EP1024804A4 - Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels - Google Patents

Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels

Info

Publication number: EP1024804A4
Authority: EP; European Patent Office
Prior art keywords: soluble vitamin; lipid levels; fat soluble; serum lipid; therapeutic combinations
Prior art date: 1997-05-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP98918680A

Other languages

German (de)

French (fr)

Other versions

EP1024804A1 (en

Inventor

Richard E Gregg

John R Ii Wetterau

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-01

Filing date

1998-04-23

Publication date

2001-03-21

1998-04-23 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2000-08-09 Publication of EP1024804A1 publication Critical patent/EP1024804A1/en

2001-03-21 Publication of EP1024804A4 publication Critical patent/EP1024804A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP98918680A 1997-05-01 1998-04-23 Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels Withdrawn EP1024804A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4540597P	1997-05-01	1997-05-01
US45405P		1997-05-01
PCT/US1998/008269 WO1998050028A1 (en)	1997-05-01	1998-04-23	Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels

Publications (2)

Publication Number	Publication Date
EP1024804A1 EP1024804A1 (en)	2000-08-09
EP1024804A4 true EP1024804A4 (en)	2001-03-21

Family

ID=21937689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP98918680A Withdrawn EP1024804A4 (en)	1997-05-01	1998-04-23	Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels

Country Status (5)

Country	Link
EP (1)	EP1024804A4 (en)
JP (1)	JP2001527551A (en)
AU (1)	AU748608B2 (en)
CA (1)	CA2286341A1 (en)
WO (1)	WO1998050028A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19929012A1 (en) *	1999-06-25	2000-12-28	Bayer Ag	Synergistic drug combination, especially for treating cardiovascular diseases associated with metabolic disorders, comprising bi- or tricyclic aza-heterocyclic MTP inhibitor and metabolically active drug
DE19929065A1 (en) *	1999-06-25	2000-12-28	Bayer Ag	Synergistic drug combination, especially for treating cardiovascular diseases associated with metabolic disorders, comprising bi- or tricyclic aza-heterocyclic MTP inhibitor and HMG-CoA reductase inhibitor
DE19929031A1 (en) *	1999-06-25	2000-12-28	Bayer Ag	Synergistic drug combination, especially for treating cardiovascular diseases associated with metabolic disorders, comprising bi- or tricyclic aza-heterocyclic MTP inhibitor and lipid metabolism regulator or vitamin
FR2845601B1 (en) *	2002-10-11	2005-07-08	Servier Lab	NOVEL ASSOCIATION BETWEEN A HETEROCYCLIC COMPOUND AND ANTIOXIDANT AGENT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DK1725234T4 (en)	2004-03-05	2016-05-09	Univ Pennsylvania	METHODS OF TREATING DISEASES OR DISEASES CONNECTED WITH HYPERLIPIDEMIA AND HYPERCOLESTEROLYMIA WITH MINIMIZATION OF SIDE EFFECTS
FR2868313B1 (en) *	2004-03-31	2008-08-15	Servier Lab	NOVEL ASSOCIATION BETWEEN A HETEROCYCLIC COMPOUND AND AN ANTIOXIDANT AGENT AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO2007047724A2 (en) *	2005-10-18	2007-04-26	Aegerion Pharmaceuticals	Compositions for lowering serum cholesterol and/or triglycerides
CN103690960A (en) *	2013-12-18	2014-04-02	北京科源创欣科技有限公司	Lomitapide mesylate medicinal composition and preparation method thereof
AT15657U1 (en)	2016-10-06	2018-04-15	Bioenergy Healthcare GmbH	lipid-lowering agents
EP4188372A1 (en)	2020-07-29	2023-06-07	Amryt Pharmaceuticals Inc.	Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0584446A2 (en) *	1992-03-06	1994-03-02	E.R. SQUIBB & SONS, INC.	Microsomal triglyceride transfer protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3674836A (en) *	1968-05-21	1972-07-04	Parke Davis & Co	2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
JPS5612114B2 (en) *	1974-06-07	1981-03-18
US5739135A (en) *	1993-09-03	1998-04-14	Bristol-Myers Squibb Company	Inhibitors of microsomal triglyceride transfer protein and method

1998
- 1998-04-23 EP EP98918680A patent/EP1024804A4/en not_active Withdrawn
- 1998-04-23 JP JP54813898A patent/JP2001527551A/en active Pending
- 1998-04-23 CA CA002286341A patent/CA2286341A1/en not_active Abandoned
- 1998-04-23 AU AU71559/98A patent/AU748608B2/en not_active Ceased
- 1998-04-23 WO PCT/US1998/008269 patent/WO1998050028A1/en not_active Ceased

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0584446A2 (en) *	1992-03-06	1994-03-02	E.R. SQUIBB & SONS, INC.	Microsomal triglyceride transfer protein

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9850028A1 *

Also Published As

Publication number	Publication date
AU7155998A (en)	1998-11-27
WO1998050028A1 (en)	1998-11-12
AU748608B2 (en)	2002-06-06
JP2001527551A (en)	2001-12-25
EP1024804A1 (en)	2000-08-09
CA2286341A1 (en)	1998-11-12

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EP1210075A4 (en)	2004-09-01	Compositions and methods for modification of skin lipid content
EP1024804A4 (en)	2001-03-21	Mtp inhibitors and fat soluble vitamin therapeutic combinations to lower serum lipid levels
ZA986003B (en)	1999-01-28	Compositions and methods for enhancing delivery of therapeutic agents to cells
ATA159197A (en)	2001-12-15	PHARMACEUTICAL PREPARATION CONTAINING VITAMIN K-DEPENDENT INDIVIDUAL FACTORS
PL335402A1 (en)	2000-04-25	Complementation of proteins in transgenous plants
GB9725946D0 (en)	1998-02-04	Lipid compositions and their use
ATA6897A (en)	1998-10-15	PREPARATION COMPREHENSIVE THIOL GROUP-PROTEINS
AU6894298A (en)	1998-10-30	Human fatty acid binding protein
ZA986047B (en)	1999-02-01	6-pyrrolidin-2-ylpyrindines their preparation and their therapeutic application
AU1456899A (en)	1999-06-15	Human protein kinase and kinase inhibitors
TW428769U (en)	2001-04-01	Joint-portion structure between pedal and heel-plate of foot pedal
PL346796A1 (en)	2002-02-25	Methods of downmodulating the immune response to therapeutic proteins
GB9718664D0 (en)	1997-11-05	Improvements in or relating to capsules
GB9726246D0 (en)	1998-02-11	Preparation of esters
GB9726247D0 (en)	1998-02-11	Preparation of esters

Legal Events

Date	Code	Title	Description
2000-06-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2000-08-09	17P	Request for examination filed	Effective date: 19991201
2000-08-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2001-03-14	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 31/355 A, 7A 61K 31/34 B, 7A 61K 31/075 B, 7A 61K 31/445 B, 7A 61K 31/495 B, 7A 61K 31/50 B, 7A 61K 45/06 B, 7A 61P 9/00 B
2001-03-21	A4	Supplementary search report drawn up and despatched	Effective date: 20010131
2001-03-21	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2004-03-31	17Q	First examination report despatched	Effective date: 20040216
2005-01-14	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2005-03-02	18D	Application deemed to be withdrawn	Effective date: 20040827