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EP1401387A1 - Carnitine et acylcarnitines destinees au traitement et a la prophylaxie de defauts de pigmentation - Google Patents

Carnitine et acylcarnitines destinees au traitement et a la prophylaxie de defauts de pigmentation

Info

Publication number
EP1401387A1
EP1401387A1 EP02747355A EP02747355A EP1401387A1 EP 1401387 A1 EP1401387 A1 EP 1401387A1 EP 02747355 A EP02747355 A EP 02747355A EP 02747355 A EP02747355 A EP 02747355A EP 1401387 A1 EP1401387 A1 EP 1401387A1
Authority
EP
European Patent Office
Prior art keywords
polyethylene glycol
acid
ether
advantageously
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02747355A
Other languages
German (de)
English (en)
Inventor
Werner Berens
Thomas Blatt
Reza Keyhani
Claudia Mundt
Melanie Schmidt
Rainer Wolber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP1401387A1 publication Critical patent/EP1401387A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • Melanin is formed as the final stage of an oxidative process, in which tyrosine with the help of the enzyme tyrosinase via 3,4-dihydroxyphenylalanine (dopa), dopa-quinone, leucodopachrome, dopachrome, 5,6-dihydroxyindole and indole-5,6-quinone finally in Melanin is converted.
  • tyrosine with the help of the enzyme tyrosinase via 3,4-dihydroxyphenylalanine (dopa), dopa-quinone, leucodopachrome, dopachrome, 5,6-dihydroxyindole and indole-5,6-quinone finally in Melanin is converted.
  • L-Carnitine [3-hydroxy-4- (trimethylammonio) butyric acid betaine] has the structural formula
  • Medical topical compositions in the sense of the present invention generally contain one or more medicaments in an effective concentration.
  • medicaments in an effective concentration.
  • Esters of benzalmalonic acid preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester,
  • alkanolamides such as Cocamide MEA / DEA / MIPA
  • amine oxides such as cocoamidopropylamine oxide
  • ethers for example ethoxylated / propoxylated alcohols, ethoxyherten / propoxyherte esters, ethoxyherte / propoxyherte Glyce ⁇ nester, ethoxyherte / propoxyherte Choleste ⁇ - ne, ethoxylated / propoxylated triglyceride esters, ethoxylated propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkyl polyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside.
  • alkyl polyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside.
  • the surface-active substance can be present in the preparations according to the invention in a concentration between 1 and 95% by weight, based on the total weight of the preparations.
  • silicone oils of a similar constitution to the compounds described above, the organic side chains of which are derivatized, for example polyethoxylated and / or polypropoxylated.
  • these include, for example, polysiloxane-polyalkyl-polyether copolymers such as the cetyl-dimethicone copolyol, the (cetyl-dimethicone copolyol (and) polyglyceryl-4-isostearate (and) hexyl laurate)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne l'utilisation de carnitine et/ou d'une ou plusieurs acylcarnitines dans la fabrication de préparations cosmétiques ou dermatologiques destinées au traitement et/ou à la prophylaxie de défauts de pigmentation.
EP02747355A 2001-06-19 2002-06-07 Carnitine et acylcarnitines destinees au traitement et a la prophylaxie de defauts de pigmentation Withdrawn EP1401387A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129504 2001-06-19
DE10129504A DE10129504A1 (de) 2001-06-19 2001-06-19 Verwendung von Carnitin und/oder einem oder mehreren Acyl-Carnitinen zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe von Pigmentierungsstörungen
PCT/EP2002/006255 WO2002102338A1 (fr) 2001-06-19 2002-06-07 Carnitine et acylcarnitines destinees au traitement et a la prophylaxie de defauts de pigmentation

Publications (1)

Publication Number Publication Date
EP1401387A1 true EP1401387A1 (fr) 2004-03-31

Family

ID=7688677

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02747355A Withdrawn EP1401387A1 (fr) 2001-06-19 2002-06-07 Carnitine et acylcarnitines destinees au traitement et a la prophylaxie de defauts de pigmentation

Country Status (5)

Country Link
US (1) US20040170585A1 (fr)
EP (1) EP1401387A1 (fr)
JP (1) JP2004534067A (fr)
DE (1) DE10129504A1 (fr)
WO (1) WO2002102338A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2519998A1 (fr) * 2003-03-28 2004-10-14 Lonza Inc. Compositions topiques de l-carnitine
ITMI20041603A1 (it) * 2004-08-04 2004-11-04 Vama Farmacosmetica S R L Materia prima cosmetica a base di 1-carnitina per preparato ad effetto idratante di lunga durata e preparato cosmetico ottenuto con questa materia prima
US20070122509A1 (en) * 2004-12-02 2007-05-31 Molecular Research Center, Inc. Antioxidant dietary supplement compositions and methods for maintaining healthy skin
US9579298B2 (en) 2004-12-02 2017-02-28 Piotr Chomczynski Antioxidant dietary supplement compositions and methods for maintaining healthy skin
DE102004060314A1 (de) * 2004-12-08 2006-08-31 Beiersdorf Ag Wirkstoffkombinationen aus einem oder mehreren Isoflavonoiden und Carnitin und/oder einem oder mehreren Acyl-Carnitinen
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
DE102005062356A1 (de) * 2005-12-23 2007-06-28 Henkel Kgaa Verringerung der Haaralterung
CA2686905C (fr) * 2007-05-11 2015-07-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Gel utile pour l'apport d'ingredients cosmetiques actifs
DE102009044975A1 (de) * 2009-07-23 2011-01-27 Henkel Ag & Co. Kgaa Verwendung von Carnitin und Dihydroquercetin zur positiven Beeinflussung des natürlichen Pigmentierungsprozesses
DE102009044974A1 (de) * 2009-07-23 2011-01-27 Henkel Ag & Co. Kgaa Verwendung von Dihydroquercetin und mindestens einer Aminosäure zur positiven Beeinflussung des natürlichen Pigmentierungsprozesses
DE102009044964A1 (de) * 2009-09-24 2011-03-31 Henkel Ag & Co. Kgaa Verwendung einer Kombination aus Carnitin und/oder eines Carnitin-Derivats mit Purin und/oder einem Purin-Derivat zur Beeinflussung des natürlichen Pigmentierungsprozesses
WO2012021733A2 (fr) 2010-08-12 2012-02-16 Pacific Biosciences Of California, Inc. Systèmes et composés pour atténuer une photodégradation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839159A (en) * 1988-02-08 1989-06-13 Topicarn, Inc. Topical L-carnitine composition
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
JP3229517B2 (ja) * 1995-04-18 2001-11-19 カネボウ株式会社 美白化粧料
US5939082A (en) * 1995-11-06 1999-08-17 The Procter & Gamble Company Methods of regulating skin appearance with vitamin B3 compound
US5834513A (en) * 1996-04-25 1998-11-10 Avon Products, Inc. Oxa diacids and related compounds for treating skin conditions
US6337320B1 (en) * 1996-10-11 2002-01-08 Thione International, Inc. Reparatives for ultraviolet radiation skin damage
DE19806890A1 (de) * 1998-02-19 1999-08-26 Beiersdorf Ag Kosmetische und dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Antioxidans sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
DE19806947A1 (de) * 1998-02-19 1999-08-26 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Chinon und oder mindestens einem Hydrochinon sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
DE19806889A1 (de) * 1998-02-19 1999-08-26 Beiersdorf Ag Verwendung von Acyl-Carnitin
DE19806946A1 (de) * 1998-02-19 1999-09-09 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus mindestens einer Substanz gewählt aus der Gruppe, bestehend aus Carnitin und den Acylcarnitinen, und mindestens einem Retinoid sowie Zubereitungen mit einem Gehalt an solchen Wirkstoffkombinationen
US20020044913A1 (en) * 2000-02-11 2002-04-18 Hamilton Nathan D. Cosmetics to support skin metabolism
DE10032964B4 (de) * 2000-07-06 2017-10-12 Beiersdorf Ag Verwendung von Kreatin in kosmetischen oder dermatologischen Zubereitungen
DE10036797A1 (de) * 2000-07-28 2002-02-07 Beiersdorf Ag Verwendung von Kombinationen mit einem Gehalt an Carnitinen
WO2002011717A1 (fr) * 2000-08-07 2002-02-14 Juvenon, Inc. Cosmetiques destines a aider le metabolisme cutane

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO02102338A1 *

Also Published As

Publication number Publication date
DE10129504A1 (de) 2003-01-09
WO2002102338A1 (fr) 2002-12-27
JP2004534067A (ja) 2004-11-11
US20040170585A1 (en) 2004-09-02

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Inventor name: WOLBER, RAINER

Inventor name: MUNDT, CLAUDIA

Inventor name: SCHMIDT, MELANIE

Inventor name: KEYHANI, REZA

Inventor name: BLATT, THOMAS

Inventor name: BERENS, WERNER

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