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EP0855997A4 - Derives de formyle en tant que milieux de contraste non ioniques - Google Patents

Derives de formyle en tant que milieux de contraste non ioniques

Info

Publication number
EP0855997A4
EP0855997A4 EP96918506A EP96918506A EP0855997A4 EP 0855997 A4 EP0855997 A4 EP 0855997A4 EP 96918506 A EP96918506 A EP 96918506A EP 96918506 A EP96918506 A EP 96918506A EP 0855997 A4 EP0855997 A4 EP 0855997A4
Authority
EP
European Patent Office
Prior art keywords
contrast media
nonionic contrast
formyl derivatives
formyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96918506A
Other languages
German (de)
English (en)
Other versions
EP0855997A1 (fr
Inventor
Milos Sovak
Ronald C Terry
James Gordon Douglass Iii
Allen Seligson
Jason Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biophysica Foundation
Original Assignee
Biophysica Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biophysica Foundation filed Critical Biophysica Foundation
Publication of EP0855997A1 publication Critical patent/EP0855997A1/fr
Publication of EP0855997A4 publication Critical patent/EP0855997A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96918506A 1995-06-16 1996-06-13 Derives de formyle en tant que milieux de contraste non ioniques Withdrawn EP0855997A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49113595A 1995-06-16 1995-06-16
US491135 1995-06-16
PCT/US1996/010433 WO1997000240A1 (fr) 1995-06-16 1996-06-13 Derives de formyle en tant que milieux de contraste non ioniques

Publications (2)

Publication Number Publication Date
EP0855997A1 EP0855997A1 (fr) 1998-08-05
EP0855997A4 true EP0855997A4 (fr) 1998-10-07

Family

ID=23950938

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96918506A Withdrawn EP0855997A4 (fr) 1995-06-16 1996-06-13 Derives de formyle en tant que milieux de contraste non ioniques

Country Status (7)

Country Link
EP (1) EP0855997A4 (fr)
JP (1) JPH11502231A (fr)
KR (1) KR19990022943A (fr)
AU (1) AU6114396A (fr)
CA (1) CA2229664A1 (fr)
NO (1) NO975880L (fr)
WO (1) WO1997000240A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
US7250153B2 (en) * 2002-12-12 2007-07-31 Biophysica Research, Inc. Contrast media formulations having improved biological tolerance
CA2692646C (fr) * 2007-07-12 2014-09-09 Mikkel Thaning Produits de contraste
JP2011500531A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
US20100221191A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
JP2011500533A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
US20100221192A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
CN102271715A (zh) * 2009-01-09 2011-12-07 通用电气医疗集团股份有限公司 对比剂组合物
NZ605674A (en) 2010-07-12 2014-11-28 Ge Healthcare As X-ray imaging at low contrast agent concentrations and/or low dose radiation
US9474808B2 (en) 2010-12-21 2016-10-25 Ge Healthcare As Desalination of a composition comprising a contrast agent
EP2758319B1 (fr) 2011-09-21 2016-06-08 GE Healthcare AS Emballage de produits de contraste
CA2881852A1 (fr) * 2012-09-27 2014-04-03 Ge Healthcare As Preparation d'un compose intermediaire d'ioforminol
US11065201B2 (en) 2014-11-21 2021-07-20 Technical University Of Denmark Gel formulations for local drug release
WO2017198858A1 (fr) 2016-05-20 2017-11-23 Technical University Of Denmark Composition de marquage palpable
EP3982922A1 (fr) 2019-06-12 2022-04-20 Technical University of Denmark Formulations de disaccharides pour la libération contrôlée de médicaments

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
WO1994014478A1 (fr) * 1992-12-24 1994-07-07 Bracco S.P.A. Compositions aqueuses injectables utilisees pour le radiodiagnostic contenant des composes aromatiques iodes servant de substances de contraste aux rayons x

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4341756A (en) * 1980-01-31 1982-07-27 The Regents Of The University Of California Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001292A1 (de) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin Nichtionische 5-c-substituierte 2,4,6-trijod-isophthalsaeure-derivate
WO1994014478A1 (fr) * 1992-12-24 1994-07-07 Bracco S.P.A. Compositions aqueuses injectables utilisees pour le radiodiagnostic contenant des composes aromatiques iodes servant de substances de contraste aux rayons x

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9700240A1 *
Y. LIN ET AL.: "New nonionic Triiodated X-Ray Contrst Media ....", INVESTIGATIVE RADIOLOGY, vol. 29, - 1994, pages s275 - s277, XP002068744 *

Also Published As

Publication number Publication date
JPH11502231A (ja) 1999-02-23
EP0855997A1 (fr) 1998-08-05
CA2229664A1 (fr) 1997-01-03
MX9710220A (es) 1998-10-31
AU6114396A (en) 1997-01-15
KR19990022943A (ko) 1999-03-25
NO975880L (no) 1998-02-13
WO1997000240A1 (fr) 1997-01-03

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19971210

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Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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18W Application withdrawn

Withdrawal date: 20000817