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EP1545551A4 - Abgabe von modulatoren der glutamat-vermittelten neurotransmission an das innenohr - Google Patents

Abgabe von modulatoren der glutamat-vermittelten neurotransmission an das innenohr

Info

Publication number
EP1545551A4
EP1545551A4 EP02768820A EP02768820A EP1545551A4 EP 1545551 A4 EP1545551 A4 EP 1545551A4 EP 02768820 A EP02768820 A EP 02768820A EP 02768820 A EP02768820 A EP 02768820A EP 1545551 A4 EP1545551 A4 EP 1545551A4
Authority
EP
European Patent Office
Prior art keywords
internal ear
glutamatergic neurotransmission
ear administration
neurotransmission modulators
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02768820A
Other languages
English (en)
French (fr)
Other versions
EP1545551A1 (de
Inventor
Jean-Luc Puel
Remy Pujol
Yves Christen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Durect Corp
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Durect Corp filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Publication of EP1545551A1 publication Critical patent/EP1545551A1/de
Publication of EP1545551A4 publication Critical patent/EP1545551A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP02768820A 2002-09-06 2002-09-06 Abgabe von modulatoren der glutamat-vermittelten neurotransmission an das innenohr Withdrawn EP1545551A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/028519 WO2004022069A1 (en) 2002-09-06 2002-09-06 Delivery of modulators of glutamate-mediated neurotransmission to the inner ear

Publications (2)

Publication Number Publication Date
EP1545551A1 EP1545551A1 (de) 2005-06-29
EP1545551A4 true EP1545551A4 (de) 2008-10-22

Family

ID=31975588

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02768820A Withdrawn EP1545551A4 (de) 2002-09-06 2002-09-06 Abgabe von modulatoren der glutamat-vermittelten neurotransmission an das innenohr

Country Status (5)

Country Link
EP (1) EP1545551A4 (de)
JP (1) JP2006502158A (de)
AU (2) AU2002331830A1 (de)
CA (1) CA2497867A1 (de)
WO (1) WO2004022069A1 (de)

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KR101189261B1 (ko) * 2004-03-29 2012-10-09 앵스티띠 나셔날 드 라 쌍뜨 에 드 라 르셰르슈 메디깔 와우각 흥분독성에 의해 유발된 이명의 치료를 위한 nmda 수용체 길항제의 용도
US20060063802A1 (en) * 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US9072662B2 (en) 2004-03-29 2015-07-07 Auris Medical Ag Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en) 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
DE102005004343A1 (de) 2005-01-25 2006-08-10 Eberhard-Karls-Universität Tübingen Universitätsklinikum Behandlung von Phantomphänomenen
JP2008531726A (ja) * 2005-03-04 2008-08-14 ニューロシステック コーポレイション 改良されたガシクリジン製剤
JP5058163B2 (ja) * 2005-07-22 2012-10-24 メドトロニック，インコーポレイテッド 薬剤を吐出する小型ポンプ
BRPI0520588B8 (pt) * 2005-09-28 2021-05-25 Auris Medical Ag uso de composições farmacêuticas para o tratamento de doenças do ouvido interno
CN104840416A (zh) * 2005-09-28 2015-08-19 奥里斯医学股份有限公司 治疗内耳疾病的药用组合物
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
EP2056793A4 (de) * 2006-07-31 2011-08-17 Neurosystec Corp Nanopartikel mit freier base aus gacyclidine
EP2548552B1 (de) * 2007-09-12 2015-11-18 Merz Pharma GmbH & Co. KGaA Titrationspaket für 1-Amino-Alkylcyclohexane
DE102007063210A1 (de) 2007-12-20 2009-06-25 Eberhard-Karls-Universität Tübingen Universitätsklinikum Arzneimittel zur Behandlung von Phantomphänomenen
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
AU2009307825A1 (en) * 2008-10-22 2010-04-29 Rick FRIEDMAN Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor
CN106344495A (zh) * 2008-12-22 2017-01-25 奥德纳米有限公司 用于治疗耳部病症的控制释放耳感觉细胞调节剂组合物
US20110294890A1 (en) * 2010-05-28 2011-12-01 Merz Pharma Gmbh & Co. Kgaa Neramexane for the treatment or prevention of inner ear disorders
WO2013087090A1 (en) 2011-12-12 2013-06-20 Auris Medical Ag Treatment of tinnitus through modulation of chloride co-transporter nkcc1 in the auditory system
EP3598971B1 (de) 2013-01-22 2024-03-20 Vistagen Therapeutics, Inc. Dosierungsformen und therapeutische verwendungen von l-4-chlorkynurenin
US10500392B2 (en) 2016-08-24 2019-12-10 Cochlear Limited Monitoring stimulating assembly insertion
US11918778B2 (en) 2021-08-19 2024-03-05 Innovative Health Strategies Llc Smart self-activating wearable device for automatically injecting medicines

Citations (2)

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US6066652A (en) * 1995-08-02 2000-05-23 Tinnitus Forschungs-Und Entwicklungs Gmbh Method for treating diseases of the inner ear using adamantane derivatives
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms

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US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms

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DENK D-M ET AL: "CAROVERINE IN TINNITUS TREATMENT A PLACEBO-CONTROLLED BLIND STUDY", ACTA OTO-LARYNGOLOGICA, SCANDINAVIAN UNIVERSITY PRESS, OSLO, NO, vol. 117, no. 6, 1 November 1997 (1997-11-01), pages 825 - 830, XP009043354, ISSN: 0001-6489 *
HIRBEC H ET AL: "GACYCLIDINE: A NEW NEUROPROTECTIVE AGENT ACTING AT THE N-METHYL-D-ASPARTATE RECEPTOR", CNS DRUG REVIEWS, BRANFORD, CT, US, vol. 2, no. 7, 1 January 2001 (2001-01-01), pages 172 - 198, XP008032600, ISSN: 1080-563X *
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See also references of WO2004022069A1 *
SEIDMAN M D: "GLUTAMATE ANTAGONISTS, STEROIDS, AND ANTIOXIDANTS AS THERAPEUTIC OPTIONS FOR HEARING LOSS AND TINNITUS AND THE USE OF AN INNER EAR DRUG DELIVERY SYSTEMS", INTERNATIONAL TINNITUS JOURNAL, BAD KISSINGEN, vol. 4, no. 2, 1 January 1998 (1998-01-01), pages 148 - 154, XP009043381, ISSN: 0946-5448 *
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Also Published As

Publication number Publication date
JP2006502158A (ja) 2006-01-19
CA2497867A1 (en) 2004-03-18
AU2009233659A1 (en) 2009-11-26
AU2002331830A1 (en) 2004-03-29
WO2004022069A1 (en) 2004-03-18
EP1545551A1 (de) 2005-06-29

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