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EP1683579A1 - Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren - Google Patents

Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren Download PDF

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Publication number
EP1683579A1
EP1683579A1 EP05405038A EP05405038A EP1683579A1 EP 1683579 A1 EP1683579 A1 EP 1683579A1 EP 05405038 A EP05405038 A EP 05405038A EP 05405038 A EP05405038 A EP 05405038A EP 1683579 A1 EP1683579 A1 EP 1683579A1
Authority
EP
European Patent Office
Prior art keywords
enclosure
tubular
chamber
axial
fixed axial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05405038A
Other languages
English (en)
French (fr)
Inventor
Jean-Denis Rochat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP05405038A priority Critical patent/EP1683579A1/de
Priority to EP06700529A priority patent/EP1871530B1/de
Priority to AT06700529T priority patent/ATE480333T1/de
Priority to DE602006016762T priority patent/DE602006016762D1/de
Priority to CA002592275A priority patent/CA2592275A1/fr
Priority to AU2006208525A priority patent/AU2006208525A1/en
Priority to JP2007551529A priority patent/JP2008528066A/ja
Priority to US11/814,587 priority patent/US8070664B2/en
Priority to PCT/CH2006/000049 priority patent/WO2006079238A1/fr
Publication of EP1683579A1 publication Critical patent/EP1683579A1/de
Priority to US13/287,551 priority patent/US8348823B2/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B04B11/082—Skimmers for discharging liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/10—Centrifuges combined with other apparatus, e.g. electrostatic separators; Sets or systems of several centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B9/00—Drives specially designed for centrifuges; Arrangement or disposition of transmission gearing; Suspending or balancing rotary bowls
    • B04B9/12—Suspending rotary bowls ; Bearings; Packings for bearings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0478—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with filters in the separation chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B2007/005—Retaining arms for gripping the stationary part of a centrifuge bowl or hold the bowl itself

Definitions

  • the present invention relates to a disposable device for the continuous separation by centrifugation of a physiological liquid, in particular blood, comprising a fixed axial input and output element around the axis of which a plastic centrifuge chamber. is rotatably mounted, an inlet channel for the centrifugal blood passing longitudinally through said axial inlet and outlet element and the dispensing opening of which is located near the bottom of said centrifuge chamber, an outlet passage for at least one separate component, the inlet opening of which is close to the end of said enclosure opposite said bottom and in a zone of concentration of at least one of the separated constituents having the lowest specific mass for the continuously withdrawing, this passage passing through a longitudinal portion of said fixed axial input and output element, a rotary joint between said element fixed axial and said centrifuge chamber.
  • the known cups or separation bowls of this type are intended for semi-continuous separation, which consists in progressively evacuating the plasma separated from the red blood cells and storing the red blood cells.
  • the reason why the red blood cells are not removed from the separation chamber as they separate, as the plasma is due to the fact that the tangential force applied to them is relatively high and the deceleration that it would suffer during the abrupt passage in a fixed evacuation conduit would cause a high rate of hemolysis.
  • the flexible tube rotating on itself at the speed - ⁇ is subjected to a tensile stress generated by the centrifugal force, to a bending stress due to the rotation on itself of the portion of the tube forming the open loop at the speed - ⁇ , and a heating generated by the work of the viscous forces in the material due to the aforementioned bending.
  • the temperature should not be> 40 ° C.
  • the rotational speed of the centrifuge bowl is limited, so that the diameter of this bowl can not be too small or it could affect the quality of the separation.
  • the drive mechanism of the bowl and the flexible tube is relatively complex and expensive.
  • the object of the present invention is to overcome, at least in part, the aforementioned drawbacks.
  • the present invention relates to a disposable device for the continuous separation by centrifugation of a physiological liquid, in particular blood according to claim 1.
  • the tubular centrifugal receptacle has a cylindrical tightening at its upper end to engage with guide rollers and in which a rotating seal is housed between the fixed axial element and the receptacle to ensure the sterility of the liquid. centrifugation course.
  • the small diameter of the cylindrical tightening makes it possible to reduce the tolerance of this diameter by reducing the amount of shrinkage of the plastic, the importance of which is proportional to the size of the piece.
  • the fact that the rotary joint also works on a part of small diameter reduces the heating.
  • the precision of the guidance of the centrifugation device makes it possible to use the seal only for sealing and not to compensate for the decentering defects of the rotating centrifuge chamber relative to the fixed axial input element. and output. Therefore, the preload to which the seal must be subjected can be reduced to a minimum, that is to say that it is only a function of the only conditions necessary for sealing and therefore no longer constitutes an hybrid, which also reduces heating.
  • Figure 1 is a front elevational view of a centrifugal separator for using the device object of the present invention
  • Figure 2 is a partial perspective view of Figure 1;
  • Figure 3 is a top view of Figure 2;
  • Figure 4 is a partial view in axial section on a larger scale of the first embodiment of the disposable centrifuge device
  • Figure 5 is a view similar to Figure 4 of a second embodiment of this device.
  • the housing of the centrifugal separator intended to use the device according to the present invention and illustrated schematically in FIG. 1 comprises two elongate centrifugation enclosures 1, 2 of tubular form.
  • the first centrifugal tubular chamber 1 comprises a supply duct 3 which is connected to a fixed axial input and output element 4 of the centrifuge chamber 1.
  • This supply duct 3 is connected to a pumping device 5 which comprises two pumps 6 and 7 phase-shifted by 180 ° relative to each other to ensure a continuous flow of a physiological fluid, especially blood.
  • An air detector 10 is arranged along the supply duct 3.
  • outlet ducts 8, 9 are connected to the fixed axial element 4, to allow the continuous output of two components of different densities of the physiological fluid.
  • the outlet duct 8 is intended for the outlet of the RBC concentrated red blood cells and the duct 9 for the outlet of the platelet rich PRP plasma.
  • This outlet duct 9 comprises a valve 11 and divides into two branches 9a, 9b.
  • the branch 9a is used to recover the platelet concentrate and is controlled by a valve 12.
  • the valves 11 and 12 operate in exclusive OR logic either to pass the PRP from the chamber 1 to the chamber 2, or to empty the platelet concentrate from enclosure 2 to exit 9a.
  • FIG. 2 represents the driving and guiding mode of the centrifugal tubular enclosure 1.
  • the set of driving and guiding elements of the centrifugal tubular enclosure is located on the same support 18 connected to the housing of the centrifuge chamber. centrifugal separator by an anti-vibration suspension 19 of silentbloc type.
  • the support 18 has a vertical wall whose lower end terminates in a horizontal support arm 18a to which is attached a drive motor 20.
  • the drive shaft 20a of this motor 20 has a polygonal shape, such as a Torx® profile, complementary to an axial recess formed in a small tubular element 1a which projects under the bottom of the centrifugal tubular enclosure 1.
  • the coupling between the motor drive shaft 20 and the element tubular 1a must be made with very high precision, to ensure extremely precise guidance of this end of the tubular centrifuge chamber 1.
  • the upper end of the tubular centrifuge chamber 1 comprises a cylindrical axial guide member 1b of diameter substantially smaller than that of the tubular centrifuge chamber 1, which protrudes on its upper face.
  • the cylindrical face of this element 1b is intended to engage with three centering rollers 21 that can be seen in particular in FIG. 3.
  • One of these rollers 21 is integral with an arm 22, one end of which is pivotally mounted on an upper horizontal portion 18b of the support 18. This arm 22 is subjected to the force of a spring (not shown) or any other suitable means for communicating a torque tending to rotate in the direction of the watch, with reference to FIG.
  • a device for locking the angular position of the arm 22 corresponding to that in which its roller 21 bears against the cylindrical surface of the cylindrical axial guide member 1b is provided, to avoid having a too strong preload of the spring associated with the arm 22.
  • the span between the cylindrical axial guide element 1b and the upper end of the tubular enclosure 1 serves, in cooperation with the centering rollers 21, axial abutment, preventing disengagement between the drive shaft of the motor 20 and the axial recess of the tubular element 1a protruding under the bottom of the tubular enclosure 1.
  • An elastic element for centering and fixing 23 of the fixed axial input and output element 4 of the tubular centrifugation enclosure is integral with the upper horizontal portion 18b of the support 18.
  • This element 23 comprises two symmetrical elastic branches, of semicircular shapes and which each end with an outwardly curved portion, intended to transmit to these elastic branches forces to separate them from one another, during the lateral introduction of the fixed axial element 4 input and output between them.
  • the centrifugal tubular enclosures will have a diameter of between 10 and 40 mm, preferably 22 mm, and will be driven at a speed of rotation of between 5,000 and 100,000 rpm, so that the tangential speed at which the liquid is submitted does not exceed 26 m / s.
  • the axial length of the tubular centrifugation chamber is advantageously between 40 and 200 mm, preferably 80 mm. Such parameters make it possible to ensure a liquid flow rate of between 20 and 400 ml / min (especially for dialysis), preferably 60 ml / min, corresponding to a residence time of the liquid of 5 to 60 seconds, preferably 15 to 60 seconds. s in the tubular enclosure.
  • the tubular enclosure 1 is made from two parts which terminate in respective annular flanges 1c, 1d welded to each other.
  • the internal space of the enclosure is delimited by the substantially cylindrical wall of this enclosure.
  • the axial fixed input and output element 4 enters this tubular enclosure 1 through an axial opening formed through the cylindrical axial guide element 1b.
  • the diameter on which the tubular seal 25 rubs is small and is preferably ⁇ 10 mm, so that the heating is limited to acceptable values. It can be seen from the aforementioned possible dimensions given for the centrifugal tubular enclosure, that the axial distance between the upper and lower centering and guiding means of this enclosure is greater than five times the diameter of the cylindrical element. axial guide 1b. Given the accuracy with which the tubular enclosure 1 is guided and the accuracy that can reach the relative positioning of the fixed axial input and output element 4, the seal has practically no need to compensate for a lack of concentricity. of the tubular enclosure 1 in rotation, as is the case of the aforementioned devices of the state of the art working in semi-continuous flow. This also contributes to reducing the heating of the rotating tubular joint 25 and thus makes it possible to increase the speed of rotation of the centrifugal tubular enclosure.
  • the axial input and output fixed element 4 comprises a tubular portion 3a which extends the supply duct 3 connected to this axial fixed element 4 to close proximity from the bottom of the tubular centrifuge chamber 1 to bring blood or other physiological fluid to separate.
  • the outlet ducts 8 and 9 connected to the fixed axial inlet and outlet element 4 each comprise an axial segment 8a, respectively 9a which penetrates into the tubular enclosure and opens into the part of the fixed axial element 4d. inlet and outlet which is in the vicinity of the upper end of the tubular centrifuge chamber 1.
  • the inlet end of each of these outlet ducts 8a, 9a is formed by a circular slot. Each of these slots is formed between two disks 28, 29, respectively 30, 31, integral with the fixed axial element 4 input and output.
  • the radial distance between the edges of the discs 28, 29 and the side wall of the chamber 1 is less than the radial distance between the edges of the discs 30, 31 and the same side wall.
  • the diameter of the portion of the tubular centrifuge chamber 1 located in the exit zone of the PRP and the RBC where the discs 28 to 31 are located is slightly larger than that of the remainder of this tubular enclosure. 1, so as to increase the respective thicknesses of the PRP and RBC layers to facilitate their separate exits.
  • a dead space is formed between adjacent disks 29 and 30. Its role is to trap leukocytes, whose density is between that of RBCs and platelets, but which is much larger than RBCs and platelets.
  • the disc 30 has a filter 30a to allow the leukocytes to be separated from the plasma and to trap in the dead space between the discs 29 and 30 only the leucocytes.
  • the second embodiment of the tubular centrifuge chamber illustrated in FIG. 5 differs from that of FIG. 4 essentially in the presence of a dam 32.
  • the latter has an annular shape, comprising a cylindrical portion 32a located in front of the circular inlet opening of the PRP formed between the discs 30 and 31.
  • the diameter of this cylindrical part 32a is chosen to be situated in the space separating the edges of the discs 28, 29 of the side wall of the disc. enclosure 1 substantially corresponding to the diameter of the interface between the layers formed by the RBC and the PRP.
  • the two ends of this cylindrical portion 32a end with flat rings, 32b, 32c.
  • the plane ring 32b extends outside the cylindrical portion 32a, while the flat ring 32c extends within this cylindrical portion 32a.
  • the outer plane ring 32b is housed in a clearance of the annular flange 1d and is clamped between the two annular flanges 1c and 1d. This outer plane ring 32b is still traversed by a plurality of openings 32d to allow the passage of the RBCs.
  • This dam 32 has three roles to play. One is to create a physical barrier between the circular inlet opening of the PRP located between the discs 30 and 31 and the RBCs, so as to prevent the swirls generated by the suction at the opening of the opening. admission is likely to re-mix RBCs and PRP. A second role is to collect RBCs on the same diameter as the plasma, which reduces hemolysis because the edges of the disks 30, 31 forming the exit aperture of the RBC dipping less deeply in the RBC layer, since all the discs 28 to 31 are of the same diameter. Finally, the third role is to at least partially retain the leucocytes inside the cylindrical portion 32a of the dam 32.
  • this tubular centrifuge chamber 1 is substantially similar to the first embodiment which has just been described.
  • a leucocyte filter similar to the filter 29a of Figure 4 may also be provided to trap leukocytes between the disks 29 and 30.

Landscapes

  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
EP05405038A 2005-01-25 2005-01-25 Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren Withdrawn EP1683579A1 (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP05405038A EP1683579A1 (de) 2005-01-25 2005-01-25 Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren
AU2006208525A AU2006208525A1 (en) 2005-01-25 2006-01-23 Disposable device for the continuous centrifugal separation of a physiological fluid
AT06700529T ATE480333T1 (de) 2005-01-25 2006-01-23 Wegwerfvorrichtung für die kontinuierliche trennung einer physiologischen flüssigkeit durch zentrifugation
DE602006016762T DE602006016762D1 (de) 2005-01-25 2006-01-23 Wegwerfvorrichtung für die kontinuierliche trennung einer physiologischen flüssigkeit durch zentrifugation
CA002592275A CA2592275A1 (fr) 2005-01-25 2006-01-23 Dispositif jetable pour la separation en continu par centrifugation d'un liquide physiologique
EP06700529A EP1871530B1 (de) 2005-01-25 2006-01-23 Wegwerfvorrichtung für die kontinuierliche trennung einer physiologischen flüssigkeit durch zentrifugation
JP2007551529A JP2008528066A (ja) 2005-01-25 2006-01-23 生理学的液体の遠心分離による連続的分離のための使い捨て装置
US11/814,587 US8070664B2 (en) 2005-01-25 2006-01-23 Disposable device for the continuous centrifugal separation of a physiological fluid
PCT/CH2006/000049 WO2006079238A1 (fr) 2005-01-25 2006-01-23 Dispositif jetable pour la separation en continu par centrifugation d'un liquide physiologique
US13/287,551 US8348823B2 (en) 2005-01-25 2011-11-02 Disposable device for the continuous centrifugal separation of a physiological fluid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05405038A EP1683579A1 (de) 2005-01-25 2005-01-25 Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren

Publications (1)

Publication Number Publication Date
EP1683579A1 true EP1683579A1 (de) 2006-07-26

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Family Applications (2)

Application Number Title Priority Date Filing Date
EP05405038A Withdrawn EP1683579A1 (de) 2005-01-25 2005-01-25 Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren
EP06700529A Ceased EP1871530B1 (de) 2005-01-25 2006-01-23 Wegwerfvorrichtung für die kontinuierliche trennung einer physiologischen flüssigkeit durch zentrifugation

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP06700529A Ceased EP1871530B1 (de) 2005-01-25 2006-01-23 Wegwerfvorrichtung für die kontinuierliche trennung einer physiologischen flüssigkeit durch zentrifugation

Country Status (8)

Country Link
US (2) US8070664B2 (de)
EP (2) EP1683579A1 (de)
JP (1) JP2008528066A (de)
AT (1) ATE480333T1 (de)
AU (1) AU2006208525A1 (de)
CA (1) CA2592275A1 (de)
DE (1) DE602006016762D1 (de)
WO (1) WO2006079238A1 (de)

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US20210205734A1 (en) * 2019-06-06 2021-07-08 Pneumatic Scale Corporation Centrifuge System for Separating Cells in Suspension
US20240131529A1 (en) * 2011-11-21 2024-04-25 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US20240149280A1 (en) * 2011-11-21 2024-05-09 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension

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EP1683579A1 (de) * 2005-01-25 2006-07-26 Jean-Denis Rochat Einweggerät zur kontinuierlichen Trennung einer physiologischen Flüssigkeit mittels Zentrifugieren
EP1911520A1 (de) * 2006-10-10 2008-04-16 Jean-Denis Rochat Wegwerfset zur Bluttrennung oder zum Waschen von Blutkomponenten
US10040077B1 (en) 2015-05-19 2018-08-07 Pneumatic Scale Corporation Centrifuge system including a control circuit that controls positive back pressure within the centrifuge core
US9222067B2 (en) * 2008-04-22 2015-12-29 Pneumatic Scale Corporation Single use centrifuge system for highly concentrated and/or turbid feeds
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
EP2608816B1 (de) 2010-08-25 2023-07-05 Hemanext Inc. Verfahren zur erhöhung der qualität von erythrozyten und zur verlängerung ihrer lebensdauer während der lagerung
EP3539381B1 (de) 2010-11-05 2023-05-24 Hemanext Inc. Bestrahlung von roten blutkörperchen und anaerobe lagerung
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
US9308314B2 (en) 2011-04-08 2016-04-12 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
AU2012294269B2 (en) * 2011-08-10 2016-11-24 Hemanext Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
US11065629B2 (en) 2011-11-21 2021-07-20 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US9327296B2 (en) 2012-01-27 2016-05-03 Fenwal, Inc. Fluid separation chambers for fluid processing systems
JP6018299B2 (ja) 2012-09-25 2016-11-02 ステム セル パートナーズ，エルエルシー 単一ドナーのトロンビン血清を調製する方法および機器
BR112015010040B1 (pt) 2012-11-05 2020-11-17 Haemonetics Corporation câmara de separação de fluxo contínuo
US9877476B2 (en) 2013-02-28 2018-01-30 New Health Sciences, Inc. Gas depletion and gas addition devices for blood treatment
US10039876B2 (en) 2014-04-30 2018-08-07 Sorin Group Italia S.R.L. System for removing undesirable elements from blood using a first wash step and a second wash step
WO2015186057A1 (en) * 2014-06-04 2015-12-10 Biosafe S.A. System for multi-processing and separation of biological fluids
CN207188020U (zh) * 2014-09-25 2018-04-06 Fl史密斯公司 离心密封件和密封装置以及容纳其的离心机
KR102777156B1 (ko) 2015-03-10 2025-03-05 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
IL285359B2 (en) 2015-04-23 2024-01-01 Hemanext Inc Anaerobic blood storage containers
RU2705959C2 (ru) * 2015-05-07 2019-11-12 Биосейф С.А. Устройство, способ и система для непрерывной обработки и разделения биологических текучих сред на компоненты
EP3297641B1 (de) 2015-05-18 2025-07-09 Hemanext Inc. Verfahren zur lagerung von vollblut und zusammensetzungen davon
US10207044B2 (en) 2015-07-29 2019-02-19 Fenwal, Inc. Five-port blood separation chamber and methods of using the same
PT3463466T (pt) 2016-05-27 2022-04-04 Hemanext Inc Método de armazenamento de sangue anaeróbio e inativação de patógenos
EP4070826A3 (de) 2021-04-05 2022-11-30 Fenwal, Inc. Zentrifugationskammern mit kontinuierlichem fluss

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AU2006208525A1 (en) 2006-08-03
ATE480333T1 (de) 2010-09-15
US20120077663A1 (en) 2012-03-29
EP1871530A1 (de) 2008-01-02
US20080153686A1 (en) 2008-06-26
EP1871530B1 (de) 2010-09-08
AU2006208525A2 (en) 2006-08-03
US8348823B2 (en) 2013-01-08
WO2006079238A1 (fr) 2006-08-03
US8070664B2 (en) 2011-12-06
CA2592275A1 (fr) 2006-08-03
JP2008528066A (ja) 2008-07-31

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