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EP0950044A4 - Preparation de gabapentine - Google Patents

Preparation de gabapentine

Info

Publication number
EP0950044A4
EP0950044A4 EP97954134A EP97954134A EP0950044A4 EP 0950044 A4 EP0950044 A4 EP 0950044A4 EP 97954134 A EP97954134 A EP 97954134A EP 97954134 A EP97954134 A EP 97954134A EP 0950044 A4 EP0950044 A4 EP 0950044A4
Authority
EP
European Patent Office
Prior art keywords
gabapentin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97954134A
Other languages
German (de)
English (en)
Other versions
EP0950044A1 (fr
Inventor
Michael Pesachovich
Claude Singer
Gideon Pilarski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of EP0950044A1 publication Critical patent/EP0950044A1/fr
Publication of EP0950044A4 publication Critical patent/EP0950044A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP97954134A 1996-12-24 1997-12-24 Preparation de gabapentine Withdrawn EP0950044A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11989096 1996-12-24
IL11989096A IL119890A (en) 1996-12-24 1996-12-24 Gabapentin form iii and preparation of gabapentin form ii
PCT/US1997/023164 WO1998028255A1 (fr) 1996-12-24 1997-12-24 Preparation de gabapentine

Publications (2)

Publication Number Publication Date
EP0950044A1 EP0950044A1 (fr) 1999-10-20
EP0950044A4 true EP0950044A4 (fr) 2003-03-26

Family

ID=11069615

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97954134A Withdrawn EP0950044A4 (fr) 1996-12-24 1997-12-24 Preparation de gabapentine

Country Status (7)

Country Link
EP (1) EP0950044A4 (fr)
AU (1) AU5799098A (fr)
CA (1) CA2275912A1 (fr)
DE (1) DE97954134T1 (fr)
ES (1) ES2204362T1 (fr)
IL (1) IL119890A (fr)
WO (1) WO1998028255A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137137B1 (es) * 1998-05-25 2000-08-16 Medichem Sa Nuevo polimorfo de gabapentina no hidratada, su procedimiento de obtencion y su utilizacion para la obtencion de gabapentina de calidad farmaceutica.
IT1311984B1 (it) * 1999-03-26 2002-03-22 Bioindustria Lab Italiano Medi Procedimento per la preparzione di gabapentin.
DK1169060T3 (da) 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
ES2164527B1 (es) * 1999-04-26 2003-04-01 Medichen S A Procedimiento de obtencion de gabapentina de calidad farmaceutica.
US6294198B1 (en) 1999-08-24 2001-09-25 Purepac Pharmaceutical Co. Pharmaceutical tablet formulation containing gabapentin with improved physical and chemical characteristics and method of making the same
DE60025143T2 (de) * 1999-11-22 2006-07-06 Akzo Nobel N.V. Verfahren und Zusammensetzung zur Herstellung von Wasserstoffperoxid
IL153441A0 (en) * 2000-06-16 2003-07-06 Teva Pharma Stable gabapentin having ph within a controlled range
PT1289364E (pt) * 2000-06-16 2004-04-30 Teva Pharma Gabapentina estavel contendo mais do que 20 ppm de iao cloreto
EP1384473A1 (fr) * 2000-06-16 2004-01-28 Teva Pharmaceutical Industries Ltd. Gabapentin stable contenant plus de 20 ppm d'ions chlore
EP1430893A1 (fr) * 2000-06-16 2004-06-23 Teva Pharmaceutical Industries Ltd. Gabapentin stable contenant plus de 20 ppm d'ions chlore
US7056951B2 (en) 2000-09-26 2006-06-06 Mutual Pharmaceutical Co., Inc. Stable solid dosage forms of amino acids and processes for producing same
IT1319674B1 (it) * 2000-12-01 2003-10-23 Erregierre Spa Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico.
PT1423168E (pt) 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
US6800782B2 (en) 2001-10-09 2004-10-05 Warner-Lambert Co. Anhydrous crystalline forms of gabapentin
US20030158254A1 (en) * 2002-01-24 2003-08-21 Xenoport, Inc. Engineering absorption of therapeutic compounds via colonic transporters
US7196216B2 (en) 2002-11-18 2007-03-27 Nicholas Piramal India Limited Process for preparation of Gabapentin
ES2339756T3 (es) * 2002-11-20 2010-05-25 Hikal Ltd. Procedimiento mejorado para la preparacion de acidos aminometilcicloalcanaceticos.
WO2004093779A2 (fr) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Procede relatif a l'elaboration de gabapentine de forme-ii
WO2004093780A2 (fr) * 2003-04-21 2004-11-04 Matrix Laboratories Ltd Processus de preparation de gabapentine forme ii
WO2004106281A1 (fr) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Gabapentine cristallin
WO2004110342A2 (fr) * 2003-06-12 2004-12-23 Matrix Laboratories Ltd Nouveau polymorphe de gabapentine et sa conversion en gabapentine de forme ii
WO2004110981A1 (fr) * 2003-06-12 2004-12-23 Matrix Laboratories Ltd Procede permettant la preparation de gabapentine de forme ii
US7169812B2 (en) 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
ITMI20040579A1 (it) 2004-03-25 2004-06-25 Zambon Spa Processo di preparazione di gabapentina
GB0415076D0 (en) * 2004-07-05 2004-08-04 Sandoz Ind Products S A Process for the preparation of gabapentin
GB0416228D0 (en) * 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
WO2008106217A1 (fr) * 2007-02-28 2008-09-04 Teva Pharmaceutical Industries Ltd. Préparation de gabapentine par extraction liquide-liquide
WO2009015685A1 (fr) 2007-07-27 2009-02-05 Medichem, S.A. Procédé de préparation de la forme polymorphe ii de la gabapentine
CN102363598B (zh) * 2011-11-25 2014-02-12 浙江精进药业有限公司 高纯度加巴喷丁的制备方法
ITMI20131757A1 (it) 2013-10-22 2015-04-23 Zach System Spa Processo di preparazione di gabapentina

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4960931A (en) * 1988-05-02 1990-10-02 Warner-Lambert Company Gabapentin mohohydrate and a process for producing the same
DE3928184A1 (de) * 1989-08-25 1991-02-28 Goedecke Ag Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
EP0950044A1 (fr) 1999-10-20
ES2204362T1 (es) 2004-05-01
AU5799098A (en) 1998-07-17
IL119890A (en) 2002-03-10
DE97954134T1 (de) 2004-04-15
WO1998028255A1 (fr) 1998-07-02
CA2275912A1 (fr) 1998-07-02
IL119890A0 (en) 1997-03-18

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