EP0713391A4 - Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes - Google Patents

Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes

Info

Publication number: EP0713391A4
Authority: EP; European Patent Office
Prior art keywords: inhibiting; production; human immunodeficiency; immunodeficiency viruses; azaspiranes
Prior art date: 1993-07-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP94922684A

Other languages

German (de)

French (fr)

Other versions

EP0713391A1 (en

Inventor

Alison Mary Badger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-23

Filing date

1994-07-22

Publication date

1998-09-09

1994-07-22 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1996-05-29 Publication of EP0713391A1 publication Critical patent/EP0713391A1/en

1998-09-09 Publication of EP0713391A4 publication Critical patent/EP0713391A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EP94922684A 1993-07-23 1994-07-22 Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes Withdrawn EP0713391A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939315306A GB9315306D0 (en)	1993-07-23	1993-07-23	Methods
GB9315306		1993-07-23
PCT/US1994/008275 WO1995003041A1 (en)	1993-07-23	1994-07-22	Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes

Publications (2)

Publication Number	Publication Date
EP0713391A1 EP0713391A1 (en)	1996-05-29
EP0713391A4 true EP0713391A4 (en)	1998-09-09

Family

ID=10739328

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP94922684A Withdrawn EP0713391A4 (en)	1993-07-23	1994-07-22	Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes

Country Status (8)

Country	Link
EP (1)	EP0713391A4 (en)
CN (1)	CN1130870A (en)
AU (1)	AU7370894A (en)
CA (1)	CA2167841A1 (en)
GB (1)	GB9315306D0 (en)
NZ (1)	NZ269990A (en)
WO (1)	WO1995003041A1 (en)
ZA (1)	ZA945416B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9315351D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315340D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
BR9601909A (en) *	1995-07-13	1999-10-13	Smithkline Beecham Corp	N, n-diethyl-8,8-dipropyl-2-azaspiro (4,5) decane-2-propan amine dimaleate
AU710542B2 (en) *	1996-05-17	1999-09-23	Anormed Inc.	Use of substituted azaspirane in the treatment of asthma
TW574036B (en)	1998-09-11	2004-02-01	Elan Pharm Inc	Stable liquid compositions of botulinum toxin

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992014462A1 (en) *	1991-02-19	1992-09-03	Smithkline Beecham Corporation	Cytokine inhibitors
WO1993014760A2 (en) *	1992-01-28	1993-08-05	Smithkline Beecham Corporation	Methods
WO1993015735A1 (en) *	1992-01-28	1993-08-19	Smithkline Beecham Corporation	(non descriptive)-a method for delaying hiv individual aids by administration of substituted azaspirane compounds
WO1995003049A1 (en) *	1993-07-23	1995-02-02	Smithkline Beecham Corporation	Methods of treating hiv with azaspiranes
WO1995003042A1 (en) *	1993-07-23	1995-02-02	Smithkline Beecham Corporation	Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes
WO1995003046A1 (en) *	1993-07-23	1995-02-02	Smithkline Beecham Corporation	A method of inhibiting the production of hiv

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4963557A (en) *	1987-09-28	1990-10-16	Smithkline Beecham Corporation	Immunomodulatory azaspiranes

1993
- 1993-07-23 GB GB939315306A patent/GB9315306D0/en active Pending
1994
- 1994-07-22 AU AU73708/94A patent/AU7370894A/en not_active Abandoned
- 1994-07-22 EP EP94922684A patent/EP0713391A4/en not_active Withdrawn
- 1994-07-22 CN CN94193372A patent/CN1130870A/en active Pending
- 1994-07-22 CA CA002167841A patent/CA2167841A1/en not_active Abandoned
- 1994-07-22 WO PCT/US1994/008275 patent/WO1995003041A1/en not_active Ceased
- 1994-07-22 NZ NZ269990A patent/NZ269990A/en unknown
- 1994-07-22 ZA ZA945416A patent/ZA945416B/en unknown

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992014462A1 (en) *	1991-02-19	1992-09-03	Smithkline Beecham Corporation	Cytokine inhibitors
WO1993014760A2 (en) *	1992-01-28	1993-08-05	Smithkline Beecham Corporation	Methods
WO1993015735A1 (en) *	1992-01-28	1993-08-19	Smithkline Beecham Corporation	(non descriptive)-a method for delaying hiv individual aids by administration of substituted azaspirane compounds
WO1995003049A1 (en) *	1993-07-23	1995-02-02	Smithkline Beecham Corporation	Methods of treating hiv with azaspiranes
WO1995003042A1 (en) *	1993-07-23	1995-02-02	Smithkline Beecham Corporation	Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes
WO1995003046A1 (en) *	1993-07-23	1995-02-02	Smithkline Beecham Corporation	A method of inhibiting the production of hiv

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BADGER A M ET AL: "ANTIARTHRITIC AND SUPPRESSOR CELL INDUCING ACTIVITY OF AZASPIRANES:STRUCTURE-FUNCTION RELATIONSHIPS OF A NOVEL CLASS OF IMMUNOMODULATORY AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 11, November 1990 (1990-11-01), pages 2963 - 2970, XP000605424 *
P.S. SARIN ET AL.: "INHIBITION OF HTLV-III REPLICATION IN CELL CULTURES", NATO ASI SER., SER. A, vol. 120, 1986, pages 329 - 342, XP002069579 *
S. GOODMAN: "THERAPEUTIC EFFECTS OF ORGANIC GERMANIUM", MEDICAL HYPOTHESES, vol. 26, 1988, pages 207 - 215, XP002069578 *
See also references of WO9503041A1 *

Also Published As

Publication number	Publication date
CN1130870A (en)	1996-09-11
NZ269990A (en)	1999-07-29
CA2167841A1 (en)	1995-02-02
ZA945416B (en)	1995-05-10
AU7370894A (en)	1995-02-20
EP0713391A1 (en)	1996-05-29
GB9315306D0 (en)	1993-09-08
WO1995003041A1 (en)	1995-02-02

Publication	Publication Date	Title
EP0740682A4 (en)	1997-08-20	Process for forming integral skin micorcellular structures
GB2246345B (en)	1994-02-09	Process for the recovery of titanium values
AU7680891A (en)	1991-10-30	The method of inhibiting discoloration of produce
SG46689A1 (en)	1998-02-20	Process for the preparation of 2-h-heptafluoropropane
KR970000398B1 (en)	1997-01-09	Process for the preparation of 1,1,1,2-tetrafluoro-2-chloroethan and pentafluorethane
ZW9893A1 (en)	1993-09-15	The production of stainless steel
EP0713391A4 (en)	1998-09-09	Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes
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EP0635481A3 (en)	1996-07-17	Process for the preparation of fluoronitrobenzenes.
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EP0635486A3 (en)	1996-08-07	Process for the preparation of fluorobenzonitriles.
EP0717622A4 (en)	1998-09-09	Methods of treating hiv with azaspiranes
SG45344A1 (en)	1998-01-16	Process for the hydrocycarbonylation of lactones
HK1012278A (en)	1999-07-30	Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes
EP0641764A3 (en)	1996-03-27	Process for the preparation of hydroxyalkylaminonitrobenzene derivatives.
FI953617L (en)	1995-07-28	Process for the preparation of substituted 4-hydroxycoumarins
GB9302184D0 (en)	1993-03-24	Improvements relating to the formation of cartosn
ZA94949B (en)	1994-08-25	The production of cadmium
GB9325344D0 (en)	1994-02-16	Production of membranes
HK1012280A (en)	1999-07-30	Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes

Legal Events

Date	Code	Title	Description
1996-04-12	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1996-05-29	17P	Request for examination filed	Effective date: 19960201
1996-05-29	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1996-05-29	AX	Request for extension of the european patent	Free format text: SI PAYMENT 960201
1996-05-29	RAX	Requested extension states of the european patent have changed	Free format text: SI PAYMENT 960201
1998-09-09	A4	Supplementary search report drawn up and despatched	Effective date: 19980722
1998-09-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1999-07-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-08-18	18D	Application deemed to be withdrawn	Effective date: 19990203
2006-03-03	REG	Reference to a national code	Ref country code: HK Ref legal event code: WD Ref document number: 1012278 Country of ref document: HK