EP1107756A4 - Nouveaux agents antibacteriens a base d'isoxazolinone - Google Patents

Nouveaux agents antibacteriens a base d'isoxazolinone

Info

Publication number: EP1107756A4
Authority: EP; European Patent Office
Prior art keywords: antibacterial agents; novel; isoxazolinone antibacterial; novel isoxazolinone; isoxazolinone
Prior art date: 1998-08-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99945157A

Other languages

German (de)

English (en)

Other versions

EP1107756A1 (fr

Inventor

Lawrence B Snyder

Zhizhen Zheng

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-24

Filing date

1999-08-23

Publication date

2003-02-26

1999-08-23 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2001-06-20 Publication of EP1107756A1 publication Critical patent/EP1107756A1/fr

2003-02-26 Publication of EP1107756A4 publication Critical patent/EP1107756A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

EP99945157A 1998-08-24 1999-08-23 Nouveaux agents antibacteriens a base d'isoxazolinone Withdrawn EP1107756A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9757498P	1998-08-24	1998-08-24
US97574P		1998-08-24
PCT/US1999/019265 WO2000010566A1 (fr)	1998-08-24	1999-08-23	Nouveaux agents antibacteriens a base d'isoxazolinone

Publications (2)

Publication Number	Publication Date
EP1107756A1 EP1107756A1 (fr)	2001-06-20
EP1107756A4 true EP1107756A4 (fr)	2003-02-26

Family

ID=22264103

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99945157A Withdrawn EP1107756A4 (fr)	1998-08-24	1999-08-23	Nouveaux agents antibacteriens a base d'isoxazolinone

Country Status (22)

Country	Link
EP (1)	EP1107756A4 (fr)
JP (1)	JP2002523369A (fr)
KR (1)	KR20010072945A (fr)
CN (1)	CN1314813A (fr)
AR (1)	AR020250A1 (fr)
AU (1)	AU748750B2 (fr)
BR (1)	BR9913225A (fr)
CA (1)	CA2341271A1 (fr)
CO (1)	CO5160266A1 (fr)
CZ (1)	CZ2001669A3 (fr)
HU (1)	HUP0103433A3 (fr)
ID (1)	ID27690A (fr)
IL (1)	IL141542A0 (fr)
NO (1)	NO20010916L (fr)
NZ (1)	NZ509867A (fr)
PE (1)	PE20001063A1 (fr)
PL (1)	PL346267A1 (fr)
TR (1)	TR200100672T2 (fr)
TW (1)	TW572757B (fr)
UY (1)	UY25677A1 (fr)
WO (1)	WO2000010566A1 (fr)
ZA (1)	ZA200101505B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9928568D0 (en)	1999-12-03	2000-02-02	Zeneca Ltd	Chemical compounds
GB0009803D0 (en)	2000-04-25	2000-06-07	Astrazeneca Ab	Chemical compounds
US6465456B2 (en) *	2000-06-29	2002-10-15	Bristol-Myers Squibb Company	Isoxazolinone antibacterial agents
JP2002020366A (ja) *	2000-07-05	2002-01-23	Sumitomo Seika Chem Co Ltd	アルキルチオフェニル酢酸類の製造方法
PE20020689A1 (es)	2000-11-17	2002-08-03	Upjohn Co	Oxazolidinonas con un heterociclo de 6 o 7 miembros unidos con enlace anular al benceno
PE20030044A1 (es) *	2000-11-17	2003-02-09	Upjohn Co	Isoxazolinonas biciclicas de formula i
US6861433B2 (en)	2000-12-15	2005-03-01	Pharmacia & Upjohn Company	Oxazolidinone photoaffinity probes
US6689769B2 (en)	2000-12-21	2004-02-10	Pharmacia & Upjohn Company	Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
ES2180456B1 (es) *	2001-07-20	2004-05-01	Laboratorios S.A.L.V.A.T., S.A.	Isoxazoles sustituidos y su utilizacion como antibioticos.
WO2003031443A1 (fr)	2001-10-04	2003-04-17	Morphochem Aktiengesellschaft für kombinatorische Chemie	Antibiotiques a action duale renfermant une oxazolidinone et une quinolone ou une fraction de naphthyridinone
WO2003035073A1 (fr)	2001-10-25	2003-05-01	Astrazeneca Ab	Dérivés d'isoxazoline utilisés en tant qu'agents antimicrobiens
US6875784B2 (en)	2002-10-09	2005-04-05	Pharmacia & Upjohn Company	Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
BR0315206A (pt) *	2002-10-10	2005-08-16	Pharmacia & Upjohn Co Llc	Compostos antimicrobianos de 1-aril-diidropiridona
CA2515311A1 (fr) *	2003-02-07	2004-08-19	Warner-Lambert Company Llc	Agents antibacteriens
WO2004096221A1 (fr)	2003-04-30	2004-11-11	Morphochem Aktiengesellschaft für kombinatorische Chemie	Utilisation d'antibiotiques hybrides d'oxazolidinone-quinoleine destines au traitement de l'anthrax et d'autres infections
US8324398B2 (en)	2003-06-03	2012-12-04	Rib-X Pharmaceuticals, Inc.	Process for the synthesis of biaryl oxazolidinones
TWI454465B (zh)	2003-06-03	2014-10-01	Melinta Therapeutics Inc	聯芳基雜環化合物及製法及其用途
JP2007525468A (ja) *	2003-06-03	2007-09-06	リブ−エックスファーマシューティカルズ，インコーポレイテッド	スルホンアミド化合物ならびにその製造方法および使用方法
US20070197541A1 (en) *	2003-07-29	2007-08-23	Oyelere Adegboyega K	Biaryl heterocyclic amines,amides, and sulfur-containing compounds and methods of making and using the same
DE10340485B4 (de) *	2003-09-03	2015-05-13	Morphochem AG Aktiengesellschaft für kombinatorische Chemie	Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) *	2003-09-16	2007-12-04	Pfizer Inc.	Antibacterial agents
JP2007514782A (ja)	2003-12-17	2007-06-07	リブ−エックスファーマシューティカルズ，インコーポレイテッド	ハロゲン化ビアリール複素環式化合物ならびにその作製方法および使用方法
MXPA06006769A (es)	2003-12-18	2006-12-19	Morphochem Ag Komb Chemie	Antibioticos hibridos de oxazolidinona-quinolona.
US8158797B2 (en)	2003-12-18	2012-04-17	Morphochem Aktiengesellschaft Fur Kombinatorische Chemie	Oxazolidinone-quinolone hybrid antibiotics
WO2005082900A2 (fr) *	2004-01-28	2005-09-09	Pharmacia & Upjohn Company Llc	Amidoxines d'oxazolidinone utilisees en tant qu'agents antibacteriens
DE602006019870D1 (de)	2005-06-08	2011-03-10	Rib X Pharmaceuticals Inc	Verfahren zur synthese von triazolen
AT503354B1 (de) *	2006-02-22	2008-07-15	Dsm Fine Chem Austria Gmbh	Verfahren zur herstellung von 3,4-disubstituierten phenylessigsäuren, sowie neue zwischenverbindungen
JP4518066B2 (ja) *	2006-10-25	2010-08-04	宇部興産株式会社	ジアルコキシニトリル誘導体及びその製法
CN110423610B (zh) *	2019-08-29	2023-05-12	浙江理工大学	一种检测双光子汞离子荧光探针及其制备方法与使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3717629A (en) *	1970-09-11	1973-02-20	Boehringer Sohn Ingelheim	Nitrofuran derivatives
US4000155A (en) *	1975-12-11	1976-12-28	Eli Lilly And Company	Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
WO1997010235A1 (fr) *	1995-09-15	1997-03-20	Pharmacia & Upjohn Company	AGENTS ANTIBACTERIENS A BASE DE 5-AMIDOMETHYLE, 3-ARYLE BUTYROLACTONE α, β SATURE ET INSATURE
WO1997014690A1 (fr) *	1995-10-20	1997-04-24	Zeneca Limited	Derives de 5-(acetamidomethyl)-3-aryldihydrofuran-2-one et de tetrahydrofuran-2-one ayant une activite antibiotique
WO1998007708A1 (fr) *	1996-08-21	1998-02-26	Pharmacia & Upjohn Company	Derives d'isoxazoline utiles comme agents antimicrobiens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2147753C (fr) *	1992-12-08	2004-08-03	Michael Robert Barbachyn	Agents antibacteriens a base de derive de substitution de phenyloxazolidinone avec un groupe tropone

1999
- 1999-08-19 TW TW88114208A patent/TW572757B/zh active
- 1999-08-23 PL PL99346267A patent/PL346267A1/xx not_active Application Discontinuation
- 1999-08-23 JP JP2000565887A patent/JP2002523369A/ja active Pending
- 1999-08-23 NZ NZ509867A patent/NZ509867A/en unknown
- 1999-08-23 WO PCT/US1999/019265 patent/WO2000010566A1/fr not_active Application Discontinuation
- 1999-08-23 BR BR9913225-7A patent/BR9913225A/pt not_active IP Right Cessation
- 1999-08-23 AU AU57833/99A patent/AU748750B2/en not_active Ceased
- 1999-08-23 CZ CZ2001669A patent/CZ2001669A3/cs unknown
- 1999-08-23 CN CN99809894A patent/CN1314813A/zh active Pending
- 1999-08-23 EP EP99945157A patent/EP1107756A4/fr not_active Withdrawn
- 1999-08-23 ID IDW20010439A patent/ID27690A/id unknown
- 1999-08-23 KR KR1020017002377A patent/KR20010072945A/ko not_active Ceased
- 1999-08-23 TR TR2001/00672T patent/TR200100672T2/xx unknown
- 1999-08-23 HU HU0103433A patent/HUP0103433A3/hu unknown
- 1999-08-23 IL IL14154299A patent/IL141542A0/xx unknown
- 1999-08-23 CA CA002341271A patent/CA2341271A1/fr not_active Abandoned
- 1999-08-23 CO CO99053191A patent/CO5160266A1/es unknown
- 1999-08-24 UY UY25677A patent/UY25677A1/es unknown
- 1999-08-24 AR ARP990104229A patent/AR020250A1/es not_active Application Discontinuation
- 1999-08-24 PE PE1999000853A patent/PE20001063A1/es not_active Application Discontinuation
2001
- 2001-02-22 ZA ZA200101505A patent/ZA200101505B/en unknown
- 2001-02-23 NO NO20010916A patent/NO20010916L/no not_active Application Discontinuation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3717629A (en) *	1970-09-11	1973-02-20	Boehringer Sohn Ingelheim	Nitrofuran derivatives
US4000155A (en) *	1975-12-11	1976-12-28	Eli Lilly And Company	Herbicidal 2-methyl-4-phenyl-5-pyrazolinones[and isoxazolinones]
WO1997010235A1 (fr) *	1995-09-15	1997-03-20	Pharmacia & Upjohn Company	AGENTS ANTIBACTERIENS A BASE DE 5-AMIDOMETHYLE, 3-ARYLE BUTYROLACTONE α, β SATURE ET INSATURE
US5708169A (en) *	1995-09-15	1998-01-13	Pharmacia & Upjohn Company	5-amidomethyl α,β-saturated and -unsaturated 3-aryl butyrolactone antibacterial agents
WO1997014690A1 (fr) *	1995-10-20	1997-04-24	Zeneca Limited	Derives de 5-(acetamidomethyl)-3-aryldihydrofuran-2-one et de tetrahydrofuran-2-one ayant une activite antibiotique
WO1998007708A1 (fr) *	1996-08-21	1998-02-26	Pharmacia & Upjohn Company	Derives d'isoxazoline utiles comme agents antimicrobiens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0010566A1 *

Also Published As

Publication number	Publication date
CO5160266A1 (es)	2002-05-30
HUP0103433A2 (hu)	2002-01-28
CN1314813A (zh)	2001-09-26
KR20010072945A (ko)	2001-07-31
BR9913225A (pt)	2001-05-22
UY25677A1 (es)	2001-08-27
CA2341271A1 (fr)	2000-03-02
AU748750B2 (en)	2002-06-13
NZ509867A (en)	2003-08-29
IL141542A0 (en)	2002-03-10
NO20010916D0 (no)	2001-02-23
HUP0103433A3 (en)	2002-08-28
CZ2001669A3 (cs)	2001-08-15
EP1107756A1 (fr)	2001-06-20
PE20001063A1 (es)	2000-12-24
JP2002523369A (ja)	2002-07-30
WO2000010566A1 (fr)	2000-03-02
TR200100672T2 (tr)	2001-07-23
AR020250A1 (es)	2002-05-02
AU5783399A (en)	2000-03-14
ID27690A (id)	2001-04-19
NO20010916L (no)	2001-04-10
ZA200101505B (en)	2002-02-22
PL346267A1 (en)	2002-01-28
TW572757B (en)	2004-01-21

Publication	Publication Date	Title
IL141542A0 (en)	2002-03-10	Novel isoxazolinone antibacterial agents
EP1005356A4 (fr)	2001-08-22	Agents antibacteriens
PL330949A1 (en)	1999-08-02	Antibacterial compositions
PL341642A1 (en)	2001-04-23	Novel macrolydes
GB9801392D0 (en)	1998-03-18	Novel compounds
HUP0202514A3 (en)	2004-04-28	Antibacterial agents
EP1068213A4 (fr)	2001-05-02	Nouveaux siloxanes amino-organo-fonctionnels
AU2002216759A1 (en)	2002-01-14	Novel isoxazolinone antibacterial agents
AU3307399A (en)	1999-09-06	Novel antibacterial agents
AU3168899A (en)	1999-11-01	Antibacterial agents
GB9911210D0 (en)	1999-07-14	Counter
GB9802549D0 (en)	1998-04-01	Antibacterial agents
HK1035674A (en)	2001-12-07	Novel isoxazolinone antibacterial agents
GB9918869D0 (en)	1999-10-13	Antibacterial agents
GB9828318D0 (en)	1999-02-17	Antibacterial agents
GB9806300D0 (en)	1998-05-20	Antibacterial agents
GB9810463D0 (en)	1998-07-15	Antibacterial agents
ZA200004559B (en)	2002-05-29	Novel antibacterial agents.
AU2002300119A1 (en)	2002-12-12	Antibacterial agents
GB9817904D0 (en)	1998-10-14	Novel use
GB9721821D0 (en)	1997-12-17	Antibacterial ETC agents
GB9825756D0 (en)	1999-01-20	Novel compoundd
GB9907981D0 (en)	1999-06-02	Antibacterial agents
GB9927093D0 (en)	2000-01-12	Antibacterial agents
GB9927089D0 (en)	2000-01-12	Antibacterial agents

Legal Events

Date	Code	Title	Description
2001-05-05	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-06-20	17P	Request for examination filed	Effective date: 20010320
2001-06-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-06-20	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2003-02-26	A4	Supplementary search report drawn up and despatched	Effective date: 20030115
2003-02-26	RIC1	Information provided on ipc code assigned before grant	Ipc: 7A 61K 31/42 B Ipc: 7C 07D 413/12 B Ipc: 7C 07D 413/10 B Ipc: 7C 07D 261/12 A
2004-09-01	17Q	First examination report despatched	Effective date: 20040713
2005-01-12	RTI1	Title (correction)	Free format text: ISOXAZOLINONE ANTIBACTERIAL AGENTS
2005-06-18	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2006-06-23	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2006-07-26	18D	Application deemed to be withdrawn	Effective date: 20051103
2008-04-11	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1035674 Country of ref document: HK