EP1315510A4 - METHOD AND COMPOSITIONS FOR REPAIRING AND / OR REGENERATING THE DAMAGED HEART MUSCLE - Google Patents

METHOD AND COMPOSITIONS FOR REPAIRING AND / OR REGENERATING THE DAMAGED HEART MUSCLE

Info

Publication number: EP1315510A4
Authority: EP; European Patent Office
Prior art keywords: regenerating; repairing; compositions; heart muscle; damaged heart
Prior art date: 2000-07-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP01961855A

Other languages

German (de)

French (fr)

Other versions

EP1315510A2 (en

Inventor

Piero Anversa

Donald Orlic

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

New York Medical College

Government of the United States of America

Original Assignee

New York Medical College

US Department of Health and Human Services

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2001-07-31

Publication date

2005-08-03

2001-07-31 Application filed by New York Medical College, US Department of Health and Human Services filed Critical New York Medical College

2003-06-04 Publication of EP1315510A2 publication Critical patent/EP1315510A2/en

2005-08-03 Publication of EP1315510A4 publication Critical patent/EP1315510A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/12—Hepatocyte growth factor [HGF]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Hematology (AREA)
Immunology (AREA)
Developmental Biology & Embryology (AREA)
Cell Biology (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Cardiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Microbiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Macromonomer-Based Addition Polymer (AREA)
Dental Preparations (AREA)

EP01961855A 2000-07-31 2001-07-31 METHOD AND COMPOSITIONS FOR REPAIRING AND / OR REGENERATING THE DAMAGED HEART MUSCLE Withdrawn EP1315510A4 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US22190200P	2000-07-31	2000-07-31
US221902P		2000-07-31
US25856400P	2000-12-29	2000-12-29
US258564P		2000-12-29
US25880501P	2001-01-02	2001-01-02
US258805P		2001-01-02
PCT/US2001/024223 WO2002013760A2 (en)	2000-07-31	2001-07-31	Methods and compositions for the repair and/or regeneration of damaged myocardium

Publications (2)

Publication Number	Publication Date
EP1315510A2 EP1315510A2 (en)	2003-06-04
EP1315510A4 true EP1315510A4 (en)	2005-08-03

Family

ID=27397004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01961855A Withdrawn EP1315510A4 (en)	2000-07-31	2001-07-31	METHOD AND COMPOSITIONS FOR REPAIRING AND / OR REGENERATING THE DAMAGED HEART MUSCLE

Country Status (4)

Country	Link
EP (1)	EP1315510A4 (en)
AU (1)	AU2001283088A1 (en)
CA (1)	CA2423592A1 (en)
WO (1)	WO2002013760A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7732199B2 (en)	2001-07-12	2010-06-08	Geron Corporation	Process for making transplantable cardiomyocytes from human embryonic stem cells
GB2393734B (en)	2001-07-12	2005-07-27	Geron Corp	Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
US7527968B2 (en)	2002-07-29	2009-05-05	Robarts Research Institute	Regeneration initiating cells
ITRM20030376A1 (en)	2003-07-31	2005-02-01	Univ Roma	PROCEDURE FOR THE ISOLATION AND EXPANSION OF CARDIOC STAMIN CELLS FROM BIOPSIA.
US7452718B2 (en)	2004-03-26	2008-11-18	Geron Corporation	Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US11660317B2 (en)	2004-11-08	2023-05-30	The Johns Hopkins University	Compositions comprising cardiosphere-derived cells for use in cell therapy
EP1910518B1 (en)	2005-06-22	2019-05-08	Asterias Biotherapeutics, Inc.	Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
US8637005B2 (en)	2005-11-07	2014-01-28	Amorcyte, Inc.	Compositions and methods of vascular injury repair
US7794705B2 (en)	2005-11-07	2010-09-14	Amorcyte, Inc.	Compositions and methods of vascular injury repair
US20110076255A1 (en)	2005-11-07	2011-03-31	Pecora Andrew L	Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
US7998740B2 (en) *	2006-07-18	2011-08-16	Robert Sackstein	Cytokine induction of selectin ligands on cells
CA2743698A1 (en)	2007-11-30	2009-06-11	New York Medical College	Compositions comprising vascular and myocyte progenitor cells and methods of their use
US8124071B2 (en)	2007-11-30	2012-02-28	New York Medical College	Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
US8512696B2 (en)	2007-11-30	2013-08-20	Autologous, Llc	Methods of isolating non-senescent cardiac stem cells and uses thereof
US20090162329A1 (en) *	2007-11-30	2009-06-25	Piero Anversa	Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
KR101809863B1 (en)	2008-01-30	2017-12-15	아스테리아스 바이오세라퓨틱스, 인크.	Synthetic surfaces for culturing stem cell derived cardiomyocytes
WO2010065601A1 (en)	2008-12-03	2010-06-10	Amorcyte, Inc.	Infarct area perfusion-improving compositions and methods of vascular injury repair
US9845457B2 (en)	2010-04-30	2017-12-19	Cedars-Sinai Medical Center	Maintenance of genomic stability in cultured stem cells
US9249392B2 (en)	2010-04-30	2016-02-02	Cedars-Sinai Medical Center	Methods and compositions for maintaining genomic stability in cultured stem cells
US9884076B2 (en)	2012-06-05	2018-02-06	Capricor, Inc.	Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2882445B1 (en)	2012-08-13	2019-04-24	Cedars-Sinai Medical Center	Exosomes and micro-ribonucleic acids for tissue regeneration
CA2962444C (en)	2014-10-03	2023-09-05	Cedars-Sinai Medical Center	Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2017123662A1 (en)	2016-01-11	2017-07-20	Cedars-Sinai Medical Center	Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en)	2016-06-03	2022-06-07	Cedars-Sinai Medical Center	CDC-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (en)	2016-09-20	2020-08-05	Cedars-Sinai Medical Center	CARDIOSPHERIC CELLS AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE THE AGING PROCESS AND AGE-RELATED DISEASES
US11759482B2 (en)	2017-04-19	2023-09-19	Cedars-Sinai Medical Center	Methods and compositions for treating skeletal muscular dystrophy
US11660355B2 (en)	2017-12-20	2023-05-30	Cedars-Sinai Medical Center	Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en)	2018-02-05	2022-01-26	Cedars-Sinai Medical Center	METHODS OF THERAPEUTIC USE OF EXOSOMES AND YRNA
CN118490802B (en) *	2024-05-31	2025-03-18	中国人民解放军海军特色医学中心	A composition for improving exercise-induced myocardial injury

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998018486A1 (en) *	1996-10-25	1998-05-07	Icogen Corporation	Use of leptin to stimulate hematopoiesis
WO2000006701A1 (en) *	1998-07-31	2000-02-10	Genzyme Corporation	Improvement of cardiac function by mesenchymal stem cell transplantation

2001
- 2001-07-31 EP EP01961855A patent/EP1315510A4/en not_active Withdrawn
- 2001-07-31 CA CA002423592A patent/CA2423592A1/en not_active Abandoned
- 2001-07-31 WO PCT/US2001/024223 patent/WO2002013760A2/en not_active Ceased
- 2001-07-31 AU AU2001283088A patent/AU2001283088A1/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998018486A1 (en) *	1996-10-25	1998-05-07	Icogen Corporation	Use of leptin to stimulate hematopoiesis
WO2000006701A1 (en) *	1998-07-31	2000-02-10	Genzyme Corporation	Improvement of cardiac function by mesenchymal stem cell transplantation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TOMITA S ET AL: "AUTOLOGOUS TRANSPLANTATION OF BONE MARROW CELLS IMPROVES DAMAGED HEART FUNCTION", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 110, no. SUPPL 19, 9 November 1999 (1999-11-09), pages II - 247, XP000869909, ISSN: 0009-7322 *
TOMITA S ET AL: "AUTOTRANSPLANTED MESENCHYMAL STEM CELLS IMPROVE FUNCTION AFTER A MYOCARDIAL INFARCTION", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 98, no. 17, SUPPL, 27 October 1998 (1998-10-27), pages I - 200, XP009032355, ISSN: 0009-7322 *

Also Published As

Publication number	Publication date
WO2002013760A9 (en)	2003-09-04
EP1315510A2 (en)	2003-06-04
CA2423592A1 (en)	2002-02-21
WO2002013760A2 (en)	2002-02-21
AU2001283088A1 (en)	2002-02-25
WO2002013760A3 (en)	2002-04-18

Publication	Publication Date	Title
EP1315510A4 (en)	2005-08-03	METHOD AND COMPOSITIONS FOR REPAIRING AND / OR REGENERATING THE DAMAGED HEART MUSCLE
DE69922228D1 (en)	2004-12-30	METHOD FOR REDUCING THE MINERALIZATION OF TISSUE FOR USE IN TRANSPLANTATION
DE60143123D1 (en)	2010-11-04	METAL GLIDING ELEMENT AND METHOD FOR THE SURFACE TREATMENT THEREOF
DE60042184D1 (en)	2009-06-25	Method and composition for removing photoresist
DE60120822D1 (en)	2006-08-03	Meta-document and method for managing meta-documents
DE60043034D1 (en)	2009-11-12	Method and composition for removing photoresist layers
DE69822889D1 (en)	2004-05-06	CORROSION-RESISTANT ABRASIVE ARTICLES AND METHOD FOR PRODUCING THE SAME
DE60013420D1 (en)	2004-10-07	RING-SEALING METHOD
DE69928690D1 (en)	2006-01-05	Composition and method for binding skin irritants.
DE69806970D1 (en)	2002-09-05	METHOD FOR TREATING HARD TISSUE
DE59810547D1 (en)	2004-02-12	Dishwasher and method for operating the same
DE69928795D1 (en)	2006-01-12	SEATING AND METHOD FOR MANUFACTURING THE SAME
EP1283707A4 (en)	2006-01-18	POLYMERIZABLE COMPOSITIONS AND METHOD FOR THEIR USE
ATE282333T1 (en)	2004-12-15	METHOD FOR TREATING TOBACCO
DE60024070D1 (en)	2005-12-22	METHOD FOR ROLLING GEARS
DE50004737D1 (en)	2004-01-22	METHOD FOR PURIFYING AND PRODUCING ACRYLIC ACID OR METHACRYLIC ACID
DE69912254D1 (en)	2003-11-27	COSMETIC METHOD FOR TREATMENT
ATE269529T1 (en)	2004-07-15	METHOD FOR TREATING EXHAUST GASES IN THE STEEL INDUSTRY
EP1635801A4 (en)	2008-01-23	METHOD FOR TREATING AND PREVENTING CARDIAC ARTHYTHMIA
DE69731101D1 (en)	2004-11-11	TITANIUM-BASED DECORATION PART AND HARDENING METHOD
DE50115254D1 (en)	2010-01-21	METHOD FOR DETECTING AND / OR LIMITING SHORT-STUDENTS
DE50208871D1 (en)	2007-01-11	METHOD AND FILTRATION FOR SEPARATING CONDENSATE AND THE SIMILAR
EP1200078A4 (en)	2004-06-30	COMPILATIONS AND METHOD FOR PROMOTING NERVOUS REGENERATION
DE50307382D1 (en)	2007-07-12	PIEZOACTOR AND METHOD FOR PRODUCING THE PIEZOACTOR
EP1018866A4 (en)	2001-06-27	COMPOSITIONS AND METHODS FOR PRESERVING LIVING TISSUE

Legal Events

Date	Code	Title	Description
2003-04-18	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-06-04	17P	Request for examination filed	Effective date: 20030226
2003-06-04	AK	Designated contracting states	Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2003-06-04	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2004-02-04	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS Owner name: NEW YORK MEDICAL COLLEGE
2005-08-03	A4	Supplementary search report drawn up and despatched	Effective date: 20050616
2005-08-03	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61P 9/10 B Ipc: 7A 61K 35/28 A
2006-07-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2006-08-23	18D	Application deemed to be withdrawn	Effective date: 20060301