EP1499277A4 - Modification de comportement alimentaire - Google Patents
Modification de comportement alimentaireInfo
- Publication number
- EP1499277A4 EP1499277A4 EP02768992A EP02768992A EP1499277A4 EP 1499277 A4 EP1499277 A4 EP 1499277A4 EP 02768992 A EP02768992 A EP 02768992A EP 02768992 A EP02768992 A EP 02768992A EP 1499277 A4 EP1499277 A4 EP 1499277A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- subject
- essence
- change
- decreasing
- intake
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Liquid Developers In Electrophotography (AREA)
- Toilet Supplies (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fats And Perfumes (AREA)
- Plural Heterocyclic Compounds (AREA)
- Lubricants (AREA)
- Lasers (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20080022583 EP2050460A1 (fr) | 2001-09-24 | 2002-09-24 | PYY et ses agonistes pour la modification du comportement d'alimentation |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32440601P | 2001-09-24 | 2001-09-24 | |
| US324406P | 2001-09-24 | ||
| GBGB0200507.2A GB0200507D0 (en) | 2002-01-10 | 2002-01-10 | Appetite suppression |
| GB0200507 | 2002-01-10 | ||
| US39210902P | 2002-06-28 | 2002-06-28 | |
| US392109P | 2002-06-28 | ||
| PCT/US2002/031944 WO2003026591A2 (fr) | 2001-09-24 | 2002-09-24 | Modification de comportement alimentaire |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP20080022583 Division EP2050460A1 (fr) | 2001-09-24 | 2002-09-24 | PYY et ses agonistes pour la modification du comportement d'alimentation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP1499277A2 EP1499277A2 (fr) | 2005-01-26 |
| EP1499277A4 true EP1499277A4 (fr) | 2005-08-31 |
| EP1499277B1 EP1499277B1 (fr) | 2009-01-07 |
Family
ID=27256373
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02768992A Expired - Lifetime EP1499277B1 (fr) | 2001-09-24 | 2002-09-24 | Pyy3-36 pour pour la reduction ou la prevention de l'obesite |
| EP20080022583 Withdrawn EP2050460A1 (fr) | 2001-09-24 | 2002-09-24 | PYY et ses agonistes pour la modification du comportement d'alimentation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP20080022583 Withdrawn EP2050460A1 (fr) | 2001-09-24 | 2002-09-24 | PYY et ses agonistes pour la modification du comportement d'alimentation |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7459432B2 (fr) |
| EP (2) | EP1499277B1 (fr) |
| JP (3) | JP2005508324A (fr) |
| KR (1) | KR100989647B1 (fr) |
| CN (1) | CN100350968C (fr) |
| AT (1) | ATE419863T1 (fr) |
| AU (1) | AU2002332054B2 (fr) |
| BR (1) | BR0212985A (fr) |
| CA (1) | CA2461345A1 (fr) |
| DE (1) | DE60230818D1 (fr) |
| DK (1) | DK1499277T3 (fr) |
| ES (1) | ES2320979T3 (fr) |
| HU (1) | HU228621B1 (fr) |
| IL (3) | IL160983A0 (fr) |
| MX (1) | MXPA04002751A (fr) |
| NZ (1) | NZ532427A (fr) |
| PL (1) | PL205971B1 (fr) |
| WO (1) | WO2003026591A2 (fr) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| DE60045030D1 (de) | 1999-02-10 | 2010-11-11 | Curis Inc | Peptid yy (pyy) zur behandlung von glukose stoffwechselkrankheiten |
| US7745216B2 (en) | 1999-02-10 | 2010-06-29 | Curis, Inc. | Methods and reagents for treating glucose metabolic disorders |
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| MXPA03005388A (es) | 2000-12-14 | 2003-09-25 | Amylin Pharmaceuticals Inc | Peptido yy y agonistas de peptido yy para el tratamiento de desordenes metabolicos. |
| GB0121709D0 (en) * | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| PL205971B1 (pl) * | 2001-09-24 | 2010-06-30 | Imp Innovations Ltd | Zastosowanie PYY₃-₃₆ do wytwarzania leku na ograniczanie apetytu, zmniejszenie otyłości lub do zapobiegania otyłości |
| US20050015820A1 (en) | 2001-09-24 | 2005-01-20 | Michael Cowley | Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7138402B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | Pyrrolopyrimidines and related analogs as HSP90-inhibitors |
| US7166575B2 (en) * | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| AU2003299722A1 (en) * | 2002-12-17 | 2004-07-14 | Mdrna, Inc. | Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity |
| US7186692B2 (en) * | 2002-12-17 | 2007-03-06 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| US7229966B2 (en) * | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP1594439A2 (fr) | 2003-02-13 | 2005-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Regulation de la prise alimentaire et de la production de glucose par modulation des niveaux d'acyl-coa gras de chaine longue dans l'hypothalamus |
| WO2005000222A2 (fr) | 2003-05-30 | 2005-01-06 | Amylin Pharmaceuticals, Inc. | Nouveaux procedes et nouvelles compositions pour une administration amelioree par voie muqueuse de peptides et de proteines |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| EP1718665B1 (fr) | 2004-02-11 | 2013-04-10 | Amylin Pharmaceuticals, LLC | Polypeptides hybrides presentant des proprietes pouvant etre choisies |
| JP5638177B2 (ja) | 2004-02-11 | 2014-12-10 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 膵臓ポリペプチドファミリーモチーフおよびそのモチーフを含むポリペプチド |
| WO2005080424A2 (fr) * | 2004-02-23 | 2005-09-01 | Rheoscience A/S | Analogues du peptide yy |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| GB0411014D0 (en) * | 2004-05-18 | 2004-06-23 | Haptogen Ltd | Methods for the control treatment and management of obesity |
| WO2006007412A2 (fr) * | 2004-06-16 | 2006-01-19 | Nastech Pharmaceutical Company Inc. | Preparations a base de peptide yy presentant une stabilite accrue et une meilleure resistance aux agents microbiens |
| US9399054B2 (en) * | 2004-07-12 | 2016-07-26 | Emisphere Technologies, Inc. | Compositions for delivering peptide YY and PYY agonists |
| US7928060B2 (en) | 2004-10-08 | 2011-04-19 | Amylin Pharmaceuticals, Inc. | Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them |
| EP1841796A2 (fr) * | 2004-12-02 | 2007-10-10 | Domantis Limited | Anticorps bispecifiques de domaine visant l'albumine serique et glp-1 ou pyy |
| CA2588594C (fr) | 2004-12-13 | 2014-02-18 | Amylin Pharmaceuticals, Inc. | Motifs de famille de polypeptides pancreatiques, polypeptides et leurs methodes |
| WO2006083761A2 (fr) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solutions de solvant/polymere utilisees comme vehicules de suspension |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| PA8660701A1 (es) * | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| AU2006213607A1 (en) | 2005-02-11 | 2006-08-17 | Amylin Pharmaceuticals, Llc | GIP analog and hybrid polypeptides with selectable properties |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| GB0511986D0 (en) * | 2005-06-13 | 2005-07-20 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| EP2330125A3 (fr) | 2005-08-11 | 2012-12-12 | Amylin Pharmaceuticals, Inc. | Polypeptides hybrides ayant des propriétés sélectionnables |
| EP1922336B1 (fr) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Polypeptides hybrides presentant des proprietes selectionnables |
| EP1934245B1 (fr) * | 2005-09-21 | 2011-07-13 | 7TM Pharma A/S | Agonistes selectifs du recepteur y2 pour applications therapeutiques |
| CN101268099A (zh) | 2005-09-21 | 2008-09-17 | 7Tm制药联合股份有限公司 | 用于治疗性干预的y4选择性受体激动剂 |
| BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
| WO2007039318A2 (fr) * | 2005-10-06 | 2007-04-12 | Bayer Schering Pharma Aktiengesellschaft | Analogues du neuropeptide y |
| US20080255084A1 (en) | 2005-10-21 | 2008-10-16 | Randy Lee Webb | Combination of Organic Compounds |
| US20070232537A1 (en) * | 2005-12-19 | 2007-10-04 | Nastech Pharmaceutical Company Inc. | Intranasal pyy formulations with improved transmucosal pharmacokinetics |
| WO2007085887A1 (fr) * | 2006-01-27 | 2007-08-02 | Pfizer Products Inc. | Agonistes du pyy et leurs utilisations |
| DE602007009377D1 (de) | 2006-05-30 | 2010-11-04 | Intarcia Therapeutics Inc | Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem |
| US8977517B2 (en) * | 2006-06-05 | 2015-03-10 | Creighton University | System and methods for evaluating efficacy of appetite-affecting drugs |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| EP2359808B1 (fr) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Système de libération osmotique avec ensemble de piston |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| EP2698157B1 (fr) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras |
| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Msd株式会社 | インドールジオン誘導体 |
| CN104000779A (zh) | 2007-04-23 | 2014-08-27 | 精达制药公司 | 促胰岛素释放肽的混悬制剂及其应用 |
| WO2008151257A2 (fr) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US7814038B1 (en) * | 2007-12-06 | 2010-10-12 | Dominic John Repici | Feedback-tolerant method and device producing weight-adjustment factors for pre-synaptic neurons in artificial neural networks |
| MX2010008632A (es) * | 2008-02-08 | 2010-08-30 | Ambrx Inc | Leptina-polipeptidos modificados y sus usos. |
| CA2726861C (fr) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Dispositifs, formulations et methodes d'administration de plusieurs agents benefiques |
| EP2810951B1 (fr) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US9492505B2 (en) | 2009-01-21 | 2016-11-15 | University Of Florida Research Foundation, Inc. | Satiation peptide administration |
| JP5767582B2 (ja) * | 2009-07-02 | 2015-08-19 | 武田薬品工業株式会社 | ペプチド及びその用途 |
| NO2462246T3 (fr) | 2009-09-28 | 2018-02-03 | ||
| GB201001333D0 (en) | 2010-01-27 | 2010-03-17 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| HRP20180425T1 (hr) | 2010-12-16 | 2018-04-20 | Novo Nordisk A/S | Čvrste kompozicije koje sadrže agonist glp-1 i sol n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline |
| GB201101459D0 (en) * | 2011-01-27 | 2011-03-16 | Imp Innovations Ltd | Novel compounds and thier effects on fedding behaviour |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| PH12013501686A1 (en) | 2011-02-25 | 2017-10-25 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| EP2701736A1 (fr) | 2011-04-25 | 2014-03-05 | Advanced Bioscience Laboratories, Inc. | Protéines tronquées d'enveloppe (env) du vih, procédés et compositions associés à celles-ci |
| SMT201800491T1 (it) | 2012-03-22 | 2018-11-09 | Novo Nordisk As | Composizioni di peptidi glp-1 e relativa preparazione |
| US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
| CA2880901A1 (fr) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Composes tricycliques antidiabetiques |
| RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
| US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
| US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
| WO2014139388A1 (fr) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| WO2014166497A2 (fr) * | 2013-04-10 | 2014-10-16 | University Of Copenhagen | Peptides dérivés du neuropeptide y |
| RU2015144632A (ru) * | 2013-05-02 | 2017-06-07 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Терапевтические пептиды |
| ES2688462T3 (es) | 2013-05-02 | 2018-11-02 | Novo Nordisk A/S | Dosificación oral de compuestos de GLP-1 |
| US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| WO2015051496A1 (fr) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Composés tricycliques antidiabétiques |
| US10583172B2 (en) | 2013-11-15 | 2020-03-10 | Novo Nordisk A/S | HPYY(1-36) having a beta-homoarginine substitution at position 35 |
| JP6602760B2 (ja) | 2013-11-15 | 2019-11-06 | ノヴォ ノルディスク アー/エス | 選択的なpyy化合物及びその使用 |
| WO2015177572A1 (fr) | 2014-05-23 | 2015-11-26 | Imperial Innovations Limited | Analogues de peptide yy (pyy) |
| RU2021109549A (ru) | 2014-08-29 | 2021-05-13 | Тес Фарма С.Р.Л. | ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| AR104984A1 (es) | 2015-06-12 | 2017-08-30 | Novo Nordisk As | Compuestos selectivos para pyy y sus usos |
| KR101604212B1 (ko) * | 2015-07-17 | 2016-03-17 | 울산대학교 산학협력단 | Nad를 함유하는 비만 또는 내당능장애의 예방 및 치료용 조성물 |
| HRP20250898T1 (hr) | 2015-12-22 | 2025-09-26 | Zogenix International Limited | Pripravci fenfluramina i postupci njihove pripreme |
| WO2017112701A1 (fr) | 2015-12-22 | 2017-06-29 | Zogenix International Limited | Analogues de fenfluramine résistant au métabolisme et procédés pour les utiliser |
| US11311633B2 (en) | 2016-04-16 | 2022-04-26 | University Of Florida Research Foundation, Incorporated | Satiation peptides for weight loss and altered taste sensitivity |
| TWI754643B (zh) | 2016-05-16 | 2022-02-11 | 美商因塔希亞治療公司 | 升糖素受體選擇性多肽和彼之使用方法 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| JP2019526544A (ja) | 2016-08-24 | 2019-09-19 | ゾゲニクス インターナショナル リミテッド | 5−ht2bアゴニストの形成を阻害するための製剤およびその使用方法 |
| AU2017342083A1 (en) | 2016-10-14 | 2019-04-11 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (fr) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Composés de spirochromane antidiabétiques |
| WO2018129058A1 (fr) | 2017-01-03 | 2018-07-12 | Intarcia Therapeutics, Inc. | Méthodes comprenant l'administration continue d'un agoniste du récepteur glp-1 et la co-adminstration d'un médicament |
| EP3625247A4 (fr) * | 2017-05-16 | 2021-03-24 | The University of Chicago | Compositions et méthodes pour le traitement et/ou la prévention d'une infection fongique pathogène et pour le maintien du commensalisme du microbiome |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| GB201720188D0 (en) | 2017-12-04 | 2018-01-17 | Imperial Innovations Ltd | Analogues of PYY |
| CN112074286A (zh) * | 2018-01-23 | 2020-12-11 | 吉拉毒蜥治疗公司 | 肽yy药物制剂、组合物和方法 |
| EP3746111B1 (fr) | 2018-02-02 | 2023-07-19 | Novo Nordisk A/S | Compositions solides comportant un agoniste glp-1, du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate et un lubrifiant |
| WO2019216919A1 (fr) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions et méthodes pour traiter la mort subite provoquée par la crise épileptique |
| SG11202104378SA (en) | 2018-11-19 | 2021-05-28 | Zogenix International Ltd | Methods of treating rett syndrome using fenfluramine |
| MX2021005904A (es) | 2018-11-20 | 2021-09-08 | Tes Pharma S R L | Inhibidores de la ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa. |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
| CN113092427A (zh) * | 2021-04-02 | 2021-07-09 | 南京中医药大学 | 异硫氰酸荧光素在标记β内啡肽中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000047219A2 (fr) * | 1999-02-10 | 2000-08-17 | Ontogeny, Inc. | Procedes et reactifs pour traiter des troubles metaboliques du glucose |
| WO2001076631A2 (fr) * | 2000-04-10 | 2001-10-18 | Cedars-Sinai Medical Center | Technique de manipulation du transit gastro-intestinal superieur, du debit sanguin, et de la satiete permettant de traiter l'hyperalgie viscerale |
| WO2002047712A2 (fr) * | 2000-12-14 | 2002-06-20 | Amylin Pharmaceuticals, Inc. | Peptide yy et antagonistes de peptides yy destines au traitement des troubles du metabolisme |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| GB1560933A (en) | 1975-04-15 | 1980-02-13 | Wellcome Found | Biologically activy polypeptides |
| US4175122A (en) | 1975-04-15 | 1979-11-20 | Burroughs Wellcome Co. | Biologically active amides |
| US4223017A (en) | 1975-04-15 | 1980-09-16 | Burroughs Wellcome Co. | Biologically active amides |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| US4220653A (en) | 1979-01-24 | 1980-09-02 | Vivino A Earl | Administration of cimetidine to reduce appetite and facilitate weight loss in persons suffering from excessive weight |
| US4229389A (en) | 1979-03-16 | 1980-10-21 | Thompson Marine Corporation | Gas diffuser, aerator, or sparger apparatus |
| ATE12348T1 (de) | 1980-11-10 | 1985-04-15 | Gersonde Klaus Prof Dr | Verfahren zur herstellung von lipid-vesikeln durch ultraschallbehandlung, anwendung des verfahrens und vorrichtung zur durchfuehrung des verfahrens. |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| JPS58118008A (ja) | 1982-01-06 | 1983-07-13 | Nec Corp | デ−タ処理装置 |
| EP0088046B1 (fr) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipides en phase aqueuse |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| EP0102324A3 (fr) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipides et composés tensio-actifs en phase aqueuse |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| JPS607934A (ja) | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソ−ムの製造方法 |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3486459D1 (de) | 1983-09-26 | 1997-12-11 | Udo Dr Med Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
| EP0143949B1 (fr) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Composition pharmaceutique contenant de l'urokinase |
| US4701441A (en) | 1985-02-11 | 1987-10-20 | University Of Florida | Methods and compositions for stimulation of appetite |
| US4698327A (en) | 1985-04-25 | 1987-10-06 | Eli Lilly And Company | Novel glycopeptide derivatives |
| CA1257199A (fr) | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation contenant une substance macromoleculaire ayant des proprietes biologiques liberee pendant plusieurs mois in vivo |
| HU196755B (en) | 1986-09-16 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of new substituated amilid derivatives and medical compositions containing them |
| IE63869B1 (en) | 1986-11-06 | 1995-06-14 | Res Dev Foundation | Aerosols containing liposomes and method for their preparation |
| WO1990000194A1 (fr) | 1988-06-28 | 1990-01-11 | La Jolla Cancer Research Foundation | Suppression de la proliferation de cellules a l'aide de decorine |
| US5026685A (en) | 1988-07-15 | 1991-06-25 | The Salk Institute For Biological Studies | NPY peptide analogs |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| JP2989002B2 (ja) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| SE9002278L (sv) | 1990-06-28 | 1991-12-29 | Perstorp Ab | Anvaendning av inositoltrisfosfat foer framstaellning av ett laekemedel |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| CA2123108C (fr) | 1991-11-06 | 2003-03-25 | Lisa Selbie | Recepteur du neuropeptide y-y1 humain |
| DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
| DE69317110T2 (de) | 1992-10-28 | 1998-10-08 | Kuraray Co., Ltd., Kurashiki, Okayama | Polyurethan sowie daraus hergestellte lederähnliche folie |
| JP2961045B2 (ja) | 1993-02-24 | 1999-10-12 | 日清製粉株式会社 | 腸管粘膜増強促進剤 |
| CA2157766A1 (fr) | 1993-03-29 | 1994-10-13 | Ambikaipakan Balasubramaniam | Analogues de peptide yy et leurs utilisations |
| AU7113594A (en) | 1993-06-21 | 1995-01-17 | Enzon, Inc. | Site specific synthesis of conjugated peptides |
| GB9317618D0 (en) | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
| US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5545549A (en) | 1994-02-03 | 1996-08-13 | Synaptic Pharmaceutical Corporation | DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| US5696093A (en) | 1994-10-28 | 1997-12-09 | Crc For Biopharmaceutical Research Pty Limited | Method of treating nasal congestion using neuropeptide Y Y2 agonist peptides |
| WO1996014331A1 (fr) | 1994-11-07 | 1996-05-17 | Merck & Co., Inc. | Recepteurs neuropeptidiques y modifies |
| WO1996014336A1 (fr) | 1994-11-07 | 1996-05-17 | Kyowa Hakko Kogyo Co., Ltd. | Nouvelle oxyntomoduline |
| US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
| US5602024A (en) | 1994-12-02 | 1997-02-11 | Synaptic Pharmaceutical Corporation | DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof |
| US5989920A (en) | 1994-12-02 | 1999-11-23 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 |
| US5907030A (en) | 1995-01-25 | 1999-05-25 | University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
| US5912227A (en) | 1995-01-27 | 1999-06-15 | North Carolina State University | Method of enhancing nutrient uptake |
| US5668151A (en) | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
| US5635503A (en) | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Company | Dihydropyridine npy antagonists: piperazine derivatives |
| WO1997019682A1 (fr) | 1995-12-01 | 1997-06-05 | Synaptic Pharmaceutical Corporation | Derives aryle sulfonamide et sulfamide, et leurs utilisations |
| WO1997027840A1 (fr) | 1996-02-02 | 1997-08-07 | Alza Corporation | Administration prolongee d'un agent actif a l'aide d'un systeme implantable |
| US5962270A (en) | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
| US5965392A (en) | 1996-04-08 | 1999-10-12 | Bayer Corporation | Neuropeptide Y receptor Y5 and nucleic acid sequences |
| US5919901A (en) * | 1996-04-08 | 1999-07-06 | Bayer Corporation | Neuropeptide Y receptor Y5 and nucleic acid sequences |
| US6254854B1 (en) | 1996-05-24 | 2001-07-03 | The Penn Research Foundation | Porous particles for deep lung delivery |
| AUPO029096A0 (en) | 1996-06-05 | 1996-07-04 | Crc For Biopharmaceutical Research Pty Ltd | Npy y2 agonists |
| US6355478B1 (en) | 1996-06-17 | 2002-03-12 | Eli Lilly And Company | Rhesus monkey neuropeptide Y Y2 receptor |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| ES2283025T3 (es) | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| EP0941114B1 (fr) | 1996-11-12 | 2005-02-23 | Novo Nordisk A/S | Utilisation de peptides glp-1 |
| EP1015007A1 (fr) | 1996-11-13 | 2000-07-05 | The University Of Cincinnati | Analogues de peptide yy et leurs utilisations |
| DE69831673C5 (de) | 1997-01-07 | 2015-01-22 | Amylin Pharmaceuticals, Llc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| AU5773798A (en) | 1997-01-29 | 1998-08-18 | Polymasc Pharmaceuticals Plc | Pegylation process |
| US6048900A (en) | 1998-02-13 | 2000-04-11 | Bayer Corporation | Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists |
| US6001836A (en) | 1997-05-28 | 1999-12-14 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: cyanoguanidine derivatives |
| US5889016A (en) | 1997-06-26 | 1999-03-30 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
| US6093692A (en) | 1997-09-25 | 2000-07-25 | The University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
| EP0920864A1 (fr) | 1997-12-03 | 1999-06-09 | Pfizer Products Inc. | Thérapie de combinaison comprenant un beta-3 agoniste spécifique et un agent anorexigéne |
| DE04029691T1 (de) | 1998-02-02 | 2007-11-08 | Trustees Of Tufts College, Medford | Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus |
| FR2774674B1 (fr) | 1998-02-10 | 2000-03-24 | Atochem Elf Sa | Procede de preparation d'une solution aqueuse de peroxyde d'hydrogene directement a partir d'hydrogene et d'oxygene et dispositif permettant sa mise en oeuvre |
| AU2610899A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
| US6046167A (en) | 1998-03-25 | 2000-04-04 | University Of Cincinnati | Peptide YY analogs |
| FR2777283B1 (fr) | 1998-04-10 | 2000-11-24 | Adir | Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5993414A (en) | 1998-04-23 | 1999-11-30 | Medtronic, Inc. | Implantable device |
| EP1076644B1 (fr) | 1998-04-29 | 2004-06-23 | Ortho-McNeil Pharmaceutical, Inc. | Aminotetralines n substituees, ligands du recepteur y y5 du neuropeptide servant au traitement de l'obesite et d'autres troubles |
| DE69922676T2 (de) | 1998-10-07 | 2005-12-15 | Ortho-Mcneil Pharmaceutical, Inc. | N-aralkylaminotetraline als neuropeptid-y-y5-rezeptorliganden |
| TWI242000B (en) | 1998-12-10 | 2005-10-21 | Univ Southern California | Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use |
| AU3033500A (en) | 1999-01-15 | 2000-08-01 | Agouron Pharmaceuticals, Inc. | Non-peptide glp-1 agonists |
| US6407120B1 (en) | 1999-02-18 | 2002-06-18 | Pfizer Inc. | Neuropeptide Y antagonists |
| AU4055400A (en) | 1999-04-02 | 2000-10-23 | Neurogen Corporation | Aryl and heteroaryl fused aminoalkyl-imidazole derivatives and their use as antidiabetics |
| US6340683B1 (en) | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
| US6218408B1 (en) | 1999-06-30 | 2001-04-17 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (bicyclics) |
| MXPA01011321A (es) | 1999-05-05 | 2003-08-01 | Johnson & Johnson | Neuropeptidos y ligandos de receptores 3a, 4, 5, 9b-tetrahidro-1h-benz(e)indol-2-il amino derivados utiles en el tratamiento de obesidad y otros trastornos. |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| EP1133312B8 (fr) | 1999-06-21 | 2007-10-17 | Eli Lilly And Company | Utilisation combinee de thiazolidinediones et de peptide-1 de type glucagone et d'agonistes de ces derniers pour traiter diabetes non insulino-dependant. |
| US6225330B1 (en) | 1999-06-30 | 2001-05-01 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (tricyclics) |
| EP1076066A1 (fr) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides abaissant le taux de glucose sanguin |
| US6399631B1 (en) | 1999-07-23 | 2002-06-04 | Pfizer Inc. | Carbazole neuropeptide Y5 antagonists |
| DK1202986T3 (da) | 1999-07-28 | 2006-02-20 | Ortho Mcneil Pharm Inc | Amin- og amidderivater som ligander for neuropeptid Y-Y5-receptoren, der er nyttige ved behandlingen af obesitet og andre lidelser |
| CA2382528A1 (fr) | 1999-08-25 | 2001-03-01 | Banyu Pharmaceutical Co., Ltd. | Nouveaux derives isoindole |
| US6348472B1 (en) | 1999-08-26 | 2002-02-19 | Bristol-Myers Squibb Company | NPY antagonists: spiroisoquinolinone derivatives |
| AU6798000A (en) | 1999-08-26 | 2001-03-19 | Viropharma Incorporated | Compounds, compositions and methods for treating influenza |
| HUP0202678A3 (en) | 1999-09-30 | 2004-06-28 | Pfizer | Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines, pharmaceutical compositions containing them and their use |
| JP2003516322A (ja) | 1999-11-12 | 2003-05-13 | ノボ ノルディスク アクティーゼルスカブ | ベータ細胞変性抑制のためのglp−1アゴニストの使用 |
| US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| MXPA02004985A (es) | 1999-11-26 | 2003-10-14 | Shionogi & Co | Antagonistas del neuropeptido y, y5. |
| ATE275967T1 (de) | 2000-01-10 | 2004-10-15 | Amylin Pharmaceuticals Inc | Verwendung von exendinen und deren agonisten zur behandlung von hypertriglyceridämie |
| ES2253353T3 (es) | 2000-03-08 | 2006-06-01 | Novo Nordisk A/S | Reduccion del colesterol serico. |
| WO2001068699A2 (fr) | 2000-03-16 | 2001-09-20 | Bayer Aktiengesellschaft | Regulation du recepteur de neuropeptides humains de type y couple a la proteine g |
| IL142707A0 (en) | 2000-04-27 | 2002-03-10 | Pfizer Prod Inc | Methods of treating obesity using a neurotensin receptor ligand |
| US6432960B2 (en) | 2000-05-10 | 2002-08-13 | Bristol-Myers Squibb Company | Squarate derivatives of dihydropyridine NPY antagonists |
| US6444675B2 (en) | 2000-05-10 | 2002-09-03 | Bristol-Myers Squibb Company | 4-alkyl and 4-cycloalkyl derivatives of dihydropyridine NPY antagonists |
| AU2001259056A1 (en) | 2000-05-17 | 2001-11-26 | Eli Lilly And Company | Method for selectively inhibiting ghrelin action |
| US6256216B1 (en) * | 2000-05-18 | 2001-07-03 | Integrated Device Technology, Inc. | Cam array with minimum cell size |
| US6391881B2 (en) | 2000-05-19 | 2002-05-21 | Bristol-Myers Squibb Company | Thiourea derivatives of dihydropyridine NPY antagonists |
| CN1462191B (zh) | 2000-05-19 | 2013-07-24 | 埃米林药品公司 | Glp-1用于制备治疗急性冠脉综合征的药物的用途 |
| HUP0301830A3 (en) | 2000-07-06 | 2007-10-29 | Metabasis Therapeutics Inc | Pharmaceutical composition containing a combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| US6420352B1 (en) | 2000-07-19 | 2002-07-16 | W. Roy Knowles | Hair loss prevention |
| US6586403B1 (en) | 2000-07-20 | 2003-07-01 | Salpep Biotechnology, Inc. | Treating allergic reactions and inflammatory responses with tri-and dipeptides |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| US20020156010A1 (en) | 2000-11-20 | 2002-10-24 | Lustig Robert H. | Method of treating obesity in adult patients exhibiting primary insulin hypersecretion |
| WO2002066479A1 (fr) | 2001-02-23 | 2002-08-29 | Banyu Pharmaceutical Co.,Ltd. | Derives de l'isoindole |
| WO2002067918A1 (fr) | 2001-02-27 | 2002-09-06 | Banyu Pharmaceutical Co., Ltd. | Nouveau derive de diallylmethylamine |
| HUP0401643A3 (en) | 2001-07-26 | 2009-06-29 | Schering Corp | Substituted urea neuropeptide y y5 receptor antagonists, their use and pharmaceutical compositions containing them |
| GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| PL205971B1 (pl) | 2001-09-24 | 2010-06-30 | Imp Innovations Ltd | Zastosowanie PYY₃-₃₆ do wytwarzania leku na ograniczanie apetytu, zmniejszenie otyłości lub do zapobiegania otyłości |
| EP1474163A2 (fr) | 2002-01-10 | 2004-11-10 | Imperial College Innovations Limited | Modification des habitudes alimentaires |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| US7166575B2 (en) | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| PL1620118T3 (pl) | 2003-04-08 | 2014-11-28 | Yeda Res & Dev | Leki odwracalnie pegylowane |
| CN1220702C (zh) | 2003-07-30 | 2005-09-28 | 北京中科亚光生物科技有限公司 | 促胰岛素分泌肽及其用途 |
| WO2005035761A1 (fr) | 2003-10-16 | 2005-04-21 | Compugen Ltd. | Variants d'epissage de preproglucagon, de peptide de type glucagon 1 et d'oxyntomoduline |
| AU2005250216B2 (en) | 2004-06-01 | 2009-12-10 | Domantis Limited | Bispecific fusion antibodies with enhanced serum half-life |
| PA8660701A1 (es) | 2005-02-04 | 2006-09-22 | Pfizer Prod Inc | Agonistas de pyy y sus usos |
| GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| PL1891105T3 (pl) | 2005-06-13 | 2012-09-28 | Imperial Innovations Ltd | Analogi oksyntomoduliny i ich wpływ na zachowania żywieniowe |
| CA2628241C (fr) | 2005-11-07 | 2016-02-02 | Indiana University Research And Technology Corporation | Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees |
| WO2007100535A2 (fr) | 2006-02-22 | 2007-09-07 | Merck & Co., Inc. | Dérivés d'oxyntomoduline |
| CA2654055A1 (fr) | 2006-06-07 | 2007-12-21 | Human Genome Sciences, Inc. | Proteines de fusion d'albumine |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
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2002
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- 2002-09-24 WO PCT/US2002/031944 patent/WO2003026591A2/fr not_active Ceased
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- 2002-09-24 EP EP20080022583 patent/EP2050460A1/fr not_active Withdrawn
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2008
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000047219A2 (fr) * | 1999-02-10 | 2000-08-17 | Ontogeny, Inc. | Procedes et reactifs pour traiter des troubles metaboliques du glucose |
| WO2001076631A2 (fr) * | 2000-04-10 | 2001-10-18 | Cedars-Sinai Medical Center | Technique de manipulation du transit gastro-intestinal superieur, du debit sanguin, et de la satiete permettant de traiter l'hyperalgie viscerale |
| WO2002047712A2 (fr) * | 2000-12-14 | 2002-06-20 | Amylin Pharmaceuticals, Inc. | Peptide yy et antagonistes de peptides yy destines au traitement des troubles du metabolisme |
Non-Patent Citations (3)
| Title |
|---|
| BATTERHAM R L ET AL: "Gut hormone PYY3-36 physiologically inhibits food intake", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 418, 8 August 2002 (2002-08-08), pages 650 - 654, XP002984562, ISSN: 0028-0836 * |
| CLAPHAM J C ET AL: "ANTI-OBESITY DRUGS: A CRITICAL REVIEW OF CURRENT THERAPIES AND FUTURE OPPORTUNITIES", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 89, no. 1, January 2001 (2001-01-01), pages 81 - 121, XP001120530, ISSN: 0163-7258 * |
| ROSSI M ET AL: "Central nervous system neuropeptides involved in obesity.", HANDBOOK OF EXPERIMENTAL PHARMACOLOGY, vol. 149, 2000, 2000 Springer-Verlag GmbH & Co. KG;Springer-Verlag New York Inc. Heidelberger Platz 3, D-14197, Berlin, Germany; 175 Fifth Avenue, New York, NY, 10010-7858, USA, pages 313 - 341, XP001154661, ISSN: 0171-2004 * |
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