EP1096927A4 - Composition pour le traitement du stress - Google Patents

Composition pour le traitement du stress

Info

Publication number: EP1096927A4
Authority: EP; European Patent Office
Prior art keywords: treatment composition; stress treatment; stress; composition; treatment
Prior art date: 1998-07-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP99934107A

Other languages

German (de)

English (en)

Other versions

EP1096927A1 (fr

Inventor

Judith J Wurtman

Richard J Wurtman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Massachusetts Institute of Technology

Original Assignee

Massachusetts Institute of Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-16

Filing date

1999-07-16

Publication date

2002-09-04

1999-07-16 Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology

2001-05-09 Publication of EP1096927A1 publication Critical patent/EP1096927A1/fr

2002-09-04 Publication of EP1096927A4 publication Critical patent/EP1096927A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP99934107A 1998-07-16 1999-07-16 Composition pour le traitement du stress Withdrawn EP1096927A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9301398P	1998-07-16	1998-07-16
US93013P		1998-07-16
PCT/US1999/016153 WO2000003701A1 (fr)	1998-07-16	1999-07-16	Composition pour le traitement du stress

Publications (2)

Publication Number	Publication Date
EP1096927A1 EP1096927A1 (fr)	2001-05-09
EP1096927A4 true EP1096927A4 (fr)	2002-09-04

Family

ID=22236330

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP99934107A Withdrawn EP1096927A4 (fr)	1998-07-16	1999-07-16	Composition pour le traitement du stress

Country Status (4)

Country	Link
EP (1)	EP1096927A4 (fr)
JP (1)	JP2002520353A (fr)
CA (1)	CA2337507A1 (fr)
WO (1)	WO2000003701A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR021155A1 (es)	1999-07-08	2002-06-12	Lundbeck & Co As H	Tratamiento de desordenes neuroticos
US20050165006A1 (en) *	2002-04-03	2005-07-28	Dae-Yoon Chi	Quinoline derivatives, their preparation and pharmaceutical compositions comprising the same
CA2483093A1 (fr) *	2002-04-24	2003-11-06	Cypress Bioscience, Inc.	Prevention et traitement de troubles somatiques fonctionnels, y-compris les troubles lies au stress
RU2617512C1 (ru)	2015-10-23	2017-04-25	Общество с ограниченной ответственностью "Нормофарм"	Средство с антистрессовой, анксиолитической и антидепрессивной активностью и композиция на его основе
US12459965B2 (en)	2017-10-09	2025-11-04	Compass Pathfinder Limited	Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en)	2017-10-09	2020-05-27	Compass Pathways Ltd	Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CN113993523A (zh)	2019-04-17	2022-01-28	指南针探路者有限公司	用赛洛西宾治疗抑郁症和其他各种病症
EP4031529B1 (fr) *	2020-12-01	2023-09-27	Small Pharma Ltd	Composés de n,n-diméthyltryptamine deutérés ou partiellement deutérés

Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6147417A (ja) *	1984-08-11	1986-03-07	Kanebo Shokuhin Kk	精神安定チユ−インガム
SU1593659A1 (ru) *	1983-12-29	1990-09-23	Московская ветеринарная академия им.К.И.Скрябина	Способ профилактики стрессов у цыпл т
WO1993016695A1 (fr) *	1992-02-21	1993-09-02	Ciba-Geigy Ag	Utilisation de la brofaromine comme agent de traitement du stress post-traumatique
FR2710916A1 (fr) *	1993-10-04	1995-04-14	Pasteur Institut	Composés de nature peptidique ayant une activité modulatrice de la réponse sérotoninergique; applications diagnostiques et thérapeutiques.
EP0654264A1 (fr) *	1993-11-24	1995-05-24	Eli Lilly And Company	Traitement de l'incontinence par la venlafaxine ou un aryloxy propanamine
US5502080A (en) *	1994-11-01	1996-03-26	Hitzig; Pietr	Combined use of dopamine and serotonin agonists in the treatment of allergic disorders
JPH0940648A (ja) *	1995-08-02	1997-02-10	Yamanouchi Pharmaceut Co Ltd	新規な８−（２−アミノアルコキシ）キノリン誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU202108B (en) *	1986-07-30	1991-02-28	Sandoz Ag	Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
US5114976A (en) *	1989-01-06	1992-05-19	Norden Michael J	Method for treating certain psychiatric disorders and certain psychiatric symptoms
PT1153603E (pt) *	1993-06-28	2007-01-31	Wyeth Corp	Novos tratamentos utilizando derivados de fenetilamina
US5597826A (en) *	1994-09-14	1997-01-28	Pfizer Inc.	Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
US5852020A (en) *	1996-11-22	1998-12-22	Bristol-Myers Squibb Company	Nefazodone: use in treating post traumatic stress disorder

1999
- 1999-07-16 WO PCT/US1999/016153 patent/WO2000003701A1/fr not_active Ceased
- 1999-07-16 CA CA002337507A patent/CA2337507A1/fr not_active Abandoned
- 1999-07-16 EP EP99934107A patent/EP1096927A4/fr not_active Withdrawn
- 1999-07-16 JP JP2000559836A patent/JP2002520353A/ja active Pending

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU1593659A1 (ru) *	1983-12-29	1990-09-23	Московская ветеринарная академия им.К.И.Скрябина	Способ профилактики стрессов у цыпл т
JPS6147417A (ja) *	1984-08-11	1986-03-07	Kanebo Shokuhin Kk	精神安定チユ−インガム
WO1993016695A1 (fr) *	1992-02-21	1993-09-02	Ciba-Geigy Ag	Utilisation de la brofaromine comme agent de traitement du stress post-traumatique
FR2710916A1 (fr) *	1993-10-04	1995-04-14	Pasteur Institut	Composés de nature peptidique ayant une activité modulatrice de la réponse sérotoninergique; applications diagnostiques et thérapeutiques.
EP0654264A1 (fr) *	1993-11-24	1995-05-24	Eli Lilly And Company	Traitement de l'incontinence par la venlafaxine ou un aryloxy propanamine
US5502080A (en) *	1994-11-01	1996-03-26	Hitzig; Pietr	Combined use of dopamine and serotonin agonists in the treatment of allergic disorders
JPH0940648A (ja) *	1995-08-02	1997-02-10	Yamanouchi Pharmaceut Co Ltd	新規な８−（２−アミノアルコキシ）キノリン誘導体

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
ACTA PSYCHIATRICA BELGICA., vol. 93, no. 3, 1993, pages 121 - 35 *
CLINICAL NEUROPHARMACOLOGY., vol. 11, no. S1, 1988, pages s86 - s89 *
DATABASE MEDLINE [online] 1988, BRINDLEY D N: "Metabolic and hormonal effects of dexfenfluramine on stress situations", XP002197785, Database accession no. NLM3180110 *
DATABASE MEDLINE [online] 1993, LEPINE ET AL: "Treatment of post-traumatic stress syndrome", XP002197786, Database accession no. NLM8030427 *
DATABASE WPI Section Ch Week 198616, Derwent World Patents Index; Class B02, AN 1986-103235, XP002197787 *
DATABASE WPI Section Ch Week 199132, Derwent World Patents Index; Class B06, AN 1991-236275, XP002197788 *
DATABASE WPI Section Ch Week 199716, Derwent World Patents Index; Class B02, AN 1997-175671, XP002197789 *
DAVIDSON J R T: "BIOLOGICAL THERAPIES FOR POSTTRAUMATIC STRESS DISORDER: AN OVERVIEW", JOURNAL OF CLINICAL PSYCHIATRY, XX, XX, vol. 58, no. 9, 1997, pages 29 - 32, XP000914294, ISSN: 0160-6689 *
FRIEDMAN M J: "DRUG TREATMENT FOR PTSD. ANSWERS AND QUESTIONS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, June 1997 (1997-06-01), pages 359 - 371, XP000914298, ISSN: 0077-8923 *
GRAEFF FREDERICO G ET AL: "Role of 5-HT in stress, anxiety and depression.", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol. 54, no. 1, 1996, pages 129 - 141, XP002197781, ISSN: 0091-3057 *
MCKITTRICK CHRISTINA R ET AL: "Serotonin receptor binding in a colony model of chronic social stress.", BIOLOGICAL PSYCHIATRY, vol. 37, no. 6, 1995, pages 383 - 393, XP002197782, ISSN: 0006-3223 *
NEAL L A ET AL: "AN OPEN TRIAL OF MOCLOBEMIDE IN THE TREATMENT OF POST-TRAUMATIC STRESS DISORDER", INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, CLINICAL NEUROSCIENCE PUBLISHERS, LONDON, GB, vol. 12, no. 4, July 1997 (1997-07-01), pages 231 - 237, XP000884760, ISSN: 0268-1315 *
PAPP MARIUSZ ET AL: "Pharmacological validation of the chronic mild stress model of depression.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 296, no. 2, 1996, pages 129 - 136, XP002197783, ISSN: 0014-2999 *
See also references of WO0003701A1 *
ZETHOF THEO J J ET AL: "Stress-induced hyperthermia as a putative anxiety model.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 294, no. 1, 1995, pages 125 - 135, XP002197784, ISSN: 0014-2999 *

Also Published As

Publication number	Publication date
JP2002520353A (ja)	2002-07-09
EP1096927A1 (fr)	2001-05-09
CA2337507A1 (fr)	2000-01-27
WO2000003701A1 (fr)	2000-01-27

Publication	Publication Date	Title
DE69907162D1 (de)	2003-05-28	Organophile phyllosilikate
ID26549A (id)	2001-01-18	Komposisi-komposisi epotilon
ATE367793T1 (de)	2007-08-15	Schweisshemmende zusammensetzungen
FI981011L (fi)	1999-11-07	Uudet koostumukset
ID25977A (id)	2000-11-16	Popok sekali pakai
ID24555A (id)	2000-07-27	Popok sekali pakai
DE69943376D1 (de)	2011-06-01	Echoverminderung für einen bitserielen mehrfachrabzweigbus
ATE469550T1 (de)	2010-06-15	Antiparasitäre zusammensetzungen
DE69919953D1 (de)	2004-10-14	Funktionelle zusammensetzungen
DE69924799D1 (de)	2005-05-25	Miederhose
DE69841198D1 (de)	2009-11-12	Klebstoffzusammensetzung für chirurgische Zwecke
DE69927758D1 (de)	2006-03-02	Imidosilan-Zusammensetzungen
DE69940256D1 (de)	2009-02-26	Zusammensetzung zur hautbleichung
DE69930547D1 (de)	2006-05-11	Reinigungszusammensetzung
DE69914470D1 (de)	2004-03-04	Gesundheitsfoerdernde gewuerzmittelzusammensetzung
ID23083A (id)	2000-02-03	Popok sekali pakai
FI980221L (fi)	1999-07-31	Refraktometri
DE69918585D1 (de)	2004-08-19	Acrylelastomerzusammensetzung
ID27889A (id)	2001-05-03	Komposisi-komposisi kopolimer polisiklik
DE69920345D1 (de)	2004-10-28	Fräsmeissel
DE69827365D1 (de)	2004-12-09	Formulierungsverfahren für Schokolade
NO20003786D0 (no)	2000-07-24	Oftalmisk sammensetning
ATE296323T1 (de)	2005-06-15	Polyisocyanatzusammensetzungen
DK0969233T3 (da)	2006-05-15	Strömningsbegrænser
DE69900787D1 (de)	2002-02-28	Verbesserter biomedizinischer test

Legal Events

Date	Code	Title	Description
2001-03-23	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2001-05-09	17P	Request for examination filed	Effective date: 20010215
2001-05-09	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-07-24	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 45/08 A, 7A 61K 31/55 B, 7A 61P 9/12 B
2002-09-04	A4	Supplementary search report drawn up and despatched	Effective date: 20020718
2002-09-04	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2004-06-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2004-08-11	18D	Application deemed to be withdrawn	Effective date: 20040202