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EP1011330A4 - REGENERATION OF AXONS OF THE CENTRAL VENEER SYSTEM - Google Patents

REGENERATION OF AXONS OF THE CENTRAL VENEER SYSTEM

Info

Publication number
EP1011330A4
EP1011330A4 EP98943195A EP98943195A EP1011330A4 EP 1011330 A4 EP1011330 A4 EP 1011330A4 EP 98943195 A EP98943195 A EP 98943195A EP 98943195 A EP98943195 A EP 98943195A EP 1011330 A4 EP1011330 A4 EP 1011330A4
Authority
EP
European Patent Office
Prior art keywords
axons
regeneration
veneer system
central veneer
central
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98943195A
Other languages
German (de)
French (fr)
Other versions
EP1011330A1 (en
Inventor
Stephen M Strittmatter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of EP1011330A1 publication Critical patent/EP1011330A1/en
Publication of EP1011330A4 publication Critical patent/EP1011330A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1077Pentosyltransferases (2.4.2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893Botulinum neurotoxin (3.4.24.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/028Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a herpesvirus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98943195A 1997-08-13 1998-08-12 REGENERATION OF AXONS OF THE CENTRAL VENEER SYSTEM Withdrawn EP1011330A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5526897P 1997-08-13 1997-08-13
US55268P 1997-08-13
PCT/US1998/016794 WO1999008533A1 (en) 1997-08-13 1998-08-12 Central nervous system axon regeneration

Publications (2)

Publication Number Publication Date
EP1011330A1 EP1011330A1 (en) 2000-06-28
EP1011330A4 true EP1011330A4 (en) 2001-05-16

Family

ID=21996779

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98943195A Withdrawn EP1011330A4 (en) 1997-08-13 1998-08-12 REGENERATION OF AXONS OF THE CENTRAL VENEER SYSTEM

Country Status (5)

Country Link
EP (1) EP1011330A4 (en)
JP (1) JP2001515018A (en)
AU (1) AU735607B2 (en)
CA (1) CA2300878A1 (en)
WO (1) WO1999008533A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2214841A1 (en) * 1997-10-31 1999-04-30 Lisa Mckerracher Rho antagonists and their use to block inhibition of neurite outgrowth
US7169783B2 (en) 1998-11-02 2007-01-30 Universite De Montreal (+)-Trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion
CA2325842C (en) 2000-11-02 2007-08-07 Lisa Mckerracher Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
DE10064195A1 (en) * 2000-12-22 2002-07-11 Migragen Ag Use of a composition for stimulating nerve growth, inhibiting scar tissue formation and / or reducing secondary damage
US7795218B2 (en) 2001-04-12 2010-09-14 Bioaxone Therapeutique Inc. ADP-ribosyl transferase fusion variant proteins
CA2367636C (en) 2001-04-12 2010-05-04 Lisa Mckerracher Fusion proteins
US7442686B2 (en) 2001-04-12 2008-10-28 Bioaxone Therapeutique Inc. Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions
AU2002335824A1 (en) 2001-10-12 2003-04-22 Case Western Reserve University Neuronal regeneration
EP1334729A1 (en) * 2002-02-07 2003-08-13 Botulinum Toxin Research Associates, Inc. Therapeutic use of non-neurotoxic clostridium botulinum toxin type C2
AU2003281152A1 (en) * 2002-07-12 2004-02-02 Yihai Cao A method for inhibiting vascular permeability and tissue edema
GB0216865D0 (en) * 2002-07-19 2002-08-28 Microbiological Res Authority Targetted agents for nerve regeneration
JP2009529896A (en) * 2006-03-17 2009-08-27 マクギル ユニバーシティ Identification of CRMP4 as a convergent regulator of axonal elongation inhibition
US20160051644A1 (en) * 2013-01-16 2016-02-25 Bal Ram Singh Botulinum Chimera Compositions for Axonal Regenerative Therapy During Spinal Cord Injury
JP6497760B2 (en) 2015-04-28 2019-04-10 田辺三菱製薬株式会社 RGMa binding protein and use thereof
EP3355898B1 (en) * 2015-10-02 2020-11-25 The Regents of the University of California Induced pluripotent stem cell derived glial enriched progenitor cells for the treatment of white matter stroke

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672344A (en) * 1987-12-30 1997-09-30 The Regents Of The University Of Michigan Viral-mediated gene transfer system
US5661033A (en) * 1992-11-25 1997-08-26 The Board Of Trustees Of The Leland Stanford Junior University Gene transfer using herpes virus vectors as a tool for neuroprotection
US5645829A (en) * 1993-06-18 1997-07-08 Beth Israel Hospital Association Mesothelial cell gene therapy
AU1304895A (en) * 1993-12-07 1995-06-27 General Hospital Corporation, The Peptides to overcome inhibition of nerve growth

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
K. JALINK, E.J. VAN CORVEN ET AL.: "Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein rho", JOURNAL OF CELL BIOLOGY, vol. 126, no. 3, August 1994 (1994-08-01), pages 801 - 810, XP002915256 *
MARTIN F.B.G. GEBBINK, ET AL.: "Identification of a novel, putative rho-specific GDP/GTP exchange factor and a rhoA-binding protein: control of neuronal morphology", JOURNAL OF CELL BIOLOGY, vol. 137, no. 7, 30 July 1997 (1997-07-30), pages 1603 - 1613, XP000984783 *
P. LAMOUREUX, ET AL.: "Rac is required for growth cone function but not neurite assembly", JOURNAL OF CELL SCIENCE, vol. 110, March 1997 (1997-03-01), pages 635 - 641, XP000984782 *
R. KOZMA, ET AL.: "Rho family GTPases and neuronal growth cone remodelling: Relationship between increased complexity induced by cdc42Hs, Rac1, and acetylcholine and collapse induced by rhoA and lysophosphatidic acid", MOLECULAR AND CELLULAR BIOLOGY, vol. 17, no. 3, March 1997 (1997-03-01), pages 1201 - 1211, XP000984781 *
See also references of WO9908533A1 *

Also Published As

Publication number Publication date
AU9104298A (en) 1999-03-08
AU735607B2 (en) 2001-07-12
EP1011330A1 (en) 2000-06-28
WO1999008533A1 (en) 1999-02-25
CA2300878A1 (en) 1999-02-25
JP2001515018A (en) 2001-09-18

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