EP1307190A4 - Utilisation des antagonistes des recepteurs d'il-8 dans le traitement des infections virales - Google Patents

Utilisation des antagonistes des recepteurs d'il-8 dans le traitement des infections virales

Info

Publication number: EP1307190A4
Authority: EP; European Patent Office
Prior art keywords: treatment; receptor antagonists; virus infections; infections; virus
Prior art date: 2000-07-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP01952777A

Other languages

German (de)

English (en)

Other versions

EP1307190A1 (fr

Inventor

Susan B Dillon

Ruth Tal-Singer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-18

Filing date

2001-07-16

Publication date

2007-08-22

2001-07-16 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

2003-05-07 Publication of EP1307190A1 publication Critical patent/EP1307190A1/fr

2007-08-22 Publication of EP1307190A4 publication Critical patent/EP1307190A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP01952777A 2000-07-18 2001-07-16 Utilisation des antagonistes des recepteurs d'il-8 dans le traitement des infections virales Withdrawn EP1307190A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US21905300P	2000-07-18	2000-07-18
US219053P		2000-07-18
PCT/US2001/022328 WO2002005814A1 (fr)	2000-07-18	2001-07-16	Utilisation des antagonistes des recepteurs d'il-8 dans le traitement des infections virales

Publications (2)

Publication Number	Publication Date
EP1307190A1 EP1307190A1 (fr)	2003-05-07
EP1307190A4 true EP1307190A4 (fr)	2007-08-22

Family

ID=22817645

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP01952777A Withdrawn EP1307190A4 (fr)	2000-07-18	2001-07-16	Utilisation des antagonistes des recepteurs d'il-8 dans le traitement des infections virales

Country Status (17)

Country	Link
EP (1)	EP1307190A4 (fr)
JP (1)	JP2004509852A (fr)
KR (1)	KR20030019587A (fr)
CN (1)	CN1449285A (fr)
AR (1)	AR033830A1 (fr)
AU (1)	AU2001273497A1 (fr)
BR (1)	BR0112603A (fr)
CA (1)	CA2418162A1 (fr)
CZ (1)	CZ2003132A3 (fr)
HU (1)	HUP0300754A3 (fr)
IL (1)	IL153921A0 (fr)
MX (1)	MXPA03000500A (fr)
NO (1)	NO20030201L (fr)
NZ (1)	NZ523659A (fr)
PL (1)	PL365886A1 (fr)
WO (1)	WO2002005814A1 (fr)
ZA (1)	ZA200300474B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2006017505A2 (fr) *	2004-08-04	2006-02-16	Schering Corporation	Formulations pharmaceutiques
EA201692111A1 (ru) *	2014-05-12	2017-08-31	Глаксосмитклайн Интеллекчуал Проперти (№ 2) Лимитед	Фармацевтические композиции, содержащие данириксин, для лечения инфекционных заболеваний
EP4008325A1 (fr) *	2020-12-02	2022-06-08	Dompe' Farmaceutici S.P.A.	Inhibiteurs de cxcl8 pour leur utilisation dans le traitement de la covid-19
EP3884932A1 (fr) *	2020-03-26	2021-09-29	Dompe' Farmaceutici S.P.A.	Inhibiteurs de cxcl8 pour leur utilisation dans le traitement de la covid-19
EP4125848A1 (fr) *	2020-03-26	2023-02-08	Dompe' Farmaceutici SpA	Inhibiteurs de cxcl8 destinés à être utilisés dans le traitement de la covid-19

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996005836A2 (fr) *	1994-08-25	1996-02-29	Medical University Of South Carolina	Procedes de traitement de symptomes dus au froid au moyen de la pentoxifylline
WO2000009511A1 (fr) *	1998-08-13	2000-02-24	Astrazeneca Ab	Nouveaux composes de thiazolopyrimidine
WO2000012489A1 (fr) *	1998-09-01	2000-03-09	Astrazeneca Ab	Composes 1,2,4-triazole-3-thione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5547979A (en) *	1992-03-30	1996-08-20	Smithkline Beecham	TNF inhibition
JPH11503110A (ja) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体拮抗剤

2001
- 2001-07-16 NZ NZ523659A patent/NZ523659A/en unknown
- 2001-07-16 MX MXPA03000500A patent/MXPA03000500A/es unknown
- 2001-07-16 KR KR10-2003-7000717A patent/KR20030019587A/ko not_active Withdrawn
- 2001-07-16 WO PCT/US2001/022328 patent/WO2002005814A1/fr not_active Ceased
- 2001-07-16 AU AU2001273497A patent/AU2001273497A1/en not_active Abandoned
- 2001-07-16 IL IL15392101A patent/IL153921A0/xx unknown
- 2001-07-16 HU HU0300754A patent/HUP0300754A3/hu unknown
- 2001-07-16 AR ARP010103395A patent/AR033830A1/es not_active Application Discontinuation
- 2001-07-16 JP JP2002511746A patent/JP2004509852A/ja not_active Withdrawn
- 2001-07-16 EP EP01952777A patent/EP1307190A4/fr not_active Withdrawn
- 2001-07-16 BR BR0112603-2A patent/BR0112603A/pt not_active IP Right Cessation
- 2001-07-16 CZ CZ2003132A patent/CZ2003132A3/cs unknown
- 2001-07-16 CN CN01813095A patent/CN1449285A/zh active Pending
- 2001-07-16 CA CA002418162A patent/CA2418162A1/fr not_active Abandoned
- 2001-07-16 PL PL01365886A patent/PL365886A1/xx not_active Application Discontinuation
2003
- 2003-01-15 NO NO20030201A patent/NO20030201L/no not_active Application Discontinuation
- 2003-01-17 ZA ZA200300474A patent/ZA200300474B/en unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996005836A2 (fr) *	1994-08-25	1996-02-29	Medical University Of South Carolina	Procedes de traitement de symptomes dus au froid au moyen de la pentoxifylline
WO2000009511A1 (fr) *	1998-08-13	2000-02-24	Astrazeneca Ab	Nouveaux composes de thiazolopyrimidine
WO2000012489A1 (fr) *	1998-09-01	2000-03-09	Astrazeneca Ab	Composes 1,2,4-triazole-3-thione

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GRAHAM R: "TAKING ON THE COMMON COLD", TECHNOLOGY REVIEW, ALUMNI ASSOCIATION, CAMBRIDGE, MS, US, February 1997 (1997-02-01), pages 19 - 21, XP002906903, ISSN: 0040-1692 *
HOPKEN ET AL: "467 Increased levels of interleukin-1, interleukin-6, interleukin-8, soluble intercellular adhesion molecule, and bradykinin are detected in nasal secretions of patients during naturally acquired rhinovirus colds", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 97, no. 1, January 1996 (1996-01-01), pages 299, XP005582004, ISSN: 0091-6749 *
See also references of WO0205814A1 *
TERAN LUIS M ET AL: "Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 155, no. 4, 1997, pages 1362 - 1366, XP009086497, ISSN: 1073-449X *
WINTHER B ET AL: "Viral-induced rhinitis.", AMERICAN JOURNAL OF RHINOLOGY 1998 JAN-FEB, vol. 12, no. 1, January 1998 (1998-01-01), pages 17 - 20, XP009086496, ISSN: 1050-6586 *

Also Published As

Publication number	Publication date
IL153921A0 (en)	2003-07-31
HUP0300754A3 (en)	2009-03-02
PL365886A1 (en)	2005-01-10
NZ523659A (en)	2006-01-27
WO2002005814A1 (fr)	2002-01-24
CA2418162A1 (fr)	2002-01-24
HUP0300754A2 (hu)	2003-08-28
CZ2003132A3 (cs)	2003-09-17
BR0112603A (pt)	2004-08-24
AU2001273497A1 (en)	2002-01-30
KR20030019587A (ko)	2003-03-06
EP1307190A1 (fr)	2003-05-07
AR033830A1 (es)	2004-01-07
JP2004509852A (ja)	2004-04-02
ZA200300474B (en)	2004-08-17
MXPA03000500A (es)	2003-06-24
NO20030201L (no)	2003-03-17
CN1449285A (zh)	2003-10-15
NO20030201D0 (no)	2003-01-15

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HUS1300015I1 (hu)	2021-05-28	Humán IL-1béta elleni antitestek
EE200200484A (et)	2004-04-15	Väikeseannuseline entekaviiripreparaat ja selle kasutamine
IL141034A0 (en)	2002-02-10	Uracil compounds and use thereof
PT1317485E (pt)	2011-07-06	Antagonistas da miostatina e suas utilizações
DE60033055D1 (de)	2007-03-08	Bandscheibenbehandlungsvorrichtung
MXPA03004439A (es)	2003-08-19	Aminotiazoles y su uso como antagonistas del receptor de adenosina.
HUP0301308A3 (en)	2010-01-28	Human papilloma virus treatment
DE60026949D1 (de)	2006-05-18	Verbinder
IL152700A0 (en)	2003-06-24	Substituted 1-aminoalkyl-lactams and their use as muscarinc receptor antagonists
IL153708A0 (en)	2003-07-06	Benzimidazole derivatives, preparation and therapeutic use thereof
AR027945A1 (es)	2003-04-16	Uso de pramipexol en el tratamiento de transtornos de adiccion
HUP0401756A3 (en)	2005-06-28	Substituted benzimidazole compounds and their use
HUP0300599A3 (en)	2003-09-29	Il-8 receptor antagonists, pharmaceutical compositions containing them and their use
AU9279601A (en)	2002-04-08	Compounds and methods for use thereof in the treatment of cancer or viral infections
PL376790A1 (pl)	2006-01-09	Pochodne 3-fenylopirydoindolonu, sposób ich wytwarzania i ich zastosowanie terapeutyczne
DE60106146D1 (de)	2004-11-11	Verbinder
GB0105613D0 (en)	2001-04-25	Pharmaceutically effective compounds and their use
DE60107134D1 (de)	2004-12-23	Verbinder
HUP0300754A3 (en)	2009-03-02	Use of il-8 receptor antagonists in the treatment of virus infections
HUP0300470A3 (en)	2005-05-30	Il-8 receptor antagonists, pharmaceutical compositions containing them and their use
EP1322319A4 (fr)	2005-08-31	Utilisation de modulateurs de la proteine d'interleukine 8 dans le traitement d'infections virales
ZA200403530B (en)	2005-07-28	Chemokine receptor antagonists and methods of use thereof.

Legal Events

Date	Code	Title	Description
2003-03-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2003-05-07	17P	Request for examination filed	Effective date: 20030203
2003-05-07	AK	Designated contracting states	Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
2003-05-07	AX	Request for extension of the european patent	Extension state: AL LT LV MK RO SI
2007-08-22	A4	Supplementary search report drawn up and despatched	Effective date: 20070720
2007-08-22	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 11/02 20060101ALI20070717BHEP Ipc: A61K 45/06 20060101ALI20070717BHEP Ipc: A61K 31/00 20060101AFI20070717BHEP
2008-03-21	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-04-23	18D	Application deemed to be withdrawn	Effective date: 20071018
2010-02-26	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1056827 Country of ref document: HK