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EP1417304A4 - Methode et composition permettant d'inhiber l'activite de l'heparanase - Google Patents

Methode et composition permettant d'inhiber l'activite de l'heparanase

Info

Publication number
EP1417304A4
EP1417304A4 EP02763248A EP02763248A EP1417304A4 EP 1417304 A4 EP1417304 A4 EP 1417304A4 EP 02763248 A EP02763248 A EP 02763248A EP 02763248 A EP02763248 A EP 02763248A EP 1417304 A4 EP1417304 A4 EP 1417304A4
Authority
EP
European Patent Office
Prior art keywords
immunogen
heparanase
composition
present
heparanase activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02763248A
Other languages
German (de)
English (en)
Other versions
EP1417304A2 (fr
Inventor
Peter Bohlen
Daniel Hicklin
Paul Kussie
Yiwen Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ImClone LLC
Original Assignee
ImClone Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ImClone Systems Inc filed Critical ImClone Systems Inc
Publication of EP1417304A2 publication Critical patent/EP1417304A2/fr
Publication of EP1417304A4 publication Critical patent/EP1417304A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

L'invention concerne des méthodes permettant d'inhiber l'activité de l'héparanase et de traiter différents états par administration, à un animal, d'une quantité efficace d'un immunogène sollicitant une réponse immunitaire contre l'héparanase. Selon l'invention, l'immunogène est l'héparanase ou un fragment de celle-ci, cet immunogène étant, de préférence, une cellule présentant un antigène (APC), telle qu'une cellule dendritique (DC) affichant l'héparanase ou un fragment de celle-ci sur sa surface. L'invention concerne également des compositions contenant ledit immunogène.
EP02763248A 2001-07-13 2002-07-10 Methode et composition permettant d'inhiber l'activite de l'heparanase Withdrawn EP1417304A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30544601P 2001-07-13 2001-07-13
US305446P 2001-07-13
US35755302P 2002-02-15 2002-02-15
US357553P 2002-02-15
PCT/US2002/021773 WO2003006645A2 (fr) 2001-07-13 2002-07-10 Methode et composition permettant d'inhiber l'activite de l'heparanase

Publications (2)

Publication Number Publication Date
EP1417304A2 EP1417304A2 (fr) 2004-05-12
EP1417304A4 true EP1417304A4 (fr) 2005-11-23

Family

ID=26974593

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02763248A Withdrawn EP1417304A4 (fr) 2001-07-13 2002-07-10 Methode et composition permettant d'inhiber l'activite de l'heparanase

Country Status (4)

Country Link
EP (1) EP1417304A4 (fr)
JP (1) JP2005521379A (fr)
CA (1) CA2453566A1 (fr)
WO (1) WO2003006645A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1479764A1 (fr) * 2003-05-19 2004-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Peptides derives de Heparanas pour la vaccination des patients cancereux
ES2251289B1 (es) * 2004-02-27 2007-07-01 Bioiberica, S.A. Nuevo uso terapeutico de un grupo de polisacaridos sulfatados.
EP2987536A1 (fr) * 2008-03-31 2016-02-24 Shiseido Co., Ltd. Préparation orale, préparation d'injection, préparation externe pour la peau et procédé cosmétique pour prévenir ou améliorer les rides
CA2959624A1 (fr) * 2014-09-02 2016-03-10 The Children's Hospital Of Philadelphia Compositions et procedes permettant l'inhibition de la chondrogenese
US20230233598A1 (en) * 2020-07-02 2023-07-27 Institut Francais De Recherche Pour L'exploitation De La Mer (Ifremer) Marine Bacterial Exopolysaccharide Derivatives and Uses Thereof in the Treatment of Mucopolysaccharidoses

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011798A1 (fr) * 1997-09-02 1999-03-11 Insight Strategy & Marketing Ltd. Polynucleotide codant pour un polypeptide presentant une activite d'heparanase et son expression par des cellules transductees
WO1999057153A1 (fr) * 1998-05-01 1999-11-11 Insight Strategy & Marketing Ltd. Sondes moleculaires specifiques pour heparanase et leur mise en application dans la medecine et dans la recherche
WO2000052178A1 (fr) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide codant pour un polypeptide ayant une activite d'heparanase et expression de ce polynucleotide dans des cellules genetiquement modifiees
WO2001035967A1 (fr) * 1999-11-19 2001-05-25 Abbott Gmbh & Co. Kg Inhibiteurs d'heparanase utilises dans le traitement de l'insuffisance cardiaque

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1280613A (zh) * 1997-10-28 2001-01-17 澳大利亚国立大学 编码哺乳动物内切葡糖醛酸糖苷酶的分离的核酸分子及其应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999011798A1 (fr) * 1997-09-02 1999-03-11 Insight Strategy & Marketing Ltd. Polynucleotide codant pour un polypeptide presentant une activite d'heparanase et son expression par des cellules transductees
WO1999057153A1 (fr) * 1998-05-01 1999-11-11 Insight Strategy & Marketing Ltd. Sondes moleculaires specifiques pour heparanase et leur mise en application dans la medecine et dans la recherche
WO2000052178A1 (fr) * 1999-03-01 2000-09-08 Insight Strategy & Marketing Ltd. Polynucleotide codant pour un polypeptide ayant une activite d'heparanase et expression de ce polynucleotide dans des cellules genetiquement modifiees
WO2001035967A1 (fr) * 1999-11-19 2001-05-25 Abbott Gmbh & Co. Kg Inhibiteurs d'heparanase utilises dans le traitement de l'insuffisance cardiaque

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DEMPSEY L A ET AL: "Heparanase, a potential regulator of cell-matrix interactions", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 25, no. 8, 1 August 2000 (2000-08-01), pages 349 - 351, XP004215172, ISSN: 0968-0004 *
DONG JIAN ET AL: "Molecular cloning, chromosomal localization, and expression of mouse heparanase", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 42, March 2001 (2001-03-01), & 92ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; NEW ORLEANS, LA, USA; MARCH 24-28, 2001, pages 513 - 514, XP001204179, ISSN: 0197-016X *
LI JIN ET AL: "Immunochemical localization of heparanase in mouse and human melanomas", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 45, no. 6, 15 June 1990 (1990-06-15), pages 1088 - 1095, XP002115495, ISSN: 0020-7136 *
LIDER O ET AL: "Inhibition of T lymphocyte heparanase by heparin prevents T cell migration and T cell-mediated immunity", EUROPEAN JOURNAL OF IMMUNOLOGY, WEINHEIM, DE, vol. 20, no. 3, March 1990 (1990-03-01), pages 493 - 499, XP002094004, ISSN: 0014-2980 *
MIAO HUA-QUAN ET AL: "Cloning, expression, and purification of mouse heparanase", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 43, March 2002 (2002-03-01), & 93RD ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH; SAN FRANCISCO, CALIFORNIA, USA; APRIL 06-10, 2002, pages 535 - 536, XP001204251, ISSN: 0197-016X *
MIAO HUA-QUAN ET AL: "Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides", INTERNATIONAL JOURNAL OF CANCER, vol. 83, no. 3, 29 October 1999 (1999-10-29), pages 424 - 431, XP009041034, ISSN: 0020-7136 *
PARISH C R ET AL: "TREATMENT OF CENTRAL NERVOUS SYSTEM INFLAMMATION WITH INHIBITORS OFBASEMENT MEMBRANE DEGRADATION", IMMUNOLOGY AND CELL BIOLOGY, CARLTON, AU, vol. 76, 1998, pages 104 - 113, XP002922989 *
THURNER B ET AL: "Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 223, no. 1, 1 February 1999 (1999-02-01), pages 1 - 15, XP004155750, ISSN: 0022-1759 *

Also Published As

Publication number Publication date
EP1417304A2 (fr) 2004-05-12
WO2003006645A2 (fr) 2003-01-23
JP2005521379A (ja) 2005-07-21
WO2003006645A3 (fr) 2003-07-24
CA2453566A1 (fr) 2003-01-23

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