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EP1361917B1 - Device for mixing and homogenizing materials in laboratory test container with a stirring element - Google Patents

Device for mixing and homogenizing materials in laboratory test container with a stirring element Download PDF

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Publication number
EP1361917B1
EP1361917B1 EP01969125A EP01969125A EP1361917B1 EP 1361917 B1 EP1361917 B1 EP 1361917B1 EP 01969125 A EP01969125 A EP 01969125A EP 01969125 A EP01969125 A EP 01969125A EP 1361917 B1 EP1361917 B1 EP 1361917B1
Authority
EP
European Patent Office
Prior art keywords
laboratory test
test container
lid
cutting edges
stirring element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP01969125A
Other languages
German (de)
French (fr)
Other versions
EP1361917A1 (en
Inventor
Franz G. Bucher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miltenyi Biotec Swiss AG
Original Assignee
Medic Tools AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medic Tools AG filed Critical Medic Tools AG
Publication of EP1361917A1 publication Critical patent/EP1361917A1/en
Application granted granted Critical
Publication of EP1361917B1 publication Critical patent/EP1361917B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/86—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis co-operating with deflectors or baffles fixed to the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4534—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a rod for supporting the stirring element, e.g. stirrer sliding on a rod or mounted on a rod sliding in a tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/83—Mixing plants specially adapted for mixing in combination with disintegrating operations
    • B01F33/8305—Devices with one shaft, provided with mixing and milling tools, e.g. using balls or rollers as working tools; Devices with two or more tools rotating about the same axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/60—Safety arrangements
    • B01F35/605—Safety devices concerning the operation of the mixer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F2035/35—Use of other general mechanical engineering elements in mixing devices
    • B01F2035/351—Sealings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/836—Mixing plants; Combinations of mixers combining mixing with other treatments
    • B01F33/8361—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating
    • B01F33/83611—Mixing plants; Combinations of mixers combining mixing with other treatments with disintegrating by cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F35/32—Driving arrangements
    • B01F35/321—Disposition of the drive
    • B01F35/3213—Disposition of the drive at the lower side of the axis, e.g. driving the stirrer from the bottom of a receptacle

Definitions

  • the invention relates to a device for mixing and homogenizing of materials, especially infectious or chemical aggressive materials, in a laboratory test vessel.
  • Such Devices are known from DE-9-3 638 656 and GB-A-820574 known.
  • Magnetic stirrers and mechanical stirrers are common in the laboratory known and in use. In the crushing of infectious or chemically aggressive materials in non-hermetic Closed vessels there is a large infection and / or Contamination risk due to uncontrolled splashes, which penetrate through the opening of the laboratory test tube to the outside can, by unintentional tipping over the laboratory test vessel and through the use of reusable mixers. This is special in the case of test tubes and mixers known for this purpose.
  • the lid is designed as a disposable lid, so that it is disposed of immediately after use and thus a Contamination during further work in the laboratory safely avoided becomes.
  • Fig. 1 shows a schematic partially sectioned side View of a first embodiment of the invention.
  • a laboratory test vessel is provided with the reference numeral 20. there this is a cylindrical tube 18 with conical tapered tip 21.
  • the interior 17 of the laboratory test tube 20 is filled with the materials to be mixed 37. Subsequently the laboratory test tube 20 is in use the disposable screw cap 10 with this closed and then on upside down.
  • disposable screw cap or disposable snap cap (Snap-cap) 10 of the hermetically sealable laboratory test tube 20 is a sunken, four-sided, with radial and axial Cutting edges 29 provided plastic or metal beams 11th provided at the cutting edges 28 of the cutting ribs 12 is passed.
  • This bar 11 is using the axis 13 from outside the laboratory test vessel 20 from a six-point quick release ring 14 driven.
  • the laboratory test vessel 20 with the mixing and homogenizing Materials will be appropriate for inverted vessel position Fig. 1 frictionally via the coupling ring 14 on a external drive provided.
  • the transmitted rotary motion are located in the interior 17 of the vessel 20 Substances and liquids through the beam 11 axially, that is along the longitudinal axis 22 of the laboratory test vessel 20, aspirated and thrown radially. They are under Cutting action on the peripheral cutting ribs 12 through the Slits ejected. As a result, the mix is crushed, mixed, homogenized and then at the mixer wall 15, extending respectively between the cutting ribs 12, after upside down.
  • the set around the axis 13 sealing ring 16th prevents the leakage of the liquid.
  • the rotational energy is mechanically from the outside on the coupling ring 14 and the axis 13 transferred to the beam 11.
  • the speed is material specific set for optimal homogenization.
  • Of the Seal ring 16 may be realized by a sealing lip.
  • Fig. 2 shows a schematic plan view of the disposable lid 10 of the first embodiment of FIG. 1. Same Features are provided in all figures with the same reference numerals.
  • the cutting lips 12 are by a wave on the circumference arranged element formed, which here nine lips includes.
  • the bar 11 may, for example, be U-shaped, downwards open, be trained, so that on both sides of the beam 11 two vertical cutting edges 29 exist. These two each Cutting edges 29 are at a short distance here eighteen (two times nine) cutting edges 28 of the cutting lips 12 opposite.
  • FIG. 3 shows an isolated view of the disposable lid 10 from Fig. 1, in which all for the transmission of the rotational movement essential elements are inserted into the body 3.
  • the Fig. 4 shows an exploded view of the one-way lid 10 used drive of FIG. 1, consisting of the beam eleventh with integrally connected axle 13, the sealing ring 16 and the coupling ring 14, all about the longitudinal axis 22 of the device are arranged.
  • Fig. 5 shows a schematic partially cut side View of a second embodiment of the invention.
  • the disposable lid 10 has a body 3 having a circumferential groove 24, in which the laboratory test vessel 20 can be inserted or is screwed.
  • a sealing element 1 is used, which at the same time the interior 9 of the laboratory test tube 20 hermetically opposite the outside space concludes.
  • the sealing element 1 has at the same time via a transversely to the longitudinal axis 22 arranged, perforated Disc, which forms a cavity 30 with respect to the body 3, which forms a cylindrical cage.
  • a turnstile 2 is arranged in this cavity 30.
  • the turnstile 2 has radial 39 and peripheral 38 cutting edges attached to the corresponding cutting edges 31 of the inlet holes 25 are passed.
  • a sealing lip 5 prevents the leakage of the liquid.
  • the rotational energy becomes mechanical transferred from the outside to the hexagon socket 6 and the axis 4.
  • the speed is also material specific for a optimal homogenization.
  • Fig. 6 shows a schematic plan view of the disposable lid of the second embodiment of FIG. 5.
  • the sealing element 1 has four openings 25 in the disk area here on, which are at a radial distance from the axis 22 and are arranged at an angular distance of 90 degrees to each other.
  • the cutting element is a turnstile 2 with four arms 32. Instead of four breakthroughs 25 and a turnstile 2 with four Poor 32 are also corresponding elements with three or example five breakthroughs / arms possible.
  • the turnstile 2 can be a four-sided plastic cross.
  • FIG. 7 shows a representation of the disposable lid from FIG. 5.
  • Fig. 8 shows an exploded view of the one-way lid 10 used drive of FIG. 5, from the four Elements exists. It is indicated here by the reference numeral, the laboratory test vessel 20 is screwed into the circumferential groove which is on its outside over a corresponding thread 33 features.
  • the drive axle 4 can be thermally conductive, so that 4 heat energy into the laboratory test vessel via this drive axle 20 insertable or can be derived from this to the outside. It can be provided that in the laboratory test vessel 20 electrical Energy is introduced via the drive axle 4 and / or the electrochemical sensors are used.
  • Fig. 9 shows a schematic partially sectioned lateral View of a third embodiment of the invention.
  • the lid 10 is a rotary wing or rotor 13 in a cylindrical Cage 42 integrated.
  • the cylindrical cage 12 is used in a body 41 of the lid 10 and has four radially aligned, oval openings 26, through which the material to be homogenized into the cavity 30 in the cage 42 guided and cut off there by the rotor 13.
  • the laboratory test vessel 20 with the tissue material 27 is placed on the cover standing in the drive, so that there is a filling level 37 and the material with the cage 42 and the rotor 13 is in contact.
  • the in the Drawings not shown known drive comprises a another magnetic rotor, with which the rotational energy magnetic or transmitted electromagnetically.
  • the magnetic Field strength is dimensioned such that one for homogenization optimum torque is transmitted.
  • Fig. 10 shows a schematic plan view of the disposable lid 10 of the third embodiment of FIG. 9 and the Fig. 11 shows a representation of the disposable lid of Fig. 9.
  • the circular groove 24 allows one via a positive Seat passing passport of the laboratory test tube 20 in the lid 11.
  • the magnetic bar 13 is constructed asymmetrically, so that through the aerodynamically optimized design in one Direction of rotation a central liquid flow from top to bottom and in the other direction of rotation a lateral fluid flow along the wall of the laboratory test vessel 20 from top to bottom generated. By reversing the direction of rotation is thus the Ansaugund Output changed.
  • Fig. 12 shows a schematic sectional side view a disposable lid according to a fourth embodiment of the invention
  • Fig. 13 is a plan view of the disposable lid from Fig. 12.
  • the differences from the embodiment Fig. 1 is particularly as follows.
  • the quick coupling ring 14 has teeth on its underside, teeth 53 in one Drive shaft 54 engage.
  • the lower edge 55 of the body 3 is in particular pulled so far down that the lid 10th can be placed flat without the teeth of the quick coupling ring 14 survive.
  • the reference numeral 59 denotes a ball bearing for the shaft 13.
  • a ball bearing is for a cost-effective Manufacture of the device as a disposable lid 10 is not required. It can not in particular by a in the drawings shown slide bearing of the drive shaft 13 are replaced the seal provided by an inserted O-ring becomes. This is particularly advantageous because at a Disposable lid 10 the bearing only once and then for only one burdened for a short time and must withstand this load.
  • the cage 52 forms here simultaneously cutting edges, the not from breakthroughs as in the second embodiment and also not from a purely lateral element as in the first embodiment consist.
  • the cage 52 has down drawn lugs 56, which embrace the beam 11. This one is with equipped with two arms, but it can also be a turnstile 2 with be provided more poor.
  • the cutting edges 57 are in particular can be seen in the plan view of FIG. 13, wherein cavities 58 are adjacent lugs 56 record material to it then to cut off with the bar 11.
  • sensor lines through the Body 3 are performed on the outward-facing Page have electrical connections.
  • a sensor while mixing near the ground be arranged processing material.
  • sensor cables can also be performed a light guide or a Supply line, which in the interior 60 a radiator or a Peltier element forms.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A device for mixing and homogenizing materials, especially infectious or chemically aggressive materials, which can be inserted into a laboratory test container. A disposable lid is provided to hermetically seal said laboratory test container. A stirring element is provided in the disposable lid for processing the material that is introduced into the laboratory test container. Said stirring element is fitted with a cutting element that rotates about the longitudinal axis of the laboratory test container, said cutting element processing the material together with additional cutting edges. Complete homogenization of tissue fragments can be securely achieved by hermetically closing the laboratory test container.

Description

Die Erfindung betrifft eine Vorrichtung zum Mischen und Homogenisieren von Materialien, insbesondere infektiösen oder chemisch aggressiven Materialien, in einem Labortestgefäss. Solche Vorrichtungen sind aus der DE-9-3 638 656 und der GB-A-820574 bekannt.The invention relates to a device for mixing and homogenizing of materials, especially infectious or chemical aggressive materials, in a laboratory test vessel. Such Devices are known from DE-9-3 638 656 and GB-A-820574 known.

Magnetrührer und mechanische Rührer sind im Laborbetrieb allgemein bekannt und gebräuchlich. Bei der Zerkleinerung von infektiösen oder chemisch aggressiven Materialien in nicht hermetisch abgeschlossenen Gefässen besteht eine grosse Infektionsund/oder Kontaminationsgefahr durch unkontrollierte Spritzer, die durch die Öffnung des Labortestgefässes nach aussen dringen können, durch unbeabsichtigtes Umkippen des Labortestgefässes und durch die Verwendung von Mehrwegmixern. Dies ist insbesondere bei Reagenzgläsern und hierfür bekannte Mischer der Fall.Magnetic stirrers and mechanical stirrers are common in the laboratory known and in use. In the crushing of infectious or chemically aggressive materials in non-hermetic Closed vessels there is a large infection and / or Contamination risk due to uncontrolled splashes, which penetrate through the opening of the laboratory test tube to the outside can, by unintentional tipping over the laboratory test vessel and through the use of reusable mixers. This is special in the case of test tubes and mixers known for this purpose.

Ausgehend von diesem Stand der Technik ist es Aufgabe der vorliegenden Erfindung, eine Vorrichtung der eingangs genannten Art zu schaffen, der eine hermetische Verschliessung des Labortestgefässes und eine vollständige Durchmischung von mischbaren Stoffen und Flüssigkeiten erlaubt.Based on this prior art, it is the task of the present Invention, a device of the type mentioned to create a hermetic seal of the laboratory test vessel and a complete mixing of miscible Substances and liquids allowed.

Diese Aufgabe wird erfindungsgemäss mit einer Vorrichtung mit den Merkmalen des Anspruchs 1 gelöst.This object is achieved according to the invention with a device the features of claim 1 solved.

Dadurch, dass ein Deckel vorgesehen ist, mit dem gleichzeitig das Labortestgefäss hermetisch verschlossen wird und in dem Labortestgefäss befindliche Materialien verarbeitet werden, insbesondere gemischt und homogenisiert, wird die Arbeitssicherheit des die Verarbeitung vornehmenden Benutzers wesentlich erhöht. Damit sind auch infektiöse Gewebefragmente in sicherer Weise behandelbar. Durch die hermetische Verschliessung des Labortestgefässes kann so in sicherer Weise eine vollständige Homogenisierung der Gewebefragmente erreicht werden.The fact that a lid is provided with the same time the laboratory test vessel is hermetically sealed and in the Laboratory test tube located materials are processed, in particular mixed and homogenized, the work safety of the processing user taking substantially increased. Infectious tissue fragments can therefore also be treated safely. By the hermetic closure of the laboratory test vessel so can safely complete a complete homogenization the tissue fragments are achieved.

Vorteilhafterweise ist der Deckel als Einwegdeckel ausgestaltet, so dass er direkt nach Gebrauch entsorgt wird und somit eine Kontamination bei der weiteren Arbeit im Labor sicher vermieden wird.Advantageously, the lid is designed as a disposable lid, so that it is disposed of immediately after use and thus a Contamination during further work in the laboratory safely avoided becomes.

Die Erfindung wird nachfolgend an verschiedenen Ausführungsbeispielen unter Bezugnahme auf die beigefügten Zeichnungen näher erläutert. Es zeigen:

Fig. 1
eine schematische teilweise geschnittene seitliche Ansicht eines ersten Ausführungsbeispiels der Erfindung,
Fig. 2
eine schematische Draufsicht auf den Einwegdeckel des ersten Ausführungsbeispiels nach Fig. 1,
Fig. 3
eine Darstellung des Einwegdeckels aus Fig. 1,
Fig. 4
eine Explosionsdarstellung des in dem Einwegdeckel eingesetzten Antriebs aus Fig. 1,
Fig. 5
eine schematische teilweise geschnittene seitliche Ansicht eines zweiten Ausführungsbeispiels der Erfindung,
Fig. 6
eine schematische Draufsicht auf den Einwegdeckel des zweiten Ausführungsbeispiels nach Fig. 5,
Fig. 7
eine Darstellung des Einwegdeckels aus Fig. 5,
Fig. 8
eine Explosionsdarstellung des in dem Einwegdeckel eingesetzten Antriebs aus Fig. 5,
Fig. 9
eine schematische teilweise geschnittene seitliche Ansicht eines dritten Ausführungsbeispiels der Erfindung,
Fig. 10
eine schematische Draufsicht auf den Einwegdeckel des dritten Ausführungsbeispiels nach Fig. 9,
Fig. 11
eine Darstellung des Einwegdeckels aus Fig. 9,
Fig. 12
eine schematische geschnittene seitliche Ansicht eines Einwegdeckels nach einem vierten Ausführungsbeispiel der Erfindung, und
Fig. 13
eine Draufsicht auf den Einwegdeckel aus Fig. 12.
The invention will be explained in more detail below with reference to various embodiments with reference to the accompanying drawings. Show it:
Fig. 1
a schematic partially sectioned side view of a first embodiment of the invention,
Fig. 2
1 is a schematic plan view of the disposable lid of the first embodiment of FIG. 1,
Fig. 3
1 is an illustration of the disposable lid of FIG. 1, FIG.
Fig. 4
an exploded view of the drive used in the disposable lid of FIG. 1,
Fig. 5
a schematic partially sectioned side view of a second embodiment of the invention,
Fig. 6
1 is a schematic plan view of the disposable lid of the second embodiment of FIG. 5,
Fig. 7
a representation of the disposable lid of FIG. 5,
Fig. 8
an exploded view of the drive used in the disposable lid of FIG. 5,
Fig. 9
a schematic partially sectioned side view of a third embodiment of the invention,
Fig. 10
a schematic plan view of the disposable lid of the third embodiment of FIG. 9,
Fig. 11
a representation of the disposable lid of FIG. 9,
Fig. 12
a schematic sectional side view of a disposable lid according to a fourth embodiment of the invention, and
Fig. 13
a plan view of the disposable lid of FIG. 12th

Die Fig. 1 zeigt eine schematische teilweise geschnittene seitliche Ansicht eines ersten Ausführungsbeispiels der Erfindung. Ein Labortestgefäss ist mit dem Bezugszeichen 20 versehen. Dabei handelt es sich hier um ein zylindrisches Röhrchen 18 mit konisch zulaufender Spitze 21. Das Innere 17 des Labortestgefässes 20 wird mit den zu mischenden Materialien 37 gefüllt. Anschliessend wird das Labortestgefäss 20 ist im Einsatz des Einweg-Schraubverschlussdeckels 10 mit diesem verschlossen und dann auf den Kopf gestellt.Fig. 1 shows a schematic partially sectioned side View of a first embodiment of the invention. A laboratory test vessel is provided with the reference numeral 20. there this is a cylindrical tube 18 with conical tapered tip 21. The interior 17 of the laboratory test tube 20 is filled with the materials to be mixed 37. Subsequently the laboratory test tube 20 is in use the disposable screw cap 10 with this closed and then on upside down.

Im Einweg-Schraubverschlussdeckel oder Einweg-Schnappkappe (Snap-Cap) 10 des hermetisch abdichtbaren Labortestgefässes 20 ist ein eingelassener, vierkantiger, mit radialen und axialen Schneidekanten 29 versehener Kunststoff- oder Metallbalken 11 vorgesehen, der an den schneidenden Kanten 28 der Schneidrippen 12 vorbeigeführt wird. Dieser Balken 11 wird mit Hilfe der Achse 13 von ausserhalb des Labortestgefässes 20 von einem Innensechspunkte-Schnellkupplungsring 14 angetrieben.In disposable screw cap or disposable snap cap (Snap-cap) 10 of the hermetically sealable laboratory test tube 20 is a sunken, four-sided, with radial and axial Cutting edges 29 provided plastic or metal beams 11th provided at the cutting edges 28 of the cutting ribs 12 is passed. This bar 11 is using the axis 13 from outside the laboratory test vessel 20 from a six-point quick release ring 14 driven.

Das Labortestgefäss 20 mit den zu mischenden und homogenisierenden Materialien wird bei kopfstehender Gefässstellung entsprechend Fig. 1 kraftschlüssig über den Kupplungsring 14 auf einen externen Antrieb gestellt. Durch die übertragene Drehbewegung werden die sich im Innenraum 17 des Gefässes 20 befindlichen Stoffe und Flüssigkeiten durch den Balken 11 axial, das heisst entlang der longitudinalen Achse 22 des Labortestgefässes 20, angesaugt und radial weggeschleudert. Dabei werden sie unter Schneideinwirkung an den peripheren Schneidrippen 12 durch die Schlitze ausgestossen. Dadurch wird das Mixgut zerquetscht, gemischt, homogenisiert und anschliessend an der Mischerwand 15, die sich jeweils zwischen den Schneidrippen 12 erstreckt, nach oben umgelenkt. Der um die Achse 13 gelegte Dichtungsring 16 verhindert das Auslaufen der Flüssigkeit. Die Rotationsenergie wird mechanisch von aussen auf den Kupplungsring 14 und die Achse 13 auf den Balken 11 übertragen. Die Drehzahl ist materialspezifisch für eine optimale Homogenisierung festgelegt. Der Dichtungsring 16 kann durch eine Dichtungslippe realisiert sein.The laboratory test vessel 20 with the mixing and homogenizing Materials will be appropriate for inverted vessel position Fig. 1 frictionally via the coupling ring 14 on a external drive provided. By the transmitted rotary motion are located in the interior 17 of the vessel 20 Substances and liquids through the beam 11 axially, that is along the longitudinal axis 22 of the laboratory test vessel 20, aspirated and thrown radially. They are under Cutting action on the peripheral cutting ribs 12 through the Slits ejected. As a result, the mix is crushed, mixed, homogenized and then at the mixer wall 15, extending respectively between the cutting ribs 12, after upside down. The set around the axis 13 sealing ring 16th prevents the leakage of the liquid. The rotational energy is mechanically from the outside on the coupling ring 14 and the axis 13 transferred to the beam 11. The speed is material specific set for optimal homogenization. Of the Seal ring 16 may be realized by a sealing lip.

Die Fig. 2 zeigt eine schematische Draufsicht auf den Einwegdekkel 10 des ersten Ausführungsbeispiels nach Fig. 1. Gleiche Merkmale sind in allen Fig. mit den gleichen Bezugszeichen versehen. Die Schneidlippen 12 sind durch ein wellenförmig am Umkreis angeordnetes Element ausgebildet, welches hier neun Lippen umfasst. Der Balken 11 kann beispielsweise U-förmig, nach unten offen, ausgebildet sein, so dass auf beiden Seiten des Balkens 11 zwei vertikale Schneidkanten 29 bestehen. Diese jeweils zwei Schneidkanten 29 stehen in einem geringen Abstand den hier achtzehn (zwei mal neun) Schneidkanten 28 der Schneidlippen 12 gegenüber.Fig. 2 shows a schematic plan view of the disposable lid 10 of the first embodiment of FIG. 1. Same Features are provided in all figures with the same reference numerals. The cutting lips 12 are by a wave on the circumference arranged element formed, which here nine lips includes. The bar 11 may, for example, be U-shaped, downwards open, be trained, so that on both sides of the beam 11 two vertical cutting edges 29 exist. These two each Cutting edges 29 are at a short distance here eighteen (two times nine) cutting edges 28 of the cutting lips 12 opposite.

Die Fig. 3 zeigt eine isolierte Darstellung des Einwegdeckels 10 aus Fig. 1, bei dem alle für die Übertragung der Drehbewegung wesentlichen Elemente in den Körper 3 eingesetzt sind. Die Fig. 4 zeigt eine Explosionsdarstellung des in dem Einwegdeckel 10 eingesetzten Antriebs aus Fig. 1, bestehend aus dem Balken 11 mit einstückig verbundener Achse 13, dem Dichtungsring 16 und dem Kupplungsring 14, die alle um die Längsachse 22 der Vorrichtung angeordnet sind.FIG. 3 shows an isolated view of the disposable lid 10 from Fig. 1, in which all for the transmission of the rotational movement essential elements are inserted into the body 3. The Fig. 4 shows an exploded view of the one-way lid 10 used drive of FIG. 1, consisting of the beam eleventh with integrally connected axle 13, the sealing ring 16 and the coupling ring 14, all about the longitudinal axis 22 of the device are arranged.

Die Fig. 5 zeigt eine schematische teilweise geschnittene seitliche Ansicht eines zweiten Ausführungsbeispiels der Erfindung. Fig. 5 shows a schematic partially cut side View of a second embodiment of the invention.

Der Einwegdeckel 10 verfügt über einen Körper 3, der eine Umkreisnut 24 aufweist, in die das Labortestgefäss 20 einsteckbar oder einschraubbar ist. An der Innenseite der Umkreisnut 24 ist ein Dichtungselement 1 eingesetzt, welches gleichzeitig den Innenraum 9 des Labortestgefässes 20 hermetisch gegenüber dem Aussenraum abschliesst. Das Dichtungselement 1 verfügt gleichzeitig über eine quer zur Längsachse 22 angeordnete, durchlöcherte Scheibe, die gegenüber dem Körper 3 einen Hohlraum 30 ausbildet, der einen zylindrischen Käfig formt. In diesem Hohlraum 30 ist ein Drehkreuz 2 angeordnet. Das Drehkreuz 2 hat radiale 39 und periphere 38 Schneidkanten, die an den entsprechenden Schneidkanten 31 der Einlasslöcher 25 vorbeigeführt werden. Das Labortestgefäss 20 mit den zu mit mischenden Materialien wird dann mit dem Einwegdeckel 10 verschlossen, auf den Kopf gestellt und kraftschlüssig über die Antriebsachse 4 und den Anschluss 6 auf den externen Antrieb gestellt. Eine Dichtungslippe 5 verhindert das Auslaufen der Flüssigkeit. Die Rotationsenergie wird mechanisch von aussen auf den Innensechskant 6 und die Achse 4 übertragen. Die Drehzahl wird auch hier materialspezifisch für eine optimale Homogenisierung festgelegt.The disposable lid 10 has a body 3 having a circumferential groove 24, in which the laboratory test vessel 20 can be inserted or is screwed. On the inside of the circumferential groove 24 is a sealing element 1 is used, which at the same time the interior 9 of the laboratory test tube 20 hermetically opposite the outside space concludes. The sealing element 1 has at the same time via a transversely to the longitudinal axis 22 arranged, perforated Disc, which forms a cavity 30 with respect to the body 3, which forms a cylindrical cage. In this cavity 30 is a turnstile 2 is arranged. The turnstile 2 has radial 39 and peripheral 38 cutting edges attached to the corresponding cutting edges 31 of the inlet holes 25 are passed. The laboratory test vessel 20 with the materials to be mixed with then closed with the disposable lid 10, turned upside down and non-positively on the drive shaft 4 and the terminal 6 put the external drive. A sealing lip 5 prevents the leakage of the liquid. The rotational energy becomes mechanical transferred from the outside to the hexagon socket 6 and the axis 4. The speed is also material specific for a optimal homogenization.

Die Fig. 6 zeigt eine schematische Draufsicht auf den Einwegdekkel des zweiten Ausführungsbeispiels nach Fig. 5. Das Dichtungselement 1 weist in dem Scheibenbereich hier vier Durchbrüche 25 auf, die in einem radialen Abstand von der Achse 22 stehen und im Winkelabstand von 90 Grad zueinander angeordnet sind. Hier ist das Schneidelement ein Drehkreuz 2 mit vier Armen 32. Anstelle von vier Durchbrüchen 25 und einem Drehkreuz 2 mit vier Armen 32 sind auch entsprechende Elemente mit drei oder beispielsweise fünf Durchbrüchen/Armen möglich. Das Drehkreuz 2 kann ein vierkantiges Kunststoffkreuz sein.Fig. 6 shows a schematic plan view of the disposable lid of the second embodiment of FIG. 5. The sealing element 1 has four openings 25 in the disk area here on, which are at a radial distance from the axis 22 and are arranged at an angular distance of 90 degrees to each other. Here the cutting element is a turnstile 2 with four arms 32. Instead of four breakthroughs 25 and a turnstile 2 with four Poor 32 are also corresponding elements with three or example five breakthroughs / arms possible. The turnstile 2 can be a four-sided plastic cross.

Die Fig. 7 zeigt eine Darstellung des Einwegdeckels aus Fig. 5. FIG. 7 shows a representation of the disposable lid from FIG. 5.

Die Fig. 8 zeigt eine Explosionsdarstellung des in dem Einwegdeckel 10 eingesetzten Antriebs aus Fig. 5, der aus den vier Elementen besteht. Dabei ist hier mit dem Bezugszeichen angedeutet, dass das Labortestgefäss 20 in die Umkreisnut eingeschraubt wird, die an ihrer Aussenseite über ein entsprechendes Gewinde 33 verfügt.Fig. 8 shows an exploded view of the one-way lid 10 used drive of FIG. 5, from the four Elements exists. It is indicated here by the reference numeral, the laboratory test vessel 20 is screwed into the circumferential groove which is on its outside over a corresponding thread 33 features.

Insbesondere kann die Antriebsachse 4 wärmeleitend sein, so dass über diese Antriebsachse 4 Wärmeenergie in das Labortestgefäss 20 einführbar oder aus diesem nach aussen ableitbar ist. Es kann auch vorgesehen sein, dass in das Labortestgefäss 20 elektrische Energie über die Antriebsachse 4 eingeführt wird und/oder das elektrochemische Sensoren eingesetzt sind.In particular, the drive axle 4 can be thermally conductive, so that 4 heat energy into the laboratory test vessel via this drive axle 20 insertable or can be derived from this to the outside. It can be provided that in the laboratory test vessel 20 electrical Energy is introduced via the drive axle 4 and / or the electrochemical sensors are used.

Die Fig. 9 zeigt eine schematische teilweise geschnittene seitliche Ansicht eines dritten Ausführungsbeispiels der Erfindung. In den Deckel 10 ist ein Drehflügel oder Rotor 13 in einem zylindrischen Käfig 42 integriert. Der zylindrische Käfig 12 ist in einem Körper 41 des Deckels 10 eingesetzt und verfügt über vier radial ausgerichtete, ovale Durchbrüche 26, durch die das zu homogenisierende Material in den Hohlraum 30 in dem Käfig 42 geführt und dort von dem Rotor 13 abgeschnitten wird.Fig. 9 shows a schematic partially sectioned lateral View of a third embodiment of the invention. In the lid 10 is a rotary wing or rotor 13 in a cylindrical Cage 42 integrated. The cylindrical cage 12 is used in a body 41 of the lid 10 and has four radially aligned, oval openings 26, through which the material to be homogenized into the cavity 30 in the cage 42 guided and cut off there by the rotor 13.

Der inerte Rotor 13, der aus einem Stabmagnet 43 gebildet sein kann oder diesen als Kern umfasst, hat radiale 39 und periphere 38 Schneidkanten, die an den entsprechenden Schneidkanten 31, das heisst den Rändern der Öffnungen 26, des zylindrischen Käfigs 42 vorbeigeführt werden. Das Labortestgefäss 20 mit dem Gewebematerial 27 wird auf dem Deckel stehend in den Antrieb gestellt, so dass sich eine Füllhöhe 37 ergibt und das Material mit dem Käfig 42 und dem Rotor 13 in Kontakt steht. Der in den Zeichnungen nicht dargestellte bekannte Antrieb umfasst einen weiteren magnetischen Rotor, mit dem die Rotationsenergie magnetisch oder elektromagnetisch übertragen wird. Die magnetische Feldstärke ist so dimensioniert, dass ein für die Homogenisierung optimales Drehmoment übertragen wird.The inert rotor 13, which may be formed of a bar magnet 43 may or includes this as a core, has radial 39 and peripheral 38 cutting edges, which at the corresponding cutting edges 31, that is, the edges of the openings 26, the cylindrical cage 42 are passed. The laboratory test vessel 20 with the tissue material 27 is placed on the cover standing in the drive, so that there is a filling level 37 and the material with the cage 42 and the rotor 13 is in contact. The in the Drawings not shown known drive comprises a another magnetic rotor, with which the rotational energy magnetic or transmitted electromagnetically. The magnetic Field strength is dimensioned such that one for homogenization optimum torque is transmitted.

Die Fig. 10 zeigt eine schematische Draufsicht auf den Einwegdeckel 10 des dritten Ausführungsbeispiels nach Fig. 9 und die Fig. 11 zeigt eine Darstellung des Einwegdeckels aus Fig. 9. Die kreisförmige Nut 24 gestattet einen über einen formschlüssigen Sitz hinausgehenden Passitz des Labortestgefässes 20 in dem Dekkel 11. Der Magnetstab 13 ist asymmetrisch aufgebaut, so dass durch den strömungstechnisch optimierten Aufbau in der einen Drehrichtung ein zentraler Flüssigkeitsstrom von oben nach unten und in der anderen Drehrichtung ein lateraler Flüssigkeitsstrom entlang der Wand des Labortestgefässes 20 von oben nach unten erzeugt. Durch eine Drehrichtungsumkehr wird somit die Ansaugund Ausstosswirkung geändert.Fig. 10 shows a schematic plan view of the disposable lid 10 of the third embodiment of FIG. 9 and the Fig. 11 shows a representation of the disposable lid of Fig. 9. The circular groove 24 allows one via a positive Seat passing passport of the laboratory test tube 20 in the lid 11. The magnetic bar 13 is constructed asymmetrically, so that through the aerodynamically optimized design in one Direction of rotation a central liquid flow from top to bottom and in the other direction of rotation a lateral fluid flow along the wall of the laboratory test vessel 20 from top to bottom generated. By reversing the direction of rotation is thus the Ansaugund Output changed.

Die Fig. 12 zeigt eine schematische geschnittene seitliche Ansicht eines Einwegdeckels nach einem vierten Ausführungsbeispiel der Erfindung, und die Fig. 13 eine Draufsicht auf den Einwegdeckel aus Fig. 12. Dabei ist hier zusätzlich noch der Anschluss dargestellt. Die Unterschiede zu dem Ausführungsbeispiel aus Fig. 1 sind insbesondere wie folgt. Der Schnellkupplungsring 14 verfügt an seiner Unterseite über Zähne, die in Zähne 53 einer Antriebswelle 54 eingreifen. Die Unterkante 55 des Körpers 3 ist insbesondere so weit nach unten gezogen, dass der Deckel 10 flach hingestellt werden kann, ohne dass die Zähne des Schnellkupplungsringes 14 überstehen.Fig. 12 shows a schematic sectional side view a disposable lid according to a fourth embodiment of the invention, and Fig. 13 is a plan view of the disposable lid from Fig. 12. Here is also the connection shown. The differences from the embodiment Fig. 1 is particularly as follows. The quick coupling ring 14 has teeth on its underside, teeth 53 in one Drive shaft 54 engage. The lower edge 55 of the body 3 is in particular pulled so far down that the lid 10th can be placed flat without the teeth of the quick coupling ring 14 survive.

Mit dem Bezugszeichen 59 ist ein Kugellager für die Welle 13 bezeichnet. Solch ein Kugellager ist jedoch für eine kostengünstige Fertigung der Vorrichtung als Einwegdeckel 10 nicht erforderlich. Sie kann insbesondere durch eine in den Zeichnungen nicht dargestellte Gleitlagerung der Antriebswelle 13 ersetzt werden, wobei die Abdichtung durch einen eingelegten O-Ring vorgesehen wird. Dies ist insbesondere deshalb von Vorteil, weil bei einem Einweg-Deckel 10 das Lager nur einmalig und dann für nur eine kurze Zeit belastet wird und diese Last aushalten muss.The reference numeral 59 denotes a ball bearing for the shaft 13. However, such a ball bearing is for a cost-effective Manufacture of the device as a disposable lid 10 is not required. It can not in particular by a in the drawings shown slide bearing of the drive shaft 13 are replaced the seal provided by an inserted O-ring becomes. This is particularly advantageous because at a Disposable lid 10 the bearing only once and then for only one burdened for a short time and must withstand this load.

Der Käfig 52 bildet hier gleichzeitig Schneidkanten aus, die nicht aus Durchbrüchen wie im zweiten Ausführungsbeispiel und auch nicht aus einem rein seitlichen Element wie im ersten Ausführungsbeispiel bestehen. Der Käfig 52 verfügt über nach unten gezogene Nasen 56, die den Balken 11 umfangen. Dieser ist mit zwei Armen ausgestattet, es kann aber auch ein Drehkreuz 2 mit mehr Armen vorgesehen sein. Die Schneidkanten 57 sind insbesondere in der Draufsicht der Fig. 13 zu erkennen, wobei Hohlräume 58 sind benachbarten Nasen 56 Material aufnehmen, um es anschliessend mit dem Balken 11 abzuschneiden.The cage 52 forms here simultaneously cutting edges, the not from breakthroughs as in the second embodiment and also not from a purely lateral element as in the first embodiment consist. The cage 52 has down drawn lugs 56, which embrace the beam 11. This one is with equipped with two arms, but it can also be a turnstile 2 with be provided more poor. The cutting edges 57 are in particular can be seen in the plan view of FIG. 13, wherein cavities 58 are adjacent lugs 56 record material to it then to cut off with the bar 11.

In den Zeichnungen nicht dargestellt sind folgende Merkmale, die in allen in den Fig. dargestellten Ausführungsformen aufgenommen werden können. Seitlich zu dem Balken, beispielsweise in der Fig. 12 im Bereich 60 und 61 können Sensorleitungen durch den Körper 3 durchgeführt werden, die auf der nach aussen weisenden Seite über elektrische Verbindungen verfügen. Somit kann in einfacher Weise ein Sensor während des Mischens in Bodennähe des zu bearbeitenden Materials angeordnet werden. Anstelle von Sensorleitungen kann auch ein Lichtleiter durchgeführt werden oder eine Zuleitung, welche im Innenraum 60 einen Heizkörper oder ein Peltierelement ausbildet.Not shown in the drawings are the following features taken in all embodiments shown in FIGS can be. Laterally to the beam, for example in the Fig. 12 in the area 60 and 61 can sensor lines through the Body 3 are performed on the outward-facing Page have electrical connections. Thus, in easier Assemble a sensor while mixing near the ground be arranged processing material. Instead of sensor cables can also be performed a light guide or a Supply line, which in the interior 60 a radiator or a Peltier element forms.

Claims (8)

  1. A device for mixing and homogenizing materials, in particular infectious or chemically aggressive materials (17, 27), in a laboratory test container (20) with a stirring element (2, 11, 13), wherein a lid (10) is provided to seal the laboratory test container (20) hermetically, and wherein the aforesaid stirring element (2, 11, 13) is provided in the lid (10) to process the material (17, 27) that can be introduced into the laboratory test container (20), characterized in that the stirring element is provided with a cutting element (29; 38, 39) which rotates about the longitudinal axis (22) of the laboratory test container (20) and which is arranged in the immediate vicinity of further cutting edges (12, 28; 31).
  2. The device as claimed in claim 1, characterized in that the further cutting edges (12, 28; 31) on the body (3, 41) of the lid (10) are provided in one piece or as an additional element (1, 42).
  3. The device as claimed in claim 1 or 2, characterized in that the lid is a disposable lid (10) and/or in that it has a screw closure or a snap closure, which is complementary to a corresponding element on the laboratory test container (20).
  4. The device as claimed in one of claims 1 to 3, characterized in that the laboratory test containers (20) are cylindrical or cuboid and/or in that the laboratory test containers (20) consist of plastic or glass.
  5. The device as claimed in one of claims 1 to 4, characterized in that the cutting element has radial (29, 38) and/or peripheral (39) cutting edges which, in particular, consist of plastic or metal.
  6. The device as claimed in one of claims 1 to 5, characterized in that the lid (10) has a sealing ring (5, 16) for the hermetic closure between the interior (17) of the laboratory test container (20) and the external environment.
  7. The device as claimed in one of claims 1 to 6, characterized in that the rotational energy supplied is supplied from the outside via a mechanical internal-hexagon quick coupling ring (14) or a mechanical plug-in connection (6) or a non-contact magnetic coupling (13 and 43), the cutting element comprising a magnetic bar (13) which can be rotated from outside about the longitudinal axis (22) by a rotating electromagnetic field.
  8. The device as claimed in one of claims 1 to 7, characterized in that thermal energy can be introduced into the laboratory test container (20) or dissipated to the outside from the latter via the thermally conductive drive shaft.
EP01969125A 2001-02-22 2001-10-04 Device for mixing and homogenizing materials in laboratory test container with a stirring element Expired - Lifetime EP1361917B1 (en)

Applications Claiming Priority (7)

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CH324012001 2001-02-22
CH3242001 2001-02-22
CH351012001 2001-02-27
CH3512001 2001-02-27
CH113901 2001-06-23
CH11392001 2001-06-23
PCT/CH2001/000597 WO2002066147A1 (en) 2001-02-22 2001-10-04 Device for mixing and homogenizing materials in laboratory test container with a stirring element

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EP1361917B1 true EP1361917B1 (en) 2004-08-04

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EP (1) EP1361917B1 (en)
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DE (1) DE50103166D1 (en)
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CA2438342A1 (en) 2002-08-29
WO2002066147A1 (en) 2002-08-29
AU2001289471B2 (en) 2006-05-18
PT1361917E (en) 2004-11-30
JP2004528960A (en) 2004-09-24
ATE272439T1 (en) 2004-08-15
CA2438342C (en) 2009-09-29
EP1361917A1 (en) 2003-11-19
DK1361917T3 (en) 2004-12-06
ES2225601T3 (en) 2005-03-16
NZ527657A (en) 2006-02-24
US20040252582A1 (en) 2004-12-16
US7165734B2 (en) 2007-01-23
DE50103166D1 (en) 2004-09-09

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