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EP1199955A2 - Methode pour traiter et prevenir les affections des ongles - Google Patents

Methode pour traiter et prevenir les affections des ongles

Info

Publication number
EP1199955A2
EP1199955A2 EP00944155A EP00944155A EP1199955A2 EP 1199955 A2 EP1199955 A2 EP 1199955A2 EP 00944155 A EP00944155 A EP 00944155A EP 00944155 A EP00944155 A EP 00944155A EP 1199955 A2 EP1199955 A2 EP 1199955A2
Authority
EP
European Patent Office
Prior art keywords
piston
dispensing
chamber
housing
fmger
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00944155A
Other languages
German (de)
English (en)
Inventor
Kristin Lewis Moody
Mannie Lee Clapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of EP1199955A2 publication Critical patent/EP1199955A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D29/00—Manicuring or pedicuring implements
    • A45D29/16—Cuticle sticks
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
    • A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
    • A45D34/042—Appliances specially adapted for applying liquid, e.g. using roller or ball using a brush or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D2200/00—Details not otherwise provided for in A45D
    • A45D2200/05—Details of containers
    • A45D2200/054—Means for supplying liquid to the outlet of the container
    • A45D2200/055—Piston or plunger for supplying the liquid to the applicator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A61K2800/872—Pencils; Crayons; Felt-tip pens

Definitions

  • the present invention relates to a method of preventing or treating finger disorders. Specifically, the present invention relates to improved methods of delivery and application of nail and cuticle treatment compositions.
  • finger or fingernail treatments exist in today's market. Such fingernail treatments range from the purely decorative to the almost completely medicinal. Ideally, such fmger or nail treatments should be both decorative and medicating. These twin goals, however, are often difficult to achieve in single application treatments. For example, decorative fingernail treatments, typically, require non-medicating components such as film-forming polymers or pigments which are not designed for application to the cuticle or neighboring skin and, oftentimes, adversely affect such areas of the fmger (e.g., promote dryness).
  • non-medicating components such as film-forming polymers or pigments which are not designed for application to the cuticle or neighboring skin and, oftentimes, adversely affect such areas of the fmger (e.g., promote dryness).
  • Medicating fingernail treatments help smooth and soften the nail surface. Specifically, such treatments nourish and soften the cuticle and surrounding skin tissues while reducing the brittleness of the nail itself. This is particularly important for persons with dry and brittle nails.
  • the application of finger or finger nail treatments should be both convenient and controllable.
  • the consumer should retain control over the amount of the treatment applied for efficacy as well as aesthetic purposes (i.e., smooth and even applications).
  • aesthetic purposes i.e., smooth and even applications.
  • Such ease of use and control properties also avoid messy excess applications of the treatment composition and help promote improved consumer compliance regarding the use of such treatments.
  • the present inventors have found that the methods of the present invention provide improved delivery of finger or fingernail treatment compositions, resulting in improved convenience, aesthetics and improved consumer compliance regarding such treatments.
  • an aspect of the present invention is to provide new and improved methods for treating or preventing fmger disorders, especially nail and cuticle disorders.
  • An additional aspect is to provide methods for moisturizing, smoothing, and softening the surface of the nails and of the skin and tissues surrounding the nail.
  • a further aspect of the present invention is to provide methods for moisturizing, smoothing, and softening the surface of the nails and of the skin and tissues surrounding the nail comprising the application of fmger or fingernail treatment compositions using an improved application device.
  • the present invention relates to methods of treating or preventing fmger disorders comprising the steps of :
  • A.) providing a dispensing device for dispensing a finger treatment composition comprising: i.) housing defining a chamber having a dispensing end and an actuating end, said dispensing end having an application portion and said chamber having an interior surface, said application portion providing a smooth and even surface distribution of the finger treatment composition; ii.) a piston located within said chamber, said piston being capable of translational movement within said chamber, said piston having a top side facing towards said dispensing end of said housing and having an j advancing mechanism opposite said top side, said top side of said piston forming a variable volume portion of said chamber between said chamber and said top side of said piston, wherein said variable volume portion is for storing said nail and cuticle composition; and iii.) an adjuster movably mounted to said housing and movably engaging said internal surface at said actuating end of said housing, said adjuster engaging said advancing mechanism for advancing said piston directionally toward said dispensing end; wherein the device is pre-filled with the fmger treatment composition,
  • FIG. 1 is a perspective view of a preferred embodiment of the dispensing device of the present invention
  • FIG. 2 is a vertical, cross-sectional view of the dispensing device seen in FIG. 1 without the cap;
  • FIG. 3 is a vertical, cross-sectional view of the dispensing device seen in FIG. 1 with the cap installed and having an alternative embodiment of the product elevator;
  • a fmger treating dispensing device for dispensing a fmger treating composition, such as a fluid, cream, semisolid, gel, past, liquid, or the like.
  • the dispensing devise 10 comprises , in part, an adjuster, which can be a rotatable hand wheel, generally indicated at 51, movably connected to a housing 20 which is attached to an applicator, generally indicated as 80.
  • the adjuster can be any mechanism suitable for advancing a piston. For example, pushbutton or push type ratcheting advance mechanisms are suitable alternatives.
  • a cap 14 having a closed end 17 and an open end 18 is also, optionally, provided. Cap 14 is removably connected to the dispensing device 10, for example, by frictional engagement with applicator 80.
  • housing 20 is hollow and elongated and has an axis extending lengthwise therethrough.
  • Housing 20 has a chamber 21 therein and includes an open dispensing end 24 located opposite an actuating end 26 with actuating end 26 having an interior surface 28.
  • interior surface 28 is cylindrical.
  • Cylindrical, as used herein refers to a three-dimensional shape that is elongated while also having a generally circular cross-section.
  • interior surface 28 extends from actuating end 26 to dispensing end 24 of housing 20.
  • the cross-sectional shape of chamber 21 can alternatively be of various shapes, such as oval, rectangular, oblong, irregular, or the like.
  • interior surface 28 includes a lip 30 and at least one detent 32.
  • Detent 32 comprises a substantially localized indentation, recessed area, or protrusion in interior surface 28.
  • Interior surface 28 can include a plurality of detents 32 and preferably these detents 32 are radially spaced along interior surface 28.
  • lip 30 is positioned adjacent to and aft of the radially spaced detents 32.
  • Dispensing end 24 can include a first reducer 23 which acts to reduce or decrease the cross section through which product passes when being dispensed.
  • first reducer 23 is frusta-conical in shape.
  • dispensing end 24 of housing 20 preferably has an exterior surface 34 which includes a ridge 36.
  • Exterior surface 34 is preferably cylindrical.
  • Housing 20 is preferably constructed from a material such as nylon, acrylonitrile butadiene styrene (ABS), polypropylene (PP), polyethylene (PE), styrene-acrylonitrile (SAN), or more preferably, a material such as polybutylene terapthalate (PBT) with ABS, or most preferably, a rubber modified acrylonitrile copolymer which is commercially available as BAREX.TM. 210 from BP Chemicals can be used.
  • ABS acrylonitrile butadiene styrene
  • PP polypropylene
  • PE polyethylene
  • SAN styrene-acrylonitrile
  • PBT polybutylene terapthalate
  • BAREX.TM. 210 from BP Chemicals can be used.
  • a piston 40 is located within chamber 21 of housing 20. This piston 40 is preferably limited to axial or translational movement within chamber 21 and preferably does not rotate relative to interior surface 28. Piston 40 has a top-side 42 facing dispensing end 24 of housing 20 and a bottom-side 44 opposite top-side 42. As piston 40 axially translates within chamber 21, top-side 42 of piston 40 forms a variable volume portion 22 within chamber 21. This variable volume portion 22 is used for storing the product that is to be dispensed from the twist-up dispensing device 10. In a preferred embodiment, top-side 42 of piston 40 is provided with an upper-sealing rim 43 which sealingly engages interior surface 28.
  • Bottom-side 44 of piston 40 can also be provided with a lower-sealing rim 45 which sealingly engages interior surface 28.
  • Extending radially outward from top-side 42 and bottom-side 44 of piston 40 are upper-sealing rim 43 and lower-sealing rim 45, respectively.
  • upper-sealing rim 43 and lower- sealing rim 45 prevent the product stored in variable volume portion 22 from leaking past piston 40 toward actuating end 26 of housing 20 or any other part of chamber 21.
  • the sealing engagement and the frictional forces between upper-sealing rim 43 and lower- sealing rim 45 with interior surface 28 inhibit rotation of piston 40.
  • piston 40 is generally limited to translational movement. These frictional forces can be increased or decreased by varying the amount of surface contact between upper-sealing rim 43 or lower-sealing rim 45 and interior surface 28.
  • Housing 20 is preferably cylindrical in shape having a generally circular cross-section.
  • housing 20 may have a generally oval cross-section or even an irregular cross-section.
  • the contour or cross-sectional shape of chamber 21 further prevents rotation of piston 40, since piston 40 preferably has the same contour as chamber 21.
  • piston 40 is constructed from a fluorinated high-density polyethylene (HDPE) although many other flexible polymers can also be used.
  • HDPE fluorinated high-density polyethylene
  • piston 40 also has a threaded rod 46 extending therefrom, opposite top-side 42.
  • threaded rod 46 extends from bottom-side 44 of piston 40 toward actuating end 26 of housing 20.
  • threaded rod 46 is made from an acetal.
  • Upper-end 47 of threaded rod 46 is fixedly attached to bottom-side 44 of piston 40.
  • both threaded rod 46 and piston 40 move in unison and that movement is limited to axial translation.
  • the combination of piston 40 being attached to threaded rod 46 forms a product elevator 48 which functions to move the product by pushing it outof variable volume portion 22 of chamber 21 in housing 20.
  • product elevator 48 can be a single component which includes threaded rod 46 being integrally formed with piston 40.
  • piston 40 and threaded rod 46 can be separate components.
  • a rod stop 49 can be provided on threaded rod 46 at the end opposite upper-end 47 of threaded rod 46.
  • the amount of travel of product elevator 48 can also be limited by product elevator 48 or piston 40 simply bottoming out in the variable volume portion 22 of chamber 21.
  • Alternative methods of limiting axial travel can be used, such as, threaded rod 46 can be partially threaded, threaded rod 46 or piston 40 can be made shorter or longer, piston 40 can be provided with a protrusion on top side 42, or various other methods known in the art for limiting axial travel of similar components.
  • an actuator 50 having a threaded aperture 52 therethrough is provided on the hand wheel 51.
  • threaded aperture 52 is concentric within actuator 50.
  • Actuator 50 engages interior surface 28 at actuating end 26 of housing 20 and is adapted to rotate with respect to housing 20 in only one direction, that being an advancing direction. Since the threads on threaded rod 46 mate with threaded aperture 52, threaded rod 46 engages with threaded aperture 52 such that advancement of piston 40 toward dispensing end 24 of housing 20 occurs when actuator 50 is rotated, thereby causing the product to be dispensed from dispensing device 10.
  • the hand wheel 51 is preferably a single integral component which includes both actuator 50 and a grip portion 54.
  • hand wheel 51 includes actuator 50 having a threaded aperture 52 therethrough and has a grip portion 54 connected to actuator 50.
  • Grip portion 54 extends from actuating end 26 of housing 20 and preferably has a grooved or knurled surface in order for the user to easily grasp hand wheel 51.
  • a cavity 59 extends axially through grip portion 54 of hand wheel 51 in order to provide access to threaded aperture 52. More preferably, threaded aperture 52 is smaller than rod stop 49 while cavity 59 allows rod stop 49 to pass therethrough.
  • Actuator 50 includes a groove 56 which engages with or is captured by lip 30 on interior surface 28 at actuating end 26 of housing 20 such that actuator 50 is rotatable but cannot move axially relative to interior surface 28.
  • This arrangement allows rotation of hand wheel 51 while prohibiting axial movement of hand wheel 51.
  • hand wheel 51 is unitarily formed using an injection molding process from a plastic material such as ABS which is commercially available as MAGNUM.TM. 9015 from DOW Chemicals or a PP homopolymer or copolymer with a calcium carbonate filler having a loading level of from about 5% to about 40% by weight can also be used.
  • Actuator 50 on hand wheel 51 also preferably includes at least one resilient arm 58 extending radially outwardly therefrom and can be inclined radially toward interior surface 28.
  • Resilient refers to the nature of resilient arm 58 which urges it to return to its original position upon being deflected from its original position.
  • Resilient arms 58 can be better seen with reference to FIG. 4 in which a full cross-section of dispensing device 10 taken along line 4—4 of FIG. 2 is shown.
  • Resilient arms 58 engage detents 32 located on interior surface 28 such that actuator 50 is rotatable in an advancing direction but not in an opposite direction.
  • actuator 50 has at least two resilient arms 58.
  • resilient arms 58 are oriented at an angle directed radially outwardly toward interior surface 28 such that resilient arms 58 engage detents 32 and are deflected inward by detents 32 when hand wheel 51 is rotated in an advancing direction.
  • the engagement of threaded rod 46 with threaded aperture 52 causes piston 40 to translate toward dispensing end 24. Any attempted rotation of hand wheel 51 in the opposite direction is limited and causes resilient arms 58 to abut detents 32 which prevents rotation of hand wheel 51 in an opposite direction. Since hand wheel 51 is limited to rotation in only the advancing direction, product elevator 48 is only allowed to translate in one direction. Thus, dispensing device 10 is unidirectional in nature.
  • Hand wheel 51 is rotated by the user in order to dispense the product in a controlled manner from dispensing device 10.
  • detents 32 are radially spaced about interior surface 28 and resilient arms 58 engage and disengage with detents 32 as hand wheel 51 is rotated in the advancing direction.
  • Each engagement of resilient arms 58 with detents 32 provides a certain incremental translational movement of piston 40 and thus provides incremental movement of product elevator 48.
  • the radial spacing between detents 32 can be varied to provide more or less axial translation of piston 40 with each increment of rotation.
  • detents 32 can be uniformly spaced apart, irregularly spaced, or even intermittently spaced at varying distances about interior surface 28.
  • variable volume portion 22 The amount of product dispensed from variable volume portion 22 is controlled by the incremental movement of piston 40 and an incremental volume of product is dispensed thus achieving incremental dosing of the product. This incremental dosing assists the user in dispensing an accurate or regulated amount of product and helps avoid messy or wasteful over-dispensing.
  • One advantage of this configuration is that an audible sound is produced as hand wheel 51 is rotated in the advancing direction. This clicking sound is created when resilient arm 58 springs back against detent 32 and contacts interior surface 28 of housing 20 during rotation of actuator 50. Additionally, a tactile signal is produced as hand wheel 51 is rotated in the advancing direction. The feel of intermittent resistance to rotation is created when tension is created by resilient arm 58 being deflected inward while riding over interior surface 28 between each detent 32. This tension is released when resilient arm 58 springs back outward toward and into detent 32. For example, an incremental dose is achieved by rotating hand wheel 51 a certain number of clicks which can be specified in order to provide accurate dosing of the product.
  • An applicator 80 can be attached at dispensing end 24 of housing 20 in fluid communication with variable volume portion 22 of chamber 21 such that the product is dispensed through applicator 80.
  • Applicator 80 is hollow and includes ferrule 82 and application portion 84.
  • Preferably applicator 80 is constructed of a plastic material such as PP, PE, polyethylene terapthalate (PET), nylon, or even a polyester like those commercially available as HYTREL.TM. 5526 by DuPont.
  • Ferrule 82 is located opposite application portion 84 and is attached to dispensing end 24 of housing 20.
  • Ferrule 82 includes an internal surface 85 having a bead 89.
  • Bead 89 mates with ridge 36 on dispensing end 24 forming a snap-fit 79 engagement between ferrule 82 and dispensing end 24 thereby attaching applicator 80 to housing 20.
  • Application portion 84 of applicator 80 has at least one orifice 86 therein in order to dispense the product through applicator 80.
  • Preferably orifice 86 can have a diameter of from between about 0.25 mm (0.01 inch) to about 5 mm (0.2 inch).
  • Fiber bristles 72 of this type can be tapered and preferably fiber bristles 72 have a thickness or diameter of from about 0.1 mm (0.004 inch) to about 0.05 mm (0.002 inch).
  • These fiber bristles 72 can be made from various materials but preferably are made of a plastic such as nylon, and more preferably made of polybutylene terapthalate (PBT).
  • PBT polybutylene terapthalate
  • an interior shoulder 88 and a platform lock 95 are formed within applicator 80.
  • platform lock 95 is spaced axially toward orifice 86 while also being spaced radially inward from interior shoulder 88 in a stair-stepped fashion.
  • Platform lock 95 is in the form of four inwardly protruding struts being equally spaced apart.
  • platform lock 95 can be in the form of any radially inward protrusion.
  • a transition piece 90 having an edge 96 extending radially therefrom is positioned within dispensing end 24 of housing 20 such that edge 96 is captured between the interior shoulder 88 and dispensing end 24 of housing 20.
  • edge 96 separates transition piece 90 into an upper transition 97 and a lower transition 93.
  • Transition piece 90 can be constructed of a fluorinated HDPE or some other flexible polymer. Transition piece 90 has a passageway 92 therethrough which places orifice 86 and fiber bristles 72 in fluid communication with variable volume portion 22 of chamber 21. Within passageway 92 can be located a second reducer 25, similar to first reducer 23, which acts to reduce or decrease the cross section through which product passes when being dispensed and thereby functioning to reduce the flow area through passageway 92. Preferably, transition piece 90 is positioned such that it extends through ferrule 82 into application portion 84 of applicator 80. Alternatively, transition piece 90 having passageway 92 therethrough can extend through applicator 80 and beyond application portion 84.
  • annular platform 94 having a central opening therein is affixed to fiber bristles 72 forming a brush tip 74.
  • Upper transition 97 of transition piece 90 extends through the central opening in annular platform 94.
  • Annular platform 94 is captured between edge 96 on transition piece 90 and platform lock 95 such that annular platform 94 positions fiber bristles 72 of brush tip 74 relative to orifice 86 in application portion 84.
  • cap 14 is shown in the installed position on applicator 80 of dispensing device 10 thereby sealingly enclosing orifice 86 and application portion 84 of applicator 80.
  • closed-end 17 of cap 14 is spaced away from and does not contact applicator 80.
  • Cap 14 is removable, as shown in FIG. 1.
  • An applicator rib 16 is provided on applicator 80 and a cap locking rib 19 is provided on the interior of cap 14.
  • Cap locking rib 19 can be in the form of an intermittent or continuous protrusion.
  • open-end 18 engages applicator 80 such that applicator rib 16 engages with cap locking rib 19. Accordingly, a user can simply snap cap 14 into place on applicator 80 when dispensing device 10 is not in use and can also easily remove cap 14 in order to access applicator 80.
  • cap locking rib 19 or applicator rib 16 deflects slightly and then returns to its normal position to ensure cap 14 stays in place until the user removes cap 14 in order to dispense the product.
  • the interior of cap 14 is also provided with a sealing bead 15 which is positioned so as to align with sealing land 81 on applicator 80.
  • cap 14 Sealing bead 15 on cap 14 engages with sealing land 81 of applicator 80 providing sealing engagement of cap 14 and applicator 80 such that when cap 14 is installed on applicator 80 an airtight seal is created between cap 14 and applicator 80.
  • cap 14 sealingly engages ferrule 82 on applicator 80 prohibiting any product escape or drying out of the product contained within variable volume portion 22 of dispensing device 10.
  • a smooth or flush contour is generated between the exterior of cap 14 and applicator 80 and housing 20 when cap 14 is in the installed position.
  • Assembly of dispensing device 10, as shown in FIG. 2 and 3, is easily accomplished and one can start by threadably connecting product elevator 48 to hand wheel 51.
  • Threaded rod 46 is engaged with threaded aperture 52 in a manner that allows bottom-side 44 of piston 40 to be attached to upper-end 47 of threaded rod 46 if needed.
  • Product elevator 48 and hand wheel 51 are then inserted into actuating end 26 of housing 20 such that groove 56 and lip 30 engage, thereby rotatably connecting hand wheel 51 in place while also positioning piston 40 within chamber 21 and forming variable volume portion 22. Care should be taken during assembly to orient resilient arms 58 for proper engagement with detents 32 in order to avoid loading or creep of resilient arms 58.
  • Variable volume portion 22 can then be filled with product.
  • Transition piece 90 if needed, can be placed in dispensing end 24 of housing 20 and, if needed, brush tip 74 can be installed over transition piece 90.
  • Applicator 80 can be attached at dispensing end 24, over transition piece 90 and capturing brush tip 74, if installed.
  • Cap 14 can also be removably attached on applicator 80.
  • assembly may also be initiated by inverting housing 20 such that actuating end 26 is facing upward and then placing piston 40 into chamber 21 of housing 20 through actuating end 26 such that bottom-side 44 is facing upward.
  • Hand wheel 51 can then be inserted into actuating end 26 of housing 20 and upper-end 47 of threaded rod 46 can be attached to bottom-side 44 of piston 40 through cavity 59 while engaging threaded aperture 52 of hand wheel 51.
  • various products such as fluids, flowable materials, semisolids, or liquids can be dispensed utilizing dispensing device 10 described herein, of particular interest are finger treatment compositions free of film- forming polymers and/or pigments. A uniform thin film is achieved when a fmger or fingernail treatment composition is dispensed and applied using this dispensing device 10.
  • a particularly preferred dispensing device is the UC18C pencil available from Mitsubishi Pencil Kabushiki Kaisha. A more detailed description of the UC18C pencil can be found in PCT application number PCT/JP99/01450, herein incorporated by reference in its entirety.
  • compositions of the present invention can comprise, consist of, or consist essentially of the essential elements and limitations of the invention described herein, as well any of the additional or optional ingredients, components, or limitations described herein.
  • fmger or fmger nail means the fmger nail and portion of the finger surrounding the fingernail including the cuticle and surrounding skin tissue.
  • fertilizer disorders includes, but is not limited to brittle nail, dry nails, peeling nails, tearing nails, cracked skin, dry skin, peeling skin, ashy skin, callous skin, and hangnail.
  • safe and effective amount means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a moisturizing and softening benefit, more preferably the visual reduction of dryness, including independently the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
  • treatment means any treatment of nail or skin disorders around the nail in a mammal, including:
  • An essential component of the present invention is an oily component.
  • suitable oily components include fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils, and silicone oils.
  • the fats and oils include natural fats and oils, such as soybean oil, bran oil (rice polishing oil), jojoba oil, avocado oil, almond oil, olive oil, cacao oil, safflower oil, sunflower seed oil, sesame oil, persic oil (apricot karnel oil), castor oil, palm oil, mink oil, tallow, and lard; hardened oils obtained by hydrogenation of these natural fats and oils; and synthetic triglycerides, such as trimyristin and glyceryl tri(2-ethylhexanoate).
  • Examples of the wax include carnauba wax, whale wax, bees wax, and lanolin.
  • Examples of the hydrocarbon include liquid paraffin, vaseline, paraffin microcrystalhne wax, ceresin, squalane, and pristane.
  • Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolin fatty acid, and isostearic acid.
  • Examples of the higher alcohol include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and 2-hexyldecanol.
  • ester examples include cetyl octanoate, glyceryl trioctanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesteryl isostearate, and polyoxyethylene (POE) sorbitol fatty acid ester.
  • POE polyoxyethylene
  • the essential oil examples include mentha oil, jasmine oil, camphor oil, hinoki oil, orange peel oil, ryu oil, turpentine oil, cinnamon oil, bergamot oil, mandarin oil, calamus oil, pine oil, lavender oil, bay oil, clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, thyme oil, peppermint oil, sage oil, menthol, cineole, eugenol, citral, citronellal, borneol, linalool, geraniol, camphor, thymol, spilanthol, pinene, limonene, and terpene compounds.
  • silicone oil examples include dimethylpolysiloxane. These oily components may be used either individually or as a combination of two or more thereof. In the present invention, it is preferred to use glyceryl myristate, glyceryl tri-(2-ethylhexanoate), lanolin, liquid paraffin, vaseline, paraffin microcrystalhne wax, squalane, lauric acid, myristic acid, palmitic acid, linoleic acid, linolenic acid, isostearic acid, cetyl alcohol, stearyl alcohol, oleyl alcohol, cholesterol, cetyl octanoate, glyceryl trioctanoate, isopropyl myristate, octyldodecyl myristate, cholesterol isostearate, POE sorbitol fatty acid esters, mentha oil, orange peel oil, cinnamon oil, rose oil, menthol, cineole, eugenol
  • the oily component preferably comprises from about 1% to about 99%, more preferably from about 50% to about 95%, most preferably from about 75% to about 90% of the fmger treatment composition.
  • the finger treatment compositions of the present invention are preferably substantially free of film-forming agents.
  • substantially free means that the level of such film forming agents is about 1% or less, more preferably about 0.5% or less, most preferably 0.1% or less, even more preferably 0% or no more than about 0.05%.
  • Typical film formers include, without limitation: acrylamide/sodium acrylate copolymer; ammonium acrylates copolymer; Balsam Peru; polyurethane and polyurethane derivatives such as aliphatic polyether polyurethanes; cellulose gum; cellulosic polymers (e.g., cellulose esters such as nitrocellulose), ethylene/maleic anhydride copolymer; hydroxyethylcellulose; hydroxypropylcellulose; polyacrylamide; polyethylene; polyvinyl alcohol; pvm/MA copolymer (polyvinyl methylether/malei c anhydride); PVP
  • polyvinylpyrrolidone polyvinylpyrrolidone
  • maleic anhydride copolymer such as PA-18 available from Gulf Science and Technology
  • PVP/hexadecene copolymer such as Ganex V-216 available from GAF Corporation
  • acryliclacrylate copolymer and the like. Additional examples of film formers are found in U.S. Patent 5,639,447, herein incorporated by reference in its entirety.
  • the present invention is directed improving skin feel (i.e., softening and moisturizing the skin) and improving the overall appearance of the skin (i.e., the evening of skin tone and the reduction of the "ashy" appearance of skin).
  • Substantially Free of Pigments The fmger treatment compositions of the present invention are preferably substantially free of pigments. In general, the phrase "substantially free,” as used herein, means that the level of such coloring components or pigments is about 0.1% or less, more preferably about 0.075% or less, most preferably 0% or no more than about 0.05%.
  • Typical pigments include, but are not limited to organic and inorganic pigments and dyes.
  • the organic pigments are generally various aromatic types including azo, indigoid, triphenylmethane, anthraquinone, and xanthine dyes which are designated as D&C and FD&C blues, browns, greens, oranges, reds, yellows, etc.
  • Organic pigments generally consist of insoluble metallic salts of certified color additives, referred to as the Lakes.
  • Inorganic pigments include iron oxides, ultramarine and chromium or chromium hydroxide colors, and mixtures thereof.
  • pigments adversely affect the healthiness of the cuticle and the skin tissue surrounding the nail as perceived by consumers. Consumers typically avoid applying pigments to these areas of the skin to maintain the healthy and youthful appearance of these areas.
  • the finger treatment compositions according to the invention can contain cosmetic auxiliaries as they are conventionally used in such formulations, for example preservatives, skin care actives such as biotin, vitamin B 5 and derivatives thereof (e.g., panthenol), vitamin B 3 and derivatives thereof (e.g., niacinamide), vitamin E and derivatives thereof (e.g., tocopherol nicotinate), phospholipids, alpha hydroxy acids (e.g., glycolic acid, lactic acid), beta hydroxy acids (e.g., salicylic acid), vitamin A and derivatives thereof (e.g., retinoids and retinoid esters), vitamin C and vitamin D; bactericides; perfumes; foam inhibitors; thickeners; surface-active substances; emulsifiers; plasticizers; moisturizers and/or humectants; fats and waxes other than those disclosed as essential ingredients; or other conventional components of a cosmetic product such as alcohols, polyols or water; foam
  • the composition can be in the form of water-in-oil or oil-in-water emulsions.
  • the emulsion is a water-in-oil emulsion.
  • the methods for treating and preventing fmger disorder involves topically applying to the finger, especially the nails a safe and effective amount of the finger treatment composition of the present invention.
  • the amount of the composition which is applied, the frequency of application and the period of use will vary widely depending upon the level of treatment desired, e.g., in light of the progression of the fmger disorder and the rate of further clinical presentations.
  • the composition is chronically applied to the fmger, especially the fmger nail.
  • chromenic topical application is meant continued topical application of the composition over an extended period during the subject's lifetime, preferably for a period of at least about one week, more preferably for a period of at least about one month, even more preferably for at least about three months, even more preferably for at least about six months, and more preferably still for at least about one year. While benefits are obtainable after various maximum periods of use (e.g., five, ten or twenty years), it is preferred that chronic application continue throughout the subject's lifetime. Typically applications would be on the order of about once per day over such extended periods, however application rates can vary from about once per week up to about three times per day or more.
  • compositions of the present invention can be employed to provide a fmger and/or fmger nail appearance and/or feel benefit.
  • Quantities of the present compositions which are typically applied per application are, in mg composition/cm ⁇ skin and nail, from about 0.1 mg/cm ⁇ to about 100 mg/cm ⁇ .
  • a particularly useful application amount is about 10 mg/cm ⁇ .
  • the methods of the present invention are preferably practiced by applying a composition in the form of an oil composition, or a oil-in-water or water-in-oil emulsion, or the like which is intended to be left on the skin for some aesthetic, prophylactic, therapeutic or other benefit (i.e., a "leave-on" composition).
  • a composition in the form of an oil composition or a oil-in-water or water-in-oil emulsion, or the like which is intended to be left on the skin for some aesthetic, prophylactic, therapeutic or other benefit (i.e., a "leave-on" composition).
  • a composition in the form of an oil composition or a oil-in-water or water-in-oil emulsion, or the like which is intended to be left on the skin for some aesthetic, prophylactic, therapeutic or other benefit (i.e., a "leave-on" composition).
  • After applying the composition to the skin it is preferably left on the skin for a period of at
  • compositions can be prepared using conventional formulation and mixing techniques.
  • Component amounts are listed as weight percents and include minor materials such as diluents, filler, and so forth.
  • the listed formulations therefore, comprise the listed components and any minor materials associated with such components.
  • Example I A method for treating finger disorders by using the dispensing device to apply the following fmger treatment composition in the form of an oil composition.
  • the above components added to a stainless steel vessel and are mixed thoroughly using conventional mixing technology.
  • the finger treatment oil is then loaded into the dispensing device and applied to the fmger, especially the nails and cuticle, using the dispensing device.
  • Example II A method for treating fmger disorders by using the dispensing device to apply the following fmger treatment composition in the form of an water-in-oil emulsion.
  • the oils unsunflower seed oil, safflower oil, and soybean oil
  • the emulsifier are mixed and heated to 150 F with stirring.
  • the water, glycerine, niacinamide and preservatives are added with stirring and mixed until homogeneous.
  • the oil and water mixtures are then mixed together and cooled with agitation to room temperature.
  • the fmger treatment emulsion is then loaded into the dispensing device and applied to the finger, especially the nail and cuticle, using the dispensing device.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Cosmetics (AREA)
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Abstract

La présente invention concerne une méthode permettant de prévenir ou de traiter les affections des ongles. La présente invention concerne plus particulièrement des méthodes améliorées d'apport et d'application de compositions destinées à traiter les ongles et les cuticules.
EP00944155A 1999-07-30 2000-07-24 Methode pour traiter et prevenir les affections des ongles Withdrawn EP1199955A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14662799P 1999-07-30 1999-07-30
US146627P 1999-07-30
PCT/IB2000/001019 WO2001008529A2 (fr) 1999-07-30 2000-07-24 Methode pour traiter et prevenir les affections des ongles

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EP1199955A2 true EP1199955A2 (fr) 2002-05-02

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EP00944155A Withdrawn EP1199955A2 (fr) 1999-07-30 2000-07-24 Methode pour traiter et prevenir les affections des ongles

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EP (1) EP1199955A2 (fr)
JP (1) JP2003505175A (fr)
CN (1) CN1367658A (fr)
AU (1) AU5838700A (fr)
MX (1) MXPA02001144A (fr)
WO (1) WO2001008529A2 (fr)

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ITMI20022154A1 (it) * 2002-10-10 2004-04-11 Gibo Italia Srl Struttura di contenitore composito, particolarmente per cosmetici.
CN100421596C (zh) * 2003-12-02 2008-10-01 株式会社常盘 带涂敷工具的容器
JP2006068297A (ja) * 2004-09-02 2006-03-16 Tokiwa Corp 塗布具
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
BRPI1003698A2 (pt) * 2010-10-22 2013-02-19 Antonio Carlos Wiezorkoski aplicaÇço tàpica de pelÍcula isolante protetora para Área do eponÍquio e prega periungueal do dedo
BRPI1003668A2 (pt) * 2010-10-22 2013-02-19 Antonio Carlos Wiezorkoski composiÇço cosmÉtica para aplicaÇço tàpica de pelÍcula isolante protetora para Área do eponÍquio e prega periungueal do dedo
KR101779573B1 (ko) * 2010-11-04 2017-09-18 김종출 압축식 화장품 용기
US9339096B2 (en) * 2013-02-21 2016-05-17 Hct Packaging, Inc. Cuticle care system
MX363386B (es) 2013-10-03 2019-03-20 Dow Pharmaceutical Sciences Formulaciones de efinaconazol estabilizadas.
CN105848719A (zh) 2013-11-22 2016-08-10 道尔医药科学公司 抗感染的方法、组合物和装置
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Publication number Publication date
AU5838700A (en) 2001-02-19
WO2001008529A3 (fr) 2001-08-23
WO2001008529A2 (fr) 2001-02-08
CN1367658A (zh) 2002-09-04
MXPA02001144A (es) 2002-08-20
JP2003505175A (ja) 2003-02-12

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