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EP1185261A4 - Antagonistes des recepteurs de l'il-8 - Google Patents

Antagonistes des recepteurs de l'il-8

Info

Publication number
EP1185261A4
EP1185261A4 EP00942843A EP00942843A EP1185261A4 EP 1185261 A4 EP1185261 A4 EP 1185261A4 EP 00942843 A EP00942843 A EP 00942843A EP 00942843 A EP00942843 A EP 00942843A EP 1185261 A4 EP1185261 A4 EP 1185261A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00942843A
Other languages
German (de)
English (en)
Other versions
EP1185261A1 (fr
Inventor
Gregory Martin Benson
Robert P Hertzberg
Anthony J Jurewicz
Melvin Clarence Rutledge
Daniel F Veber
Katherine L Widdowson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1185261A1 publication Critical patent/EP1185261A1/fr
Publication of EP1185261A4 publication Critical patent/EP1185261A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
EP00942843A 1999-06-16 2000-06-15 Antagonistes des recepteurs de l'il-8 Withdrawn EP1185261A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13967599P 1999-06-16 1999-06-16
US139675P 1999-06-16
PCT/US2000/016499 WO2000076495A1 (fr) 1999-06-16 2000-06-15 Antagonistes des recepteurs de l'il-8

Publications (2)

Publication Number Publication Date
EP1185261A1 EP1185261A1 (fr) 2002-03-13
EP1185261A4 true EP1185261A4 (fr) 2004-02-25

Family

ID=22487790

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00942843A Withdrawn EP1185261A4 (fr) 1999-06-16 2000-06-15 Antagonistes des recepteurs de l'il-8

Country Status (20)

Country Link
EP (1) EP1185261A4 (fr)
JP (1) JP2003501459A (fr)
KR (1) KR20020010709A (fr)
CN (1) CN1355697A (fr)
AR (1) AR030391A1 (fr)
AU (1) AU766083B2 (fr)
BR (1) BR0010802A (fr)
CA (1) CA2377341A1 (fr)
CO (1) CO5200760A1 (fr)
CZ (1) CZ20014471A3 (fr)
HK (1) HK1044483A1 (fr)
HU (1) HUP0201571A3 (fr)
IL (1) IL145761A0 (fr)
MX (1) MXPA01013004A (fr)
NO (1) NO20016053L (fr)
NZ (1) NZ514695A (fr)
PL (1) PL352232A1 (fr)
TR (1) TR200103680T2 (fr)
WO (1) WO2000076495A1 (fr)
ZA (1) ZA200109479B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521479B2 (en) * 2001-04-16 2009-04-21 Panacea Pharmaceuticals, Inc. Methods of treating prion disease in mammals
GB0201882D0 (en) * 2002-01-28 2002-03-13 Novartis Ag Organic compounds
CA2493253A1 (fr) * 2002-08-01 2004-02-12 Neurosearch A/S Composes utilises dans le traitement de maladies sensibles a une therapie anti-angiogenetique
US7550499B2 (en) 2004-05-12 2009-06-23 Bristol-Myers Squibb Company Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
US7326729B2 (en) * 2004-05-12 2008-02-05 Schering Corporation CXCR1 and CXCR2 chemokine antagonists
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
EP1809619A1 (fr) 2004-10-21 2007-07-25 Transtech Pharma, Inc. Composes bissulfonamide utilises en tant qu'agonistes du galr1, compositions, et procedes d'utilisation associes
ATE499370T1 (de) 2005-01-19 2011-03-15 Bristol Myers Squibb Co 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen
WO2006089871A2 (fr) * 2005-02-23 2006-08-31 Neurosearch A/S Derives de diphenyluree utiles en tant qu'agents d'ouverture de canal erg pour le traitement d'arythmies cardiaques
DE602006017694D1 (de) 2005-06-27 2010-12-02 Bristol Myers Squibb Co C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
US7714002B2 (en) 2005-06-27 2010-05-11 Bristol-Myers Squibb Company Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
KR20080027890A (ko) 2005-06-27 2008-03-28 브리스톨-마이어스 스큅 컴퍼니 혈전성 증상의 치료에 유용한 ｐ2ｙ1 수용체의 ｎ-연결헤테로시클릭 길항제
ATE502924T1 (de) 2005-06-27 2011-04-15 Bristol Myers Squibb Co Lineare harnstoffmimetika-antagonisten des p2y1- rezeptors zur behandlung von thromboseleiden
US7960569B2 (en) 2006-10-17 2011-06-14 Bristol-Myers Squibb Company Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
JP2008184403A (ja) * 2007-01-29 2008-08-14 Japan Health Science Foundation 新規ｃ型肝炎ウイルス阻害剤
KR100982661B1 (ko) * 2008-04-22 2010-09-17 전남대학교산학협력단 플라스멥신 ⅱ 활성을 저해하는 화합물을 유효성분으로함유하는 말라리아 예방 및 치료를 위한 약학 조성물 및이를 이용한 말라리아 치료방법
KR100970940B1 (ko) * 2010-05-03 2010-07-20 전남대학교산학협력단 플라스멥신 ⅱ 활성을 저해하는 화합물을 유효성분으로 함유하는 말라리아 예방 및 치료를 위한 약학 조성물 및 이를 이용한 말라리아 치료방법
US10093617B1 (en) * 2015-10-30 2018-10-09 Sumitomo Chemical Company, Limited Method for producing 2-amino-4-substituted phenol

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996025157A1 (fr) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Antagonistes des recepteurs d'il-8
WO2000016768A1 (fr) * 1998-09-18 2000-03-30 Smithkline Beecham Corporation Inhibiteurs de cxcr2 et adhesion pmn et chimiotactisme des lymphocytes t

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996025157A1 (fr) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Antagonistes des recepteurs d'il-8
WO1997029743A1 (fr) * 1995-02-17 1997-08-21 Smithkline Beecham Corporation Antagonistes de recepteurs de l'interleukine-8
WO2000016768A1 (fr) * 1998-09-18 2000-03-30 Smithkline Beecham Corporation Inhibiteurs de cxcr2 et adhesion pmn et chimiotactisme des lymphocytes t

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Interleukin-8 receptor antagonists", EXPERT OPINION ON THERAPEUTIC PATENTS 1998 UNITED KINGDOM, vol. 8, no. 4, 1998, pages 471 - 473, XP002265289, ISSN: 1354-3776 *
HOWARD O M Z ET AL: "CHEMOKINES: PROGRESS TOWARD IDENTIFYING MOLECULAR TARGETS FOR THERAPEUTIC AGENTS", TRENDS IN BIOTECHNOLOGY, ELSEVIER, AMSTERDAM,, GB, vol. 14, February 1996 (1996-02-01), pages 46 - 51, XP002919059, ISSN: 0167-7799 *
PONATH P D: "CHEMOKINE RECEPTOR ANTAGONISTS: NOVEL THERAPEUTICS FOR IMFLAMMATIONAND AIDS", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 7, no. 1, January 1998 (1998-01-01), pages 1 - 18, XP000882089, ISSN: 1354-3784 *
See also references of WO0076495A1 *

Also Published As

Publication number Publication date
WO2000076495A1 (fr) 2000-12-21
CO5200760A1 (es) 2002-09-27
JP2003501459A (ja) 2003-01-14
IL145761A0 (en) 2002-07-25
BR0010802A (pt) 2002-02-19
CZ20014471A3 (cs) 2002-08-14
AR030391A1 (es) 2003-08-20
AU5741300A (en) 2001-01-02
MXPA01013004A (es) 2002-07-30
CA2377341A1 (fr) 2000-12-21
NZ514695A (en) 2004-05-28
HUP0201571A2 (en) 2002-08-28
TR200103680T2 (tr) 2002-07-22
CN1355697A (zh) 2002-06-26
EP1185261A1 (fr) 2002-03-13
ZA200109479B (en) 2002-11-18
HK1044483A1 (zh) 2002-10-25
NO20016053D0 (no) 2001-12-11
HUP0201571A3 (en) 2002-11-28
KR20020010709A (ko) 2002-02-04
PL352232A1 (en) 2003-08-11
NO20016053L (no) 2001-12-11
AU766083B2 (en) 2003-10-09

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