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EP1735020A1 - Alginates reticules et non reticules, injectables, et leur utilisation en medecine et en chirurgie esthetique - Google Patents

Alginates reticules et non reticules, injectables, et leur utilisation en medecine et en chirurgie esthetique

Info

Publication number
EP1735020A1
EP1735020A1 EP05707688A EP05707688A EP1735020A1 EP 1735020 A1 EP1735020 A1 EP 1735020A1 EP 05707688 A EP05707688 A EP 05707688A EP 05707688 A EP05707688 A EP 05707688A EP 1735020 A1 EP1735020 A1 EP 1735020A1
Authority
EP
European Patent Office
Prior art keywords
alginate
use according
crosslinked
solution
microcapsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05707688A
Other languages
German (de)
English (en)
Inventor
Roland Reiner
Peter Geigle
Herma GLÖCKNER
Frank THÜRMER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellmed AG
Original Assignee
Cellmed AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellmed AG filed Critical Cellmed AG
Publication of EP1735020A1 publication Critical patent/EP1735020A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Definitions

  • the chemical denervation eg by Botulmumtoxm A
  • the surface leveling and on the third the treatment with "fillers” - the dermis is relined with endogenous or foreign substances.
  • the present invention describes the novel use of alginates for the application as "F ⁇ ller M substance.
  • foreign fillers which mainly consist of biological substances such as collagen or hyaluronic acid (eg: collagen: Zyderm ® , Zyplast ® , Atelocollagen ® , Resoplast ® ® .
  • Hyaluronic acid is a mucopolysaccharide that is found in almost every part of a living organism and especially in the skin. Chemically, hyaluronic acid is made from straight polymer chains. ten with a molecular weight in the range of several hundred thousand to million daltons, which contain repeating disaccharide units from N-acetylglucosamine and glucuronic acid, which are linked together by glycosidic bonds.
  • GSD gastroesophageal reflux disease
  • Gastroosophageal reflux disease describes the backflow of acidic, enzymatic fluid from the stomach to the esophagus. It causes heartburn , Regurgitation and vomiting of gastric acid in the mouth or even in the lungs.
  • the consequences of "GERD” are burns of the esophagus and the formation of ulcers, whereby the normal epithelial tissue is replaced by pathological tissue.
  • the lower oesophageal sphincter muscle closes after eating. This does not happen in patients suffering from “GERD”, instead the muscle relaxes and the gastric acid can flow through the esophagus if the stomach contracts. This is the main cause of "GERD”, other causes are possible.
  • the material should be injectable through a narrow cannula without the geometric shapes, e.g. Microcapsules are destroyed. 2. The material must be so variable for the different applications that short to long-term stability can be achieved in vivo. 3. The material should remain at the injection site and not migrate. 4. The material should be soluble in an emergency or after the end of the indication. 5. The material must be biocompatible.
  • the alkali salts of the alginates are water-soluble, while the salts of the alginates with most divalent or polyvalent cations form insoluble gels (so-called hydrogels) in aqueous solution.
  • the large physical range of variation of the alginates is given by a number of factors: viscosity (or molecular weight distribution), concentration, ratio of the monomers and the affinity of the cation used for the crosslinking. For example, it is known that alginates cross-linked with calcium form less stable hydrogels than alginates cross-linked with barium.
  • substances can also be added to the algmat or covalently bound to the alginate which create a histological connection after the injection between the algmat capsules or the algae gel and the surrounding tissue.
  • adhesion proteins eg RGD tripeptides.
  • the microcapsules for the treatment of urinary incontinence and the vesico-ureteral reflux disease are injected into the ureteral sphincter, the bladder sphincter or the urethral muscles.
  • the sphincter volume increases in proportion to the volume of the microcapsules injected. This reduces the inner lumen of the sphincter muscle and allows a better contraction of the muscle, which reduces the likelihood of urinary incontinence.
  • other forms of use described above can also be used, e.g. B. Injection of calcium crosslinked microcapsules from alginate or injection of uncrosslinked algae gel with and without methods for in situ crosslinking.
  • the implantation should preferably be carried out using standard techniques which correspond to the state of the art, e.g. endoscopic or laparoscopic techniques.

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

La présente invention concerne l'utilisation de microcapsules implantables, ou de microparticules ou de gels produits à partir d'alginates réticulés avec deux cations ou plus, ou d'alginates non réticulés, pour traiter des défauts cutanés, par ex. des rides, pour traiter des troubles de reflux gastro-oesophagien, l'incontinence urinaire et des troubles de reflux vésico-uretéral.
EP05707688A 2004-04-16 2005-03-02 Alginates reticules et non reticules, injectables, et leur utilisation en medecine et en chirurgie esthetique Withdrawn EP1735020A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004019241A DE102004019241A1 (de) 2004-04-16 2004-04-16 Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie
PCT/EP2005/002201 WO2005105167A1 (fr) 2004-04-16 2005-03-02 Alginates reticules et non reticules, injectables, et leur utilisation en medecine et en chirurgie esthetique

Publications (1)

Publication Number Publication Date
EP1735020A1 true EP1735020A1 (fr) 2006-12-27

Family

ID=34961026

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05707688A Withdrawn EP1735020A1 (fr) 2004-04-16 2005-03-02 Alginates reticules et non reticules, injectables, et leur utilisation en medecine et en chirurgie esthetique

Country Status (5)

Country Link
US (2) US8163714B2 (fr)
EP (1) EP1735020A1 (fr)
BR (1) BRPI0509924A (fr)
DE (1) DE102004019241A1 (fr)
WO (1) WO2005105167A1 (fr)

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DE102004019241A1 (de) 2005-11-03
US20070189114A1 (en) 2007-08-16
BRPI0509924A (pt) 2007-09-18
US20070179117A1 (en) 2007-08-02
US8163714B2 (en) 2012-04-24

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