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EP1069121A4 - Reagent for singlet oxygen determination - Google Patents

Reagent for singlet oxygen determination

Info

Publication number
EP1069121A4
EP1069121A4 EP99912055A EP99912055A EP1069121A4 EP 1069121 A4 EP1069121 A4 EP 1069121A4 EP 99912055 A EP99912055 A EP 99912055A EP 99912055 A EP99912055 A EP 99912055A EP 1069121 A4 EP1069121 A4 EP 1069121A4
Authority
EP
European Patent Office
Prior art keywords
singlet oxygen
reagent
alkyl
represents hydrogen
independently represents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99912055A
Other languages
German (de)
French (fr)
Other versions
EP1069121B1 (en
EP1069121A1 (en
Inventor
Tetsuo Nagano
Naoki Umezawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NAGANO TESTUO
Original Assignee
NAGANO TESTUO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NAGANO TESTUO filed Critical NAGANO TESTUO
Publication of EP1069121A1 publication Critical patent/EP1069121A1/en
Publication of EP1069121A4 publication Critical patent/EP1069121A4/en
Application granted granted Critical
Publication of EP1069121B1 publication Critical patent/EP1069121B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
    • G01N31/225—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for oxygen, e.g. including dissolved oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compounds represented by general formula (I) or salts thereof, wherein R?1, R2, R3, R4, R5, and R6¿ each independently represents hydrogen, halogeno, C¿1-6? alkyl, or C1-6 alkoxyl; R?7 and R8¿ each independently represents C¿1-6? alkyl or optionally substituted aryl; R?9 and R10¿ each independently represents hydrogen, C¿1-6? alkyl, or C1-6 alkoxyl; and R?11¿ represents hydrogen or C¿1-12? alkanoyl. The compounds are substantially nonfluorescent and react with singlet oxygen under physiological conditions to give a fluorescent substance. They are hence useful as a reagent for singlet oxygen determination.
EP99912055A 1998-03-31 1999-03-31 Reagent for singlet oxygen determination Expired - Lifetime EP1069121B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8608698 1998-03-31
JP8608698 1998-03-31
PCT/JP1999/001658 WO1999051586A1 (en) 1998-03-31 1999-03-31 Reagent for singlet oxygen determination

Publications (3)

Publication Number Publication Date
EP1069121A1 EP1069121A1 (en) 2001-01-17
EP1069121A4 true EP1069121A4 (en) 2002-08-28
EP1069121B1 EP1069121B1 (en) 2003-07-16

Family

ID=13876908

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99912055A Expired - Lifetime EP1069121B1 (en) 1998-03-31 1999-03-31 Reagent for singlet oxygen determination

Country Status (7)

Country Link
US (1) US6525088B1 (en)
EP (1) EP1069121B1 (en)
JP (1) JP4373608B2 (en)
AU (1) AU3053599A (en)
CA (1) CA2326561A1 (en)
DE (1) DE69909611T2 (en)
WO (1) WO1999051586A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
JP4695811B2 (en) 2000-02-28 2011-06-08 哲雄 長野 Zinc fluorescent probe
AU3599601A (en) * 2000-02-28 2001-09-03 Daiichi Pure Chemicals Co Ltd Measuring method using long life fluorescence of excitation type
EP1260508B1 (en) 2000-02-29 2010-04-14 Sekisui Medical Co., Ltd. Reagents for the quantitation of active oxygen
WO2002018362A1 (en) * 2000-08-31 2002-03-07 Daiichi Pure Chemicals Co., Ltd. Reagent for determining singlet oxygen
CN1213050C (en) * 2000-11-23 2005-08-03 拜尔公司 Use of oxadicyclo [2.2.1] heptane derivative as pesticide
EP1517684B1 (en) 2002-06-27 2009-07-22 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
EP1606291A2 (en) * 2002-07-02 2005-12-21 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its dervatives
US7524974B2 (en) * 2002-07-08 2009-04-28 Tetsuo Nagano Fluorescent probe
WO2004040296A1 (en) * 2002-10-16 2004-05-13 Daiichi Pure Chemicals Co., Ltd. Reagents for the measurement of peroxynitrites
US7696245B2 (en) * 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
US7378282B2 (en) * 2003-05-14 2008-05-27 Tetsuo Nagano Method for measuring hypochlorite ion
US20050214807A1 (en) * 2003-11-19 2005-09-29 Iain Johnson Environmental sensitive fluorogenic compounds and their application for singlet oxygen and protein detection
JP2005194244A (en) * 2004-01-09 2005-07-21 Shigenobu Yano Zinc ion fluorescence sensor
WO2005085811A1 (en) * 2004-03-04 2005-09-15 Daiichi Pure Chemicals Co., Ltd. Fluorescent probes
WO2006093252A1 (en) * 2005-03-04 2006-09-08 The University Of Tokyo Membrane-anchoring fluorescent probe
US8410164B2 (en) 2008-05-16 2013-04-02 The University Of Tokyo Reagent for measurement of active oxygen
KR101994902B1 (en) 2010-12-28 2019-06-28 가부시키가이샤 한도오따이 에네루기 켄큐쇼 Organoboron compound and method for manufacturing the same
TWI518078B (en) * 2010-12-28 2016-01-21 半導體能源研究所股份有限公司 Benzo[b]naphtho[1,2-d]furan compound serving as a light-emitting element material
US10564164B2 (en) 2014-06-17 2020-02-18 Osaka University Fluorescent probe, singlet oxygen detection agent, and singlet oxygen detection method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242835A (en) 1987-11-03 1993-09-07 Radiometer A/S Method and apparatus for determining the concentration of oxygen
DK576187D0 (en) * 1987-11-03 1987-11-03 Radiometer As METHOD OF DETERMINING OXYGEN CONCENTRATION

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
EP1069121B1 (en) 2003-07-16
DE69909611D1 (en) 2003-08-21
CA2326561A1 (en) 1999-10-14
WO1999051586A1 (en) 1999-10-14
JP4373608B2 (en) 2009-11-25
EP1069121A1 (en) 2001-01-17
AU3053599A (en) 1999-10-25
DE69909611T2 (en) 2004-04-15
US6525088B1 (en) 2003-02-25

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