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EP1666583B1 - Plaque de micro-titrage - Google Patents

Plaque de micro-titrage Download PDF

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Publication number
EP1666583B1
EP1666583B1 EP05014724A EP05014724A EP1666583B1 EP 1666583 B1 EP1666583 B1 EP 1666583B1 EP 05014724 A EP05014724 A EP 05014724A EP 05014724 A EP05014724 A EP 05014724A EP 1666583 B1 EP1666583 B1 EP 1666583B1
Authority
EP
European Patent Office
Prior art keywords
laser
frame
plastic
plate according
microtitration plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP05014724A
Other languages
German (de)
English (en)
Other versions
EP1666583A1 (fr
Inventor
Jürgen Löhn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Publication of EP1666583A1 publication Critical patent/EP1666583A1/fr
Application granted granted Critical
Publication of EP1666583B1 publication Critical patent/EP1666583B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials

Definitions

  • the invention relates to a microtiter plate.
  • Microtiter plates are used in particular for a variety of microbiological, cell culture and immunological operations.
  • microtiter plates find application in PCR and the growth of microorganisms or cells.
  • Known are microtiter plates having a frame with a plurality of vessels for receiving sample liquid.
  • the vessels are also referred to as "wells". They are for example formed as depressions in an overall plate-shaped frame.
  • the frame has a plate to which the vessels are connected. They have an opening at the top of the plate and protrude from the bottom of the plate.
  • the frame may have a circumferential jacket which also protrudes from the underside of the plate.
  • Microtiter plates in the sense of this application are in particular microtiter plates according to the recommendations of the SBS (Society for Biomolecular Screening), PCR plates, deepwell plates, culture plates, filter plates etc.
  • SBS Society for Biomolecular Screening
  • microtiter plates are already provided with vessel markings for the identification of the vessels.
  • a column with letters on the top of the frame are arranged above the arranged in parallel rows and columns a series with numbers and left and / or right of the vessels. If the numbers and letters are only embossed, they only stand out from the ground with little contrast and are difficult to read.
  • microtiter plates with printed numbers and letters This marking is washable and not lightfast. This also applies to printed barcodes used to identify microtiter plates. Sticked barcodes can come off.
  • the microtiter plate has in a substrate a plurality of receptacles comprising a bottom and an upstanding wall formed by receiving separate zones.
  • the soil and separation zones with the upstanding surfaces have different hydrophilic properties and the soils are surface treated to improve the dynamics of liquid spreading.
  • the receptacles have a hydrophilic bottom and are separated from each other by hydrophobic separation zones and upstanding surfaces.
  • the soil is particularly well wetted by aqueous solutions.
  • the receptacles have a hydrophobic bottom and are separated from each other by hydrophilic separation zones and raised surfaces.
  • the soil is particularly well wetted by organic solutions.
  • each recording can be filled with a liquid volume exceeding its volume. This allows particularly thin microtiter plates.
  • a hydrophobic layer is applied to a hydrophilic substrate, and then patternwise removed the hydrophobic layer to produce images of a hydrophilic bottom.
  • a further production method is specified to apply pattern-like hydrophobic separation zones and high-standing surfaces on a hydrophilic substrate.
  • a heat-sensitive material comprising a support and a hydrophobic layer coated thereon and a hydrophilic layer coated thereon are used.
  • the superimposed hydrophilic layer is pattern-removed, so that recordings with a hydrophobic base and hydrophilic, upstanding surfaces, which are separated from each other by hydrophilic separation zones arise.
  • the hydrophobic layer may be the substrate of the microtiter plate itself or a layer applied to a carrier. Thus, when the hydrophobic layer is the substrate of the microtiter plate, it replaces the carrier with the hydrophobic layer applied thereon.
  • the object of the invention is to provide a microtiter plate which allows labeling with better application properties.
  • microtiter plate with the features of claim 1.
  • Advantageous embodiments of the microtiter plate are specified in the subclaims.
  • the microtiter plate according to the invention is produced from at least two plastics.
  • At least one laser-inscribable plastic is used for the frame or at least a portion of the frame.
  • This can be a plastic that is basically laser-inscribable or laser-inscribable by the addition of additive (s).
  • the frame or at least a portion of the frame is laser markable.
  • another plastic is used, which can be chosen in particular with regard to its suitability for the operations to be carried out with the microtiter plate operations. This in particular with a view to avoiding unwanted interactions with samples to be filled into the vessels.
  • the laser-writable plastic does not affect the samples because it is limited to the frame. If the microtiter plate were made entirely of a laser-inscribable plastic, interference with the analysis or other treatment of the samples by the laser-inscribable plastic or components thereof could not be ruled out.
  • the laser marking of the microtiter plate is readable even under unfavorable viewing angles and in low light. It is also recognizable by a thin layer of ice or frost. It is not washable, not destructible by solvents and lightfast. An individual laser inscription of individual microtiter plates is possible. Furthermore, the laser marking can be attached with high precision.
  • the microtiter plate is relatively easy to produce in the multi-component injection molding process.
  • the production takes place in Kemschreibzugsmaschine, which is cheaper than other multi-component injection molding, in particular cheaper than the Umsetzverfabren.
  • the frame has a plate in which the vessels are formed or with which the vessels are connected.
  • the vessels lining layers are made of a plastic other than the laser-inscribable plastic.
  • vessels made of the other plastic which are connected only at their upper edge region with the plate and protrude beyond the underside of the plate.
  • the plate moreover, in total or in at least one area of the laser-inscribable plastic. This makes it possible, in particular, for the laser inscription on the top that is particularly visible when the microtiter plate is used.
  • a region of the plate which surrounds all of the vessels in the manner of a frame is produced as a whole or in at least one region from the laser-inscribable plastic.
  • On the area framing the vessels is e.g. a vessel identification and / or an individual plate marking and / or a manufacturer identification and / or a label by the user easily visible attachable.
  • a jacket of the frame surrounding the plate as a whole or in at least one region consists of a laser-inscribable plastic. On the jacket is e.g. an individual plate marking attachable.
  • an upper layer of the frame as a whole or in at least one region consists of the laser-inscribable plastic.
  • the laser marking on the outside of the frame is clearly visible attachable.
  • the underlying layer of the frame may be made of a plastic which is advantageous, for example, in terms of connection to the vessels or in terms of stability. In particular, this plastic may be the same plastic as the plastic for the vessels.
  • the vessels, a central region of the plate connected to the vessels, the shell and the central region with the jacket connecting webs of the same plastic and a region of the frame disposed between the central region of the plate and the shell all or part of the laser-inscribable plastic can be ordered in a two-component injection molding process. It is particularly suitable for production in the cost-effective core retraction process.
  • the laser-inscribable plastic has a different color than non-laser inscribable areas of the frame and / or the vessels. This allows optical highlighting of the laser marking, which facilitates their attachment and readability.
  • the microtiter plate comprises a plurality of regions of laser-inscribable plastic with different colors. The areas of different colors can be used to identify different operations.
  • the laser inscription has a different color than the laser inscribable having laser writable area. According to an embodiment which further improves the readability, the laser inscription has a different color than the non-laser inscribable regions of the frame and / or the vessels.
  • the laser-inscribable plastic has an adhesive connection and / or a connection via undercuts and / or a latching connection with adjacent regions of the frame and / or the vessels.
  • the adhesive bond is made according to a further embodiment by fusing different plastics or by connecting different plastics by means of adhesive. When manufactured in multi-component injection molding process management is possible in such a way that the different plastics merge together at the contact points.
  • the connection via undercuts and the latching connection is advantageous, for example, for the connection of plastics, between which no adhesive bond or only one adhesive bond of low loadability can be produced.
  • the laser-inscribable plastic can be laser-marked by color change and / or carbonization and / or foaming and / or material removal.
  • the laser inscribability by color change is given according to a further embodiment by a laser-inscribable plastic comprising a base material with a laser additive.
  • the base material preferably corresponds substantially to the plastic non-laser-inscribable areas of the frame and / or with the plastic of the vessels. As a result, an adhesive bond between the different plastics is favored.
  • the base material of the laser-inscribable plastic is PP (polypropylene) or PS (polystyrene) or another thermoplastic or thermoplastic elastomer.
  • PP and PS designed vessels are suitable for many applications. Therefore, their use as a base material is particularly advantageous.
  • the laser-writable by color change plastic PC polycarbonate
  • PVC polyvinyl chloride
  • the plastic is not laser-inscribable areas of the frame and / or the vessels PP, PS, PC, PVC or another thermoplastic or thermoplastic elastomer.
  • PP, PS, PC or PVC containers are suitable for many applications. According to the above, they can be advantageously combined with a suitably designed base material of the laser-inscribable plastic.
  • the vessels are at least partially made of a transparent plastic.
  • the transparent plastic is particularly advantageous for performing optical measurements of samples in the vessels.
  • the microtiter plate has at least one laser inscription.
  • the laser marking is present in at least one laser-writable area, e.g. introduced by the manufacturer of the microtiter plate or by the user.
  • the laser inscription can be designed in many ways. According to one embodiment, it is a vessel identification with a number series and a letter series for identification of each vessel of the microtiter plate and / or a plate identification for identification of the entire microtiter plate and / or a manufacturer identification and / or a location identifier for identifying the orientation of the microtiter plate.
  • the microtiter plate has the position identification at a corner of the frame.
  • the location marking can be easily introduced by the manufacturer or the customer according to specific customer requirements.
  • the numbers of the vessel identification are present on one side of a region of the frame surrounding the central region of the frame and the letters of the vessel identification on a side of the frame which surrounds the central region in a frame-like manner.
  • the plate identification is a barcode.
  • the microtiter plate can be manufactured as a complete product in the clean room. There is no risk of contamination of purchased components, such as when using adhesive labels.
  • the laser inscription is losier- and manipulation-proof. It is as resistant to aging as the microtiter plate itself.
  • the laser inscription can be formed without restriction on the plate edges.
  • a circumferential edge e.g. serves for the sealing application of a sealing film.
  • annular projecting from the openings of the vessel collar which also serve the sealing pads of a sealing film.
  • the positionability is better than with the foil rear spraying and pad printing. Splashed labels are also very accurate.
  • the type of coating can be applied in a visible and easy to read manner. Coating parameters, coating data (e.g., expiration date) may be subsequently noted by laser inscription on the plate.
  • the user can at any time subsequently write information to the disk.
  • These are just as captive, rich in contrast, etc. as attached by the manufacturer of the microtiter plate information.
  • the contrast to the laser inscription can be increased. Different colors of the frames or areas of the frames can be used by the user for different operations in the sample treatment.
  • Laser marking makes it possible to switch from light to dark and from dark to light.
  • a microtiter plate 1 consists of a frame 2 with a substantially rectangular, flat plate 3 and four of the four sides of the plate 3 approximately vertically downwardly directed side walls 4, 5, 6, 7, which form a total of a jacket 8.
  • the plates 3 With the plate 3, a plurality of tubular vessels 9 are connected.
  • the vessels 9 are connected at their upper edge to the plate 3. They each have in the plane of the plate 3 from the top accessible opening 10. Furthermore, they have a below the plate 3 downwardly projecting receptacle 11, which is closed at the bottom by a bottom.
  • the vessels 9 are arranged in a central region 12 of the plate 3 in eight rows and twelve columns. A total of 96 vessels 9 are available.
  • a region 13 of the plate 3 which surrounds the central region 12 in a frame-like manner has, on one side next to the rows, numerals 14 (from 1 to 12) and on one side next to the columns letters 15 (from A to H) for the identification of the vessels 9 Region 13 at the corner, which is adjacent to the vessel 9 marked with A1, a position identification 16.
  • Fig. 2 In a first manufacturing step, the central region 12 with the vessels 9, the jacket 8 and the central region 12 and the jacket 8 are joined together to form webs 18. Instead of the central region 12, the webs 18 may be connected to vessels 9. These areas of the microtiter plate are injection-molded in one piece from a non-laser-inscribable plastic that is allowed to come into contact with the samples to be processed without adversely affecting it (eg PP, PS).
  • a non-laser-inscribable plastic that is allowed to come into contact with the samples to be processed without adversely affecting it (eg PP, PS).
  • the labeling explained above is introduced by laser inscription.
  • the laser types according to the above list are used.
  • the laser marking can be done by the manufacturer or by the user.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Laser Beam Processing (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)

Claims (23)

  1. Plaque de micro-titrage, avec
    • un cadre (2, 8), qui est fait entièrement ou au moins dans une région (13) d'au moins une matière plastique inscrivable par laser et qui comporte au moins une inscription par laser (14, 15), et
    • une pluralité de vaisseaux (9), disposés dans le cadre et ayant une ouverture (10) sur un côté du cadre (2, 8) et faites d'une autre matière plastique que la matière plastique inscrivable par laser.
  2. Plaque de micro-titrage selon la revendication 1, dans laquelle le cadre (2, 8) présente une plaque (2) dans laquelle les vaisseaux (9) sont formés ou avec laquelle les vaisseaux (8) sont reliés.
  3. Plaque de micro-titrage selon la revendication 1 ou 2, dans laquelle la plaque (2) est faite entièrement ou au moins dans une région (13) de la matière plastique inscrivable par laser.
  4. Plaque de micro-titrage selon la revendication 2 ou 3, dans laquelle une région (13) de la plaque (2) en forme de cadre et entourant tous les vaisseaux (9) est faite entièrement ou au moins dans une région de la matière plastique inscrivable par laser.
  5. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 4, dans laquelle une enveloppe (8) du cadre (2, 8) entourant la plaque (2) est faite entièrement ou au moins dans une région de la matière plastique inscrivable par laser.
  6. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 5, dans laquelle une couche supérieure du cadre (2, 8) est faite entièrement ou au moins dans une région de la matière plastique inscrivable par laser.
  7. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 6, dans laquelle les vaisseaux (9), une région centrale (12) de la plaque (2) reliée avec les vaisseaux (9), l'enveloppe (8) et des barreaux (18) reliant la région centrale (12) avec l'enveloppe (8) sont faites de la même matière plastique, et une région (13) du cadre (2,8) disposé entre la région centrale (12) de la plaque (2) et enveloppe (8) est faite entièrement ou partiellement de la matière plastique inscrivable par laser.
  8. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 7, dans laquelle la matière plastique inscrivable par laser a une autre couleur que des régions pas inscrivables du cadre (2, 8) et/ou les vaisseaux (9).
  9. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 8, qui comporte plusieurs régions (13) faites de matière plastique inscrivables par laser qui ont des couleurs différentes.
  10. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 9, dans laquelle la matière plastique inscrivable par laser présent une liaison par adhésion et/ou une liaison par contre-dépouille et/ou une liaison par encliquetage avec des régions adjacentes du cadre (2, 8) et/ou des vaisseaux (9).
  11. Plaque de micro-titrage selon la revendication 10, dans laquelle la liaison par adhésion est une fusion de différentes matières plastiques ou une liaison de différentes matières plastiques à l'aide de colle.
  12. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 11, dans laquelle la matière plastique inscrivable par laser est inscrivable avec le laser par changement de couleur et/ou carbonisation et/ou bouillonnement et/ou abrasion de matériau.
  13. Plaque de micro-titrage selon la revendication 12, dans laquelle la matière plastique inscrivable par laser comporte un matériau de base avec un additif pour laser.
  14. Plaque de micro-titrage selon la revendication 13, dans laquelle le matériau de base est essentiellement coïncident avec la matière plastique de régions du cadre non inscrivables par laser et/ou avec la matière plastique des vaisseaux (9).
  15. Plaque de micro-titrage selon la revendication 13 ou 14, dans laquelle le matériau de base de la matière plastique inscrivable par laser est du PP ou PPS ou un autre matériau thermoplastique ou un élastomère thermoplastique.
  16. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 15, dans laquelle la matière plastique inscrivable par laser est du PC ou PVC ou une autre matière plastique inscrivable par laser sans additifs pour laser.
  17. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 16, dans laquelle la matière plastique de régions non inscrivables par laser du cadre (2, 8) ou des vaisseaux (9) est du PP, PS, PC, PVC ou un autre matériau thermoplastique ou un élastomère thermoplastique.
  18. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 17, dans laquelle les vaisseaux (9) sont au moins partiellement faites d'une matière plastique transparente.
  19. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 19, avec une inscription par laser (14, 15) qui a une autre couleur que des régions non inscrivables du cadre (2, 8) et/ou les vaisseaux (9).
  20. Plaque de micro-titrage selon l'une quelconque des revendications 1 à 19, dans laquelle l'inscription par laser est une identification de vaisseau (14, 15) par une série de nombres et une série de lettres pour l'identification de chaque vaisseau (9) de la plaque de micro-titrage, et/ou une identification de plaque (18) pour identifier la plaque de micro-titrage entière et/ou une identification de fournisseur (17) et/ou une identification de position (16) pour désigner l'alignement de la plaque de micro-titrage.
  21. Plaque de micro-titrage selon la revendication 20, qui a l'identification de position (16) dans un coin du cadre (2, 8).
  22. Plaque de micro-titrage selon la revendication 20 ou 21, qui présente la série de nombres de l'identification de vaisseau (14, 15) dans un côté d'une région (13) du cadre (2, 8) entourant en forme de cadre une région centrale (12) du cadre (2, 8), et l'identification par lettres dans un côté perpendiculaire à cela de la région (13) du cadre (2, 8) entourant en forme de cadre la région centrale (12).
  23. Plaque de micro-titrage selon l'une quelconque des revendications 20 à 22, dans laquelle l'identification de plaque (18) est un code à barres ou un code à points (Dot Code) à deux dimensions.
EP05014724A 2004-12-06 2005-07-07 Plaque de micro-titrage Expired - Lifetime EP1666583B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE202004018921U DE202004018921U1 (de) 2004-12-06 2004-12-06 Mikrotiterplatte

Publications (2)

Publication Number Publication Date
EP1666583A1 EP1666583A1 (fr) 2006-06-07
EP1666583B1 true EP1666583B1 (fr) 2011-02-23

Family

ID=34202990

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05014724A Expired - Lifetime EP1666583B1 (fr) 2004-12-06 2005-07-07 Plaque de micro-titrage

Country Status (3)

Country Link
US (1) US8636965B2 (fr)
EP (1) EP1666583B1 (fr)
DE (2) DE202004018921U1 (fr)

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JP2008026112A (ja) * 2006-07-20 2008-02-07 Seiko Instruments Inc 包埋カセット
US20080305279A1 (en) * 2006-10-31 2008-12-11 Duncan Young Method of marking a surgical article
EP3652293A2 (fr) 2017-07-13 2020-05-20 Greiner Bio-One North America, Inc. Plaques de culture pour imagerie
US11786903B2 (en) 2020-03-17 2023-10-17 Covaris, Llc Multi-component sample holder
AR130935A1 (es) 2022-11-02 2025-02-05 Novo Nordisk As Compuestos de cnp

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DE2902026C3 (de) * 1979-01-19 1981-10-29 Peters, J. Hinrich, Dr., 5064 Rösrath Biologisches Gefäß
US5357095A (en) * 1992-07-16 1994-10-18 Schiapparelli Biosystems, Inc. Reagent bottle identification and reagent monitoring system for a chemical analyzer
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DE10028536B4 (de) * 2000-06-08 2004-08-19 Eppendorf Ag Mikrotiterplatte
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US20050221358A1 (en) * 2003-09-19 2005-10-06 Carrillo Albert L Pressure chamber clamp mechanism

Also Published As

Publication number Publication date
EP1666583A1 (fr) 2006-06-07
DE202004018921U1 (de) 2005-02-17
DE502005010994D1 (de) 2011-04-07
US8636965B2 (en) 2014-01-28
US20060120927A1 (en) 2006-06-08

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