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EP0831841A1 - Agents pour le traitement de dommages causes par des irradiations - Google Patents

Agents pour le traitement de dommages causes par des irradiations

Info

Publication number
EP0831841A1
EP0831841A1 EP96914004A EP96914004A EP0831841A1 EP 0831841 A1 EP0831841 A1 EP 0831841A1 EP 96914004 A EP96914004 A EP 96914004A EP 96914004 A EP96914004 A EP 96914004A EP 0831841 A1 EP0831841 A1 EP 0831841A1
Authority
EP
European Patent Office
Prior art keywords
group
methoxy
represent
alkaloids
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP96914004A
Other languages
German (de)
English (en)
Inventor
Wassyl Nowicky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0831841A1 publication Critical patent/EP0831841A1/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Definitions

  • the present invention relates to the use of phosphorus derivatives of alkaloids for the production of a medicament for the treatment of radiation damage.
  • AT-PS-377 988 and AT-PS-354 644 describe processes for the preparation of new phosphorus derivatives of alkaloids or of new salts of alkaloid derivatives of thiophosphoric acid. Such compounds have a pharmacological activity and can be used as cytostatics.
  • R 1 , R 2 and R 3 each independently represent H or methoxy, where R 1 and R * or R 2 and R 3 together can also represent a methylenedioxy group;
  • SPARE BLADE (RULE 26) Is ring system, R 6 -CH 3 and double bonds in position 1, 2 and / or 7, 8 may be present; or
  • R 6 and R 7 together with the C and N atoms to which they adhere form an optionally hydrogenated benzo or naphthoring system, which in turn can be substituted by methoxy, oxo, methyl or dioxymethyl groups, the CN -Binding in position 1, 2 may be absent and R 4 and R 5 are H;
  • R 1 represents 2H, -CH 2 -CH 2 -, H or -CH 2 -CH 2 C1;
  • X is 0 or N
  • REPLACEMENT BLA ⁇ (RULE 26) wherein n is 1, 2 or 3; m represents 1, 2 or 3; R 1 , R 2 and R 3 each independently mean hydrogen or methoxy, where R 1 and R 2 or R 2 and R 3 together can also represent a methylene dioxy group; R 4 represents hydrogen, hydroxy or methyl; and, if R 6 is hydrogen, R 5 and R 7 together form the group
  • A represents a monovalent or the equivalent part of a multivalent anion is disclosed in AT-PS 354 644.
  • reaction product of the alkaloids of Chelidonium aijus L. with thiophosphoric triaziridide is used for
  • REPLACEMENT BLADE (RULE 26) Provision of a drug used for the treatment or prophylaxis of radiation damage.
  • the medicaments produced according to the invention preferably consist of an aqueous solution of the alkaloid phosphorus derivatives used or their salts, optionally together with other auxiliaries known per se.
  • the drug according to the invention is preferably administered by injection, for example intraperitoneally, intramuscularly or intravenously, the dosage depending on the case and being related to the severity of the disease to be treated and the condition of the patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne l'utilisation de dérivés phosphoriques d'alcaloïdes, de formule générale (I), tels que divulgués dans AT-PS 377 988 ou dans AT-PS 354 644, pour la fabrication d'un médicament destiné au traitement ou à la prophylaxie de dommages causés par des irradiations.
EP96914004A 1995-06-01 1996-05-30 Agents pour le traitement de dommages causes par des irradiations Ceased EP0831841A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT0093695A AT407833B (de) 1995-06-01 1995-06-01 Mittel zur behandlung von strahlenschäden
AT936/95 1995-06-01
PCT/AT1996/000099 WO1996038154A1 (fr) 1995-06-01 1996-05-30 Agents pour le traitement de dommages causes par des irradiations

Publications (1)

Publication Number Publication Date
EP0831841A1 true EP0831841A1 (fr) 1998-04-01

Family

ID=3503254

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96914004A Ceased EP0831841A1 (fr) 1995-06-01 1996-05-30 Agents pour le traitement de dommages causes par des irradiations

Country Status (15)

Country Link
US (1) US5981512A (fr)
EP (1) EP0831841A1 (fr)
JP (1) JPH11505851A (fr)
KR (1) KR19990022036A (fr)
CN (1) CN1167423C (fr)
AT (1) AT407833B (fr)
AU (1) AU713853B2 (fr)
CA (1) CA2222539A1 (fr)
CZ (1) CZ290489B6 (fr)
DE (1) DE19680394D2 (fr)
NZ (1) NZ308024A (fr)
SK (1) SK282832B6 (fr)
UA (1) UA42842C2 (fr)
WO (1) WO1996038154A1 (fr)
ZA (1) ZA964387B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH695417A5 (de) * 2001-11-15 2006-05-15 Ddr Wassyl Nowicky Dipl Ing Verfahren zur Umsetzung von Alkaloiden.
EP1459753A1 (fr) 2003-03-18 2004-09-22 Nowicky, Wassyl, Dipl.-Ing. DDr. Dérivés quaternaires de chelidonine et d'alkaloides, procédé pour leur préparation et leur utilisation dans la préparation de médicaments
EP1833839A1 (fr) * 2004-09-20 2007-09-19 Wassyl Nowicky Derivies alcaloides quaternaires de chelidonium majus l
WO2014017046A1 (fr) 2012-07-23 2014-01-30 国立大学法人東京大学 Agent prophylactique et/ou thérapeutique pour une radiolésion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT354644B (de) * 1975-12-19 1980-01-25 Nowicky Wassili Verfahren zur herstellung von neuen salzen von alkaloidderivaten von thiophosphorsaeure
AT377988B (de) * 1976-06-28 1985-05-28 Nowicky Wassili Verfahren zur herstellung von neuen phosphorderivaten von alkaloiden
DE3128018A1 (de) * 1981-07-13 1983-04-07 Wassyl 1060 Wien Nowicky "verfahren zum diagnostizieren und fuer die therapeutische behandlung von tumoren und/oder infektioesen krankheiten verschiedenster art unter praeparativem einsatz von alkaloid-verbindungen bzw. deren salze"
US4970212A (en) * 1982-05-18 1990-11-13 Nowicky Wassili Method of treating human illnesses which compromise the ability to mount an effective immunological response
EP0326627A1 (fr) * 1988-02-01 1989-08-09 Vipont Pharmaceutical, Inc. Méthode pour l'inhibition de résorption d'os et libération de collagénase
US4735945A (en) * 1986-03-13 1988-04-05 Vipont Laboratories, Inc. Method for inhibiting bone resorption and collagenase release

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9638154A1 *

Also Published As

Publication number Publication date
KR19990022036A (ko) 1999-03-25
NZ308024A (en) 2000-08-25
SK162597A3 (en) 1998-05-06
AT407833B (de) 2001-06-25
CA2222539A1 (fr) 1996-12-05
CN1188412A (zh) 1998-07-22
AU5754996A (en) 1996-12-18
CZ374197A3 (cs) 1998-04-15
JPH11505851A (ja) 1999-05-25
ZA964387B (en) 1996-12-09
CN1167423C (zh) 2004-09-22
WO1996038154A1 (fr) 1996-12-05
US5981512A (en) 1999-11-09
AU713853B2 (en) 1999-12-09
CZ290489B6 (cs) 2002-08-14
ATA93695A (de) 2000-11-15
SK282832B6 (sk) 2002-12-03
DE19680394D2 (de) 2000-01-27
UA42842C2 (uk) 2001-11-15

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