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EP0919215B1 - Ampoule en verre pour contenir du liquide - Google Patents

Ampoule en verre pour contenir du liquide Download PDF

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Publication number
EP0919215B1
EP0919215B1 EP97890231A EP97890231A EP0919215B1 EP 0919215 B1 EP0919215 B1 EP 0919215B1 EP 97890231 A EP97890231 A EP 97890231A EP 97890231 A EP97890231 A EP 97890231A EP 0919215 B1 EP0919215 B1 EP 0919215B1
Authority
EP
European Patent Office
Prior art keywords
ampoule
area
glass ampoule
coating
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97890231A
Other languages
German (de)
English (en)
Other versions
EP0919215A1 (fr
Inventor
Horst Rüther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to DE59706326T priority Critical patent/DE59706326D1/de
Priority to EP97890231A priority patent/EP0919215B1/fr
Priority to US09/000,948 priority patent/US5948366A/en
Priority to JP10332133A priority patent/JP3062687B2/ja
Publication of EP0919215A1 publication Critical patent/EP0919215A1/fr
Application granted granted Critical
Publication of EP0919215B1 publication Critical patent/EP0919215B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Definitions

  • the invention relates to a glass ampoule for holding a liquid, for example a drug, a calibration or quality control fluid, with a substantially flat floor or with an inside of the Ampoule retracted bottom area, the bottom area due to its shape has a defined predetermined breaking area, which requires little effort is mechanically destructible.
  • a liquid for example a drug, a calibration or quality control fluid
  • Such ampoules are used in large numbers, especially in medical laboratories as well as used in medical practices and clinics, with the glass ampoules for removal their contents are usually broken open by hand and used for their purpose Need to become.
  • EP 0 694 498 B1 describes a device for automatic removal of a liquid from a sealed glass ampoule became known, in which the glass ampoule in an upright, the bottom the ampoule is held upward in a holder. The The bottom of the glass ampoule becomes mechanical through a rigid-walled, single-lumen cannula destroyed, this cannula at the same time to aspirate the liquid serves a splinter-free area of the glass ampoule.
  • FR 1 241 230 A is a glass ampoule with one on the inside the ampoule retracted bottom area, which due to its Forming has a defined predetermined breaking area.
  • the object of the invention is to provide known glass ampoules for holding liquids to further develop such that problem-free opening through the floor area is guaranteed by automatically operating removal devices.
  • the floor area preferably a coating of the center of the drawn-in area a material, for example ceramic, which has tension forces between the coated floor area and the coating.
  • a coating of a material which has tensile forces between the coated floor area and the coating.
  • This ceramic coating for example, can also be in a punctiform formation on the center of the drawn-in area or limit the point of attack of a removal element.
  • the floor area is asymmetrical, conical Has depression, the lowest point is arranged off-center.
  • Such asymmetrical, conical depressions can, for example, with a blower is manufactured during the manufacturing process, wherein Wall parts of the ampoule bottom in a reproducible form and depth inside of the ampoule. Arches of approximately half the diameter the ampoule has proven to be advantageous. To strengthen the Wall area can be specifically cooled during the blowing and the optimal arching can be subjected to an automatic optical control. The reduced rigidity of the floor area due to the asymmetry allows es, a withdrawal cannula with much less effort in the glass ampoule introduce, the splintering essentially on the asymmetrical shaped area remains limited.
  • Targeted asymmetries naturally have advantages over manufacturing-related asymmetries, such as e.g. known from GB 198,993 A, on.
  • the indented floor area is a comparison reduced to the wall thickness of the glass ampoule, preferably reduced by 30 to 60% Has wall thickness.
  • the wall thickness of the glass ampoule preferably reduced by 30 to 60% Has wall thickness.
  • glass ampoules with an to provide essential flat ground, again for local weakening the surface tension of the soil preferably in its central Area has a ceramic coating, and possibly also the Bottom of the glass ampoule, especially in its central area, one in comparison reduced to the wall thickness of the glass ampoule, preferably by 30 to 60% reduced wall thickness.
  • the glass ampoule 1 shown in Fig. 1a for receiving a liquid has a bottom region 2 drawn in to the inside of the ampoule.
  • the cylindrical Shank area 3 of the ampoule 1 goes into a neck area 4 and this into a head area 5 over.
  • the areas 3 to 4 can essentially be any be carried out, it only has to be guaranteed that the ampoule in one Device for automatic withdrawal of ampoule liquid - such as this is known from EP 0 694 498 B1 - can be used.
  • the bottom region 2 of the ampoule according to FIG. 1a has a conical depression on, which in the center of the retracted area 2 a punctiform ceramic Has coating 7 (see also Fig. 1b).
  • the embodiment according to FIGS. 2a and 2b has an asymmetrical, conical recess 6 'with reduced wall thickness, which means a central in the direction of the axis 1 'of the ampoule removal element 12 a reduced mechanical resistance when opening the floor.
  • the ceramic coating 7 is also asymmetrical here, namely arranged at the deepest point of the conical recess 6 '.
  • the base region 2 of the ampoule 1 executed with a substantially cylindrical recess 8, which a has flat or slightly curved floor 9.
  • the wall thickness of the fed Floor area 2 can be entirely or only in a central area a reduced wall thickness compared to the wall thickness of the glass ampoule 1 exhibit.
  • a glass ampoule 1 which has a substantially flat bottom 10, this for Whole or in its central area for easier penetration of the removal element has a reduced wall thickness (30 - 60%).
  • Such floors can, for example, be welded or melted onto the shaft of the ampoule become.
  • a ceramic one can also be found in the central area Coating 7 can be applied in the form of a ceramic point. It is also possible that the bottom area or the bottom 10 of the glass ampoule 1 is scored, preferably has a circular scoring 12.
  • an elastomer coating indicated in FIG. 4a can be used in all design variants 11 can be provided, which on a to the floor 10 (or Bottom region 2) of the cylindrical shaft region 3 adjoining the glass ampoule 1 is applied. This elastomer coating serves to prevent any splinters in the to hold the lower shaft area.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)

Claims (7)

  1. Ampoule de verre (1) destinée à contenir un liquide, de préférence un médicament, un fluide de calibrage ou de contrôle-qualité, avec une zone de fond (2) incurvée vers l'intérieur, cette zone (2) ayant, de par sa forme (6'), une zone de rupture définie, pouvant être défoncée mécaniquement avec un faible effort,
    caractérisée en ce que
    la zone de fond (2), et de préférence le centre de la zone emboutie comporte un revêtement (7) d'un matériau, par exemple de céramique, créant des forces de tension entre la zone de fond (2) revêtue, et son revêtement (7).
  2. Ampoule de verre selon la revendication 1,
    caractérisée en ce que
    la zone de fond (2) présente un creux (6') asymétrique, conique dont le point le plus enfoncé est excentré.
  3. Ampoule de verre selon la revendication 2,
    caractérisée en ce que
    la zone de fond en creux (2) présente une épaisseur réduite de 30 à 60 % par rapport à l'épaisseur de l'ampoule (1).
  4. Ampoule de verre (1) destinée à contenir un liquide, de préférence un médicament, un fluide de calibrage ou de contrôle-qualité, avec un fond (10) pratiquement plan,
    caractérisée en ce que
    le fond (10) dans sa partie centrale, comporte un revêtement d'un matériau, par exemple, céramique (7), créant des tensions entre le fond (10) et le revêtement (7).
  5. Ampoule de verre selon la revendication 4,
    caractérisée en ce que
    le fond (10) de l'ampoule de verre, en particulier dans sa zone centrale, présente une épaisseur réduite de 30 à 60 % par rapport à l'épaisseur de l'ampoule.
  6. Ampoule de verre selon la revendication 4,
    caractérisée en ce que
    le fond (10) de l'ampoule de verre (1) présente une empreinte (12), de préférence circulaire.
  7. Ampoule de verre selon l'une des revendications 2 à 6,
    caractérisée en ce que
    la zone cylindrique (3) faisant suite à la zone (2) du fond ou au fond (10) de l'ampoule de verre (1) comporte un revêtement d'élastomère (11).
EP97890231A 1997-11-24 1997-11-24 Ampoule en verre pour contenir du liquide Expired - Lifetime EP0919215B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE59706326T DE59706326D1 (de) 1997-11-24 1997-11-24 Glasampulle zur Aufnahme einer Flüssigkeit
EP97890231A EP0919215B1 (fr) 1997-11-24 1997-11-24 Ampoule en verre pour contenir du liquide
US09/000,948 US5948366A (en) 1997-11-24 1997-12-30 Glass ampoule for holding a drug a calibration liquid or a quality control liquid
JP10332133A JP3062687B2 (ja) 1997-11-24 1998-11-24 薬剤、較正用液又は品質管理用液用ガラス製アンプル

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97890231A EP0919215B1 (fr) 1997-11-24 1997-11-24 Ampoule en verre pour contenir du liquide

Publications (2)

Publication Number Publication Date
EP0919215A1 EP0919215A1 (fr) 1999-06-02
EP0919215B1 true EP0919215B1 (fr) 2002-02-06

Family

ID=8231126

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97890231A Expired - Lifetime EP0919215B1 (fr) 1997-11-24 1997-11-24 Ampoule en verre pour contenir du liquide

Country Status (4)

Country Link
US (1) US5948366A (fr)
EP (1) EP0919215B1 (fr)
JP (1) JP3062687B2 (fr)
DE (1) DE59706326D1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340097B1 (en) * 1998-10-22 2002-01-22 Closure Medical Corporation Applicator with protective barrier
US20060042373A1 (en) * 2004-08-25 2006-03-02 Kirollos Kirollos S Smoke generating device
WO2006029252A1 (fr) * 2004-09-08 2006-03-16 The Dial Corporation Procedes et appareil pour un dispositif de dispersion de vapeur economique
CN102057268B (zh) 2008-06-06 2012-05-09 卡皮托塑料制品有限责任公司 带有小瓶的瓶架
DE102009013211B4 (de) 2009-03-17 2012-04-19 Aap Biomaterials Gmbh Vakuum-Mischvorrichtung für Knochenzement sowie Verfahren zum Mischen von Knochenzement
DE102011112516B4 (de) 2011-09-07 2024-02-29 Stryker European Operations Holdings Llc Gebinde mit einem Behälter zur Aufnahme einer Flüssigkeit und einer Flüssigkeitsentnahmeeinrichtung
DK3647781T3 (da) 2018-10-29 2024-08-05 EXIAS Medical GmbH Målepatron til måling af en flydende prøve
CN116744819B (zh) 2021-01-20 2024-12-03 莱雅公司 玻璃注射器滴管

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191501531A (en) * 1914-12-02 1915-12-30 Wilfred Ambrose Whatmough Improved Construction of Ampoule or the like with Means for Applying the Contents to the Body.
GB198993A (en) * 1922-06-06 1924-08-13 Friedrich Wilhelm Horst Improvements in flasks for containing chemicals, and in means for opening the same and discharging their contents
US1951743A (en) * 1930-04-25 1934-03-20 Iso Ges M B H Method of producing a prepared breaking point in ampulle
FR721646A (fr) 1930-11-14 1932-03-05 Negoce Et Ind Ampoule destinée à contenir de l'anhydride sulfureux ou tout autre gaz liquéfié sous pression. et appareil pour briser cette ampoule et diffuser le gaz qu'elle contient dans un liquide quelconque
CH287394A (fr) * 1950-07-07 1952-11-30 Owens Illinois Glass Co Récipient en verre et procédé pour sa fabrication.
FR1241230A (fr) * 1959-08-04 1960-09-16 Prolabo Sa Ampoule pour le conditionnement de réactifs
US3535070A (en) * 1966-02-03 1970-10-20 Owens Illinois Inc Method of inducing stress in glass containers and container made with a stressed zone
US3749271A (en) * 1971-06-22 1973-07-31 Becton Dickinson Co Resealable ampoule closure
FR2237643B1 (fr) * 1973-07-17 1978-03-17 Steiner Maurice
SU607138A1 (ru) * 1975-10-27 1978-05-15 Предприятие П/Я Г-4236 Ампула дл инжектировани в хроматограф продуктов реакции
US4096683A (en) * 1977-02-16 1978-06-27 Cozzoli Machine Company Ampoule filling and sealing machine
US4266681A (en) * 1977-02-28 1981-05-12 Oceanography International Corporation Multiple breakpoint resealable ampoule
IL60740A (en) * 1980-08-01 1983-06-15 Tadiran Israel Elect Ind Ltd Electrolyte container for use in reserve cells
ES530426A0 (es) * 1983-03-10 1985-04-16 Dehais Claude Perfeccionamientos en las maquinas para elaborar ampollas farmaceuticas y similares y anpolla obtenida.
SE8505542L (sv) * 1985-11-25 1987-05-26 Vestsvensk Medicinteknik Ab Anordning for brytning av ampuller
US5179024A (en) * 1991-05-30 1993-01-12 Harald Dahms Sealed vials containing improved karl fischer solutions, and process for water determination using these vials
US5221311A (en) * 1992-01-10 1993-06-22 Rising Peter E Evacuated sampling vial
AT404827B (de) 1994-07-28 1999-03-25 Avl Verbrennungskraft Messtech Verfahren und vorrichtung zur entnahme einer flüssigkeit aus einer verschlossenen glasampulle

Also Published As

Publication number Publication date
US5948366A (en) 1999-09-07
JP3062687B2 (ja) 2000-07-12
EP0919215A1 (fr) 1999-06-02
DE59706326D1 (de) 2002-03-21
JPH11221266A (ja) 1999-08-17

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