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EP1360992A3 - Apparatus for the operation of a microfluidic device - Google Patents

Apparatus for the operation of a microfluidic device Download PDF

Info

Publication number
EP1360992A3
EP1360992A3 EP03017747A EP03017747A EP1360992A3 EP 1360992 A3 EP1360992 A3 EP 1360992A3 EP 03017747 A EP03017747 A EP 03017747A EP 03017747 A EP03017747 A EP 03017747A EP 1360992 A3 EP1360992 A3 EP 1360992A3
Authority
EP
European Patent Office
Prior art keywords
microchip
physical unit
supply systems
ease
proposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP03017747A
Other languages
German (de)
French (fr)
Other versions
EP1360992A2 (en
Inventor
Manfred Berndt
Patrick Kaltenbach
Colin B. Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caliper Life Sciences Inc
Agilent Technologies Inc
Original Assignee
Caliper Life Sciences Inc
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caliper Life Sciences Inc, Agilent Technologies Inc filed Critical Caliper Life Sciences Inc
Priority claimed from EP00944720A external-priority patent/EP1187677B1/en
Publication of EP1360992A2 publication Critical patent/EP1360992A2/en
Publication of EP1360992A3 publication Critical patent/EP1360992A3/en
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

In a system for operation or handling of a laboratory micro chip (41) for chemical processing or analysis, the microchip (41) is mounted in a first physical unit (42). The microchip (41) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit (42) comprises an optical device (43) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.
EP03017747A 1999-06-22 2000-06-15 Apparatus for the operation of a microfluidic device Ceased EP1360992A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14021599P 1999-06-22 1999-06-22
US140215P 1999-06-22
EP00944720A EP1187677B1 (en) 1999-06-22 2000-06-15 Apparatus for the operation of a microfluidic device

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP00944720A Division EP1187677B1 (en) 1999-06-22 2000-06-15 Apparatus for the operation of a microfluidic device

Publications (2)

Publication Number Publication Date
EP1360992A2 EP1360992A2 (en) 2003-11-12
EP1360992A3 true EP1360992A3 (en) 2004-05-19

Family

ID=29252124

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03017747A Ceased EP1360992A3 (en) 1999-06-22 2000-06-15 Apparatus for the operation of a microfluidic device

Country Status (1)

Country Link
EP (1) EP1360992A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101304808B (en) * 2005-11-02 2011-03-23 安捷伦科技有限公司 Electric contact element for micro-current control chip

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811668B1 (en) 1999-06-22 2004-11-02 Caliper Life Sciences, Inc. Apparatus for the operation of a microfluidic device
US7514046B2 (en) 2000-10-31 2009-04-07 Caliper Life Sciences, Inc. Methods and systems for processing microscale devices for reuse
EP2637787A1 (en) * 2010-11-08 2013-09-18 Reactrix Systems, Inc. Sample assembly for a measurement device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0695941A2 (en) * 1994-06-08 1996-02-07 Affymax Technologies N.V. Method and apparatus for packaging a chip
US5534328A (en) * 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
WO1998005424A1 (en) * 1996-08-02 1998-02-12 Caliper Technologies Corporation Analytical system and method
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
WO1999010735A1 (en) * 1997-08-28 1999-03-04 Caliper Technologies Corporation Improved controller/detector interfaces for microfluidic systems
WO1999038612A1 (en) * 1998-01-30 1999-08-05 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
WO2000002038A1 (en) * 1998-07-02 2000-01-13 Molecular Dynamics, Inc. Robotic microchannel bioanalytical instrument

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5534328A (en) * 1993-12-02 1996-07-09 E. I. Du Pont De Nemours And Company Integrated chemical processing apparatus and processes for the preparation thereof
EP0695941A2 (en) * 1994-06-08 1996-02-07 Affymax Technologies N.V. Method and apparatus for packaging a chip
WO1998005424A1 (en) * 1996-08-02 1998-02-12 Caliper Technologies Corporation Analytical system and method
WO1999010735A1 (en) * 1997-08-28 1999-03-04 Caliper Technologies Corporation Improved controller/detector interfaces for microfluidic systems
WO1999038612A1 (en) * 1998-01-30 1999-08-05 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
WO2000002038A1 (en) * 1998-07-02 2000-01-13 Molecular Dynamics, Inc. Robotic microchannel bioanalytical instrument
EP1092146A1 (en) * 1998-07-02 2001-04-18 Molecular Dynamics Robotic microchannel bioanalytical instrument

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101304808B (en) * 2005-11-02 2011-03-23 安捷伦科技有限公司 Electric contact element for micro-current control chip

Also Published As

Publication number Publication date
EP1360992A2 (en) 2003-11-12

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