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EP1373307A4 - COVALENT-REACTIVE TRANSITIONAL ANALOGUE AND METHOD OF USE THEREOF - Google Patents

COVALENT-REACTIVE TRANSITIONAL ANALOGUE AND METHOD OF USE THEREOF

Info

Publication number
EP1373307A4
EP1373307A4 EP02757911A EP02757911A EP1373307A4 EP 1373307 A4 EP1373307 A4 EP 1373307A4 EP 02757911 A EP02757911 A EP 02757911A EP 02757911 A EP02757911 A EP 02757911A EP 1373307 A4 EP1373307 A4 EP 1373307A4
Authority
EP
European Patent Office
Prior art keywords
transitional
analogue
covalent
reactive
transitional analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02757911A
Other languages
German (de)
French (fr)
Other versions
EP1373307A2 (en
Inventor
Sudhir Paul
Yasuhiro Nishiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of EP1373307A2 publication Critical patent/EP1373307A2/en
Publication of EP1373307A4 publication Critical patent/EP1373307A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP02757911A 2001-03-31 2002-04-01 COVALENT-REACTIVE TRANSITIONAL ANALOGUE AND METHOD OF USE THEREOF Withdrawn EP1373307A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28062401P 2001-03-31 2001-03-31
US280624P 2001-03-31
PCT/US2002/010116 WO2002079223A2 (en) 2001-03-31 2002-04-01 Covalently reactive transition state analogs and methods of use thereof

Publications (2)

Publication Number Publication Date
EP1373307A2 EP1373307A2 (en) 2004-01-02
EP1373307A4 true EP1373307A4 (en) 2006-01-25

Family

ID=23073896

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02757911A Withdrawn EP1373307A4 (en) 2001-03-31 2002-04-01 COVALENT-REACTIVE TRANSITIONAL ANALOGUE AND METHOD OF USE THEREOF

Country Status (3)

Country Link
EP (1) EP1373307A4 (en)
CA (1) CA2442693A1 (en)
WO (1) WO2002079223A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980646B2 (en) * 2003-03-26 2015-03-17 Sudhir Paul Proteolytic and covalent antibodies
US9006388B2 (en) * 2003-03-26 2015-04-14 Sudhir Paul Covalent attachment of ligands to nucleophilic proteins guided by non-covalent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048925A1 (en) * 1998-03-23 1999-09-30 University Of Nebraska Board Of Regents Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952462A (en) * 1983-11-29 1999-09-14 Igen International Inc. Transition state analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048925A1 (en) * 1998-03-23 1999-09-30 University Of Nebraska Board Of Regents Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NISHIYAMA YASUHIRO ET AL: "Covalent reactivity of phosphonate monophenyl esters with serine proteinases: An overlooked feature of presumed transition state analogs", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 402, no. 2, 15 June 2002 (2002-06-15), pages 281 - 288, XP002341245, ISSN: 0003-9861 *
PAUL SUDHIR ET AL: "Phosphonate ester probes for proteolytic antibodies", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 30, 27 July 2001 (2001-07-27), pages 28314 - 28320, XP002341032, ISSN: 0021-9258 *
See also references of WO02079223A3 *

Also Published As

Publication number Publication date
WO2002079223A2 (en) 2002-10-10
WO2002079223A3 (en) 2003-07-24
EP1373307A2 (en) 2004-01-02
WO2002079223A9 (en) 2003-01-09
CA2442693A1 (en) 2002-10-10

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20031020

AK Designated contracting states

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AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 12N 9/00 A

A4 Supplementary search report drawn up and despatched

Effective date: 20051215

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20060322