EP0949915A4 - TREATMENT OF AIDS-VIRUS (HIV-1) INFECTIVE DEGENSION WITH NITRONE-FREE RADICAL TRAP - Google Patents

TREATMENT OF AIDS-VIRUS (HIV-1) INFECTIVE DEGENSION WITH NITRONE-FREE RADICAL TRAP

Info

Publication number: EP0949915A4
Authority: EP; European Patent Office
Prior art keywords: degension; nitrone; infective; hiv; aids
Prior art date: 1996-04-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97920402A

Other languages

German (de)

French (fr)

Other versions

EP0949915A1 (en

Inventor

Robert Floyd

William Garland

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Oklahoma Medical Research Foundation

Centaur Pharmaceuticals Inc

Original Assignee

Oklahoma Medical Research Foundation

Centaur Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-17

Filing date

1997-04-17

Publication date

2001-07-04

1997-04-17 Application filed by Oklahoma Medical Research Foundation, Centaur Pharmaceuticals Inc filed Critical Oklahoma Medical Research Foundation

1999-10-20 Publication of EP0949915A1 publication Critical patent/EP0949915A1/en

2001-07-04 Publication of EP0949915A4 publication Critical patent/EP0949915A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP97920402A 1996-04-17 1997-04-17 TREATMENT OF AIDS-VIRUS (HIV-1) INFECTIVE DEGENSION WITH NITRONE-FREE RADICAL TRAP Withdrawn EP0949915A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1570996P	1996-04-17	1996-04-17
US15709P		1996-04-17
PCT/US1997/006253 WO1997038683A1 (en)	1996-04-17	1997-04-17	Nitrone free radical trap treatment of dementia associated with aids virus (hiv-1) infection

Publications (2)

Publication Number	Publication Date
EP0949915A1 EP0949915A1 (en)	1999-10-20
EP0949915A4 true EP0949915A4 (en)	2001-07-04

Family

ID=21773092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97920402A Withdrawn EP0949915A4 (en)	1996-04-17	1997-04-17	TREATMENT OF AIDS-VIRUS (HIV-1) INFECTIVE DEGENSION WITH NITRONE-FREE RADICAL TRAP

Country Status (5)

Country	Link
EP (1)	EP0949915A4 (en)
AU (1)	AU725432B2 (en)
CA (1)	CA2251800A1 (en)
NZ (1)	NZ332315A (en)
WO (1)	WO1997038683A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991005552A1 (en) *	1989-10-17	1991-05-02	Oklahoma Medical Research Foundation	Method and compositions for inhibition of disorders associated with oxidative damage
US5185324A (en) *	1988-12-14	1993-02-09	Hoechst Aktiengesellschaft	Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof
US5314917A (en) *	1991-03-22	1994-05-24	E. B. Michaels Research Associates, Inc.	Method for inactivating enveloped viruses and sperm

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5488145A (en) *	1993-12-23	1996-01-30	Oklahoma Medical Research Foundation	2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

1997
- 1997-04-17 NZ NZ332315A patent/NZ332315A/en unknown
- 1997-04-17 CA CA002251800A patent/CA2251800A1/en not_active Abandoned
- 1997-04-17 AU AU24606/97A patent/AU725432B2/en not_active Ceased
- 1997-04-17 EP EP97920402A patent/EP0949915A4/en not_active Withdrawn
- 1997-04-17 WO PCT/US1997/006253 patent/WO1997038683A1/en not_active Ceased

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5185324A (en) *	1988-12-14	1993-02-09	Hoechst Aktiengesellschaft	Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof
WO1991005552A1 (en) *	1989-10-17	1991-05-02	Oklahoma Medical Research Foundation	Method and compositions for inhibition of disorders associated with oxidative damage
US5314917A (en) *	1991-03-22	1994-05-24	E. B. Michaels Research Associates, Inc.	Method for inactivating enveloped viruses and sperm

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FLOYD R A ET AL: "The neurotoxic role of nitric oxide in AIDS dementia and stroke and the prevention of its formation by alpha-phenyl-tert-butylnitrone (PBN).", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 22, no. 1-3, 1996, 26th Annual Meeting of the Society for Neuroscience;Washington, D.C., USA; November 16-21, 1996, pages 2141, XP000998212, ISSN: 0190-5295 *
See also references of WO9738683A1 *
TABATABAIE TAHEREH ET AL: "In vivo trapping of nitric oxide in the brain of neonatal rats treated with the HIV-1 envelope protein gp 120: Protective effects of alpha-phenyl-tert-butylnitrone.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 221, no. 2, 1996, pages 386 - 390, XP000991161, ISSN: 0006-291X *
THOMAS, CRAIG E. ET AL: "In vitro and in vivo activity of a novel series of radical trapping agents in model systems of CNS oxidative damage", ANN. N. Y. ACAD. SCI. ( 1994 ), 738(NEUROBIOLOGY OF NO.BUL. AND.BUL.OH), 243-249, 1994, XP000992143 *
YUE, TIAN LI ET AL: "Neuroprotective effects of phenyl-t-butyl-nitrone in gerbil global brain ischemia and in cultured rat cerebellar neurons", BRAIN RES. ( 1992 ), 574(1-2), 193-7, 1992, XP000992139 *

Also Published As

Publication number	Publication date
CA2251800A1 (en)	1997-10-23
EP0949915A1 (en)	1999-10-20
AU725432B2 (en)	2000-10-12
WO1997038683A1 (en)	1997-10-23
NZ332315A (en)	2000-03-27
AU2460697A (en)	1997-11-07

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DE3875016D1 (en)	1992-11-05	THERAPEUTIC FOR TREATING AIDS.
EP0949915A4 (en)	2001-07-04	TREATMENT OF AIDS-VIRUS (HIV-1) INFECTIVE DEGENSION WITH NITRONE-FREE RADICAL TRAP
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DE69108357D1 (en)	1995-04-27	Treatment of dilute acidic solutions.

Legal Events

Date	Code	Title	Description
1999-09-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1999-10-20	17P	Request for examination filed	Effective date: 19981027
1999-10-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
1999-10-20	AX	Request for extension of the european patent	Free format text: AL PAYMENT 19981113;LT PAYMENT 19981113;LV PAYMENT 19981113;RO PAYMENT 19981113;SI PAYMENT 19981113
2001-06-27	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 31/165 A, 7A 61K 31/135 B, 7A 61K 31/44 B
2001-07-04	A4	Supplementary search report drawn up and despatched	Effective date: 20010514
2001-07-04	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2002-01-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2002-03-06	18D	Application deemed to be withdrawn	Effective date: 20010802