EP1181550A4 - Methods for the identification of compounds for the treatment of alzheimer's disease - Google Patents

Methods for the identification of compounds for the treatment of alzheimer's disease

Info

Publication number: EP1181550A4
Authority: EP; European Patent Office
Prior art keywords: alzheimer; disease; identification; compounds; treatment
Prior art date: 1999-04-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00928500A

Other languages

German (de)

French (fr)

Other versions

EP1181550A1 (en

Inventor

Ralph A Nixon

Anne M Cataldo

Paul M Mathews

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH

NATHAN S KLINE INST FOR PSYCHI

Original Assignee

NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH

NATHAN S KLINE INST FOR PSYCHI

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-30

Filing date

2000-04-28

Publication date

2005-03-02

2000-04-28 Application filed by NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH, NATHAN S KLINE INST FOR PSYCHI filed Critical NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH

2002-02-27 Publication of EP1181550A1 publication Critical patent/EP1181550A1/en

2005-03-02 Publication of EP1181550A4 publication Critical patent/EP1181550A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Environmental Sciences (AREA)
Neurology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Hematology (AREA)
Animal Husbandry (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Urology & Nephrology (AREA)
Biodiversity & Conservation Biology (AREA)
Analytical Chemistry (AREA)
Public Health (AREA)
General Physics & Mathematics (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)

EP00928500A 1999-04-30 2000-04-28 Methods for the identification of compounds for the treatment of alzheimer's disease Withdrawn EP1181550A4 (en)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US13189099P	1999-04-30	1999-04-30
US13199199P	1999-04-30	1999-04-30
US131991P		1999-04-30
US131890P		1999-04-30
US14064499P	1999-06-23	1999-06-23
US14064399P	1999-06-23	1999-06-23
US140643P		1999-06-23
US140644P		1999-06-23
PCT/US2000/011401 WO2000067016A1 (en)	1999-04-30	2000-04-28	Methods for the identification of compounds for the treatment of alzheimer's disease

Publications (2)

Publication Number	Publication Date
EP1181550A1 EP1181550A1 (en)	2002-02-27
EP1181550A4 true EP1181550A4 (en)	2005-03-02

Family

ID=27494932

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP00928500A Withdrawn EP1181550A4 (en)	1999-04-30	2000-04-28	Methods for the identification of compounds for the treatment of alzheimer's disease
EP00928662A Ceased EP1181308A4 (en)	1999-04-30	2000-04-28	Methods for the treatment of neuronal atrophy-associated dementia

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP00928662A Ceased EP1181308A4 (en)	1999-04-30	2000-04-28	Methods for the treatment of neuronal atrophy-associated dementia

Country Status (5)

Country	Link
EP (2)	EP1181550A4 (en)
JP (2)	JP2002543425A (en)
AU (2)	AU784048B2 (en)
CA (2)	CA2370177A1 (en)
WO (2)	WO2000067016A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002256422A1 (en) *	2001-05-02	2002-11-11	Blanchette Rockefeller Neurosciences Institute	Carbonic anhydrase activators for enhancing learning and memory
US20070155771A1 (en) *	2003-04-11	2007-07-05	David Rubinsztein	Methods and means for treating protein conformational disorders
TW201206425A (en)	2004-05-18	2012-02-16	Brni Neurosciences Inst	Treatment of depressive disorders
ES2301280A1 (en) *	2005-05-16	2008-06-16	Fina Biotech S.L.U.	Method for the diagnosis of alzheimer's disease
US10278774B2 (en)	2011-03-18	2019-05-07	Covidien Lp	Selectively expandable operative element support structure and methods of use
JP6391318B2 (en) *	2014-06-27	2018-09-19	学校法人順天堂	Screening method for Alzheimer's disease prevention and treatment
JP7344546B2 (en) *	2019-08-28	2023-09-14	日本メナード化粧品株式会社	APEH production promoter
CN111686129A (en) *	2020-04-14	2020-09-22	南开大学	Application of lysosome in preparation of medicine for treating Alzheimer's disease and delaying senile mental decline
CN114209716B (en) *	2021-11-26	2024-06-25	南开大学	Application of modified lysosome in preparing medicines for treating protein misfolding or processing diseases

Citations (1)

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Publication number	Priority date	Publication date	Assignee	Title
WO1994007144A1 (en) *	1992-09-21	1994-03-31	United States Of America, As Represented By The Secretary, Department Of Health And Human Services	A method of screening compounds and methods for treating alzheimer's disease

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US5028622A (en) *	1988-05-06	1991-07-02	Ajinomoto Company, Inc.	Administration of amino acids as treatment for neurodegenerative disorders
US6294520B1 (en) *	1989-03-27	2001-09-25	Albert T. Naito	Material for passage through the blood-brain barrier
US5538983A (en) *	1990-05-16	1996-07-23	The Rockefeller University	Method of treating amyloidosis by modulation of calcium
US5686269A (en) *	1994-07-28	1997-11-11	The Mclean Hospital Corporation	Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in cerebrospinal fluid
AUPN991796A0 (en) *	1996-05-17	1996-06-13	Women's And Children's Hospital	Early detection of lysosomal storage disorders
WO1998021589A1 (en) *	1996-11-15	1998-05-22	The Trustees Of The University Of Pennsylvania	Screening for modulators of amyloid processing
US6268479B1 (en) *	1997-03-12	2001-07-31	The Trustees Of Columbia University In The City Of New York	Intracellular amyloid-beta peptide binding (ERAB) polypeptide

2000
- 2000-04-28 CA CA002370177A patent/CA2370177A1/en not_active Abandoned
- 2000-04-28 WO PCT/US2000/011401 patent/WO2000067016A1/en active IP Right Grant
- 2000-04-28 JP JP2000615804A patent/JP2002543425A/en active Pending
- 2000-04-28 CA CA002372190A patent/CA2372190A1/en not_active Abandoned
- 2000-04-28 WO PCT/US2000/011739 patent/WO2000066617A1/en active Application Filing
- 2000-04-28 EP EP00928500A patent/EP1181550A4/en not_active Withdrawn
- 2000-04-28 AU AU46863/00A patent/AU784048B2/en not_active Expired - Fee Related
- 2000-04-28 EP EP00928662A patent/EP1181308A4/en not_active Ceased
- 2000-04-28 JP JP2000615646A patent/JP2003514216A/en active Pending
- 2000-04-28 AU AU46734/00A patent/AU772054B2/en not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994007144A1 (en) *	1992-09-21	1994-03-31	United States Of America, As Represented By The Secretary, Department Of Health And Human Services	A method of screening compounds and methods for treating alzheimer's disease

Non-Patent Citations (3)

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Title
CATALDO A M ET AL: "COLOCALIZATION OF LYSOSOMAL HYDROLASE AND BETA-AMYLOID IN DIFFUSE PLAQUES OF THE CEREBELLUM AND STRIATUM IN ALZHEIMER'S DISEASE AND DOWN'S SYNDROME", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, NEW YORK, NY, US, vol. 55, no. 6, June 1996 (1996-06-01), pages 704 - 715, XP001070366, ISSN: 0022-3069 *
NIXON R A ET AL: "The endosomal-lysosomal system of neurons: new roles.", TRENDS IN NEUROSCIENCES. NOV 1995, vol. 18, no. 11, November 1995 (1995-11-01), pages 489 - 496, XP002298359, ISSN: 0166-2236 *
See also references of WO0067016A1 *

Also Published As

Publication number	Publication date
WO2000067016A1 (en)	2000-11-09
CA2372190A1 (en)	2000-11-09
WO2000066617A1 (en)	2000-11-09
AU4673400A (en)	2000-11-17
AU784048B2 (en)	2006-01-19
CA2370177A1 (en)	2000-11-09
EP1181308A4 (en)	2004-10-27
JP2003514216A (en)	2003-04-15
WO2000067016A9 (en)	2002-07-11
EP1181308A1 (en)	2002-02-27
EP1181550A1 (en)	2002-02-27
AU4686300A (en)	2000-11-17
AU772054B2 (en)	2004-04-08
JP2002543425A (en)	2002-12-17

Publication	Publication Date	Title
EP1043991A4 (en)	2005-02-02	Treatment for alzheimer's disease
AU2001233299A1 (en)	2001-08-14	Methods for treating alzheimer's disease
EE200200716A (en)	2004-08-16	Compounds for the Treatment of Alzheimer's Disease
AU2003206413A8 (en)	2003-07-24	Substituted amino carboxamides for the treatment of alzheimer's disease
AU2002315131A1 (en)	2002-12-23	Aminediols as agents for the treatment of alzheimer's disease
NO20001869D0 (en)	2000-04-11	Procedures for the treatment of Alzheimer's disease
AU6932000A (en)	2001-04-10	Tacrine derivatives for treating alzheimer's disease
AU2001236592A1 (en)	2001-08-14	Methods for diagnosis of alzheimer's disease
EP1181550A4 (en)	2005-03-02	Methods for the identification of compounds for the treatment of alzheimer's disease
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ZA962715B (en)	1997-10-06	Pharmaceutical agents for the treatment of Alzheimer's disease.
AU1405899A (en)	1999-06-07	Treatment for alzheimer's disease
GB0011408D0 (en)	2000-06-28	Therapeutic combination for treating Alzheimer's Disease
GB0011430D0 (en)	2000-06-28	Acombination of therapeutic agents for treating Alzheimer's Disease
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HUP0103149A3 (en)	2003-03-28	Pharmaceutical composition for treatment of alzheimer's disease
GB9922194D0 (en)	1999-11-17	Compounds for improved treatment of parkinson's disease
GB9709416D0 (en)	1997-07-02	Methods for treatment of alzheimer's disease using azaspiranes
AU6265600A (en)	2001-01-09	Method for detection of early-onset alzheimer's disease
AU2002320537A1 (en)	2003-01-29	Diaminediols for the treatment of alzheimer's disease
AU2002316622A1 (en)	2003-01-29	Aminediols for the treatment of alzheimer's disease
AU2001255439A1 (en)	2001-10-30	Method of treating alzheimer's disease
AU2002350043A1 (en)	2003-05-12	Hydroxy substituted amides for the treatment of alzheimer's disease

Legal Events

Date	Code	Title	Description
2002-01-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2002-02-27	17P	Request for examination filed	Effective date: 20011130
2002-02-27	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-02-27	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2002-05-02	RIN1	Information on inventor provided before grant (corrected)	Inventor name: CATALDO, ANNE M. Inventor name: NIXON, RALPH A. Inventor name: MATHEWS, PAUL M.
2004-11-24	RIC1	Information provided on ipc code assigned before grant	Ipc: 7G 01N 33/50 B Ipc: 7A 61K 49/00 B Ipc: 7A 01K 67/027 A Ipc: 7G 01N 33/68 B
2005-03-02	A4	Supplementary search report drawn up and despatched	Effective date: 20050114
2007-10-10	17Q	First examination report despatched	Effective date: 20070906
2008-09-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2008-10-08	18D	Application deemed to be withdrawn	Effective date: 20080317