EP1450793A2 - Traitement de l'hypertonie durant la phase aigue d'apoplexie cerebrale - Google Patents
Traitement de l'hypertonie durant la phase aigue d'apoplexie cerebraleInfo
- Publication number
- EP1450793A2 EP1450793A2 EP02799727A EP02799727A EP1450793A2 EP 1450793 A2 EP1450793 A2 EP 1450793A2 EP 02799727 A EP02799727 A EP 02799727A EP 02799727 A EP02799727 A EP 02799727A EP 1450793 A2 EP1450793 A2 EP 1450793A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- use according
- stroke
- treatment
- blood pressure
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000006011 Stroke Diseases 0.000 title claims abstract description 42
- 238000011282 treatment Methods 0.000 title claims abstract description 15
- 230000001154 acute effect Effects 0.000 title description 6
- 206010008190 Cerebrovascular accident Diseases 0.000 title description 2
- 206010020852 Hypertonia Diseases 0.000 title 1
- 208000026106 cerebrovascular disease Diseases 0.000 title 1
- 239000000126 substance Substances 0.000 claims abstract description 9
- 230000036454 renin-angiotensin system Effects 0.000 claims abstract description 8
- 230000036772 blood pressure Effects 0.000 claims description 12
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 8
- 206010020772 Hypertension Diseases 0.000 claims description 5
- 229960004349 candesartan cilexetil Drugs 0.000 claims description 5
- 239000005541 ACE inhibitor Substances 0.000 claims description 4
- 229940125364 angiotensin receptor blocker Drugs 0.000 claims description 4
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims description 4
- 201000006474 Brain Ischemia Diseases 0.000 claims description 3
- 239000002053 C09CA06 - Candesartan Substances 0.000 claims description 3
- 206010008120 Cerebral ischaemia Diseases 0.000 claims description 3
- 229960000932 candesartan Drugs 0.000 claims description 3
- 206010008118 cerebral infarction Diseases 0.000 claims description 3
- 230000003205 diastolic effect Effects 0.000 claims description 3
- 238000011321 prophylaxis Methods 0.000 claims description 3
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 claims description 2
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 claims description 2
- 239000002083 C09CA01 - Losartan Substances 0.000 claims description 2
- 239000002080 C09CA02 - Eprosartan Substances 0.000 claims description 2
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims description 2
- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims description 2
- 239000005537 C09CA07 - Telmisartan Substances 0.000 claims description 2
- 108010007859 Lisinopril Proteins 0.000 claims description 2
- 229960004530 benazepril Drugs 0.000 claims description 2
- 229960004563 eprosartan Drugs 0.000 claims description 2
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims description 2
- 229960002490 fosinopril Drugs 0.000 claims description 2
- 229960002198 irbesartan Drugs 0.000 claims description 2
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims description 2
- 229960002394 lisinopril Drugs 0.000 claims description 2
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims description 2
- 229960004773 losartan Drugs 0.000 claims description 2
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 claims description 2
- LVRLSYPNFFBYCZ-VGWMRTNUSA-N omapatrilat Chemical group C([C@H](S)C(=O)N[C@H]1CCS[C@H]2CCC[C@H](N2C1=O)C(=O)O)C1=CC=CC=C1 LVRLSYPNFFBYCZ-VGWMRTNUSA-N 0.000 claims description 2
- 229950000973 omapatrilat Drugs 0.000 claims description 2
- 229960002582 perindopril Drugs 0.000 claims description 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 claims description 2
- 229960003401 ramipril Drugs 0.000 claims description 2
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims description 2
- 229960005187 telmisartan Drugs 0.000 claims description 2
- 229960004699 valsartan Drugs 0.000 claims description 2
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims description 2
- 108010061435 Enalapril Proteins 0.000 claims 1
- 229960000830 captopril Drugs 0.000 claims 1
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical group SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims 1
- 229960000873 enalapril Drugs 0.000 claims 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims 1
- 229940097258 other antihypertensives in atc Drugs 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 abstract description 5
- 238000002560 therapeutic procedure Methods 0.000 description 14
- 230000003276 anti-hypertensive effect Effects 0.000 description 5
- 229940068196 placebo Drugs 0.000 description 4
- 239000000902 placebo Substances 0.000 description 4
- 230000035487 diastolic blood pressure Effects 0.000 description 3
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 2
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 229940030600 antihypertensive agent Drugs 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000007971 neurological deficit Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000009862 primary prevention Effects 0.000 description 2
- 230000009863 secondary prevention Effects 0.000 description 2
- 230000035488 systolic blood pressure Effects 0.000 description 2
- BFCDFTHTSVTWOG-PXNSSMCTSA-N (1r,2s)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol Chemical compound CCCCCCCCN[C@@H](C)[C@H](O)C1=CC=C(SC(C)C)C=C1 BFCDFTHTSVTWOG-PXNSSMCTSA-N 0.000 description 1
- RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- YGULWPYYGQCFMP-CEAXSRTFSA-N Metoprolol tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 YGULWPYYGQCFMP-CEAXSRTFSA-N 0.000 description 1
- -1 Quinalapril Chemical compound 0.000 description 1
- 206010042957 Systolic hypertension Diseases 0.000 description 1
- 208000032109 Transient ischaemic attack Diseases 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 230000007211 cardiovascular event Effects 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- RZTAMFZIAATZDJ-UHFFFAOYSA-N felodipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-UHFFFAOYSA-N 0.000 description 1
- 229960003580 felodipine Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229960002003 hydrochlorothiazide Drugs 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 229960002237 metoprolol Drugs 0.000 description 1
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000009861 stroke prevention Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 201000010875 transient cerebral ischemia Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- the invention relates to the use of antihypertensives - in particular substances for inhibiting the renin-angiotensin system (angiotensin receptor blockers, ACE inhibitors, vasopeptidase inhibitors) and combinations with these and other antihypertensive agents in the treatment of acute stroke for the reduction the risk of cerebro resp. cardiovascular events and improvement of the patient's neurological survival.
- substances for inhibiting the renin-angiotensin system angiotensin receptor blockers, ACE inhibitors, vasopeptidase inhibitors
- Stroke is the 3rd leading cause of death in Germany. Many patients retain severe neurological deficits, only a few become fully able to work again. More than 1 million patients in Germany currently have to live with permanent disabilities as a result of the stroke, which often leads to professional decline and social isolation. The numbers underline the importance of dealing with the basics, with therapy, with the prevention and aftercare of the stroke. The most common causes of stroke are ischemic haemorrhages with 80-90%. The recurrence rate is 5% per year after a transient ischemic attack, 10% after an overt stroke, and 15% after a severe stroke. 50-75% of the affected patients become somewhat independent again, 25% remain in need of care.
- preferred substances for inhibiting the renin-angiotensin system are:
- Angiotensin receptor blockers ACE inhibitors and vasopeptidase inhibitors.
- candesartan irbesartan, valsartan, losartan
- Fosinopril and omapatrilat and their pharmacologically acceptable salts and esters.
- the substance for inhibiting the renin-angiotensin system should still be present during the acute phase of the stroke, preferably 0 to 72 hours, particularly preferably 0 to 36, and 0 to 24 hours after the stroke has occurred until at least 7 days after the stroke be administered.
- acute stroke means in particular cerebral ischemia and particularly preferably acute cerebral ischemia.
- the treatment of patients with elevated blood pressure is particularly preferred, in particular of patients with a systolic blood pressure of over 180 mmHg and / or a diastolic blood pressure of over 105 mmHg.
- the dose can be increased to 1 tablet or 2 tablets once a day if blood pressure values (> 160 mmHg systolic and / or> 100 mmHg diastolic) are not sufficiently lowered (corresponds to 8 mg or 16 mg candesartan cilexetil or Placebo).
- a combination therapy can be started from the 7th day of therapy for blood pressure values of> 160 mmHg systolic and / or> 100 mmHg diastolic.
- the basis for changes in therapy is the average of at least 3 blood pressure measurements per day.
- Exemplary combination partners are listed below:
- Salureticum Hydrochlorothiazide: (e.g. Esidrix) 12.5 - 25 mg,
- Felodipine (e.g. Modip) 2.5 - 5 mg
- Beta blocker Metoprolol: (e.g. Beloc) 50 - 100 mg.
- the desired reduction in blood pressure is 10-15% within 24 hours.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne l'utilisation d'une substance d'inhibition du système rénine-angiotensine, lors du traitement de l'apoplexie cérébrale.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10157474 | 2001-11-23 | ||
| DE10157474 | 2001-11-23 | ||
| DE10158030 | 2001-11-27 | ||
| DE10158030 | 2001-11-27 | ||
| PCT/EP2002/013238 WO2003043615A2 (fr) | 2001-11-23 | 2002-11-25 | Traitement de l'hypertonie durant la phase aigue d'apoplexie cerebrale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1450793A2 true EP1450793A2 (fr) | 2004-09-01 |
Family
ID=26010631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02799727A Withdrawn EP1450793A2 (fr) | 2001-11-23 | 2002-11-25 | Traitement de l'hypertonie durant la phase aigue d'apoplexie cerebrale |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050009893A1 (fr) |
| EP (1) | EP1450793A2 (fr) |
| JP (1) | JP2005511631A (fr) |
| AU (1) | AU2002364381A1 (fr) |
| BR (1) | BR0214383A (fr) |
| CA (1) | CA2467095A1 (fr) |
| MX (1) | MXPA04004844A (fr) |
| PL (1) | PL370270A1 (fr) |
| WO (1) | WO2003043615A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| MXPA02001694A (es) * | 1999-08-30 | 2002-08-06 | Aventis Pharma Gmbh | Uso de inhibidores del sistema renina-angiotensina en la prevencion de eventos cardiovasculares. |
| EP2606242A4 (fr) | 2010-08-20 | 2016-07-20 | Integenx Inc | Dispositifs microfluidiques pourvus de soupapes à diaphragme mécaniquement scellées |
| US8633158B1 (en) | 2012-10-02 | 2014-01-21 | Tarix Pharmaceuticals Ltd. | Angiotensin in treating brain conditions |
| US9333233B2 (en) * | 2014-02-25 | 2016-05-10 | Tarix Pharmaceuticals Ltd. | Methods and compositions for the delayed treatment of stroke |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| CA2048699A1 (fr) * | 1990-09-04 | 1992-03-05 | Abraham Sudilovsky | Methode de prevention ou de traitement des maladies cerebro-vasculaires faisant appel au ceronapril |
| US20010018448A1 (en) * | 1990-12-14 | 2001-08-30 | Smithkline Beecham P.L.C. | Medicament |
| GB9027199D0 (en) * | 1990-12-14 | 1991-02-06 | Smithkline Beecham Plc | Medicaments |
| US6162802A (en) * | 1992-03-10 | 2000-12-19 | Papa; Joseph | Synergistic combination therapy using benazepril and amlodipine for the treatment of cardiovascular disorders and compositions therefor |
| JP4316013B2 (ja) * | 1996-03-29 | 2009-08-19 | スミスクライン・ビーチャム・コーポレイション | エプロサルタン二水和物ならびにその製法および処方 |
| PL193215B1 (pl) * | 1997-10-17 | 2007-01-31 | Eurogene Ltd | Zastosowanie lipofilnych inhibitorów układu renina-angiotensyna |
| US6248729B1 (en) * | 1998-06-17 | 2001-06-19 | Bristol-Myers Squibb Co. | Combination of an ADP-receptor blocking antiplatelet drug and antihypertensive drug and a method for preventing a cerebral infarction employing such combination |
| FR2783422A1 (fr) * | 1998-09-21 | 2000-03-24 | Sanofi Sa | Composition pharmaceutique contenant un antagoniste des recepteurs at1 de l'angiotensine ii et un antiagregant plaquettaire |
| US6852743B1 (en) * | 1999-07-21 | 2005-02-08 | Takeda Pharmaceutical Company Limited | Preventives for the recurrence of cerebrovascular failure and agents for ameliorating troubles following cerebrovascular failure and inhibiting progress thereof |
| MXPA02001694A (es) * | 1999-08-30 | 2002-08-06 | Aventis Pharma Gmbh | Uso de inhibidores del sistema renina-angiotensina en la prevencion de eventos cardiovasculares. |
| AU2001242184A1 (en) * | 2000-03-28 | 2001-10-08 | Queen:S University At Kingston | Methods for effecting neuroprotection using a potassium channel modulator |
| SK14642002A3 (sk) * | 2000-04-12 | 2003-05-02 | Novartis Ag | Kombinované farmaceutické prostriedky obsahujúce antagonistu AT1-receptora a/alebo inhibítor HMG-CoA reduktázy a/alebo ACE inhibítor |
| MXPA03005462A (es) * | 2000-12-18 | 2003-09-25 | Novartis Ag | Combinacion terapeutica de amlodipina y benazepril. |
| DE10115668A1 (de) * | 2001-03-29 | 2002-10-10 | Max Delbrueck Centrum | Mittel zur Behandlung des Schlaganfalls |
-
2002
- 2002-11-25 BR BR0214383-6A patent/BR0214383A/pt not_active IP Right Cessation
- 2002-11-25 JP JP2003545296A patent/JP2005511631A/ja not_active Withdrawn
- 2002-11-25 WO PCT/EP2002/013238 patent/WO2003043615A2/fr not_active Ceased
- 2002-11-25 MX MXPA04004844A patent/MXPA04004844A/es unknown
- 2002-11-25 EP EP02799727A patent/EP1450793A2/fr not_active Withdrawn
- 2002-11-25 PL PL02370270A patent/PL370270A1/xx not_active Application Discontinuation
- 2002-11-25 CA CA002467095A patent/CA2467095A1/fr not_active Abandoned
- 2002-11-25 AU AU2002364381A patent/AU2002364381A1/en not_active Abandoned
-
2004
- 2004-05-24 US US10/851,660 patent/US20050009893A1/en not_active Abandoned
Non-Patent Citations (2)
| Title |
|---|
| None * |
| See also references of WO03043615A3 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003043615A3 (fr) | 2004-02-19 |
| CA2467095A1 (fr) | 2003-05-30 |
| JP2005511631A (ja) | 2005-04-28 |
| AU2002364381A1 (en) | 2003-06-10 |
| PL370270A1 (en) | 2005-05-16 |
| WO2003043615A2 (fr) | 2003-05-30 |
| US20050009893A1 (en) | 2005-01-13 |
| BR0214383A (pt) | 2004-11-03 |
| MXPA04004844A (es) | 2004-07-30 |
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