EP1161431A4 - Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine - Google Patents

Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine

Info

Publication number: EP1161431A4
Authority: EP; European Patent Office
Prior art keywords: releasing hormone; gonadotropin releasing; hormone antagonists; azaindole compounds; azaindole
Prior art date: 1999-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP00917757A

Other languages

German (de)

English (en)

Other versions

EP1161431A1 (fr

Inventor

Thomas F Walsh

Feroze Ujjainwalla

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-10

Filing date

2000-03-06

Publication date

2002-04-24

2000-03-06 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2001-12-12 Publication of EP1161431A1 publication Critical patent/EP1161431A1/fr

2002-04-24 Publication of EP1161431A4 publication Critical patent/EP1161431A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Immunology (AREA)
Gynecology & Obstetrics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EP00917757A 1999-03-10 2000-03-06 Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine Withdrawn EP1161431A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12362099P	1999-03-10	1999-03-10
US123620P		1999-03-10
PCT/US2000/005799 WO2000053602A1 (fr)	1999-03-10	2000-03-06	Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine

Publications (2)

Publication Number	Publication Date
EP1161431A1 EP1161431A1 (fr)	2001-12-12
EP1161431A4 true EP1161431A4 (fr)	2002-04-24

Family

ID=22409767

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP00917757A Withdrawn EP1161431A4 (fr)	1999-03-10	2000-03-06	Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine

Country Status (5)

Country	Link
EP (1)	EP1161431A4 (fr)
JP (1)	JP2002539124A (fr)
AU (1)	AU3868500A (fr)
CA (1)	CA2366615A1 (fr)
WO (1)	WO2000053602A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3514200A (en) *	1999-03-10	2000-09-28	Merck & Co., Inc.	6-azaindole compounds as antagonists of gonadotropin releasing hormone
GB0022670D0 (en)	2000-09-15	2000-11-01	Astrazeneca Ab	Molecules
TWI262920B (en) *	2000-10-27	2006-10-01	Elbion Ag	New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
SE0100566D0 (sv)	2001-02-20	2001-02-20	Astrazeneca Ab	Compounds
SE0101692D0 (sv)	2001-05-14	2001-05-14	Astrazeneca Ab	Compounds
GB0219472D0 (en)	2002-08-21	2002-10-02	Astrazeneca Ab	Chemical compounds
AU2003267551A1 (en)	2002-08-21	2004-03-11	Astrazeneca Ab	Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone
TW200407127A (en)	2002-08-21	2004-05-16	Astrazeneca Ab	Chemical compounds
DE60314158T2 (de)	2002-08-21	2008-01-31	Astrazeneca Ab	Pyrazolderivate als gnrh-inhibitoren
TW200413351A (en) *	2002-08-21	2004-08-01	Astrazeneca Ab	Chemical compounds
US20070167428A1 (en) *	2004-02-20	2007-07-19	Astrazeneca Ab	Thienopyrroles as antagonists of gnrh
WO2005121140A1 (fr)	2004-06-09	2005-12-22	Glaxo Group Limited	Derives de pyrrolopyridine
DE102004033902A1 (de)	2004-07-14	2006-02-16	Zentaris Gmbh	Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)
ATE485300T1 (de)	2004-07-16	2010-11-15	Sunesis Pharmaceuticals Inc	Als aurora-kinase-inhibitoren nutzbare thienopyrimidine
AU2006272876A1 (en)	2005-07-22	2007-02-01	Sunesis Pharmaceuticals, Inc.	Pyrazolo pyrimidines useful as aurora kinase inhibitors
CL2008001933A1 (es)	2007-06-29	2009-09-25	Millennium Pharm Inc	Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
CN101743242A (zh)	2007-06-29	2010-06-16	苏尼西斯制药有限公司	用作raf激酶抑制剂的杂环化合物
EP2095818A1 (fr)	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Utilisation d'antagonistes LHRH dans des doses n'impliquant pas de castration
IL279977B2 (en)	2018-07-09	2024-06-01	Boehringer Ingelheim Animal Health Usa Inc	Heterocyclic anthelmintic compounds
CA3133100A1 (fr)	2019-03-19	2020-09-24	Boehringer Ingelheim Animal Health USA Inc.	Composes d'aza-benzothiophene et d'aza-benzofurane anthelminthiques
MX2022015038A (es)	2020-05-29	2023-01-04	Boehringer Ingelheim Animal Health Usa Inc	Compuestos heterociclicos como anthelminticos.
AU2021358123A1 (en)	2020-10-05	2023-06-08	Enliven Inc.	5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
IL312412A (en)	2021-11-01	2024-06-01	Boehringer Ingelheim Vetmedica Gmbh	Pyrrolopyridazine compounds against worms

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997021703A1 (fr) *	1995-12-14	1997-06-19	Merck & Co., Inc.	Antagonistes de l'hormone de liberaiton de la gonadotropine
WO1997021707A1 (fr) *	1995-12-14	1997-06-19	Merck & Co., Inc.	Antagonistes de la gonadoliberine
US5756507A (en) *	1995-12-14	1998-05-26	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US5780437A (en) *	1995-12-14	1998-07-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2298199A (en) *	1995-02-21	1996-08-28	Merck Sharp & Dohme	Synthesis of azaindoles
ES2213984T3 (es) *	1998-10-30	2004-09-01	Eli Lilly And Company	Derivados de azaindol y su uso como agentes antitrombicos.

2000
- 2000-03-06 EP EP00917757A patent/EP1161431A4/fr not_active Withdrawn
- 2000-03-06 CA CA002366615A patent/CA2366615A1/fr not_active Abandoned
- 2000-03-06 AU AU38685/00A patent/AU3868500A/en not_active Abandoned
- 2000-03-06 WO PCT/US2000/005799 patent/WO2000053602A1/fr not_active Ceased
- 2000-03-06 JP JP2000604039A patent/JP2002539124A/ja not_active Withdrawn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997021703A1 (fr) *	1995-12-14	1997-06-19	Merck & Co., Inc.	Antagonistes de l'hormone de liberaiton de la gonadotropine
WO1997021707A1 (fr) *	1995-12-14	1997-06-19	Merck & Co., Inc.	Antagonistes de la gonadoliberine
US5756507A (en) *	1995-12-14	1998-05-26	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US5780437A (en) *	1995-12-14	1998-07-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0053602A1 *

Also Published As

Publication number	Publication date
AU3868500A (en)	2000-09-28
CA2366615A1 (fr)	2000-09-14
WO2000053602A1 (fr)	2000-09-14
EP1161431A1 (fr)	2001-12-12
JP2002539124A (ja)	2002-11-19

Publication	Publication Date	Title
EP1161431A4 (fr)	2002-04-24	Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine
EP1171135A4 (fr)	2002-05-15	Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine
EP1067930A4 (fr)	2002-09-18	Antagonistes de l'hormone liberant la gonadotropine (gnrh)
EE200100483A (et)	2002-12-16	Põletikuvastaste vahenditena kasutatavad ühendid
MA27011A1 (fr)	2004-12-20	Derives de dihydro-benzo[b] [1,4] diazepine-2-one utilises comme antagonistes i de mglur2
DZ3218A1 (fr)	2001-04-19	Pyrimidine-7-ones 5-(2-substitutees-5-heterocyclylsulphonylpyride-3-yl)-dihydropyrazolo[4,3-d] servant d'inhibiteurs de la phosphodiesterase
FR08C0004I2 (fr)	2009-01-15	Composition orale d' une dose pour une libération prolongée
ATE280157T1 (de)	2004-11-15	4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
EP1229910A4 (fr)	2003-10-01	Antagonistes des recepteurs d'integrine
EP1150965A4 (fr)	2002-05-15	Derives de la benzazepine utilises comme antagonistes du recepteur alpha-v de l'integrine
EP1027046A4 (fr)	2002-04-03	Antagonistes de l'hormone de liberation de la gonadothrophine
IL135863A0 (en)	2001-05-20	Cyclopentene derivatives useful as antagonists of the motilin receptor
EP1171126A4 (fr)	2002-03-27	Composes 6-azaindole utilises comme antagonistes d'une hormone liberant la gonadotropine
AU4834900A (en)	2000-12-05	Antagonists of gonadotropin releasing hormone
IL144720A0 (en)	2002-06-30	Heterocyclic benzenesulphonamide compounds as bradykinine antagonists
IL148623A0 (en)	2002-09-12	Thienoisoxazolyl-and thienylpyrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists
PL350536A1 (en)	2002-12-16	Biphenyl derivatives as antagonists of the neurokinine-1 receptor
DE50008020D1 (de)	2004-11-04	Substituierte pyrrolidin-2,3,4-trion-derivate wirksam als nmda-rezeptor-antagonisten
ITMI991657A0 (it)	1999-07-27	Procedimento per la preparazione di ossidi olefinici
EP1165076A4 (fr)	2002-05-15	Composes de 6-azaindole comme antagonistes de la gonadoliberine
MA26544A1 (fr)	2004-12-20	Derives de pyrrolopyrrolone comme inhibiteurs d'elastase de neutrophiles
IL143451A0 (en)	2002-04-21	NEW- β-AMIDE AND β-SULFONAMIDE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS
NO20011309L (no)	2001-03-15	Benzotieno [3,2-c]pyridiner som<alfa>2-antagonister
GB9805718D0 (en)	1998-05-13	Antagonists of gonadotropin releasing hormone
GB9806694D0 (en)	1998-05-27	Antagonists of gonadotropin releasing hormone

Legal Events

Date	Code	Title	Description
2001-10-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-12-12	17P	Request for examination filed	Effective date: 20011010
2001-12-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-12-12	AX	Request for extension of the european patent	Free format text: AL PAYMENT 20011010;LT PAYMENT 20011010;LV PAYMENT 20011010;MK PAYMENT 20011010;RO PAYMENT 20011010;SI PAYMENT 20011010
2002-04-24	A4	Supplementary search report drawn up and despatched	Effective date: 20020308
2002-04-24	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-04-24	RIC1	Information provided on ipc code assigned before grant	Free format text: 7C 07D 471/04 A, 7C 07D 471/08 B, 7C 07D 401/06 B, 7C 07D 401/12 B, 7A 61K 31/44 B, 7A 61K 31/435 B, 7A 61P 15/00 B
2002-11-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2003-01-02	18D	Application deemed to be withdrawn	Effective date: 20020701