EP1578455A4 - POLYMER HYDROGEL MICROSPHERES ASSOCIATED WITH RADIOISOTOPES AND METHODS OF MAKING AND USING THE SAME - Google Patents

POLYMER HYDROGEL MICROSPHERES ASSOCIATED WITH RADIOISOTOPES AND METHODS OF MAKING AND USING THE SAME

Info

Publication number: EP1578455A4
Authority: EP; European Patent Office
Prior art keywords: radioisotopes; making; methods; same; polymer hydrogel
Prior art date: 2002-11-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP03779133A

Other languages

German (de)

French (fr)

Other versions

EP1578455A2 (en

Inventor

James A Krom

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biosphere Medical Inc

Original Assignee

Biosphere Medical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-11-04

Filing date

2003-10-17

Publication date

2008-12-31

2003-10-17 Application filed by Biosphere Medical Inc filed Critical Biosphere Medical Inc

2005-09-28 Publication of EP1578455A2 publication Critical patent/EP1578455A2/en

2008-12-31 Publication of EP1578455A4 publication Critical patent/EP1578455A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1255—Granulates, agglomerates, microspheres
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Dispersion Chemistry (AREA)
Optics & Photonics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP03779133A 2002-11-04 2003-10-17 POLYMER HYDROGEL MICROSPHERES ASSOCIATED WITH RADIOISOTOPES AND METHODS OF MAKING AND USING THE SAME Withdrawn EP1578455A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US42354702P	2002-11-04	2002-11-04
US423547P		2002-11-04
PCT/US2003/033140 WO2004040972A2 (en)	2002-11-04	2003-10-17	Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same

Publications (2)

Publication Number	Publication Date
EP1578455A2 EP1578455A2 (en)	2005-09-28
EP1578455A4 true EP1578455A4 (en)	2008-12-31

Family

ID=32312672

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP03779133A Withdrawn EP1578455A4 (en)	2002-11-04	2003-10-17	POLYMER HYDROGEL MICROSPHERES ASSOCIATED WITH RADIOISOTOPES AND METHODS OF MAKING AND USING THE SAME

Country Status (4)

Country	Link
EP (1)	EP1578455A4 (en)
AU (1)	AU2003285905A1 (en)
CA (1)	CA2507404A1 (en)
WO (1)	WO2004040972A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7449236B2 (en)	2002-08-09	2008-11-11	Boston Scientific Scimed, Inc.	Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7588825B2 (en)	2002-10-23	2009-09-15	Boston Scientific Scimed, Inc.	Embolic compositions
US7311861B2 (en)	2004-06-01	2007-12-25	Boston Scientific Scimed, Inc.	Embolization
CA2579612A1 (en) *	2004-09-24	2006-04-06	Biosphere Medical, Inc.	Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof
US20080095822A1 (en) *	2004-11-16	2008-04-24	Universite De Liege	Active Substance Delivery System Comprising A Hydrogel Atrix And Microcarriers
EP1838354A2 (en) *	2004-12-17	2007-10-03	A.S.B.L. Facultes Universitaires Notre-Dame De La Paix	Radioactive device
US7727555B2 (en)	2005-03-02	2010-06-01	Boston Scientific Scimed, Inc.	Particles
US7963287B2 (en)	2005-04-28	2011-06-21	Boston Scientific Scimed, Inc.	Tissue-treatment methods
US9463426B2 (en)	2005-06-24	2016-10-11	Boston Scientific Scimed, Inc.	Methods and systems for coating particles
US20070141727A1 (en) *	2005-12-15	2007-06-21	Kimberly-Clark Worldwide, Inc.	Luminescent metallic cluster particles and uses thereof
US7501179B2 (en)	2005-12-21	2009-03-10	Boston Scientific Scimed, Inc.	Block copolymer particles
WO2009046281A2 (en) *	2007-10-05	2009-04-09	Boston Scientific Scimed, Inc.	Injectable particles
EP2968165B1 (en)	2013-03-13	2023-09-13	Biosphere Medical, Inc.	Compositions and associated methods for radioisotope-binding microparticles
EP2923712A1 (en)	2014-03-28	2015-09-30	Spago Imaging AB	Nanostructures and applications thereof
EP3465697B1 (en) *	2016-05-24	2020-03-25	QSA Global Inc.	Low density spherical iridium source
CN111012929B (en) *	2019-11-27	2022-05-17	原子高科股份有限公司	Suppository carrying radioactive particles and preparation method thereof
EP4241792A1 (en)	2022-03-08	2023-09-13	Spago Nanomedical AB	Nanostructures and applications thereof
EP4241793A1 (en)	2022-03-08	2023-09-13	Spago Nanomedical AB	Globular nanostructures
CN118806966A (en) *	2023-04-06	2024-10-22	苏州大学	A polymer microsphere loaded with active metal particles and its preparation method and application
TW202525349A (en) *	2023-12-28	2025-07-01	白金科技股份有限公司	Microsphere and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5648100A (en) *	1991-05-29	1997-07-15	Assistance Publique Hopitaux De Paris	Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
WO2000023054A1 (en) *	1998-10-16	2000-04-27	Biosphere Medical, S.A.	Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same
US6248057B1 (en) *	1998-07-28	2001-06-19	Innerdyne, Inc.	Absorbable brachytherapy and chemotherapy delivery devices and methods
WO2002034300A1 (en) *	2000-10-25	2002-05-02	Sirtex Medical Limited	Polymer based radionuclide containing particulate material

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6015541A (en) *	1997-11-03	2000-01-18	Micro Therapeutics, Inc.	Radioactive embolizing compositions

2003
- 2003-10-17 CA CA002507404A patent/CA2507404A1/en not_active Abandoned
- 2003-10-17 WO PCT/US2003/033140 patent/WO2004040972A2/en not_active Ceased
- 2003-10-17 AU AU2003285905A patent/AU2003285905A1/en not_active Abandoned
- 2003-10-17 EP EP03779133A patent/EP1578455A4/en not_active Withdrawn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5648100A (en) *	1991-05-29	1997-07-15	Assistance Publique Hopitaux De Paris	Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
US6248057B1 (en) *	1998-07-28	2001-06-19	Innerdyne, Inc.	Absorbable brachytherapy and chemotherapy delivery devices and methods
WO2000023054A1 (en) *	1998-10-16	2000-04-27	Biosphere Medical, S.A.	Polyvinyl alcohol microspheres, and methods for making and therapeutic uses of the same
WO2002034300A1 (en) *	2000-10-25	2002-05-02	Sirtex Medical Limited	Polymer based radionuclide containing particulate material

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUCRET R P ET AL: "Therapeutic Embolization: Enhanced Radiolabeled Monitoring", RADIOLOGY, vol. 177, 1990, pages 571 - 575, XP002501359 *
SAKAKIBARA Y ET AL: "Prevascularization with gelatin micro spheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, vol. 124, no. 1, 1 July 2002 (2002-07-01), pages 50 - 56, XP002984640, ISSN: 0022-5223 *
VAN ES R J ET AL: "Tumour embolization of the Vx2 rabbit head and neck cancer model with Dextran hydrogel and Holmium-poly(L-lactic acid) microspheres: a radionuclide and histological pilot study", JOURNAL OF CRANIO-MAXILLO-FACIAL SURGERY : OFFICIAL PUBLICATION OF THE EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO-FACIAL SURGERY OCT 2001,, vol. 29, no. 5, 1 October 2001 (2001-10-01), pages 289 - 297, XP002500322 *
XP007906214, Retrieved from the Internet <URL:http://www.springer.com/chemistry/book/978-88-470-1103-8> [retrieved on 20081103] *

Also Published As

Publication number	Publication date
EP1578455A2 (en)	2005-09-28
AU2003285905A1 (en)	2004-06-07
WO2004040972A3 (en)	2004-10-14
WO2004040972A2 (en)	2004-05-21
CA2507404A1 (en)	2004-05-21

Publication	Publication Date	Title
EP1578455A4 (en)	2008-12-31	POLYMER HYDROGEL MICROSPHERES ASSOCIATED WITH RADIOISOTOPES AND METHODS OF MAKING AND USING THE SAME
AU2003256217A8 (en)	2004-03-29	New polymers and applications
ATE394844T1 (en)	2008-05-15	DATA TRANSMISSION WITH NON-UNIFORM DISTRIBUTION OF DATA RATES FOR A MULTIPLE INPUTS AND MULTIPLE OUTPUTS SYSTEM
GB0208909D0 (en)	2002-05-29	Three-dimensional computer modelling
EP1273610A4 (en)	2005-03-30	POLYESTER RINE AND PRODUCTION PROCESS
EP1461665A4 (en)	2006-11-02	ELECTRONIC COLOR DISPLAY USED FOR THE PRODUCTION OF A SCREEN TEST
AU2002358097A1 (en)	2003-07-09	Process and equipment for the production of granules of expandable thermoplastic polymers
PL371491A1 (en)	2005-06-13	Superabsorbent polymer particles
AU2003235865A1 (en)	2003-11-11	Styrene polymer resin and composition thereof
AU2002304212A1 (en)	2003-05-01	Plastic cartridge case and device for the production thereof
SG110031A1 (en)	2005-04-28	Ethylene-based polymer resin
DE60236188D1 (en)	2010-06-10	POLYMERIC HYDROGEL
DE60237990D1 (en)	2010-11-25	A POLYMER PARTICLE DISPERSION AND TONER PRODUCTION METHOD
AU7921500A (en)	2001-05-14	High-purity polymer granules and method for the production thereof
AU2003245245A1 (en)	2003-09-04	Non-woven shaped fiber media loaded with expanded polymer microspheres
AU2003271931A1 (en)	2004-05-04	Moulded thermoplastic articles and processto make them
DE60318658D1 (en)	2008-03-06	Flat fiber optic cables and their production process
AU2003221357A1 (en)	2003-09-22	Spherical calcium phosphate molding and use thereof
GB0222194D0 (en)	2002-10-30	Polymer film production
AU2002250760A1 (en)	2003-11-10	Securing and identifying label and the production and use thereof
EP1720025A4 (en)	2008-04-09	TEST EQUIPMENT AND GUIDE-CABLES UNIT
EP1517879A4 (en)	2006-09-13	AMINOALKYLPHENOLS AND METHODS OF USE AND MANUFACTURE
AU2003223267A8 (en)	2003-10-13	Novel polymer/substrate and polymer/polymer interfaces and methods of modeling and forming same
AU2002230410A1 (en)	2003-06-10	Incrementally increasing or decreasing the available functionalities of a computer program
GB0122532D0 (en)	2001-11-07	Novel polymers monomers and their production and use

Legal Events

Date	Code	Title	Description
2005-08-12	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2005-09-28	17P	Request for examination filed	Effective date: 20050601
2005-09-28	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
2005-09-28	AX	Request for extension of the european patent	Extension state: AL LT LV MK
2006-02-22	DAX	Request for extension of the european patent (deleted)
2007-04-13	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 1094764 Country of ref document: HK
2007-08-29	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: BIOSPHERE MEDICAL, INC.
2008-12-10	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 51/12 20060101AFI20081106BHEP
2008-12-31	A4	Supplementary search report drawn up and despatched	Effective date: 20081203
2009-02-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2009-03-18	18W	Application withdrawn	Effective date: 20090211
2013-05-10	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1094764 Country of ref document: HK