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EP1397092A2 - Element optique, en particulier implant oculaire - Google Patents

Element optique, en particulier implant oculaire

Info

Publication number
EP1397092A2
EP1397092A2 EP02758255A EP02758255A EP1397092A2 EP 1397092 A2 EP1397092 A2 EP 1397092A2 EP 02758255 A EP02758255 A EP 02758255A EP 02758255 A EP02758255 A EP 02758255A EP 1397092 A2 EP1397092 A2 EP 1397092A2
Authority
EP
European Patent Office
Prior art keywords
filler
optical component
component according
optical
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02758255A
Other languages
German (de)
English (en)
Inventor
Wolfgang MÜLLER-LIERHEIM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coronis GmbH
Original Assignee
Coronis GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coronis GmbH filed Critical Coronis GmbH
Publication of EP1397092A2 publication Critical patent/EP1397092A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties

Definitions

  • the invention relates to an optical component made of a translucent material, in particular an eye implant, for example an intraocular lens.
  • the implant In the case of optical components which are used in particular as eye implants, such as intraocular lenses and the like, efforts are being made to achieve small geometrical dimensions, so that the cut required for the implantation can be kept small. If the implant is to be used as an intraocular lens in the optical system of the eye, it is necessary to achieve the highest possible refractive index of the component material, e.g. obtained by a high electron density of the material. In addition, the implant material must be biocompatible. Various polymers, polymethyl methacrylate and hydrogels, such as HEMA, and silicones are known for this purpose.
  • the object of the invention is therefore to provide an optical component, in particular eye implant, which can be manufactured in the direction of the optical beam path due to its increased refractive index with reduced thickness, ie small geometrical dimensions.
  • This object is achieved according to the invention by adding to the light-transmissive material of the optical component, in particular an eye implant, a substantially translucent filler having a higher refractive index than the surrounding component material and having a particle size at which substantially no light scattering takes place in the component material ,
  • the optically clear or translucent filler has a high electron density, which leads to the increased refractive index.
  • This high electron density can be achieved by sparingly soluble oxides with highly charged cation, for example by heavy metal, in particular lead and bismuth compounds.
  • heavy metal compounds are present in crystalline, in particular nanocrystalline, deposited form, for example as silicates, germanates, aluminates or titanates.
  • the heavy metals are firmly integrated in the crystal matrix and are not dissolved out in the biological environment of the eye.
  • the fillers therefore do not impair the biocompatibility of the translucent component material or implant material, in which they are distributed in finely divided particle form, in particular as nanoparticles.
  • a preferred filler is rutile (TiÜ 2 ).
  • This filler is biocompatible and biocompatible. It is inert and sparingly soluble, thermally stable and thus autoclavable. Furthermore, it is available inexpensively in larger quantities.
  • This filler can be deposited nanocrystalline and thus produced technically in a particle size at which practically no light scattering is caused in the component material.
  • the refractive index of the acrylate through the filler can be increased to about 1.78.
  • the refractive index of the silicone rubber optical material can be increased to about 1.68. This makes it possible to increase the effective refractive index difference, for example, of a foldable implanted intraocular lens in the surrounding aqueous humor by a factor of -2 to 3.5. This makes it possible to produce the foldable intraocular lenses with reduced thickness and improved folding capability.
  • optical components with different filler content can be produced in different zones of the component.
  • Chemically homogeneous components with zones of different refractive indices are obtained.
  • bi- or multifocal lenses can be produced in this way. The transition between areas with different refractive indices is not at risk of breakage.
  • the surface in particular bi- or multifocal lenses may have a homogeneous course, in particular a homogeneous curvature.
  • the optical component can be designed as a medical device or part of a medical device.
  • the optical component can thus be, for example, a spectacle lens, a contact lens for the vision correction of an eye, a component of an endoscope optic or an eye implant, in particular an intraocular lens.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
  • Eyeglasses (AREA)
  • Dental Preparations (AREA)

Abstract

L'invention porte sur un élément optique, en particulier un implant oculaire, fait d'un matériau translucide auquel on ajoute une substance de remplissage translucide d'indice de réfraction plus élevé que celui du matériau translucide, et présentant une taille de particules telle qu'aucune diffusion de lumière ne se produise dans le matériau translucide.
EP02758255A 2001-06-20 2002-06-20 Element optique, en particulier implant oculaire Withdrawn EP1397092A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129787A DE10129787A1 (de) 2001-06-20 2001-06-20 Optisches Bauelement, insbesondere Augenimplantat
DE10129787 2001-06-20
PCT/EP2002/006854 WO2003001278A2 (fr) 2001-06-20 2002-06-20 Element optique, en particulier implant oculaire

Publications (1)

Publication Number Publication Date
EP1397092A2 true EP1397092A2 (fr) 2004-03-17

Family

ID=7688866

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02758255A Withdrawn EP1397092A2 (fr) 2001-06-20 2002-06-20 Element optique, en particulier implant oculaire

Country Status (10)

Country Link
US (1) US20040155312A1 (fr)
EP (1) EP1397092A2 (fr)
JP (1) JP2004530940A (fr)
KR (1) KR20040017236A (fr)
CN (1) CN1533261A (fr)
AU (1) AU2002325257A1 (fr)
BR (1) BR0210535A (fr)
DE (1) DE10129787A1 (fr)
RU (1) RU2004101282A (fr)
WO (1) WO2003001278A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007005249A2 (fr) * 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticules et hydrogels a base de polymeres dendritiques les renfermant
EP1792923B1 (fr) * 2005-12-01 2011-03-30 CORONIS GmbH Composition de polymères avec un haut indice de réfraction
DE102007021954A1 (de) * 2007-05-10 2008-11-13 Neue Materialien Würzburg GmbH Vorrichtung zum Reflektieren elektromagnetischer Strahlung
BR112012004574B8 (pt) 2009-09-01 2021-07-27 Bradley Arthur lente ótica corretiva adaptada para se mover com e mudar o alcance do olho de um usuário, par de lentes óticas corretivas e método de adaptação de uma lente ótica para ter mais do que um alcance
JP5880768B1 (ja) * 2015-07-03 2016-03-09 東亞合成株式会社 無機微粒子分散体組成物およびその硬化物
JP6843022B2 (ja) * 2017-09-07 2021-03-17 信越化学工業株式会社 光硬化型組成物、ヒドロゲル、及びその成形品

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US2601124A (en) * 1949-04-08 1952-06-17 American Optieal Company Solution for reducing light reflection
US3557261A (en) * 1967-10-05 1971-01-19 Ceskoslovenska Akademie Ved Method of centrifugally casting layered contact lenses
DE2242394A1 (de) * 1972-08-29 1974-03-14 Basf Ag Unter lichteinwirkung haertbare stoffgemische
US3996187A (en) * 1975-04-29 1976-12-07 American Optical Corporation Optically clear filled silicone elastomers
US4079470A (en) * 1977-02-16 1978-03-21 American Optical Corporation Artificial intraocular lens
US4418165A (en) * 1980-06-03 1983-11-29 Dow Corning Corporation Optically clear silicone compositions curable to elastomers
JPS62148903A (ja) * 1985-12-24 1987-07-02 Canon Inc 可変焦点光学素子
US5236970A (en) * 1987-02-05 1993-08-17 Allergan, Inc. Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses
JPS63240856A (ja) * 1987-03-28 1988-10-06 キヤノン株式会社 眼内レンズ
JPS63267350A (ja) * 1987-04-27 1988-11-04 Canon Inc 眼内レンズ
US4778462A (en) * 1987-08-24 1988-10-18 Grendahl Dennis T Multiple element zone of focus artificial lens
US5096626A (en) * 1988-06-10 1992-03-17 Asahi Kogaku Kogyo Kabushiki Kaisha Process of molding a coated plastic lens
DE3927667A1 (de) * 1989-08-22 1991-02-28 Espe Stiftung Verwendung von photopolymerisierbaren massen als introkularlinsen-fuellmaterial bei der bekaempfung von katarakt und anderen augenkrankheiten
US5171631A (en) * 1990-07-19 1992-12-15 Aluminum Company Of America Spacer/extender for titanium dioxide in pigment systems for coatings
US5160463A (en) * 1990-10-30 1992-11-03 Pilkington Visioncare, Inc. Method of manufacturing a contact lens
AU650156B2 (en) * 1992-08-05 1994-06-09 Lions Eye Institute Limited Keratoprosthesis and method of producing the same
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DE4420012A1 (de) * 1994-06-08 1995-12-14 Basf Ag Verfahren zur Herstellung von strahlungshärtbaren Acrylaten
JP4034365B2 (ja) * 1995-03-09 2008-01-16 大日本印刷株式会社 超微粒子含有反射防止フィルム、偏光板及び液晶表示装置
JPH08280721A (ja) * 1995-04-20 1996-10-29 Menicon Co Ltd 眼内レンズ
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JP4219485B2 (ja) * 1999-05-21 2009-02-04 株式会社メニコン 光学性含水ゲルからなる眼科用材料
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Non-Patent Citations (1)

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Title
See references of WO03001278A2 *

Also Published As

Publication number Publication date
AU2002325257A1 (en) 2003-01-08
JP2004530940A (ja) 2004-10-07
RU2004101282A (ru) 2005-02-10
KR20040017236A (ko) 2004-02-26
WO2003001278A3 (fr) 2003-12-11
WO2003001278A2 (fr) 2003-01-03
CN1533261A (zh) 2004-09-29
US20040155312A1 (en) 2004-08-12
DE10129787A1 (de) 2003-01-09
BR0210535A (pt) 2004-08-10

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