptable salts are described in WO99 / 2433. For their preparation, the therapeutically active compound should be present in a concentration of 0.5 to 90 wt .-% of the total mixture. However, it has been found that the low water solubility and instability of vardenafil in numerous organic solvents conflict with a conventional formulation of vardenafil to intravenously applicable formulations. Furthermore, said concentration of the active ingredient in the formulation only allows rapid intravenous delivery of the drug, for example as a bolus injection or infusion at a very low rate of infusion.
Entsprechend der vorliegenden Erfindung kann eine einfach handzuhabende und gut verträgliche intravenös anwendbare Formulierung von PDE 5-Inhibitoren wie Vardenafil erhalten werden, wenn 0,0004 bis 0,1 % (m/v) des PDE-Inhibitors in Form der freien Base oder eines Salzes in einem wässrigen Lösungsmittel aufgelöst werden. Besonders bevorzugt sind hierbei Lösungen, die neben dem PDE-Inhibitor eine Säure enthalten. Dabei ist ein molares Mengenverhältnis von 1 : 0,9 bis 1 : 2,0 (PDE-Inhibitor : Säure) besonders bevorzugt. Bei Einsatz von PDE-Inhibitoren in Form eines Salzes reduziert sich die zuzugebende Säuremenge um die Menge, die bereits zur Salzbildung eingesetzt worden war. Im Falle mehrprotoniger Säuren kann in Abhängigkeit von der Säurestärke der jeweiligen Dissoziationsstufe die angegebene Säuremenge gegebenenfalls durch die Anzahl der pro Molekül Säure abgegebenen Protonen dividiert werden.In accordance with the present invention, an easily handled and well tolerated intravenous formulation of PDE 5 inhibitors such as vardenafil can be obtained when 0.0004 to 0.1% (w / v) of the PDE inhibitor is free base or a salt be dissolved in an aqueous solvent. Particular preference is given to solutions which contain an acid in addition to the PDE inhibitor. In this case, a molar ratio of 1: 0.9 to 1: 2.0 (PDE inhibitor: acid) is particularly preferred. When using PDE inhibitors in the form of a salt, the amount of acid to be added is reduced by the amount that has already been used for salt formation. In the case of polybasic acids, depending on the acid strength of the particular dissociation stage, the stated amount of acid may optionally be divided by the number of protons released per molecule of acid.
Im Vergleich zu den bislang bekannten Formulierungen beispielsweise von Vardenafil haben die erfindungs gemäßen Infusionslösungen den Vorteil der guten Verträglichkeit nach parenteraler Applikation, einen praktisch sofortigen Aufbau wirksamer Plasmakonzentrationen, eine gute Steuerbarkeit der Arzneistoffzufuhr, da die Infusionsgeschwindigkeit bei Auftreten unerwünschter Nebenwirkungen reduziert werden kann. Einen besonderen Vorteil stellt die sehr hohe Bioverfügbarkeit nach Gabe der erfindungsgemäßen Zubereitungen dar, die überraschenderweise 6 bis 7fach über der einer oral gegebenen Tablette liegt.Compared to the previously known formulations of vardenafil, for example, the infusion solutions according to the invention have the advantage of being well tolerated after parenteral administration Application, a virtually immediate establishment of effective plasma concentrations, good controllability of drug delivery, since the infusion rate can be reduced if undesirable side effects occur. A particular advantage is the very high bioavailability after administration of the preparations according to the invention, which is surprisingly 6 to 7 times greater than that of an orally administered tablet.
Im Einzelnen wird zur Herstellung der erfindungsgemäßen Lösungen der PDE 5-Inhibitor in amorpher, kristalliner oder lösungsmittelhaltiger Form in einem wässrigen Lösungsmittel gelöst. Hierzu werden diesem eine oder mehrere Säuren zugesetzt. Als Säuren kommen beispielsweise in Frage: Essigsäure, Adipinsäure, Ascorbinsäure, Asparaginsäure, Benzolsulfonsäure, Benzoesäure, Citronensäure, Ethansulfonsäure, 2-Hydroxy-Ethansulfonsäure, Fumarsäure, Glucgheptonsäure, Gluconsäure, Glucuronsäure, Glutaminsäure, Salzsäure, Milchsäure, Lactobionsäure, Maleinsäure, Äpfelsäure, Malonsäure, Methansulfonsäure, Naphtalensulfonsäure, Naphtalen-disulfonsäure, Salpetersäure, Phosphorsäure, Bernsteinsäure, Schwefelsäure, Weinsäure, Toluolsulfonsäure, Mono- oder Diester der Orthophosphorsäure wie beispielsweise Glycerin-phosphat. Im Falle mehr- protoniger Säuren können auch deren sauren Salze wie beispielsweise Natriumhydrpgensulfat oder Natriumdjhydrogenphosphat eingesetzt werden.In detail, the PDE 5 inhibitor in amorphous, crystalline or solvent-containing form is dissolved in an aqueous solvent to prepare the solutions according to the invention. For this purpose, one or more acids are added to this. Suitable acids are, for example, acetic acid, adipic acid, ascorbic acid, aspartic acid, benzenesulfonic acid, benzoic acid, citric acid, ethanesulfonic acid, 2-hydroxyethanesulfonic acid, fumaric acid, glucgheptonic acid, gluconic acid, glucuronic acid, glutamic acid, hydrochloric acid, lactic acid, lactobionic acid, maleic acid, malic acid, malonic acid , Methanesulfonic acid, naphthalenesulfonic acid, naphthalene-disulfonic acid, nitric acid, phosphoric acid, succinic acid, sulfuric acid, tartaric acid, toluenesulfonic acid, mono- or diesters of orthophosphoric acid such as glycerol-phosphate. In the case of polyproteinic acids, it is also possible to use their acidic salts, for example sodium hydrogen sulfate sulfate or sodium dihydrogen phosphate.
Ferner kann cfen erfindungsgemäßen Formulierungen ein Isotonisierungsmittel zugesetzt werden, beispielsweise Natriumchlorid, Glucose, Fruktose, Mannit, Sorbit, Glycerin, Acetat-, Citrat- Phosphat- oder Laktatpuffer oder Aminosäuren.Furthermore, an isotonizing agent may be added to formulations according to the invention, for example sodium chloride, glucose, fructose, mannitol, sorbitol, glycerol, acetate, citrate, phosphate or lactate buffers or amino acids.
Der pH der Zubereitungen kann mit einer der genannten Säuren oder bei bereits zu saurem pH mit einer Base wie Natriumhydroxid, Trometamol, Arginin oder Lysin eingestellt werden. Dabei ist ein pH-Bereich von 3 bis 7 für die erfindungsgemäßen Formulierungen bevorzugt.The pH of the preparations can be adjusted with one of the acids mentioned or at already too acidic pH with a base such as sodium hydroxide, trometamol, arginine or lysine. In this case, a pH range of 3 to 7 is preferred for the formulations according to the invention.
Zu Verbesserung der Löslichkeit ist auch ein Zusatz parenteral applizierbarer organischer Lösungsmittel wie Ethanol, Propylenglykol oder Polyethylenglykol, von Tensiden oder Polymeren wie Polyvinylpyrrolidon, Polysorbat, Poloxamer, Cremophor, Solutol HS 15, von Phospholipiden sowie nativer oder substituierter Cyclodextrine möglich.To improve the solubility, it is also possible to add parenterally administrable organic solvents such as ethanol, propylene glycol or polyethylene glycol, surfactants or polymers such as polyvinylpyrrolidone, polysorbate, poloxamer, Cremophor, Solutol HS 15, phospholipids and native or substituted cyclodextrins.
Die erfindungsgemäßen Formulierungen werden in bekannte Behältnisse zur parenteralen Applikation abgefüllt, beispielsweise in Injektionsfläschchen oder Infusionsflaschen aus Glas mit Stopfen, in Flexibags oder in andere groß- oder kleinvolumige Behältnisse aus Kunststoff, in Fertigspritzen oder Carpulen. Die Abfüllung ist auch im Blow-Fill-Seal- Verfahren in Kunststoffbehältnisse möglich. Zur Herstellung der erfindungs gemäßen Zubereitungen werden beispielsweise Vardenafil oder ein Vardenafil-Salz zusammen mit Säure, Isotonisierungsmitteln und gegebenenfalls weiteren Hilfs- stoffen im Lösungsmittel (meist Wasser) gelöst. Nach Einstellen des pH wird mit Wasser auf die Gesamteinsatzmenge aufgefüllt, durch 0.2 μm-Filtermembranen sterilfiltriert und abgefüllt. Ob- wohl ein gänzlich aseptisches Herstellungsverfahren oder eine Lyophilisation der erfindungsgemäßen Formulierungen möglich sind, wird im Allgemeinen eine Sterilisation der abgefüllten Lösung im Endbehältnis bevorzugt, beispielsweise über 15 Minuten bei 1210C. Bei Verwendung von Packmitteln, die diese Temperatur nicht schadlos überstehen, ist jedoch eine aseptische Herstellung ohne oder mit nachfolgender Wärmebehandlung, eventuell bei niedrigeren Tempe- raturen als 1210C möglich.The formulations according to the invention are filled into known containers for parenteral administration, for example in injection vials or glass infusion bottles with stoppers, in flexibags or in other large or small-volume containers made of plastic, in prefilled syringes or carpules. The filling is also possible in the blow-fill-seal process in plastic containers. Vardenafil or a vardenafil salt, for example, are dissolved in the solvent (usually water) together with acid, isotonizing agents and optionally further auxiliaries to produce the preparations according to the invention. After adjusting the pH is made up with water to the total amount used, sterile filtered through 0.2 micron filter membranes and bottled. Even though a completely aseptic manufacturing process or a lyophilization of the formulations of the invention are possible, in general, a sterilization of the filled solution is preferably in the final container, for example for 15 minutes at 121 0 C. The use of packaging materials that survive this temperature is not harmless, is However, aseptic preparation without or with subsequent heat treatment, possibly at lower temperatures than 121 0 C possible.
Eine besondere Ausführungsform der Erfindung stellen Konzentrate dar. Um den aufwändigen Transport und Lagerung großvolumiger Behältnisse zu vermeiden, wird zunächst eine konzentrierte Lösung von Vardenafil hergestellt und in den Verkehr gebracht. Die Herstellung der erfindungs gemäßen Infusionslösung erfolgt dann durch den Anwender, beispielsweise durch Zugabe der Konzentratlösung zu einer Standardinfusion oder durch kontinuierliche Verdünnung des Konzentrates über ein Y-Stück.Concentrates represent a particular embodiment of the invention. In order to avoid the time-consuming transport and storage of large-volume containers, a concentrated solution of vardenafil is first prepared and marketed. The preparation of the inventive infusion solution is then carried out by the user, for example by adding the concentrate solution to a standard infusion or by continuous dilution of the concentrate via a Y-piece.
Die erfindungsgemäßen Infusionslösungen können in Abhängigkeit von der Wirkstoffdosis, der Wirkstoffkonzentration und dem Anwendungsgebiet in unterschiedlicher Weise intravenös appliziert werden. Möglich sind die Gabe als Bolusinjektion, die Applikation in Form einer Schwer- kraft-Tropfinfusion oder das Pumpen durch eine Infusionsschlauchpumpe oder Infusionsspritzenpumpe. Im Allgemeinen werden die Infusionen in periphere Venen appliziert, bei Patienten in intensivmedizinischer Versorgung ist aber auch eine zentralvenöse oder in besonderen Fällen auch eine arterielle Gabe möglich.The infusion solutions according to the invention can be administered intravenously in different ways, depending on the drug dose, the drug concentration and the field of application. The administration as bolus injection, the application in the form of a gravity drip infusion or pumping through an infusion tube pump or infusion syringe pump are possible. In general, the infusions are administered to peripheral veins, but in patients undergoing intensive care, central venous or, in special cases, arterial administration is also possible.
Die im Folgenden aufgeführten Vergleichsbeispiele 1 — 2 stellen nicht erfindungsgemäße Zube- reitungen dar, welche zur Verdeutlichung des Fortschrittes aufgeführt werden, die durch die erfindungsgemäßen Formulierungen erzielt wurden. Beispiel 1 (Vergleich):The comparative examples 1 to 2 below do not represent preparations according to the invention, which are listed to illustrate the progress achieved by the formulations according to the invention. Example 1 (comparison):
Nicht erfindungsgemäße Zubereitung, Wirkstoffkonzentration 0.005 mg/mlNon-inventive preparation, drug concentration 0.005 mg / ml
Vardenafil dihydrat 0.005 gVardenafil dihydrate 0.005 g
Natriumchlorid 9.00 gSodium chloride 9.00 g
Wasser für Injektionszwecke 991 gWater for injections 991 g
Die Lösung enthält in erheblichem Maße ungelöste Wirkstoffanteile und ist zur intravenösen Infusion nicht geeignet.The solution contains to a considerable extent undissolved active substance components and is not suitable for intravenous infusion.
Beispiel 2 (Vergleich):Example 2 (comparison):
Nicht erfϊndungsgemäße Zubereitung mit 70 % Polyethylenglykol 400Non-inventive preparation with 70% polyethylene glycol 400
Vardenafil dihydrat 0.50 gVardenafil dihydrate 0.50 g
Polyethylenglykol 400 700 gPolyethylene glycol 400 700 g
Wasser für Injfektionszwecke 299,5 gInjection water 299.5 g
Die Lösung ist instabil. Bereits bei Herstellen der Lösung bildet sich 6,5 % Vardenafil N-oxid. Dessen Gehalt nimmt nach Hitzesterilisation der Lösung auf 11 % zu.The solution is unstable. When the solution is prepared, 6.5% of vardenafil N-oxide forms. Its content increases to 11% after heat sterilization of the solution.
Beispiel 3:Example 3:
Stabilität und biologischer Nachweis der guten Verträglichkeit und außerordentlichen Bioverfügbarkeit erfindungsgemäßer FormulierungenStability and biological proof of good compatibility and extraordinary bioavailability of formulations according to the invention
Vardenafil hydrochlorid trihy drat 0.119 gVardenafil hydrochloride trihyate 0.119 g
Natriumchlorid 9.00 gSodium chloride 9.00 g
Milchsäurelösung 20 % 5.00 gLactic Acid Solution 20% 5.00 g
2-M-Natriumhydroxidlösung ad pH 4.0 0 bis 10 g2 M sodium hydroxide solution ad pH 4.0 0 to 10 g
Wasser für Injektionszwecke bis Gesamteinsatzmenge 1 005.1 gWater for injections up to total use 1 005.1 g
20 ml dieser Lösung (entsprechend 2 mg freier Base von Vardenafil) wurde jeweils 12 Probanden im Cross-over- Versuch im Vergleich zu einer Tablette mit 11.85 mg Vardenafil HCl trihy drat (entsprechend 10 mg Vardenafil freier Base) verabreicht. Hierzu wurde die Lösung über etwa 1 Stunde kontinuierlich infundiert. Die Verträglichkeit der Infusion war gut. Alle beobachteten Nebenwirkungen waren generell mild bis moderat und nach Studienablauf reversibel. Nur bei einem Probanden wurde eine milde Reaktion an der Injektionsstelle beobachtet. Die aus den Plasmakonzentrationen bestimmte Bioverfügbarkeit AUC war für die erfindungsgemäße Infusionsformulierung 35.4 μg*h/l (geometrisches Mittel) und für die Tablette 25.7 μg*h/l (geometrisches Mittel). Unter Berücksichtigung der verabreichten Dosen ergibt dies für die Infusionslösung eine Bioverfügbarkeit von 689 % der Tablette.20 ml of this solution (equivalent to 2 mg of vardenafil free base) was compared to 12 subjects in a cross-over study compared to a tablet containing 11.85 mg Vardenafil HCl trihydrate (equivalent to 10 mg vardenafil free base). For this purpose, the solution was continuously infused over about 1 hour. The tolerability of the infusion was good. All adverse reactions observed were generally mild to moderate and reversible after study. Only one subject had a mild reaction at the injection site. The bioavailability AUC determined from the plasma concentrations was 35.4 μg * h / l (geometric mean) for the infusion formulation according to the invention and 25.7 μg * h / l for the tablet (geometric mean). Taking the administered doses into account, this results in a bioavailability of 689% of the tablet for the infusion solution.
Ferner wurde die Stabilität dieser Lösung über 13 "Wochen bei 6°C, 25°C und 4O0C überprüft. Der Gehalt an Vardenafil lag anfänglich bei 0.100 mg/ml und am Ende der Lagerung unter allen Bedingungen bei 0.099 mg/ml. Die Summe aller Abbauprodukte war anfänglich nicht nachweisbar (< 0.02 %); nach 13 Wochen bei 60C ebenfalls nicht nachweisbar (< 0.02 %), nach 13 Wochen bei 250C < 0.1 % und nach 13 Wochen bei 4O0C 0.1 %. Die Werte zeigen die hervorragende Stabilität der erfindungsgemäßen Formulierungen.Further, the stability of this solution over 13 "weeks at 6 ° C, 25 ° C and 4O 0 C was examined. The content of Vardenafil was initially at 0.100 mg / ml and at the end of storage under all conditions at 0.099 mg / ml. The sum of all degradation products was initially undetectable (<0.02%), also undetectable after 13 weeks at 6 0 C (<0.02%), after 13 weeks at 25 0 C <0.1% and after 13 weeks at 4O 0 C 0.1%. The values show the excellent stability of the formulations according to the invention.
Beispiel 4Example 4
0,268 kg Väϊdenafil Dihydrat, 61,5 g Methansulfonsäure und 25.9 kg Mannitol werden in 174.7 kg Wasser für Injektionszwecke unter aseptischen Bedingungen gelöst. Die Lösung wird sterilfiltriert und zu jeweils 1.6 g in Injektionsfläschchen abgefüllt. Die Lösung wird in den Injektions- fläschchen lyophilisiert, verstopft und zugebördelt. In dieser Form wird das Präparat in Verkehr gebracht. Der Anwender rekonstituiert dann das Lyophilisat und überführt es in 100 ml 5 %ige Glucoselösung, die dann bei Anwendung folgende Zusammensetzung hat:0.268 kg of vasϊdenafil dihydrate, 61.5 g of methanesulfonic acid and 25.9 kg of mannitol are dissolved in 174.7 kg of water for injection under aseptic conditions. The solution is sterile filtered and filled in injection vials of 1.6 g each. The solution is lyophilized, clogged and beaded in the injection vial. In this form the drug is placed on the market. The user then reconstitutes the lyophilizate and converts it to 100 ml of 5% glucose solution which, when used, has the following composition:
Vardenafil Dihydrat (entspr. 2.00 mg Vardenafil) 2.15 mgVardenafil dihydrate (equivalent to 2.00 mg vardenafil) 2.15 mg
Methansulfonsäure 0.492 mgMethanesulfonic acid 0.492 mg
Mannitol 200 mgMannitol 200 mg
Glucose . 5.00 gGlucose. 5.00 g
Wasser für Injektionszwecke 96.6 gWater for injections 96.6 g
Beispiel 5Example 5
Es werden 107.4 mg Vardenafil Dihydrat, 27.7 mg Weinsäure und 9 g Natriumchlorid in einem Liter Wasser für Iηjektionszwecke gelöst. Die Lösung wird sterilfiltriert, zu 2 ml in Fertigspritzen abgefüllt und sterilisiert. Jede Fertigspritze enthält 0.2 mg Vardenafil. Beispiel 6107.4 mg of vardenafil dihydrate, 27.7 mg of tartaric acid and 9 g of sodium chloride are dissolved in one liter of water for injection purposes. The solution is sterile filtered, filled to 2 ml in pre-filled syringes and sterilized. Each pre-filled syringe contains 0.2 mg vardenafil. Example 6
Es werden 859 mg Vardenafil Dihydrat und 452 mg Citronensäure in 900 ml Wasser für Injektionszwecke aufgelöst. Danach wird mit Wasser für Injektionszwecke auf 1 Liter aufgefüllt. Die Lösung wird über 0.2 μm Filter sterilfiltriert, in Vials zu 5.0 ml abgefüllt und bei 1210C über 15 Minuten hitzesterilisiert. Die Lösung wird vor Anwendung zu 500 ml 5 % Glucoselösung gegeben und langsam infundiert.859 mg of vardenafil dihydrate and 452 mg of citric acid are dissolved in 900 ml of water for injections. Then it is made up to 1 liter with water for injections. The solution is sterilized by filtration through 0.2 μm filters, filled to 5.0 ml in vials and heat sterilized at 121 ° C. for 15 minutes. The solution is added to 500 ml of 5% glucose solution before administration and slowly infused.
Beispiel 7Example 7
5.72 mg Vardenafil dimesilat monohydrat wird in 1000 ml physiologische Kochsalzlösung gefüllt. Die Lösung wird sterilfiltriert und unter aseptischen Bedingungen zu 250 ml in Infusionsflaschen gefüllt. Jede Infusionsflasche enthält 1 mg Vardenafil.5.72 mg vardenafil dimesilate monohydrate is filled in 1000 ml physiological saline. The solution is sterile filtered and filled under aseptic conditions to 250 ml in infusion bottles. Each infusion bottle contains 1 mg vardenafil.
Beispiel 8Example 8
10 g Sildenafil, 500 g 0.1 M Salzsäure und 5 kg Glucose werden in 96,1 kg Wasser für Injektionszwecke gelöst, sterilfiltriert und unter aseptischen Bedingungen zu 100 ml in Infusionsflaschen gefüllt.10 g of sildenafil, 500 g of 0.1 M hydrochloric acid and 5 kg of glucose are dissolved in 96.1 kg of water for injection, sterile filtered and filled under aseptic conditions to 100 ml in infusion bottles.
Beispiel 9Example 9
0,005 kg Tadalafil wird in 30 kg Polyethylenglykol 400 und 30 kg Ethanol 96 % aufgelöst. Es wird mit Wasser für Injektionszwecke auf 200 Liter aufgefüllt. Die Lösung wird sterilfiltriert und aseptisch in Infusionsflaschen zu 100 ml abgefüllt. 0.005 kg of tadalafil is dissolved in 30 kg of polyethylene glycol 400 and 30 kg of ethanol 96%. It is made up to 200 liters with water for injections. The solution is sterile filtered and aseptically filled into infusion bottles to 100 ml.

Claims

Patentansprüche claims
1. Intravenöse Zubereitungsformen, enthaltend mindestens einen PDE 5-Inhibitor oder ein Salz davon.1. Intravenous preparation forms containing at least one PDE 5 inhibitor or a salt thereof.
2. Intravenöse Zubereitungsformen gemäß Anspruch 1, enthaltend als PDE 5-Inhibitor Vardenafil, Tadalafil und/oder Sildenafil und/oder deren Salze.2. Intravenous preparation forms according to claim 1, containing as PDE 5 inhibitor vardenafil, tadalafil and / or sildenafil and / or salts thereof.
3. Intravenöse Zubereitungsformen gemäß Anspruch 1, enthaltend als PDE 5-Inhibitor Vardenafil und/oder ein Salz von Vardenafil.3. Intravenous preparation forms according to claim 1, containing as PDE 5 inhibitor vardenafil and / or a salt of vardenafil.
4. Verwendung von intravenösen Zubereitungsformen enthaltend mindestens einen PDE 5- Inhibitor zur Behandlung von portaler Hypertension, Schlaganfall, Schädel-Hirn Trauma, vorzeitigen Wehen, akutem Nierenversagen, akutem Glaukomanfall, Pankreatitis, Gehörsturz, Tinnitus, Achalasie und spastischer Ösophagus Erkrankung.4. Use of intravenous formulations containing at least one PDE 5 inhibitor for the treatment of portal hypertension, stroke, traumatic brain injury, preterm labor, acute renal failure, acute glaucoma, pancreatitis, hearing loss, tinnitus, achalasia and spastic esophageal disease.
5. Verwendung von intravenösen Zubereitungsformen enthaltend Vardenafil, Sildenafil oder Tadalafil zur Behandlung von portaler Hypertension, Schlaganfall, Schäde4-Hirn Trauma, vorzeitigen Wehen, akutem Nierenversagen, akutem Glaukomanfall, Pankreatitis, Gehör- Achalasie und spastischer Ösophagus Erkrankung.5. Use of Intravenous Formulations Containing Vardenafil, Sildenafil or Tadalafil for the Treatment of Portal Hypertension, Stroke, 4-Brain Trauma, Premature Labor, Acute Renal Failure, Acute Glaucoma, Pancreatitis, Hearing Achalasia and spastic esophageal disease.
6. Intravenöse Zubereitungsformen gemäß einem der Ansprüche 1 bis 3, enthaltend Vardenafil in einer Konzentration von 0,005 bis 0,1 Gew.%6. Intravenous preparation forms according to any one of claims 1 to 3, containing vardenafil in a concentration of 0.005 to 0.1 wt.%
7. Intravenöse Zubereitungsformen gemäß einem der Ansprüche 1 bis 4, enthaltend Vardenafil und Säure im molaren Verhältnis von 1 zu 0.9 bis 2.0.7. Intravenous preparation forms according to one of claims 1 to 4, containing vardenafil and acid in a molar ratio of 1 to 0.9 to 2.0.
8. Verwendung von intravenösen Zubereitungsformen enthaltend mindestens einen PDE 5- Inhibitor zur differenzierten Behandlung und selektiven Adressierung der verschiedenen von cGMP regulierten Vorgänge. 8. Use of intravenous preparation forms comprising at least one PDE 5 inhibitor for the differentiated treatment and selective addressing of the various cGMP-regulated processes.
EP06706165A 2005-01-15 2006-01-05 Intravenous formulations of pde-5 inhibitors Withdrawn EP1843772A1 (en)

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