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EP0717662A1 - Bouchon pouvant etre perce pour recipient a echantillon biologique - Google Patents

Bouchon pouvant etre perce pour recipient a echantillon biologique

Info

Publication number
EP0717662A1
EP0717662A1 EP95924125A EP95924125A EP0717662A1 EP 0717662 A1 EP0717662 A1 EP 0717662A1 EP 95924125 A EP95924125 A EP 95924125A EP 95924125 A EP95924125 A EP 95924125A EP 0717662 A1 EP0717662 A1 EP 0717662A1
Authority
EP
European Patent Office
Prior art keywords
cap
probe
skirt portion
side wall
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95924125A
Other languages
German (de)
English (en)
Inventor
Victor Daykin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samco Scientific LLC
Original Assignee
Samco Scientific LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samco Scientific LLC filed Critical Samco Scientific LLC
Publication of EP0717662A1 publication Critical patent/EP0717662A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Definitions

  • the present invention relates to a perforable sealing cap for biological specimen containers, particularly for use in automated sample accessioning equipment and automated clinical analyzers.
  • the present invention provides for a cap for sealing a biological sample tube for use in an automated analyzer.
  • the cap comprises a skirt portion forming the side wall of the cap and having thread members on the interior surface of the side wall, the skirt portion having an open top with ah inwardly extending rim.
  • the cap also includes a top portion of a flexible elastomeric material sealed to the skirt portion through engagement with the inwardly extending rim and closing off the open top of the skirt portion.
  • the flexible elastomeric material is selected to permit puncture by a needle or probe such that the hole formed by the puncture of the needle or probe permits passing of the needle or the probe therethrough and reseals after removal of the needle or probe.
  • the present invention provides for a cap for sealing a biological sample tube for use in automated sample accessioning equipment and automated clinical analyzers.
  • the cap comprises a skirt portion forming the side wall of the cap and having thread members on the interior surface of the side wall, the skirt portion having an open top with an inwardly extending rim.
  • the cap also includes a top portion of a flexible elastomeric material sealed to the skirt portion through engagement with the inwardly extending rim and closing off the open top of the skirt portion.
  • the flexible elastomeric material is selected to permit puncture by a needle or probe such that the hole formed by the puncture of the needle or probe permits passing of the needle or the probe therethrough and reseals after removal of the needle or probe.
  • the top portion also includes an upwardly extending sealing surface near the periphery of the top portion. The sealing surface defines a cavity to the interior thereof which may be sealed against the external environment when the sealing surface contacts a planar surface.
  • a sample tube for use in automated sample accessioning equipment and automated clinical analyzers.
  • the sample tube has generally cylindrical side wall with an open top and bottom and thread members provided on the exterior of the side wall near the top.
  • the tube further has a cone- shaped sample holding divider located in the interior of the tube intermediate the top and bottom.
  • the cone-shaped sample holding divider has an angular measurement to allow for a relatively small sample volume to be utilized such that a sample probe will be able to pick up the proper analysis volume from such relatively small sample volume.
  • Figure 1 is a perspective view of a preferred embodiment of a biological specimen tube having a first embodiment of a cap according to the present invention
  • Figure 2 is a side elevation view of the tube and cap of Figure 1;
  • Figure 3 is a side elevation view in cross- section of the cap of Figure 1;
  • Figure 4 is a perspective view of a biological specimen tube having a second embodiment of a cap according to the present invention.
  • Figure 5 is a side elevation view in cross- section of the cap and tube of Figure 4.
  • Figure 6 is a side elevation view in cross- section of the cap of Figure 4 secured to the tube;
  • Figure 7 is side elevation view in cross-section of an automated analyzer sample probe contacting the cap of Figure 4;
  • Figure 8 is a side elevation view in cross- section of an automated sample accessioning probe in contact with the cap of Figure 4.
  • FIG. 1 to 3 A first preferred embodiment of the closure cap of the present invention is illustrated in Figures 1 to 3 generally indicated by the numeral 10.
  • the closure cap 10 is shown in association with a sample tube 12 for use in a automated clinical chemistry analyzer.
  • Tube 12 is generally cylindrical in shape having side walls 14 and an open top 16 provided with thread members 18 on the exterior surface of the side wall 14 near the top.
  • Tube 12 illustrated in the figures is for use with a sample analyzer utilizing microsampling where the sample probe may not travel the full depth of the tube 12.
  • tube 12 is provided with a conical false bottom being a cone-shaped sample holding divider 20 located intermediate the top and bottom of the tube.
  • the sample holding divider 20 is preferably cone-shaped to allow for a relatively small sample volume to be utilized such that the probe will be able to pick up the proper analysis volume from even such relatively small sample volumes.
  • the angle A between the side wall and the cone-shaped sample holding divider is about 30° as this angle has been found to maximize the use of very small sample volumes with such analyzers.
  • Tube 12 may be of any suitable material which will not affect the sample so as to interfere with the analysis while being non-toxic such that the tube 12 may be disposed of by incineration.
  • the tube 12 is of a suitable thermoplastic material such as polypropylene, polyethylene or copolymers thereof.
  • Cap 10 has a first skirt portion 22 forming the side wall of the cap as is shown in Figure 3.
  • the skirt portion has thread members 24 on the interior surface of the side wall. Thread members 24 are complementary to the thread members 18 provided on the exterior of the tube 12.
  • the skirt portion 22 is provided with an inwardly extending rim 26 defining a relatively open top.
  • the skirt portion 22 on the exterior surface may be provided with knurls or serrations 28 which aid the user in gripping the cap 10 when placing the cap 10 on the tube 12 or removing the cap 10 from same.
  • the closure cap 10 is also provided with a top portion 30 sealed to the skirt portion 22 through engagement with the inwardly extending rim 26 thereby closing off the open top of the skirt portion 22.
  • a top portion 30 sealed to the skirt portion 22 through engagement with the inwardly extending rim 26 thereby closing off the open top of the skirt portion 22.
  • the underside of the top portion may be provided with a dimple 32 such that the thickness of the top portion is reduced in the area through which the probe will pass.
  • the closure cap 10 is also designed to be of low cost and constructed of non-toxic materials enabling the safe combustion without the generation of toxic by-products so that the sample tube and its contents may be destroyed by way of incineration upon completion of the testing.
  • the skirt portion 22 is molded or extruded from a suitable polymeric material, preferably a olefinic thermoplastic such as suitably stiff forms of polypropylene or polyethylene or copolymers thereof to provide for the necessary mechanical support. More preferably, the skirt portion is molded or extruded from a polypropylene or polypropylene polyethylene blend.
  • the top portion 30 is of a flexible elastomeric material, preferably a class 6 medical grade material which is acceptable for contact with biological specimens and will not alter the specimen.
  • Such material is a thermoplastic elastomer, preferably a butyl-based material, more preferably, an elastomeric butyl-based olefinic thermoplastic and is fused to the inwardly extended rim 26 of the skirt portion 22 during the manufacturing process of the cap.
  • the closure cap 10 is preferably produced by a two-step injection molding process.
  • the process comprises the steps of providing an adjustable double-faced reversible mold for two shot injection molding of a two component closure, the mold having a first cavity portion on one face to receive the first injection for the skirt portion and an adjoining cavity portion on the reverse second face in the mold to receive simultaneous second injection for the top portion.
  • the method involves injecting the polymer for the skirt portion, cooling the thus formed stiff skirt portion, resetting the mold by reversal and injecting the elastomeric material for the cap portion in fusing relation at interfaces with the first skirt portion, cooling the mold and ejecting the molded article.
  • FIG. 40 A second embodiment of the closure cap of the present invention particularly adapted for use with a closed sample accessioning system is illustrated in Figures 4 to 7 generally indicated by the numeral 40.
  • the cap 40 has a skirt portion 42 having an inwardly extending rim 4 . Attached to the inwardly extending rim 44 is a top portion 46.
  • the top portion 46 is provided with a upwardly extending sealing surface 48 to provide for a sealed cavity 50 when the cap is used with a closed sample accessioning system.
  • the cap 40 is used with a sample tube 52 having a cone-shaped sample holding divider 54 located intermediate the top and bottom.
  • the exterior surface of the side wall 56 near the top is provided with thread members 58 which are complementary to thread members 60 located on the interior of the skirt portion 42 of the cap 40.
  • the skirt portion 42 of the cap 40 may also be provided with a knurled surface for ease of gripping of the cap.
  • Figure 7 illustrates the use of the cap 40 of the present invention with a automated clinical analyzer.
  • the flexible elastomeric nature of the top portion 46 permits the stretching of the top portion 46 until such time as it reaches its break point at which point the probe 62 tears through the material of the top portion 46 and is passed through into the interior of the tube 52.
  • the hole produced in the top portion 46 seals around the walls of the probe 62.
  • the underside of the top portion 46 may be provided with a dimple 64 such that the thickness of the top portion 46 is reduced in the area through which the probe 62 will pass.
  • FIG. 8 illustrates the use of the closure cap 40 with a closed sample accessioning system.
  • closed sample accessioning systems utilize a sample transfer probe 70 for transferring a sample from a blood collection tube to the sample tube 52.
  • the probe 70 is generally provided with a cannula 72 having a first tip 74 for insertion into the blood collection tube, a second tip 76 for insertion into the sample tube 52 and a sealing plate 78 intermediate the tips 74 and 76 which seals against the sealing surface 48 to exclude any extraneous air from the sealed cavity 50.
  • the sample is transferred from the blood collection tube into the sample tube 52 through application of a differential pressure either by creating an increased positive pressure in the blood collection tube or a decreased negative pressure in the sample tube 52. In this way, the specimen may be transferred from the blood collection tube to the sample tube 52 without the necessity of human intervention, thereby reducing the exposure of the operator to contact with the potentially infectious biological specimen.
  • the top portion 46 may be formed such that it has a slightly convex-shape as is illustrated in figures. This convex-shaping has advantages especially during the withdrawal of the probe 70 as it allows the probe to be withdrawn from the cap with reduced friction.
  • the elastomeric material from which the top portion is formed preferably incorporates therein, a small proportion of an agent which allows for reduced friction such as, for example, a polyterfluorethylene (PTF) or similar such material.
  • PPF polyterfluorethylene

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Closures For Containers (AREA)

Abstract

L'invention concerne un bouchon (10) conçu pour fermer hermétiquement un tube à essai biologique destiné à être utilisé dans un analyseur automatisé. Le bouchon comporte une jupe (22) formant la paroi latérale de celui-ci, présentant des filets (24) sur sa surface intérieure, et comprenant un sommet ouvert doté d'un rebord (26) s'étendant vers l'intérieur. Il comprend également une partie supérieure (30) en matériau élastomère souple auto-étanchéifiant scellé à la jupe par emboîtement avec le rebord s'étendant vers l'intérieur. La partie supérieure peut également présenter, à proximité de sa périphérie, une surface d'étanchement s'étendant vers le haut (48) définissant une cavité qui peut être isolée de manière étanche à l'environnement extérieur lorsque ladite surface vient en contact avec une surface plane. L'invention porte également sur un tube à essai (12) qui présente une paroi latérale (14) généralement cylindrique doté d'un sommet ouvert (16) et d'un fond, des filets (19) étant prévus à l'extérieur de la paroi, à proximité du sommet. Le tube comprend également un élément de séparation conique (20) contenant l'échantillon situé à l'intérieur du tube, à mi-chemin entre le sommet et le fond.
EP95924125A 1994-06-14 1995-06-14 Bouchon pouvant etre perce pour recipient a echantillon biologique Withdrawn EP0717662A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA 2125811 CA2125811A1 (fr) 1994-06-14 1994-06-14 Bouchon perforable pour contenant d'echantillons biologiques
CA2125811 1994-06-14
PCT/CA1995/000344 WO1995034381A2 (fr) 1994-06-14 1995-06-14 Bouchon pouvant etre perce pour recipient a echantillon biologique

Publications (1)

Publication Number Publication Date
EP0717662A1 true EP0717662A1 (fr) 1996-06-26

Family

ID=4153810

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95924125A Withdrawn EP0717662A1 (fr) 1994-06-14 1995-06-14 Bouchon pouvant etre perce pour recipient a echantillon biologique

Country Status (3)

Country Link
EP (1) EP0717662A1 (fr)
CA (1) CA2125811A1 (fr)
WO (1) WO1995034381A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2326606A1 (es) * 2001-05-25 2009-10-15 Manuel Gonzalez Perez Recipiente para almacenamiento de material genetico y archivo historico de la familia.

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030582A (en) * 1998-03-06 2000-02-29 Levy; Abner Self-resealing, puncturable container cap
US7243689B2 (en) 2000-02-11 2007-07-17 Medical Instill Technologies, Inc. Device with needle penetrable and laser resealable portion and related method
BE1014096A3 (nl) * 2001-04-03 2003-04-01 Terumo Europ Nv Afsluitinrichting voor een verzamelbuisje of dergelijke.
US7798185B2 (en) 2005-08-01 2010-09-21 Medical Instill Technologies, Inc. Dispenser and method for storing and dispensing sterile food product
US6957752B2 (en) 2001-10-16 2005-10-25 Medical Instill Technologies, Inc. Dispenser with sealed chamber and one-way valve for providing metered amounts of substances
WO2004000100A2 (fr) 2002-06-19 2003-12-31 Medical Instill Technologies, Inc. Machine de remplissage sterile comprenant une station de remplissage par aiguille a l'interieur d'une chambre a faisceau d'electrons
PL375626A1 (en) 2002-09-03 2005-12-12 Medical Instill Technologies, Inc. Sealed containers and methods of making and filling same
USD533670S1 (en) 2002-09-03 2006-12-12 Medical Instill Technologies, Inc. Vial
USD561908S1 (en) 2002-09-03 2008-02-12 Medical Instill Technologies, Inc. Vial
USD485365S1 (en) 2002-09-03 2004-01-13 Medical Instill Technologies, Inc. Vial
USD522663S1 (en) 2002-09-03 2006-06-06 Medical Instill Technologies, Inc. Vial
EP1631496B1 (fr) 2003-04-28 2014-02-26 Medical Instill Technologies, Inc. Contenant a ensemble soupape pour le remplissage et la distribution de substances, et dispositif et procede pour le remplissage
US7810677B2 (en) 2004-12-04 2010-10-12 Medical Instill Technologies, Inc. One-way valve and apparatus and method of using the valve
EP2567132A4 (fr) 2010-05-07 2015-08-26 Alps Llc Vanne pour machine distributrice et procédé associé
ITMI20121793A1 (it) 2012-10-23 2014-04-24 Copan Italia Spa Elemento di chiusura di un contenitore per fluidi biologici
CN107629939B (zh) * 2016-07-18 2024-06-21 广州迪澳生物科技有限公司 一种样品处理装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE26912T1 (de) * 1979-11-02 1987-05-15 Labco Limited Blutentnahmevorrichtungen.
JPS61247459A (ja) * 1985-04-25 1986-11-04 テルモ株式会社 医療容器用栓体
US4967919A (en) * 1988-11-23 1990-11-06 Sherwood Medical Company Blood collection tube safety cap
JPH02212768A (ja) * 1989-02-13 1990-08-23 Terumo Corp 採液管
JPH0536364U (ja) * 1991-10-22 1993-05-18 東亜医用電子株式会社 検体容器

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9534381A3 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2326606A1 (es) * 2001-05-25 2009-10-15 Manuel Gonzalez Perez Recipiente para almacenamiento de material genetico y archivo historico de la familia.
ES2326606B1 (es) * 2001-05-25 2010-07-07 Manuel Gonzalez Perez Recipiente para almacenamiento de material genetico y archivo historico de la familia.

Also Published As

Publication number Publication date
WO1995034381A3 (fr) 1996-04-04
CA2125811A1 (fr) 1995-12-15
WO1995034381A2 (fr) 1995-12-21

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