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EP1024850A1 - Dispositif d'inhalation - Google Patents

Dispositif d'inhalation

Info

Publication number
EP1024850A1
EP1024850A1 EP98949139A EP98949139A EP1024850A1 EP 1024850 A1 EP1024850 A1 EP 1024850A1 EP 98949139 A EP98949139 A EP 98949139A EP 98949139 A EP98949139 A EP 98949139A EP 1024850 A1 EP1024850 A1 EP 1024850A1
Authority
EP
European Patent Office
Prior art keywords
medicament
reservoir
sealing means
mandrel
inhalation device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP98949139A
Other languages
German (de)
English (en)
Other versions
EP1024850B1 (fr
Inventor
Alastair R. Rhone-Poulenc Rorer Limited Clarke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of EP1024850A1 publication Critical patent/EP1024850A1/fr
Application granted granted Critical
Publication of EP1024850B1 publication Critical patent/EP1024850B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A61M2202/066—Powder made from a compacted product by abrading

Definitions

  • This invention relates to a device for the administration of powdered medicaments by inhalation, more particularly to a multiple-dose inhalation device with metering means for
  • European Patent 407028 discloses a multiple-dose inhalation device in which a dose of medicament is metered by abrading a fixed volume from a compacted body of powdered medicament.
  • the compacted body of medicament comprises a cylinder which is held within a reservoir and which fits over an inner mandrel.
  • the mandrel provides support for some or all of the medicament compact and provides an axis around which the reservoir and compact is turned in order to abrade a dose of medicament from the compact.
  • the metered dose is then entrained in a through-going pathway of the device and is inhaled by the patient, the means for abrading being, for example, a helical blade.
  • the device of EP 407028 was improved in EP 691865 by providing a shuttering system to isolate the compacted body of medicament from the through-going pathway of the device.
  • sealing means between the medicament reservoir and the inner mandrel of the inhalation device. Surprisingly it has been found that although a gap must be left in the sealing means in order to accommodate the pathway between the medicament reservoir and the dispersion chamber leakage is substantially reduced. Another advantage of the seal is that it provides a frictional brake which allows the ratchet mechanism rotating the medicament reservoir to
  • a medicament inhalation device including a housing having a through-going pathway connecting an air inlet with an air outlet, a medicament reservoir adapted to receive a compacted body of powdered medicament, an inner mandrel around which the medicament reservoir rotates and metering means for dispensing a predetermined dose of medicament from the reservoir into the pathway, the metering means including means for abrading the compacted body; characterised in that there is provided between the medicament reservoir and the inner mandrel of the device a sealing means extending round less than 360° of the mandrel.
  • the sealing means is adapted to provide a frictional braking force on the medicament reservoir sufficient to prevent movement of the
  • this force will comprise a
  • the sealing means may be produced as an integral feature of the inner mandrel in a single production operation. This may be particularly advantageous when the material of construction of the mandrel is such that the sealing means feature is suitably resilient to
  • the sealing means may be added to the mandrel during production by any standard process method, allowing the mandrel body and sealing ring to be formed from different materials.
  • One such method is known as insert moulding.
  • insert moulding the mandrel body is formed by a standard moulding process.
  • the mandrel body is transferred to a separate tool where the sealing means is moulded into position on the mandrel body.
  • This process gives a good mechanical fit between the mandrel body and the sealing means but no adhesive or chemical bond.
  • a second method is co-moulding.
  • the mandrel body is formed by a standard moulding process. Co-incident with or slightly after the formation of the mandrel the sealing means is moulded in place using the same machine. In this process a chemical
  • the sealing means may comprise a separate partial sealing ring. It is preferred
  • sealing ring be formed in a single moulding process rather than being provided as a
  • the sealing means may conveniently be produced from any suitable resilient material. It is
  • ABS or Polyolefin plastic materials are preferred and a particularly preferred material is polypropylene.
  • the ring may be of any cross sectional shape capable of providing a good seal.
  • a particularly advantageous shape for the cross section is a generally 'V shape with the point of the 'V aligned to face the medicament compact.
  • the arm of the 'V next to the inner mandrel is flush with the mandrel.
  • the section of the ring in contact with the inner mandrel may be thicker and, therefore, less flexible than the section sealing the medicament reservoir.
  • the sealing means is formed integral with the mandrel the V may be formed by a flap extending from the mandrel.
  • the proportion of the circumference of the mandrel sealed by the sealing means should be as high as possible, with the gap in the sealing means being sized to accommodate the pathway between the medicament reservoir and the inhalation chamber.
  • the sealing ring should extend for about 250° - 330° around the mandrel and more preferably
  • sealing ring Since the sealing ring is formed from resilient material it can be held in position during
  • the sealing ring may be held in position by an adhesive bond between the sealing ring and
  • a sealing means comprising a partial ring extending about 250° -330° , preferably about 300° , of a full ring circumference, whose cross section is generally V shaped.
  • Figure 1 is a longitudinal view in partial section of a device according to the present invention.
  • Figure 2 is a longitudinal view in partial section of the device of Figure 1 in the second metering position
  • Figure 3 is a longitudinal section showing in detail the position of the sealing ring and through-going pathway of a device according to the invention in the first/rest position;
  • Figure 4 is a longitudinal section of a portion of the device of Figure 3 showing the position of the sealing ring and shoulder features;
  • Figure 5 is a perspective view of a sealing ring according to a preferred embodiment of the
  • a device includes a housing (1) having a mandrel (54) and a through-going pathway (2) connecting an air inlet (3) with an air outlet in the form of mouthpiece (4).
  • a dispersion chamber (5) having tangential air inlets (6,6a) is located in me through-going pathway between air inlet (3) and mouthpiece (4).
  • a generally cylindrical medicament reservoir (7) containing an annular compacted body of powdered inhalation medicament (8) is rotatably mounted on the mandrel (54) adjacent to
  • Sealing ring (50) is mounted between medicament reservoir (7) and a housing collar (55) located on mandrel (54), being constrained from rotation and axial movement by shoulder features (52,53) on the mandrel collar (55).
  • a shutter (9) comprising a metal blade (10) is mounted on a carrier (11) which is adapted to move axially within the housing between a first/rest position in which the compacted body (8) is isolated from the through-going pathway (2), and a second/metering position in which the compacted body (8) is in communication with the through-going pathway (2).
  • the end of carrier (11) remote from the shutter (9) is provided with a lug (12) adapted to interact with a cam (13) provided on the inside of a drive sleeve (14) rotatably mounted on the
  • the carrier (11) is biased against the cam (13) by a half cantilever (15) provided on the carrier (11) which bears against an exterior wall of the dispersion chamber
  • the end of the carrier (11) remote from the shutter (9) is also provided with a disc
  • Disc (16) thus separates the cam (13) and reservoir drive mechanism (described below) from the through-going pathway (2) thus reducing the risk of ingress of medicament into the drive mechanism.
  • Drive sleeve (14) is also provided with a reservoir drive mechanism (not shown) which is
  • a helical blade (18) is fixedly mounted on the mandrel of the housing between the reservoir (7) and the mouthpiece (4), such that the blade (18) abuts against the face of the body of compacted medicament (8) contained in the reservoir (7).
  • Blade (18) comprises the upper surface of collar (55) as best shown in Figure 4.
  • the body of compacted medicament (8) is further urged towards blade (18) by a compression spring (19) which acts against the outer wall of medicament reservoir (5) and the interior of drive sleeve (14).
  • drive sleeve (14) is rotated in the direction of arrow A in Figure 1.
  • the initial part of the rotation causes the cam (13) to move carrier (11) axially within the housing (1)
  • the dose of medicament is drawn into dispersion chamber (5) where it is entrained in the
  • lactose One set was filled with a composition consisting of Nedocromil Sodium, lactose and flavouring. A second set was filled with a composition consisting of Salbutamol and lactose.
  • the devices were tested as follows. The device was actuated as described above to place a metered dose of medicament in the through going pathway (2). This dose was removed from the pathway and its weight measured. The device was then placed in a mechamcal shaker and shaken vigorously for some minutes. The device was then visually

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manipulator (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Sealing Devices (AREA)
  • Confectionery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Basic Packing Technique (AREA)

Abstract

Un dispositif d'inhalation contenant un médicament en poudre se présentant sous forme d'un médicament compact est pourvu d'un joint d'étanchéité comprenant une bague partielle située entre la paroi extérieure et la tige interne de la chambre pour le médicament compact. La distribution du médicament s'effectue au moyen de l'abrasion du médicament compact, cette abrasion impliquant la rotation du médicament compact autour de la tige interne contre une lame. Bien que le joint d'étanchéité n'entoure que partiellement la circonférence de la tige, ce joint empêche la poudre libre de sortir de la chambre pour le médicament compact et de se répartir dans le reste du dispositif. Le dispositif d'étanchéité assure également une force de freinage par frottement sur le réservoir pour le médicament qui est suffisante pour empêcher le réservoir pour le médicament de bouger lorsque le mécanisme d'entraînement associé au réservoir revient à sa position de départ sans pour autant rendre le dispositif difficile à manipuler par un enfant ou par un adulte infirme.
EP98949139A 1997-10-23 1998-10-23 Dispositif d'inhalation Expired - Lifetime EP1024850B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9722285.5A GB9722285D0 (en) 1997-10-23 1997-10-23 Inhalation device
GB9722285 1997-10-23
PCT/GB1998/003170 WO1999021601A1 (fr) 1997-10-23 1998-10-23 Dispositif d'inhalation

Publications (2)

Publication Number Publication Date
EP1024850A1 true EP1024850A1 (fr) 2000-08-09
EP1024850B1 EP1024850B1 (fr) 2004-03-10

Family

ID=10820902

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98949139A Expired - Lifetime EP1024850B1 (fr) 1997-10-23 1998-10-23 Dispositif d'inhalation

Country Status (22)

Country Link
US (1) US6557550B1 (fr)
EP (1) EP1024850B1 (fr)
JP (1) JP4272349B2 (fr)
KR (2) KR100526089B1 (fr)
CN (1) CN1144602C (fr)
AT (1) ATE261325T1 (fr)
AU (1) AU745896B2 (fr)
BR (1) BR9813116A (fr)
CA (1) CA2307198C (fr)
CZ (1) CZ297153B6 (fr)
DE (1) DE69822318T2 (fr)
DK (1) DK1024850T3 (fr)
ES (1) ES2217589T3 (fr)
GB (1) GB9722285D0 (fr)
HU (1) HU224666B1 (fr)
IL (1) IL135782A (fr)
NO (1) NO322702B1 (fr)
PL (1) PL189019B1 (fr)
PT (1) PT1024850E (fr)
RU (1) RU2203690C2 (fr)
WO (1) WO1999021601A1 (fr)
ZA (1) ZA989698B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2241611T3 (es) * 1999-06-05 2005-11-01 Innovata Biomed Limited Sisstema de suministro de medicamentos.
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
CA2393428A1 (fr) * 1999-12-07 2001-06-14 Kari Seppala Inhalateur de poudre multidose
SE0000935D0 (sv) * 2000-03-21 2000-03-21 Astrazeneca Ab An inhalation device
JP5154732B2 (ja) * 2001-02-06 2013-02-27 イノバータ・バイオメッド・リミテッド 薬剤
US7767872B2 (en) * 2001-09-06 2010-08-03 Mpg Biotechnologies, Llc Thimerosal removal device
US8440791B2 (en) * 2001-09-06 2013-05-14 Mgp Biotechnologies, Llc Thimerosal removal device
GB0128148D0 (en) 2001-11-23 2002-01-16 Innovata Biomed Ltd Assembly
MY143936A (en) 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
GB2407042B (en) * 2003-10-17 2007-10-24 Vectura Ltd Inhaler
DE10350555A1 (de) * 2003-10-29 2005-06-09 Hugo Kern Und Liebers Gmbh & Co. Platinen- Und Federnfabrik Inhalator
DE102004005186B3 (de) 2004-02-02 2005-10-13 Krka Tovarna Zdravil, D.D. Verfahren zur Herstellung von gereinigtem Ciprofloxacin
US20050209607A1 (en) 2004-03-22 2005-09-22 John Lipchitz Medical cannula assembly
JP2007533387A (ja) * 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
DE102004061974B4 (de) * 2004-12-23 2010-04-29 Adc Gmbh Abdichtung für Abdeckungen von Beschriftungsfeldern
GB0507100D0 (en) * 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
ATE419814T1 (de) * 2006-07-24 2009-01-15 Cardiatis Sa Vorrichtung zum reversiblen einbringen einer endoprothese
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
EP2335755A1 (fr) * 2009-12-17 2011-06-22 Sanofi-Aventis Deutschland GmbH Dispositif et procédé pour la fourniture de deux ou plusieurs agents de médicament
US20160198769A1 (en) * 2013-08-23 2016-07-14 Kimree Hi-Tech Inc. Atomization assembly and electronic cigarette
AU2014330834A1 (en) * 2013-10-01 2016-04-07 Novartis Ag Blister track inhaler device having a separate end path and methods of use thereof
AU2015248916A1 (en) * 2014-04-16 2016-10-27 Sanofi Sa Sealing member for a medical device
EP4039300A1 (fr) * 2017-07-21 2022-08-10 Boehringer Ingelheim International GmbH Nébuliseur et réservoir

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US792514A (en) * 1905-03-16 1905-06-13 Harry Gill Metallic packing-ring.
US793463A (en) * 1905-03-21 1905-06-27 James J Mcdonald Packing-ring.
US2081040A (en) * 1932-06-17 1937-05-18 J S Abercrombie Packing
US1942489A (en) * 1932-08-23 1934-01-09 S R Dresser Mfg Co Gasket
US2610846A (en) * 1949-12-02 1952-09-16 Hanna Engineering Works Packing ring
US3028166A (en) * 1957-10-09 1962-04-03 Chicago Rawhide Mfg Co Component gasket type seal
US3207524A (en) * 1962-07-23 1965-09-21 Nicholas D Trbovich Seal
US3572729A (en) * 1968-05-23 1971-03-30 Olin Corp Expanding ring seal
US3690682A (en) * 1970-05-18 1972-09-12 Dresser Ind High pressure sealing means
US3637223A (en) * 1970-06-12 1972-01-25 Exxon Production Research Co Metal-to-metal seal
US3713660A (en) * 1970-11-10 1973-01-30 Fisher Controls Co Metal seal for a control valve or the like
US4805811A (en) * 1985-03-29 1989-02-21 Aktiebolaget Draco Dosage device
EP0407028B2 (fr) 1989-05-31 1999-07-07 FISONS plc Formule médicamenteuse et appareil d'inhalation
US5176132A (en) 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
US5429122A (en) * 1990-09-26 1995-07-04 Zanen; Pieter Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
DK0642366T3 (da) * 1992-05-29 1998-07-20 Ggu Ges F R Gesundheits Und Um Anordning til frembringelse af inhalerbare aktivepartikler
US5394868A (en) * 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
GB9306703D0 (en) * 1993-03-31 1993-05-26 Fisons Plc Inhalation device
US5475467A (en) * 1993-04-19 1995-12-12 Canon Kabushiki Kaisha Sealing member, and process cartridge and image forming apparatus using same
US5435282A (en) * 1994-05-19 1995-07-25 Habley Medical Technology Corporation Nebulizer
DE4436854A1 (de) * 1994-10-15 1996-04-18 Ggu Gesundheits Umweltforsch Arzneistoff-Vorrat zur mechanischen Freisetzung von lungengängigen Wirkstoff-Aerosolen für die inhalative Applikation von Arzneistoffen
US5493954A (en) * 1994-11-18 1996-02-27 Flow International Corporation Self-venting seal assembly
JP3342351B2 (ja) * 1997-06-27 2002-11-05 ダイハツ工業株式会社 内燃機関における吸気管のシリンダヘッドへの接続装置
US6286840B1 (en) * 1999-12-13 2001-09-11 Acs Industries, Inc. Modified V seal with protrusions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9921601A1 *

Also Published As

Publication number Publication date
DE69822318T2 (de) 2005-02-17
NO20001948D0 (no) 2000-04-13
CN1144602C (zh) 2004-04-07
NO322702B1 (no) 2006-11-27
JP4272349B2 (ja) 2009-06-03
CZ297153B6 (cs) 2006-09-13
CZ20001430A3 (cs) 2000-09-13
IL135782A0 (en) 2001-05-20
JP2001520920A (ja) 2001-11-06
KR100581629B1 (ko) 2006-05-22
KR100526089B1 (ko) 2005-11-08
NO20001948L (no) 2000-06-21
DE69822318D1 (de) 2004-04-15
ZA989698B (en) 1999-05-06
KR20050088365A (ko) 2005-09-05
US6557550B1 (en) 2003-05-06
KR20010031361A (ko) 2001-04-16
PL340040A1 (en) 2001-01-15
AU9551398A (en) 1999-05-17
RU2203690C2 (ru) 2003-05-10
IL135782A (en) 2005-09-25
CN1283126A (zh) 2001-02-07
EP1024850B1 (fr) 2004-03-10
GB9722285D0 (en) 1997-12-17
CA2307198A1 (fr) 1999-05-06
AU745896B2 (en) 2002-04-11
WO1999021601A1 (fr) 1999-05-06
BR9813116A (pt) 2006-10-03
HUP0300898A2 (en) 2003-08-28
CA2307198C (fr) 2007-05-08
DK1024850T3 (da) 2004-06-21
PT1024850E (pt) 2004-08-31
ATE261325T1 (de) 2004-03-15
PL189019B1 (pl) 2005-06-30
HU224666B1 (hu) 2005-12-28
ES2217589T3 (es) 2004-11-01

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