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EP1519651A1 - Fungicidal active substance combinations - Google Patents

Fungicidal active substance combinations

Info

Publication number
EP1519651A1
EP1519651A1 EP03735610A EP03735610A EP1519651A1 EP 1519651 A1 EP1519651 A1 EP 1519651A1 EP 03735610 A EP03735610 A EP 03735610A EP 03735610 A EP03735610 A EP 03735610A EP 1519651 A1 EP1519651 A1 EP 1519651A1
Authority
EP
European Patent Office
Prior art keywords
active ingredient
plants
formula
active
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP03735610A
Other languages
German (de)
French (fr)
Inventor
Ulrike Wachendorff-Neumann
Astrid Mauler-Machnik
Manfred Jautelat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience AG
Original Assignee
Bayer CropScience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Bayer CropScience AG filed Critical Bayer CropScience AG
Publication of EP1519651A1 publication Critical patent/EP1519651A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Definitions

  • the present invention relates to a new combination of active ingredients which is derived from the known 2- [ ⁇ - ⁇ [( ⁇ -memyl-3-trifluoromethyl-benzyl) imino] oxy ⁇ -o-tolyl] -glyoxylic acid methyl ester-O- methyloxime on the one hand and a known triazole derivative on the other hand and is very suitable for combating phytopathogenic fungi.
  • the fungicidal activity of the active compound combination according to the invention is considerably higher than the sum of the effects of the individual active compounds. So there is an unforeseeable, real synergistic effect and not just an addition.
  • the component present in the active ingredient combination according to the invention in addition to the active ingredient of the formula (I) is also known.
  • the active substances are described in detail in the following publications:
  • the active ingredients are present in the active ingredient combination according to the invention in certain weight ratios, the synergistic effect is particularly evident clear.
  • the weight ratios of the active ingredients in the active ingredient combination can be varied within a relatively wide range.
  • the active ingredient combination according to the invention has very good fungicidal properties and can be used to control phytopathogenic fungi, such as plasmidiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes, Deuteromycetes, etc.
  • the active ingredient combination according to the invention is particularly suitable for combating cereal diseases, such as Erysiphe, Cochliobolus, Pyrenophora,
  • Rhynchosporium Septoria, Fusarium, Pseudocercosporella and Leptosphaeria and for combating fungal attack on non-cereal crops such as wine, fruit, peanut, vegetables, for example Phythophthora, Plasmopara, Pythium as well as powdery mildew fungi such as Sphaerofheca or Uncinula and Ventineniaerre, as well as leaf stains, such as 'Leaf blemishes', as well as 'Leaf blemishes', as well as leaf stains, as well as leaf stains, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, as well as leaf stains, such as Sphaerofheca and Uncinula, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, such as Sphaerofheca and Un
  • the fact that the active ingredient combination is well tolerated by plants in the concentrations required to combat plant diseases permits treatment of above-ground parts of plants, of propagation stock and seeds, and of the soil.
  • the active ingredient combination according to the invention can be used for leaf application or as a mordant.
  • the active ingredient combination according to the invention is also suitable for increasing the crop yield. It is also less toxic and has good plant tolerance. According to the invention, all plants and parts of plants can be treated. Plants are understood here to mean all plants and plant populations, such as desired and unwanted wild plants or crop plants (including naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which can or cannot be protected by plant breeders' rights.
  • Plant parts are to be understood to mean all above-ground and underground parts and organs of plants, such as shoots, leaves, flowers and roots, examples being leaves, needles, stems, stems, flowers, fruiting bodies, fruits and seeds, and roots, tubers and rhizomes become.
  • the plant parts also include crops and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds.
  • the treatment of the plants and parts of plants with the active compounds according to the invention is carried out directly or by acting on their surroundings, living space or storage space according to the customary treatment methods, e.g. by dipping, spraying, vaporizing, atomizing, scattering, spreading and, in the case of propagation material, in particular seeds, furthermore by single- or multi-layer coating.
  • the active ingredient combination according to the invention can be converted into the customary formulations, such as solutions, emulsions, suspensions, powders, foams, pastes, granules, aerosols, very fine encapsulations in polymeric substances and in
  • formulations are prepared in a known manner, for example by mixing the active ingredients or combinations of active ingredients with extenders, that is to say liquid solvents, pressurized liquefied gases and / or solid carriers, if appropriate using surface-active agents, ie Emulsifiers and / or dispersants and / or foaming agents. If water is used as an extender, organic solvents can, for example, also be used as auxiliary solvents.
  • extenders that is to say liquid solvents, pressurized liquefied gases and / or solid carriers, if appropriate using surface-active agents, ie Emulsifiers and / or dispersants and / or foaming agents.
  • surface-active agents ie Emulsifiers and / or dispersants and / or foaming agents.
  • organic solvents can, for example, also be used as auxiliary solvents.
  • aromatics such as xylene, toluene or allylnaphthalamine
  • chlorinated aromatics or chlorinated aliphatic hydrocarbons such as chlorobenzenes, chlorethylenes or methylene chloride
  • aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions
  • alcohols such as butanol or glycol and their ethers and esters
  • ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone
  • strongly polar solvents such as dimethylformamide and dimethyl sulfoxide, and water.
  • Liquefied gaseous extenders or carriers mean liquids which are gaseous at normal temperature and under normal pressure, for example aerosol propellants such as butane, propane, nitrogen and carbon dioxide.
  • Solid carrier materials come into question: for example natural rock powders such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic rock powders such as highly disperse silica, aluminum oxide and silicates.
  • Solid carriers for granules are possible: e.g.
  • emulsifiers and / or foam-generating agents are: for example nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkyl aryl polyglycol ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates and protein hydrolysates.
  • Possible dispersants are, for example, lignin sulfite liquor and methyl cellulose.
  • Adhesives such as carboxymethyl cellulose, natural and synthetic polymers in the form of powders, granules or latices, such as Giimmiarabicum, polyvinyl alcohol, polyvinyl acetate and natural ones, can be used in the formulations.
  • Phospholipids such as cephalins and lecithins, and synthetic phospholipids.
  • Other additives can be mineral and vegetable oils.
  • Dyes such as inorganic pigments, for example iron oxide, titanium oxide, ferrocyan blue and organic dyes, such as alizarin, azo and metal phthalocyanine dyes and trace nutrients, such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc, can be used ,
  • the formulations generally contain between 0.1 and 95% by weight of active ingredients, preferably between 0.5 and 90%.
  • the active ingredient combination according to the invention can be used as such or in its formulations also in hybrid with known fungicides, bactericides, acaricides, nematicides or insecticides, in order, for example, to broaden the spectrum of activity or to prevent the development of resistance. In many cases, synergistic effects are obtained, i.e. the effectiveness of the mixture is greater than the effectiveness of the individual components.
  • the active substance combinations can be used as such, in the form of their formulations or the use forms prepared therefrom, such as ready-to-use solutions, emulsifiable concentrates, emulsions, suspensions, wettable powders, soluble powders and granules. They are used in the usual way, e.g. by pouring, spraying, spraying, scattering, spreading, dry pickling, wet pickling, wet pickling, slurry pickling or incrusting.
  • the application rates can be varied within a substantial range, depending on the type of application.
  • the application rates of active compound combination are generally between 0.1 and 10000 g / ha, preferably between
  • the amount of active ingredients Combination of substances generally between 0.001 and 50 g per kg of seed, preferably between 0.01 and 10 g per kg of seed.
  • the active compound combination application rates are generally between 0.1 and 10,000 g / ha, preferably between 1 and 5,000 g / ha.
  • Fungicides always have a synergistic effect if the fungicidal activity of the active ingredient combinations is greater than the sum of the effects of the individually applied active ingredients.
  • X means the efficiency when using the active ingredient A in an application rate of m g / ha
  • Y means the efficiency when using the active ingredient B in an application rate of n g / ha and
  • the efficiency is determined in%. It means 0% an efficiency that corresponds to that of the control, while an efficiency of 100% means that no infection is observed. If the actual fungicidal activity is greater than calculated, the combination of the combination is superadditive, ie there is a synergistic effect. In this case, the actually observed efficiency must be greater than the value for the expected efficiency E ⁇ calculated from the above formula.
  • Emulsifier 0.6 part by weight of alkylaryl polyglycol ether
  • the plants are placed in a greenhouse at a temperature of approx. 15 ° C and a relative humidity of 80%.
  • Emulsifier 0.6 part by weight of alkylaryl polyglycol ether
  • the plants are placed in a greenhouse at a temperature of approx. 20 ° C and a relative humidity of approx. 80% in order to promote the development of rust pustules.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to the novel active substance combination on the basis of 2-(alpha (((alpha-methyl-3-trifluoromethylbenzyl)imino)oxy )-o-tolyl) glyoxylic acid methylester-O-methyloxim of formula (I) (trifloxystrobin) and the active substance of formula (II) (prothioconazole) mentioned in the description which has excellent fungicidal properties.

Description

Fungizide WirkstoffkombinationenFungicidal active ingredient combinations
Die vorliegende Erfindung betrifft eine neue Wirkstoffkombination, die aus dem be- kannten 2-[α-{[( α-Memyl-3-trifluoromethyl-benzyl)imino]oxy}-o-tolyl]-glyoxyl- säure-methylester-O-methyloxim einerseits und einem bekannten Triazol-Derivat andererseits besteht und sehr gut zur Bekämpfung von phytopathogenen Pilzen geeignet ist.The present invention relates to a new combination of active ingredients which is derived from the known 2- [α - {[(α-memyl-3-trifluoromethyl-benzyl) imino] oxy} -o-tolyl] -glyoxylic acid methyl ester-O- methyloxime on the one hand and a known triazole derivative on the other hand and is very suitable for combating phytopathogenic fungi.
Es ist bereits bekannt, dass 2-[α-{[( α-Methyl-3-trifluoromethyl-benzyl)imino]oxy}- o-tolyl]-glyoxylsäure-methylester-O-methyloxim fungizide Eigenschaften besitzt (vgl. EP-A-460 575). Die Wirksamkeit dieses Stoffes ist gut, lässt aber bei niedrigen Aufwandmengen in manchen Fällen zu wünschen übrig.It is already known that 2- [α - {[(α-methyl-3-trifluoromethyl-benzyl) imino] oxy} - o-tolyl] -glyoxylic acid methyl ester-O-methyloxime has fungicidal properties (cf. EP-A -460 575). The effectiveness of this substance is good, but leaves something to be desired in some cases at low application rates.
Femer ist schon bekannt, dass zahlreiche Azol-Derivate zur Bekämpfung von Pilzen eingesetzt werden können (vgl. Pesticide Manual, llth. Edition (1997), Seite 1144). Auch die Wirkung dieser Stoffe ist aber bei niedrigen Aufwandmengen nicht immer ausreichend.Furthermore, it is already known that numerous azole derivatives can be used to combat fungi (cf. Pesticide Manual, 11th Edition (1997), page 1144). However, the effect of these substances is not always sufficient at low application rates.
Es wurde nun gefunden, dass die neue Wirkstoffkombination ausIt has now been found that the new combination of active ingredients
2-[α- {[( α-Methyl-3-trifluoromethyl-benzyl)imino]oxy} -o-tolylj-glyoxylsäure- methylester-O-methyloxim der Formel (I)2- [α- {[(α-methyl-3-trifluoromethyl-benzyl) imino] oxy} -o-tolylj-glyoxylic acid methyl ester-O-methyloxime of the formula (I)
(Trifloxystrobin) und(Trifloxystrobin) and
der Verbindung der Formel (H)the compound of formula (H)
(Prothioconazole)(Prothioconazole)
sehr gute fungizide Eigenschaften besitzt.has very good fungicidal properties.
Überraschenderweise ist die fungizide Wirkung der erfindungsgemäßen Wirkstoffkombination wesentlich höher als die Summe der Wirkungen der einzelnen Wirkstoffe. Es liegt also ein nicht vorhersehbarer, echter synergistischer Effekt vor und nicht nur eine Wirkungsergänzung.Surprisingly, the fungicidal activity of the active compound combination according to the invention is considerably higher than the sum of the effects of the individual active compounds. So there is an unforeseeable, real synergistic effect and not just an addition.
Die in der erfindungsgemäßen Wirkstoffkombination neben dem Wirkstoff der Formel (I) vorhandene Komponente ist ebenfalls bekannt. Im Einzelnen werden die Wirkstoffe in den folgenden Publikationen beschrieben:The component present in the active ingredient combination according to the invention in addition to the active ingredient of the formula (I) is also known. The active substances are described in detail in the following publications:
Verbindung der Formel (I): EP-A-460 575Compound of formula (I): EP-A-460 575
Verbindung der Formel (H): WO 96/16048.Compound of formula (H): WO 96/16048.
Wenn die Wirkstoffe in der erfindungsgemäßen Wirkstoffkombination in bestimmten Gewichtsverhältnissen vorhanden sind, zeigt sich der synergistische Effekt besonders deutlich. Jedoch können die Gewichtsverhältnisse der Wirkstoffe in der Wirkstoffkombination in einem relativ großen Bereich variiert werden.If the active ingredients are present in the active ingredient combination according to the invention in certain weight ratios, the synergistic effect is particularly evident clear. However, the weight ratios of the active ingredients in the active ingredient combination can be varied within a relatively wide range.
Im Allgemeinen entfallen auf 1 Gewichtsteil an Wirkstoff der Formel (I)In general, 1 part by weight of active compound of the formula (I)
0,02 - 20 Gewichtsteile, vorzugsweise 0,05 - 10 Gewichtsteile an Wirkstoff der Formel (IT).0.02-20 parts by weight, preferably 0.05-10 parts by weight, of active ingredient of the formula (IT).
Die erfindungsgemäße Wirkstoffkombination besitzt sehr gute fungizide Eigen- schaften und lässt sich zur Bekämpfung von phytopathogenen Pilzen, wie Plasmo- diophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basi- diomycetes, Deuteromycetes usw. einsetzen.The active ingredient combination according to the invention has very good fungicidal properties and can be used to control phytopathogenic fungi, such as plasmidiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes, Deuteromycetes, etc.
Die erfindungsgemäße Wirkstoffkombination eignet sich besonders gut zur Bekämpfung von Getreidekrankheiten, wie Erysiphe, Cochliobolus, Pyrenophora,The active ingredient combination according to the invention is particularly suitable for combating cereal diseases, such as Erysiphe, Cochliobolus, Pyrenophora,
Rhynchosporium, Septoria, Fusarium, Pseudocercosporella und Leptosphaeria und zur Bekämpfung von Pilzbefall an Nichtgetreidekulturen wie Wein, Obst, Erdnuss, Gemüse, beispielsweise Phythophthora, Plasmopara, Pythium sowie Echte Mehltaupilze wie zum Beispiel Sphaerofheca oder Uncinula und Blattfleckenerreger wie Venturia, Alternaria und Septoria ' sowie Rhizoctonia, Botrytis, Sclerotinia undRhynchosporium, Septoria, Fusarium, Pseudocercosporella and Leptosphaeria and for combating fungal attack on non-cereal crops such as wine, fruit, peanut, vegetables, for example Phythophthora, Plasmopara, Pythium as well as powdery mildew fungi such as Sphaerofheca or Uncinula and Ventineniaerre, as well as leaf stains, such as 'Leaf blemishes', as well as 'Leaf blemishes', as well as leaf stains, as well as leaf stains, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, as well as leaf stains, such as Sphaerofheca and Uncinula, as well as leaf stains and leaf stains, as well as leaf stains and leaf stains, such as Sphaerofheca and Uncinula and Leaf stains, as well as leaf stains and leaf stains Rhizoctonia, Botrytis, Sclerotinia and
Sclerotium.Sclerotium.
Die gute Pflanzenverträglichkeit der Wirkstoffkombination in den zur Bekämpfung von Pflanzenkrankheiten notwendigen Konzentrationen erlaubt eine Behandlung von oberirdischen Pflanzenteilen, von Pflanz- und Saatgut, und des Bodens. Die erfindungsgemäße Wirkstoffkombination kann zur Blattapplikation oder auch als Beizmittel eingesetzt werden.The fact that the active ingredient combination is well tolerated by plants in the concentrations required to combat plant diseases permits treatment of above-ground parts of plants, of propagation stock and seeds, and of the soil. The active ingredient combination according to the invention can be used for leaf application or as a mordant.
Die erfindungsgemäße Wirkstoffkombination eignet sich auch zur Steigerung des Ernteertrages. Sie ist außerdem mindertoxisch und weist eine gute Pflanzenverträg- lichkeit auf. Erfindungsgemäß können alle Pflanzen und Pflanzenteile behandelt werden. Unter Pflanzen werden hierbei alle Pflanzen und Pflanzenpopulationen verstanden, wie erwünschte und unerwünschte Wildpflanzen oder Kulturpflanzen, (einschließlich natür- lieh vorkommender Kulturpflanzen). Kulturpflanzen können Pflanzen sein, die durch konventionelle Züchtungs- und Optimierungsmethoden oder durch biotechnologische und gentechnologische Methoden oder Kombinationen dieser -Methoden erhalten werden können, einschließlich der transgenen Pflanzen und einschließlich der durch Sortenschutzrechte schützbaren oder nicht schützbaren Pflanzensorten. Unter Pflan- zenteilen sollen alle oberirdischen und unterirdischen Teile und Organe der Pflanzen, wie Spross, Blatt, Blüte und Wurzel verstanden werden, wobei beispielhaft Blätter, Nadeln, Stängel, Stämme, Blüten, Fruchtkörper, Früchte und Samen sowie Wurzeln, Knollen und Rhizome aufgeführt werden. Zu den Pflanzenteilen gehört auch Erntegut sowie vegetatives und generatives Vermehrungsmaterial, beispielsweise Steck- linge, Knollen, Rhizome, Ableger und Samen.The active ingredient combination according to the invention is also suitable for increasing the crop yield. It is also less toxic and has good plant tolerance. According to the invention, all plants and parts of plants can be treated. Plants are understood here to mean all plants and plant populations, such as desired and unwanted wild plants or crop plants (including naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which can or cannot be protected by plant breeders' rights. Plant parts are to be understood to mean all above-ground and underground parts and organs of plants, such as shoots, leaves, flowers and roots, examples being leaves, needles, stems, stems, flowers, fruiting bodies, fruits and seeds, and roots, tubers and rhizomes become. The plant parts also include crops and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds.
Die erfindungsgemäße Behandlung der Pflanzen und Pflanzenteile mit den Wirkstoffen erfolgt direkt oder durch Einwirkung auf deren Umgebung, Lebensraum oder Lagerraum nach den üblichen Behandlungsmethoden, z.B. durch Tauchen, Sprühen, Verdampfen, Vernebeln, Streuen, Aufstreichen und bei Vermehrungsmaterial, insbesondere bei Samen, weiterhin durch ein- oder mehrschichtiges Umhüllen.The treatment of the plants and parts of plants with the active compounds according to the invention is carried out directly or by acting on their surroundings, living space or storage space according to the customary treatment methods, e.g. by dipping, spraying, vaporizing, atomizing, scattering, spreading and, in the case of propagation material, in particular seeds, furthermore by single- or multi-layer coating.
Die erfindungsgemäße Wirkstoffkombination kann in die üblichen Formulierungen überführt werden, wie Lösungen, Emulsionen, Suspensionen, Pulver, Schäume, Pasten, Granulate, Aerosole, Feinstverkapselungen in polymeren Stoffen und inThe active ingredient combination according to the invention can be converted into the customary formulations, such as solutions, emulsions, suspensions, powders, foams, pastes, granules, aerosols, very fine encapsulations in polymeric substances and in
Hüllmassen für Saatgut, sowie ULV-Formulierungen.Envelopes for seeds and ULV formulations.
Diese Formulierungen werden in bekannter Weise hergestellt, z.B. durch Vermischen der Wirkstoffe bzw. der Wirkstoffkombinationen mit Streckmitteln, also flüssigen Lösungsmitteln, unter Druck stehenden verflüssigten Gasen und/oder festen Trägerstoffen, gegebenenfalls unter Verwendung von oberflächenaktiven Mitteln, also Emulgiermitteln und/oder Dispergiermitteln und/oder schaumerzeugenden Mitteln. Im Falle der Benutzung von Wasser als Streckmittel können z.B. auch organische Lösungsmittel als Hilfslösungsmittel verwendet werden. Als flüssige Lösungsmittel kommen im Wesentlichen infrage: Aromaten, wie Xylol, Toluol oder Allcylnaphtha- line, chlorierte Aromaten oder chlorierte aliphatische Kohlenwasserstoffe, wie Chlorbenzole, Chlorethylene oder Methylenchlorid, aliphatische Kohlenwasserstoffe, wie Cyclohexan oder Paraffine, z.B. Erdölfraktionen, Alkohole, wie Butanol oder Glycol sowie deren Ether und Ester, Ketone, wie Aceton, Methylethylketon, Methyliso- butylketon oder Cyclohexanon, stark polare Lösungsmittel wie Dimethylformamid und Dimethylsulfoxid, sowie Wasser. Mit verflüssigten gasförmigen Streckmitteln oder Trägerstoffen sind solche Flüssigkeiten gemeint, welche bei normaler Temperatur und unter Normaldruck gasförmig sind, z.B. Aerosol-Treibgase, wie Butan, Pro- pan, Stickstoff und Kohlendioxid. Als feste Trägerstoffe kommen infrage: z.B. natürliche Gesteinsmehle, wie Kaoline, Tonerden, Talkum, Kreide, Quarz, Attapulgit, Montmorillonit oder Diatomeenerde und synthetische Gesteinsmehle, wie hochdisperse Kieselsäure, Aluminiumoxid und Silikate. Als feste Trägerstoffe für Granulate kommen infrage: z.B. gebrochene und fraktionierte natürliche Gesteine wie Calcit, Marmor, Bims, Sepiolith, Dolomit sowie synthetische Granulate aus anorganischen und organischen Mehlen sowie Granulate aus organischem Material wie Sägemehl, Kokosnussschalen, Maiskolben und Tabakstängel. Als Emulgier- und/oder schaumerzeugende Mittel kommen in Frage: z.B. nichtionogene und anionische Emulgato- ren, wie Polyoxyethylen-Fettsäureester, Polyoxyethylen-Fettalkoholether, z.B. Alkyl- arylpolyglycolether, Alkylsulfonate, Alkylsulfate, Arylsulfonate sowie Eiweißhydro- lysate. Als Dispergiermittel kommen in Frage: z.B. Lignin-Sulfitablaugen und Methylcellulose.These formulations are prepared in a known manner, for example by mixing the active ingredients or combinations of active ingredients with extenders, that is to say liquid solvents, pressurized liquefied gases and / or solid carriers, if appropriate using surface-active agents, ie Emulsifiers and / or dispersants and / or foaming agents. If water is used as an extender, organic solvents can, for example, also be used as auxiliary solvents. The following are essentially suitable as liquid solvents: aromatics, such as xylene, toluene or allylnaphthalamine, chlorinated aromatics or chlorinated aliphatic hydrocarbons, such as chlorobenzenes, chlorethylenes or methylene chloride, aliphatic hydrocarbons, such as cyclohexane or paraffins, for example petroleum fractions, alcohols, such as butanol or glycol and their ethers and esters, ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulfoxide, and water. Liquefied gaseous extenders or carriers mean liquids which are gaseous at normal temperature and under normal pressure, for example aerosol propellants such as butane, propane, nitrogen and carbon dioxide. Solid carrier materials come into question: for example natural rock powders such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth and synthetic rock powders such as highly disperse silica, aluminum oxide and silicates. Solid carriers for granules are possible: e.g. broken and fractionated natural rocks such as calcite, marble, pumice, sepiolite, dolomite as well as synthetic granules from inorganic and organic flours as well as granules from organic material such as sawdust, coconut shells, corn cobs and tobacco stems. Possible emulsifiers and / or foam-generating agents are: for example nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkyl aryl polyglycol ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates and protein hydrolysates. Possible dispersants are, for example, lignin sulfite liquor and methyl cellulose.
Es können in den Formulierungen Haftmittel wie Carboxymethylcellulose, natürliche und synthetische pulverige, körnige oder latexförmige Polymere verwendet werden, wie Giimmiarabicum, Polyvinylalkohol, Polyvinylacetat, sowie natürliche. Phospho- lipide, wie Kephaline und Lecithine, und synthetische Phospholipide. Weitere Additive können mineralische und vegetäbile Öle sein. Es können Farbstoffe wie anorganische Pigmente, z.B. Eisenoxid, Titanoxid, Ferro- cyanblau und organische Farbstoffe, wie Alizarin-, Azo- und Metallphthalocyanin- farbstoffe und Spurennährstoffe, wie Salze von Eisen, Mangan, Bor, Kupfer, Kobalt, Molybdän und Zink verwendet werden.Adhesives such as carboxymethyl cellulose, natural and synthetic polymers in the form of powders, granules or latices, such as Giimmiarabicum, polyvinyl alcohol, polyvinyl acetate and natural ones, can be used in the formulations. Phospholipids, such as cephalins and lecithins, and synthetic phospholipids. Other additives can be mineral and vegetable oils. Dyes such as inorganic pigments, for example iron oxide, titanium oxide, ferrocyan blue and organic dyes, such as alizarin, azo and metal phthalocyanine dyes and trace nutrients, such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc, can be used ,
Die Formulierungen enthalten im Allgemeinen zwischen 0,1 und 95 Gew.-% Wirkstoffe, vorzugsweise zwischen 0,5 und 90 %.The formulations generally contain between 0.1 and 95% by weight of active ingredients, preferably between 0.5 and 90%.
Die erfindungsgemäße Wirkstoffkombination kann als solche oder in ihren Formulierungen auch in Mischling mit bekannten Fungiziden, Bakteriziden, Akariziden, Nematiziden oder Insektiziden verwendet werden, um so z.B. das Wirkimgsspektrum zu verbreitern oder Resistenzentwicklungen vorzubeugen. In vielen Fällen erhält man dabei synergistische Effekte, d.h. die Wirksamkeit der Mischung ist größer als die Wirksamkeit der Einzelkomponenten.The active ingredient combination according to the invention can be used as such or in its formulations also in hybrid with known fungicides, bactericides, acaricides, nematicides or insecticides, in order, for example, to broaden the spectrum of activity or to prevent the development of resistance. In many cases, synergistic effects are obtained, i.e. the effectiveness of the mixture is greater than the effectiveness of the individual components.
Auch eine Mischung mit anderen bekannten Wirkstoffen, wie Herbiziden oder mit Düngemitteln und Wachstumsregulatoren ist möglich.A mixture with other known active ingredients, such as herbicides or with fertilizers and growth regulators, is also possible.
Die Wirkstoffkombinationen können als solche, in Form ihrer Formulierungen oder den daraus bereiteten Anwendungsformen, wie gebrauchsfertige Lösungen, emul- gierbare Konzentrate, Emulsionen, Suspensionen, Spritzpulver, lösliche Pulver und Granulate, angewendet werden. Die Anwendung geschieht in üblicher Weise, z.B. durch Gießen, Verspritzen, Versprühen, Verstreuen, Verstreichen, Trockenbeizen, Feuchtbeizen, Nassbeizen, Schlämmbeizen oder Inkrustieren.The active substance combinations can be used as such, in the form of their formulations or the use forms prepared therefrom, such as ready-to-use solutions, emulsifiable concentrates, emulsions, suspensions, wettable powders, soluble powders and granules. They are used in the usual way, e.g. by pouring, spraying, spraying, scattering, spreading, dry pickling, wet pickling, wet pickling, slurry pickling or incrusting.
Beim Einsatz der erfindimgsgemäßen Wirkstoffkombination kann die Aufwandmengen je nach Applikationsart innerhalb eines größeren Bereichs variiert werden. Bei der Behandlung von Pflanzenteilen liegen die Aufwandmengen an Wirkstoff- kombination im Allgemeinen zwischen 0,1 und 10000 g/ha, vorzugsweise zwischenWhen using the active ingredient combination according to the invention, the application rates can be varied within a substantial range, depending on the type of application. In the treatment of parts of plants, the application rates of active compound combination are generally between 0.1 and 10000 g / ha, preferably between
10 und 1 000 g/ha. Bei der Saatgutbehandlung liegen die Aufwandmengen an Wirk- Stoffkombination im Allgemeinen zwischen 0,001 und 50 g pro Kilogramm Saatgut, vorzugsweise zwischen 0,01 und 10 g pro Kilogramm Saatgut. Bei der Behandlung des Bodens liegen die Aufwandmengen an Wirkstoffkombination im Allgemeinen zwischen 0,1 und 10 000 g/ha, vorzugsweise zwischen 1 und 5 000 g/ha.10 and 1,000 g / ha. In the case of seed treatment, the amount of active ingredients Combination of substances generally between 0.001 and 50 g per kg of seed, preferably between 0.01 and 10 g per kg of seed. In the treatment of the soil, the active compound combination application rates are generally between 0.1 and 10,000 g / ha, preferably between 1 and 5,000 g / ha.
Ein synergistischer Effekt liegt bei Fungiziden immer dann vor, wenn die fungizide Wirkung der Wirkstoffkombinationen größer ist als die Summe -der Wirkungen der einzeln applizierten Wirkstoffe.Fungicides always have a synergistic effect if the fungicidal activity of the active ingredient combinations is greater than the sum of the effects of the individually applied active ingredients.
Die zu erwartende Wirkung für eine gegebene Kombination von Wirkstoffen kann nach S.R. Colby („Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967. 15, 20-22) wie folgt berechnet werden:The expected effect for a given combination of active ingredients can, according to S.R. Colby ("Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967, 15, 20-22) can be calculated as follows:
WennIf
X den Wirkungsgrad beim Einsatz des Wirkstoffes A in einer Aufwandmenge von m g/ha bedeutet,X means the efficiency when using the active ingredient A in an application rate of m g / ha,
Y den Wirkungsgrad beim Einsatz des Wirkstoffes B in einer Aufwandmenge von n g/ha bedeutet undY means the efficiency when using the active ingredient B in an application rate of n g / ha and
Bι den Wirkungsgrad beim Einsatz der Wirkstoffe A und B in Aufwandmengen von m und n g/ha bedeutet undBι means the efficiency when using the active ingredients A and B in application rates of m and n g / ha and
dann istthen
X - YX - Y
E„ = X + Y --E "= X + Y -
100100
Dabei wird der Wirkungsgrad in % ermittelt. Es bedeutet 0 % ein Wirkungsgrad, der demjenigen der Kontrolle entspricht, während ein Wirkungsgrad von 100 % bedeutet, dass kein Befall beobachtet wird. Ist die tatsächliche fungizide Wirkung größer als bereclmet, so ist die Kombination in ihrer Wirkung überadditiv, d.h. es liegt ein synergistischer Effekt vor. In diesem Fall muss der tatsächlich beobachtete Wirkungsgrad größer sein als der aus der oben angeführten Formel errechnete Wert für den erwarteten Wirkungsgrad E^. The efficiency is determined in%. It means 0% an efficiency that corresponds to that of the control, while an efficiency of 100% means that no infection is observed. If the actual fungicidal activity is greater than calculated, the combination of the combination is superadditive, ie there is a synergistic effect. In this case, the actually observed efficiency must be greater than the value for the expected efficiency E ^ calculated from the above formula.
Beispiel AExample A
Leptosphaeria nodorum-Test (Weizen) / protektivLeptosphaeria nodorum test (wheat) / protective
Lösungsmittel: 25 Gewichtsteile N,N-DimethylacetamidSolvent: 25 parts by weight of N, N-dimethylacetamide
Emulgator: 0,6 Gewichtsteile AlkylarylpolyglykoletherEmulsifier: 0.6 part by weight of alkylaryl polyglycol ether
Zur Herstellung einer zweckmäßigen Wirkstoffzubereitung vermischt man 1 Gewichtsteil Wirkstoffkombination mit den angegebenen Mengen Lösungsmittel und Emulgator und verdünnt das Konzentrat mit Wasser auf die gewünschte Konzentration. ' To produce a suitable preparation of active compound, 1 part by weight of active compound combination is mixed with the stated amounts of solvent and emulsifier and the concentrate is diluted with water to the desired concentration. '
Zur Prüfung auf protektive Wirksamkeit werden junge Pflanzen mit der Wirkstoffzubereitung in der angegebenen Aufwandmenge besprüht. Nach Antrocknen des Spritzbelages werden die Pflanzen mit einer Sporensuspension von Leptosphaeria nodorum besprüht. Die Pflanzen verbleiben 48 Stunden bei 20°C und 100 % relativerTo test for protective activity, young plants are sprayed with the active compound preparation in the stated application rate. After the spray coating has dried on, the plants are sprayed with a spore suspension of Leptosphaeria nodorum. The plants remain at 20 ° C and 100% relative for 48 hours
Luftfeuchtigkeit in einer Mcubationskabine.Humidity in a cubicle.
Die Pflanzen werden in einem Gewächshaus bei einer Temperatur von ca. 15°C und einer relativen Luftfeuchtigkeit von 80 % aufgestellt.The plants are placed in a greenhouse at a temperature of approx. 15 ° C and a relative humidity of 80%.
10 Tage nach der Inokulation erfolgt die Auswertung. Dabei bedeutet 0 % ein Wirkungsgrad, der demjenigen der Kontrolle entspricht, während ein Wirkungsgrad von 100 % bedeutet, dass kein Befall beobachtet wird. Tabelle AEvaluation is carried out 10 days after the inoculation. 0% means an efficiency that corresponds to that of the control, while an efficiency of 100% means that no infection is observed. Table A
Leptosphaeria nodorum-Test (Weizen) / protektivLeptosphaeria nodorum test (wheat) / protective
Beispiel BExample B
Puccinia-Test (Weizen) / kurativPuccinia test (wheat) / curative
Lösungsmittel: 25 Gewichtsteile N,N-DimethylacetamidSolvent: 25 parts by weight of N, N-dimethylacetamide
Emulgator: 0,6 Gewichtsteile AlkylarylpolyglykoletherEmulsifier: 0.6 part by weight of alkylaryl polyglycol ether
Zur Herstellung einer zweckmäßigen W kstoffzubereitung vermischt man 1 Gewichtsteil Wirkstoffkombination mit den angegebenen Mengen Lösungsmittel und Emulgator und verdünnt das Konzentrat mit Wasser auf die gewünschte Konzentration.To produce a suitable preparation of the material, 1 part by weight of active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.
Zur Prüfung auf kurative Wirksamkeit werden junge Pflanzen mit einer Sporensuspension von Puccinia recondita in einer 0,1 %igen wässrigen Agarlösung inokuliert. 48 Stunden nach der Inokulation werden die Pflanzen mit der Wirkstoffzübereitung in der angegebenen Aufwandmenge besprüht.To test for curative activity, young plants are inoculated with a spore suspension of Puccinia recondita in a 0.1% aqueous agar solution. 48 hours after the inoculation, the plants are sprayed with the preparation of active compound in the stated application rate.
Die Pflanzen werden in einem Gewächshaus bei einer Temperatur von ca. 20°C und einer relativen Luftfeuchtigkeit von ca. 80 % aufgestellt, um die Entwicklung von Rostpusteln zu begünstigen.The plants are placed in a greenhouse at a temperature of approx. 20 ° C and a relative humidity of approx. 80% in order to promote the development of rust pustules.
10 Tage nach der Inokulation erfolgt die Auswertung. Dabei bedeutet 0 % ein Wirkungsgrad, der demjenigen der Kontrolle entspricht, während ein Wirkungsgrad von 100 % bedeutet, dass kein Befall beobachtet wird. Tabelle BEvaluation is carried out 10 days after the inoculation. 0% means an efficiency that corresponds to that of the control, while an efficiency of 100% means that no infection is observed. Table B
Puccinia-Test (Weizen) / kurativPuccinia test (wheat) / curative

Claims

PatentansprflchePatentansprflche
Wirkstoffkombmation, enthaltend eine Verbindung der Formel (I)Combination of active substances containing a compound of the formula (I)
und and
eine Verbindung der Formel (LT)a compound of formula (LT)
(Prothioconazole)(Prothioconazole)
Mittel gemäß Anspruch 1, dadurch gekennzeichnet, dass in der Wirkstoffkombination das Gewichtsverhältnis von Wirkstoff der Formel (I)Agent according to claim 1, characterized in that in the active ingredient combination the weight ratio of active ingredient of formula (I)
zu Wirkstoff der Formel (H). 1 :0,02 bis 1 :20 beträgt.to active ingredient of formula (H). 1: 0.02 to 1:20.
Verfahren zur Bekämpfung von Pilzen, dadurch gekennzeichnet, dass man eine Wirkstoffkombination gemäß Anspruch 1 auf die Pilze und/oder deren Lebensraum ausbringt. Process for combating fungi, characterized in that an active ingredient combination according to claim 1 is applied to the fungi and / or their habitat.
. Verwendung der Wirkstoffkombination gemäß Anspruch 1 zur Bekämpfung von Pilzen., Use of the active ingredient combination according to claim 1 for combating fungi.
5. Verfahren zur Herstellung von fungiziden Mitteln, dadurch gekennzeichnet, dass man eine Wirkstoffkombination gemäß Anspruch 1 mit Streckmitteln und/oder oberflächenaktiven Stoffen vermischt. 5. A process for the preparation of fungicidal agents, characterized in that an active ingredient combination according to claim 1 is mixed with extenders and / or surface-active substances.
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RU2331192C2 (en) 2008-08-20
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PL374390A1 (en) 2005-10-17
WO2004000021A1 (en) 2003-12-31
AR039701A1 (en) 2005-03-09
GT200300123A (en) 2004-03-08
DE10228102A1 (en) 2004-01-15
ZA200410269B (en) 2006-02-22
US20060004070A1 (en) 2006-01-05
JP2005530831A (en) 2005-10-13
CA2490303A1 (en) 2003-12-31
TW200406153A (en) 2004-05-01
AU2003237930A1 (en) 2004-01-06
RU2005101615A (en) 2005-07-20

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