EP0891353A4 - Inhibiteurs de farnesyle-proteine transferase - Google Patents

Inhibiteurs de farnesyle-proteine transferase

Info

Publication number: EP0891353A4
Authority: EP; European Patent Office
Prior art keywords: farnesyle; protein transferase; transferase inhibitors; inhibitors; protein
Prior art date: 1996-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97917669A

Other languages

German (de)

English (en)

Other versions

EP0891353A1 (fr

Inventor

Christopher J Dinsmore

Theresa M Williams

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-03

Filing date

1997-03-27

Publication date

2001-08-08

1996-07-09 Priority claimed from GBGB9616736.6A external-priority patent/GB9616736D0/en

1997-03-27 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1999-01-20 Publication of EP0891353A1 publication Critical patent/EP0891353A1/fr

2001-08-08 Publication of EP0891353A4 publication Critical patent/EP0891353A4/fr

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Ophthalmology & Optometry (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP97917669A 1996-04-03 1997-03-27 Inhibiteurs de farnesyle-proteine transferase Withdrawn EP0891353A4 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1477796P	1996-04-03	1996-04-03
US14777P		1996-04-03
GBGB9616736.6A GB9616736D0 (en)	1996-07-09	1996-07-09	Inhibitors of farnesyl-protein transferase
GB9616736		1996-08-09
PCT/US1997/005060 WO1997036892A1 (fr)	1996-04-03	1997-03-27	Inhibiteurs de farnesyle-proteine transferase

Publications (2)

Publication Number	Publication Date
EP0891353A1 EP0891353A1 (fr)	1999-01-20
EP0891353A4 true EP0891353A4 (fr)	2001-08-08

Family

ID=26309841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97917669A Withdrawn EP0891353A4 (fr)	1996-04-03	1997-03-27	Inhibiteurs de farnesyle-proteine transferase

Country Status (5)

Country	Link
EP (1)	EP0891353A4 (fr)
JP (1)	JP2000507581A (fr)
AU (1)	AU716153B2 (fr)
CA (1)	CA2250192A1 (fr)
WO (1)	WO1997036892A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU712504B2 (en) *	1996-01-30	1999-11-11	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US6297239B1 (en) *	1997-10-08	2001-10-02	Merck & Co., Inc.	Inhibitors of prenyl-protein transferase
US6436960B1 (en) *	1998-02-02	2002-08-20	Lg Chemical Ltd.	Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof
FR2780892B1 (fr) *	1998-07-08	2001-08-17	Sod Conseils Rech Applic	Utilisation d'inhibiteurs de prenyltransferases pour preparer un medicament destine a traiter les pathologies qui resultent de la fixation membranaire de la proteine g heterotrimerique
US7129359B2 (en)	2002-07-09	2006-10-31	National Health Research Institutes	Imidazolidinone compounds
US7259174B2 (en)	2004-05-25	2007-08-21	National Health Research Institutes	Imidazolidinone compounds
CN101573341A (zh)	2006-06-20	2009-11-04	惠氏公司	咪唑烷酮Kv1.5钾通道抑制剂
US8637560B2 (en)	2007-07-18	2014-01-28	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Imidazolidinone compounds, methods to inhibit deubiquitination and methods of treatment
US8518968B2 (en)	2009-12-04	2013-08-27	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Hydrazone and diacyl hydrazine compounds and methods of use
JP2014040374A (ja) *	2010-12-15	2014-03-06	Taisho Pharmaceutical Co Ltd	グリシントランスポーター阻害物質

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995009001A1 (fr) *	1993-09-30	1995-04-06	Merck & Co., Inc.	Inhibiteurs de farnesyl-proteine transferase
WO1995025092A1 (fr) *	1994-03-14	1995-09-21	Merck & Co., Inc.	Inhibiteurs de la proteine farnesyl-transferase
WO1996010034A2 (fr) *	1994-09-29	1996-04-04	Merck & Co., Inc.	Inhibiteurs de la transferase de proteines farnesylees exempts de thiol
WO1996030343A1 (fr) *	1995-03-29	1996-10-03	Merck & Co., Inc.	Inhibiteurs de farnesyl-proteine transferase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3020276A (en) *	1958-03-03	1962-02-06	Petrolite Corp	Cyclic amidines
US4661602A (en) *	1985-03-29	1987-04-28	G. D. Searle & Co.	Substituted alkyl imidazole derivatives
US4810800A (en) *	1986-05-06	1989-03-07	Merrell Dow Pharmaceuticals Inc.	Novel imidazole dopamine beta hydroxylase inhibitors

1997
- 1997-03-27 JP JP09535441A patent/JP2000507581A/ja active Pending
- 1997-03-27 AU AU25932/97A patent/AU716153B2/en not_active Ceased
- 1997-03-27 CA CA002250192A patent/CA2250192A1/fr not_active Abandoned
- 1997-03-27 EP EP97917669A patent/EP0891353A4/fr not_active Withdrawn
- 1997-03-27 WO PCT/US1997/005060 patent/WO1997036892A1/fr not_active Ceased

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995009001A1 (fr) *	1993-09-30	1995-04-06	Merck & Co., Inc.	Inhibiteurs de farnesyl-proteine transferase
WO1995025092A1 (fr) *	1994-03-14	1995-09-21	Merck & Co., Inc.	Inhibiteurs de la proteine farnesyl-transferase
WO1996010034A2 (fr) *	1994-09-29	1996-04-04	Merck & Co., Inc.	Inhibiteurs de la transferase de proteines farnesylees exempts de thiol
WO1996030343A1 (fr) *	1995-03-29	1996-10-03	Merck & Co., Inc.	Inhibiteurs de farnesyl-proteine transferase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GRAHAM,S.L.: "Inhibitors of protein farnesylation : a new approach to cancer chemotherapy", EXP.OPIN.THER.PATENTS, vol. 5, no. 12, December 1995 (1995-12-01), LONDON, pages 1269 - 1285, XP001000610 *
See also references of WO9736892A1 *
WILLIAMS T M ET AL: "COMMUNICATIONS TO THE EDITOR. N-ARYLPIPERAZINONE INHIBITORS OF FARNESYLTRANSFERASE: DISCOVERY AND BIOLOGICAL ACTIVITY", JOURNAL OF MEDICINAL CHEMISTRY,AMERICAN CHEMICAL SOCIETY. WASHINGTON,US, vol. 42, 1999, pages 3779 - 3784, XP000941686, ISSN: 0022-2623 *

Also Published As

Publication number	Publication date
AU716153B2 (en)	2000-02-17
EP0891353A1 (fr)	1999-01-20
AU2593297A (en)	1997-10-22
JP2000507581A (ja)	2000-06-20
WO1997036892A1 (fr)	1997-10-09
CA2250192A1 (fr)	1997-10-09

Publication	Publication Date	Title
EP0891350A4 (fr)	2001-01-17	Inhibiteurs de farnesyle-proteine transferase
EP0841919A4 (fr)	1999-02-24	Inhibiteurs de la farnesyle-proteine transferase
EP0777475A4 (fr)	1997-12-03	Inhibiteurs de la farnesyle-proteine transferase
EP0944388A4 (fr)	2001-08-16	Inhibiteurs de la farnesyl-proteine transferase
EP1011669A4 (fr)	2001-09-12	Inhibiteurs de la farnesyl-proteine transferase
EE9800262A (et)	1999-02-15	Farnesüül-proteiini transferaasi inhibiitorid
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
ID24076A (id)	2000-07-06	Inhibitor-inhibitor protein transferase farnesil
ATE546139T1 (de)	2012-03-15	Isoprentransferase proteine inhibitoren
EP0904080A4 (fr)	2001-08-01	Inhibiteurs de farnesyle-proteine transferase
EP0668856A4 (fr)	1995-11-22	Inhibiteurs de la farnesyle-proteine transferase.
BR9611724A (pt)	1999-06-01	Inibidor de quinase c de proteína
EE9700314A (et)	1998-06-15	Farnesüül-proteiini transferaasi inhibiitorid
EP1003374A4 (fr)	2000-05-31	Inhibiteurs de farnesyl-proteine transferase
EP0891360A4 (fr)	2002-05-15	Inhibiteurs de la farnesyl-proteine transferase
PT958287E (pt)	2002-12-31	Inibidores de sulfamida-metaloprotease
PT858464E (pt)	2003-08-29	Inibidores de trombina
EP1165082A4 (fr)	2002-06-12	Inhibiteurs de la prenyle-proteine transferase
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
PT927183E (pt)	2004-12-31	Inibidores espirociclicos de metaloproteases
PT956294E (pt)	2004-10-29	Inibidores da trombina
EP0783305A4 (fr)	1998-04-01	Inhibiteurs de farnesyle-proteine transferase
EP0891349A4 (fr)	2001-01-24	Inhibiteurs de farnesyl-proteine transferase
EP0812203A4 (fr)	1999-04-14	Inhibiteurs de geranylgeranyle-proteine transferase
EP0891352A4 (fr)	2001-08-16	Inhibiteurs de la farnesyl-proteine transferase

Legal Events

Date	Code	Title	Description
1998-12-04	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1999-01-20	17P	Request for examination filed	Effective date: 19981103
1999-01-20	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2001-08-08	A4	Supplementary search report drawn up and despatched	Effective date: 20010622
2001-08-08	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2002-04-10	18D	Application deemed to be withdrawn	Effective date: 20010911