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EP1308730A4 - METHOD FOR DETECTING OR DETERMINING VBH - Google Patents

METHOD FOR DETECTING OR DETERMINING VBH

Info

Publication number
EP1308730A4
EP1308730A4 EP01956848A EP01956848A EP1308730A4 EP 1308730 A4 EP1308730 A4 EP 1308730A4 EP 01956848 A EP01956848 A EP 01956848A EP 01956848 A EP01956848 A EP 01956848A EP 1308730 A4 EP1308730 A4 EP 1308730A4
Authority
EP
European Patent Office
Prior art keywords
detecting
vbh
determining
virus
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP01956848A
Other languages
German (de)
French (fr)
Other versions
EP1308730B1 (en
EP1308730A1 (en
Inventor
N Maki
T Kimura
Y Sakamoto
S Yagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Life Science Institute Inc
Original Assignee
Advanced Life Science Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Life Science Institute Inc filed Critical Advanced Life Science Institute Inc
Publication of EP1308730A1 publication Critical patent/EP1308730A1/en
Publication of EP1308730A4 publication Critical patent/EP1308730A4/en
Application granted granted Critical
Publication of EP1308730B1 publication Critical patent/EP1308730B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G01N33/5762—Hepatitis B core antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.
EP01956848A 2000-08-11 2001-08-10 Method of detecting or assaying hbv Expired - Lifetime EP1308730B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000249202 2000-08-11
JP2000249202 2000-08-11
PCT/JP2001/006947 WO2002014871A1 (en) 2000-08-11 2001-08-10 Method of detecting or assaying hbv

Publications (3)

Publication Number Publication Date
EP1308730A1 EP1308730A1 (en) 2003-05-07
EP1308730A4 true EP1308730A4 (en) 2004-12-08
EP1308730B1 EP1308730B1 (en) 2011-12-28

Family

ID=18738979

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01956848A Expired - Lifetime EP1308730B1 (en) 2000-08-11 2001-08-10 Method of detecting or assaying hbv

Country Status (7)

Country Link
US (2) US7323331B2 (en)
EP (1) EP1308730B1 (en)
JP (1) JP3847257B2 (en)
AT (1) ATE539350T1 (en)
CA (1) CA2419046C (en)
ES (1) ES2374812T3 (en)
WO (1) WO2002014871A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE473997T1 (en) 2002-09-06 2010-07-15 Advanced Life Science Inst Inc HBV PRECORE PROTEIN CAPABILITY TO FORM PARTICLES
EP1752768B1 (en) * 2004-05-19 2010-12-29 Advanced Life Science Institute, Inc. Method of detecting hepatitis b virus
US8679762B2 (en) 2004-09-22 2014-03-25 Advanced Life Science Institute, Inc. Method of detecting hepatitis B virus s antigen
JP5163883B2 (en) * 2008-05-30 2013-03-13 東ソー株式会社 Method for measuring hepatitis B virus core antigen or antibody thereto
JP2011106834A (en) * 2009-11-12 2011-06-02 Tosoh Corp Immunoassay
CN104043120B (en) * 2013-03-13 2017-05-31 南京赛威信生物医药有限公司 Hepatitis b vaccine
CN118063563A (en) 2016-04-06 2024-05-24 华盛顿大学 Therapeutic vaccines for hepatitis B virus (HBV) using HBV core antigen
CN107012127B (en) * 2017-04-01 2018-06-29 四川迈克生物新材料技术有限公司 Monoclonal antibody, its purposes and the hybridoma for secreting the monoclonal antibody of anti-hepatitis B virus core antigen
EP4036111A4 (en) * 2019-09-27 2023-10-25 Fujirebio Inc. Immunoassay for hepatitis b virus core-related antigen and kit therefor
CN113138276B (en) * 2020-01-19 2022-09-16 厦门万泰凯瑞生物技术有限公司 Methods and antibodies for the detection of HBcAg
CN119161462B (en) * 2024-10-09 2025-08-19 深圳市第三人民医院(深圳市肝病研究所) Monoclonal antibody cAbD4 of hepatitis B virus core protein and preparation and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0271302A2 (en) * 1986-12-09 1988-06-15 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
EP0494825A1 (en) * 1991-01-11 1992-07-15 Clonatec S.A. Synthetic peptides, derived from HBc antigen of hepatitis B virus

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8746582A (en) * 1981-09-02 1983-03-10 Biogen N.V. Hepatitis b virus e type antigen
DE3327642A1 (en) * 1983-07-30 1985-02-14 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR DETERMINING A PARTNER OF AN IMMUNE REACTION AND REAGENT FOR CARRYING OUT THIS METHOD
DE3477610D1 (en) * 1983-09-14 1989-05-11 Akzo Nv Method for the immunochemical determination of hepatitis b core antigens
US4683136A (en) * 1985-03-06 1987-07-28 Scripps Clinic And Research Foundation Proteinaceous antigens with conformation-independent and conformation-dependent determinants
US4818527A (en) * 1986-12-09 1989-04-04 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
JPS6425800U (en) 1987-03-03 1989-02-13
DE4107612A1 (en) 1991-03-09 1992-09-10 Behringwerke Ag RECOMBINANT PROTEINS WITH THE IMMUNE REACTIVITY OF HEPATITIS B VIRUS E ANTIGENS (HBEAG), METHODS FOR THEIR PRODUCTION AND THEIR USE IN IMMUNOASSAYS AND VACCINE SUBSTANCES
JPH0850133A (en) * 1994-08-05 1996-02-20 Toray Ind Inc Immunochemical measuring method
JP3780599B2 (en) 1996-02-09 2006-05-31 日本光電工業株式会社 Method for measuring antigen-antibody reaction substance
WO1997035204A1 (en) 1996-03-19 1997-09-25 Akzo Nobel N.V. Method for predicting the outcome of hepatitis b infection
WO1998006949A1 (en) * 1996-08-08 1998-02-19 Hitachi Construction Machinery Co., Ltd. Hydraulic control apparatus
US6060595A (en) 1996-09-03 2000-05-09 The General Hospital Corporation Inhibition of viral replication

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0271302A2 (en) * 1986-12-09 1988-06-15 Scripps Clinic And Research Foundation T cell epitopes of the hepatitis B virus nucleocapsid protein
EP0494825A1 (en) * 1991-01-11 1992-07-15 Clonatec S.A. Synthetic peptides, derived from HBc antigen of hepatitis B virus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIMURA T ET AL: "Sensitive enzyme immunoassay for hepatitis B virus core-related antigens and their correlation to virus load", JOURNAL OF CLINICAL MICROBIOLOGY, WASHINGTON, DC, US, vol. 40, no. 2, February 2002 (2002-02-01), pages 439 - 445, XP002973925, ISSN: 0095-1137 *
NAOUMOV N V ET AL: "DIFFERENTIATION OF CORE GENE PRODUCTS OF THE HEPATITIS B VIRUS IN INFECTED LIVER TISSUE USING MONOCLONAL ANTIBODIES", JOURNAL OF MEDICAL VIROLOGY, ALAN R. LISS, NEW YORK, NY, US, vol. 53, no. 2, October 1997 (1997-10-01), pages 127 - 138, XP001007770, ISSN: 1046-6615 *

Also Published As

Publication number Publication date
ATE539350T1 (en) 2012-01-15
US20040170953A1 (en) 2004-09-02
EP1308730B1 (en) 2011-12-28
US20080138794A1 (en) 2008-06-12
ES2374812T3 (en) 2012-02-22
EP1308730A1 (en) 2003-05-07
CA2419046A1 (en) 2003-02-11
WO2002014871A1 (en) 2002-02-21
US7323331B2 (en) 2008-01-29
JP3847257B2 (en) 2006-11-22
CA2419046C (en) 2007-10-02

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