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EP1237570A4 - Fragments and antagonists of heat shock protein 60 - Google Patents

Fragments and antagonists of heat shock protein 60

Info

Publication number
EP1237570A4
EP1237570A4 EP00981586A EP00981586A EP1237570A4 EP 1237570 A4 EP1237570 A4 EP 1237570A4 EP 00981586 A EP00981586 A EP 00981586A EP 00981586 A EP00981586 A EP 00981586A EP 1237570 A4 EP1237570 A4 EP 1237570A4
Authority
EP
European Patent Office
Prior art keywords
antagonists
fragments
heat shock
shock protein
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00981586A
Other languages
German (de)
French (fr)
Other versions
EP1237570A2 (en
Inventor
Hubert Kolb
Dana Elias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Peptor Ltd
Original Assignee
Peptor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptor Ltd filed Critical Peptor Ltd
Priority to EP00981586A priority Critical patent/EP1237570A4/en
Publication of EP1237570A2 publication Critical patent/EP1237570A2/en
Publication of EP1237570A4 publication Critical patent/EP1237570A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
EP00981586A 1999-12-15 2000-12-14 Fragments and antagonists of heat shock protein 60 Withdrawn EP1237570A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP00981586A EP1237570A4 (en) 1999-12-15 2000-12-14 Fragments and antagonists of heat shock protein 60

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US17229799P 1999-12-15 1999-12-15
US172297P 1999-12-15
EP99125035 1999-12-15
EP99125035 1999-12-15
EP00981586A EP1237570A4 (en) 1999-12-15 2000-12-14 Fragments and antagonists of heat shock protein 60
PCT/IL2000/000833 WO2001043691A2 (en) 1999-12-15 2000-12-14 Fragments and antagonists of heat shock protein 60

Publications (2)

Publication Number Publication Date
EP1237570A2 EP1237570A2 (en) 2002-09-11
EP1237570A4 true EP1237570A4 (en) 2005-01-05

Family

ID=32842929

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00981586A Withdrawn EP1237570A4 (en) 1999-12-15 2000-12-14 Fragments and antagonists of heat shock protein 60

Country Status (7)

Country Link
EP (1) EP1237570A4 (en)
JP (1) JP2004501061A (en)
AU (1) AU784623B2 (en)
CA (1) CA2394504A1 (en)
NZ (1) NZ519348A (en)
WO (1) WO2001043691A2 (en)
ZA (1) ZA200204635B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL140233A0 (en) * 2000-12-11 2002-02-10 Peptor Ltd Backbone cyclized analogs of heat shock proteins
US7727974B2 (en) 2001-08-10 2010-06-01 Eisai R & D Management Co., Ltd. Methods of reducing the severity of mucositis
WO2003013440A2 (en) * 2001-08-10 2003-02-20 Eisai Co., Ltd. Treatment and prevention of heat shock protein-associated diseases and conditions
US20030077279A1 (en) * 2001-10-24 2003-04-24 Cedars-Sinai Medical Center Methods for treating vascular disease by inhibiting toll-like receptor-4
WO2003063759A2 (en) 2002-01-31 2003-08-07 Peptor Ltd. Hsp peptides and analogs for modulation of immune responses via antigen presenting cells
AU2003209623A1 (en) * 2002-02-19 2003-09-09 Yeda Research And Development Co. Ltd. Dual-effect ligands comprising anti-inflammatory hsp peptide epitopes for immunomodulation
WO2005040208A2 (en) * 2003-10-21 2005-05-06 Androclus Therapeutics, Soa Peptides derived from heat shock proteins binding toll-like receptors 2 and 4 and their use
EP1758924B1 (en) * 2004-06-01 2008-12-31 Council of Scientific and Industrial Research Peptides antagonists for inhibiting heat shock protein (hsp 16.3) of mycobacterium tuberculosis
CU23504A1 (en) * 2004-09-24 2010-04-13 Ct Ingenieria Genetica Biotech PEPTIDES AND DERIVATIVES APL TYPE OF HSP60 AND PHARMACEUTICAL COMPOSITIONS
EP1835933A4 (en) 2005-01-04 2015-01-07 Yeda Res & Dev HSP60, PEPTIDES HSP60 AND T-CELL VACCINES FOR IMMUNOMODULATION
JP4283812B2 (en) * 2006-01-06 2009-06-24 財団法人工業技術研究院 Diagnostic method of myasthenia gravis and its kit
JP2010532785A (en) 2007-07-06 2010-10-14 ウニベルジテイト・ウトレヒト・ホールディング・ビー．ブイ． Treatment and prevention of inflammatory and autoimmune diseases
EP2328911A4 (en) 2008-09-22 2012-03-14 Cedars Sinai Medical Center HUMAN MD-2 IN SHORT FORM AS NEGATIVE REGULATOR OF TOLL-4 TYPE RECEIVER SIGNALING
US9512196B2 (en) 2008-09-22 2016-12-06 Cedars-Sinai Medical Center Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
CU23701A1 (en) * 2008-12-29 2011-09-21 Ct Ingenieria Genetica Biotech METHOD OF TREATMENT OF INTESTINAL INFLAMMATORY DISEASES AND TYPE I DIABETES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004583A1 (en) * 1996-07-31 1998-02-05 Peptor Ltd. Conformationally constrained backbone cyclized somatostatin analogs
WO1998008536A2 (en) * 1996-08-30 1998-03-05 Yeda Research And Development Co. Ltd. Method of reducing the severity of host vs. graft reaction by down-regulating hsp60 autoimmunity
WO2000020019A2 (en) * 1998-10-04 2000-04-13 Yehuda Shoenfeld A composition for the prevention and/or treatment of atherosclerosis
WO2002048312A2 (en) * 2000-12-11 2002-06-20 Peptor Ltd. Backbone cyclized inhibitors of heat shock proteins

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958416A (en) * 1994-12-16 1999-09-28 Regents Of The University Of Minnesota Heat shock protein peptides and methods for modulating autoimmune central nervous system disease
IL114407A0 (en) * 1995-06-30 1995-10-31 Yeda Res & Dev Novel peptides and pharmaceutical compositions comprising them
US5985270A (en) * 1995-09-13 1999-11-16 Fordham University Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004583A1 (en) * 1996-07-31 1998-02-05 Peptor Ltd. Conformationally constrained backbone cyclized somatostatin analogs
WO1998008536A2 (en) * 1996-08-30 1998-03-05 Yeda Research And Development Co. Ltd. Method of reducing the severity of host vs. graft reaction by down-regulating hsp60 autoimmunity
WO2000020019A2 (en) * 1998-10-04 2000-04-13 Yehuda Shoenfeld A composition for the prevention and/or treatment of atherosclerosis
WO2002048312A2 (en) * 2000-12-11 2002-06-20 Peptor Ltd. Backbone cyclized inhibitors of heat shock proteins

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ABULAFIA-LAPID R ET AL: "T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 12, no. 2, March 1999 (1999-03-01), pages 121 - 129, XP002246459, ISSN: 0896-8411 *
BIRK OHAD S ET AL: "A role of Hsp60 in autoimmune diabetes: Analysis in a transgenic model", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, no. 3, 1996, pages 1032 - 1037, XP002291768, ISSN: 0027-8424 *
BOCKOVA J ET AL: "TREATMENT OF NOD DIABETES WITH A NOVEL PEPTIDE OF THE HSP 60 MOLECULE INDUCES TH2-TYPE ANTIBODIES", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 10, no. 4, August 1997 (1997-08-01), pages 323 - 329, XP000881733, ISSN: 0896-8411 *
CHEN W ET AL: "Human 60-kDa heat-shock protein: a danger signal to the innate immune system.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 MAR 1999, vol. 162, no. 6, 15 March 1999 (1999-03-15), pages 3212 - 3219, XP002291767, ISSN: 0022-1767 *
KOLB H ET AL: "HEAT SHOCK PROTEINS SIGNAL THROUGH THE LPS RECEPTOR TLR4", JOURNAL OF ENDOTOXIN RESEARCH, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 6, no. 2, 2000, pages 89,ANS49, XP001076880, ISSN: 0968-0519 *
MEDZHITOV R ET AL: "A HUMAN HOMOLOGUE OF THE DROSOPHILA TOLL PROTEIN SIGNALS ACTIVATIONOF ADAPTIVE IMMUNITY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 388, 24 July 1997 (1997-07-24), pages 394 - 396, XP002056592, ISSN: 0028-0836 *
See also references of WO0143691A3 *
VABULAS R M ET AL: "HEAT SHOCK PROTEINS AS LIGANDS OF TOLL-LIKE RECEPTORS", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, SPRINGER, BERLIN,, DE, vol. 270, 2002, pages 169 - 184, XP008017649, ISSN: 0070-217X *

Also Published As

Publication number Publication date
CA2394504A1 (en) 2001-06-21
ZA200204635B (en) 2004-05-26
NZ519348A (en) 2006-04-28
AU784623B2 (en) 2006-05-18
WO2001043691A2 (en) 2001-06-21
AU1881601A (en) 2001-06-25
JP2004501061A (en) 2004-01-15
EP1237570A2 (en) 2002-09-11
WO2001043691A3 (en) 2002-01-10

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Legal Events

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