EP1173590A4 - Systeme d'activation du zymogene - Google Patents

Systeme d'activation du zymogene

Info

Publication number: EP1173590A4
Authority: EP; European Patent Office
Prior art keywords: activation system; zymogen activation; zymogen; activation
Prior art date: 1999-04-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00922167A

Other languages

German (de)

English (en)

Other versions

EP1173590A2 (fr

Inventor

Andrew Darrow

Jensen Qi

Patricia Andrade-Gordon

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceuticals Inc

Original Assignee

Ortho McNeil Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-30

Filing date

2000-04-13

Publication date

2003-01-15

2000-04-13 Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc

2002-01-23 Publication of EP1173590A2 publication Critical patent/EP1173590A2/fr

2003-01-15 Publication of EP1173590A4 publication Critical patent/EP1173590A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP00922167A 1999-04-30 2000-04-13 Systeme d'activation du zymogene Withdrawn EP1173590A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US303162		1994-09-08
US30316299A	1999-04-30	1999-04-30
PCT/US2000/009973 WO2000066709A2 (fr)	1999-04-30	2000-04-13	Systeme d'activation du zymogene

Publications (2)

Publication Number	Publication Date
EP1173590A2 EP1173590A2 (fr)	2002-01-23
EP1173590A4 true EP1173590A4 (fr)	2003-01-15

Family

ID=23170790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00922167A Withdrawn EP1173590A4 (fr)	1999-04-30	2000-04-13	Systeme d'activation du zymogene

Country Status (6)

Country	Link
EP (1)	EP1173590A4 (fr)
JP (1)	JP2003531567A (fr)
AR (1)	AR023818A1 (fr)
AU (1)	AU4239600A (fr)
CA (1)	CA2372907A1 (fr)
WO (1)	WO2000066709A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2006271285A (ja) *	2005-03-30	2006-10-12	National Institute Of Information & Communication Technology	改良型ｈａタグ及び改良型ｈａタグを用いたスクリーニング方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5342762A (en) *	1991-01-03	1994-08-30	Wisconsin Alumni Research Foundation	Fibronectin purification vector
US5504001A (en) *	1987-11-25	1996-04-02	Zymogenetics, Inc.	Hybrid plasminogen activator
US5726038A (en) *	1993-07-08	1998-03-10	Novo Nordisk A/S	DNA construct encoding the YAP3 signal peptide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5200340A (en) *	1987-05-22	1993-04-06	Zymogenetics, Inc.	Thrombin-activated tissue plasminogen activators
US4992373A (en) *	1987-12-04	1991-02-12	Eli Lilly And Company	Vectors and compounds for direct expression of activated human protein C
US5196322A (en) *	1987-12-28	1993-03-23	Eli Lilly And Company	Vectors and compounds for expression of zymogen forms of human protein C
AU675506B2 (en) *	1993-01-15	1997-02-06	Genetics Institute, Llc	Cloning of enterokinase and method of use
EP0917566B1 (fr) *	1996-06-11	2004-09-22	Roche Diagnostics GmbH	Proteases recombinees de coagulation sanguine
NZ500736A (en) *	1997-04-25	2005-01-28	Sembiosys Genetics Inc	Method for recovery of recombinantly produced polypeptides involving the cleavage of fusion proteins

2000
- 2000-04-13 AU AU42396/00A patent/AU4239600A/en not_active Abandoned
- 2000-04-13 JP JP2000615734A patent/JP2003531567A/ja active Pending
- 2000-04-13 CA CA002372907A patent/CA2372907A1/fr not_active Abandoned
- 2000-04-13 WO PCT/US2000/009973 patent/WO2000066709A2/fr not_active Ceased
- 2000-04-13 EP EP00922167A patent/EP1173590A4/fr not_active Withdrawn
- 2000-04-28 AR ARP000102081A patent/AR023818A1/es unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5504001A (en) *	1987-11-25	1996-04-02	Zymogenetics, Inc.	Hybrid plasminogen activator
US5342762A (en) *	1991-01-03	1994-08-30	Wisconsin Alumni Research Foundation	Fibronectin purification vector
US5726038A (en) *	1993-07-08	1998-03-10	Novo Nordisk A/S	DNA construct encoding the YAP3 signal peptide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0066709A3 *

Also Published As

Publication number	Publication date
WO2000066709A3 (fr)	2001-02-15
WO2000066709A9 (fr)	2002-08-29
CA2372907A1 (fr)	2000-11-09
JP2003531567A (ja)	2003-10-28
AU4239600A (en)	2000-11-17
EP1173590A2 (fr)	2002-01-23
AR023818A1 (es)	2002-09-04
WO2000066709A2 (fr)	2000-11-09

Publication	Publication Date	Title
EP1221148A4 (fr)	2002-08-07	Systeme tactile et visuel de localisation d'issues et de determination d'une distance par rapport a une issue
GB9906929D0 (en)	1999-05-19	Assay system
GB2357360B (en)	2004-01-21	Alarm system
GB9928968D0 (en)	2000-02-02	Enzyme
GB0128794D0 (en)	2002-01-23	Loudspeaker system
GB9906245D0 (en)	1999-05-12	Enzyme
GB9901622D0 (en)	1999-03-17	Construction system
GB9912133D0 (en)	1999-07-28	Alarm system
AU1289101A (en)	2001-06-06	Paging system
AU6876100A (en)	2001-04-10	Paging system
GB9907271D0 (en)	1999-05-26	System
GB9924506D0 (en)	1999-12-15	Expression system
GB9918154D0 (en)	1999-10-06	Expression system
GB9905400D0 (en)	1999-05-05	Retention system
GB9902234D0 (en)	1999-03-24	Expression system
GB0003919D0 (en)	2000-04-05	Kinetomatic system III
GB9913588D0 (en)	1999-08-11	General alarm system
EP1173590A4 (fr)	2003-01-15	Systeme d'activation du zymogene
GB2375831B (en)	2004-04-14	Ranging system
GB9911547D0 (en)	1999-07-21	Answerphone system
GB9924634D0 (en)	1999-12-22	Enzyme
GB9911600D0 (en)	1999-07-21	Alarm system
GB9908458D0 (en)	1999-06-09	Enzyme
GB9923637D0 (en)	1999-12-08	Enzyme system
GB9903176D0 (en)	1999-04-07	Alarm system

Legal Events

Date	Code	Title	Description
2001-12-07	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2002-01-23	17P	Request for examination filed	Effective date: 20011126
2002-01-23	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-01-23	AX	Request for extension of the european patent	Free format text: AL;LT;LV;MK;RO;SI
2003-01-15	A4	Supplementary search report drawn up and despatched	Effective date: 20021129
2003-01-15	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2003-07-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
2003-09-03	18W	Application withdrawn	Effective date: 20030709